ID

45172

Beschreibung

Principal Investigator: Sharon Kardia, PhD, University of Michigan, Department of Epidemiology, Ann Arbor, MI, USA MeSH: Peripheral Arterial Disease,Coronary Atherosclerosis,Leukoaraiosis,Kidney Diseases https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000379 *The Genetic Epidemiology Network of Arteriopathy (GENOA):* GENOA is one of four research networks that form the NHLBI Family Blood Pressure Program (FBPP). From its inception in 1995, GENOA's long-term objective was to elucidate the genetics of hypertension and its arteriosclerotic target-organ damage, including both atherosclerotic (macrovascular) and arteriolosclerotic (microvascular) complications involving the heart, brain, kidneys, and peripheral arteries. Two GENOA cohorts were originally ascertained (1995-2000) through sibships in which at least 2 siblings had essential hypertension diagnosed prior to age 60 years. All siblings in the sibship were invited to participate, both normotensive and hypertensive. These include non-Hispanic White Americans from Rochester, MN (n =1583 at the 1st exam) and African Americans from Jackson, MS (N=1854 at the 1st exam). During the second exam (2000-2005), approximately 80% of participants were re-recruited. The GENOA data consists of biological samples (DNA, serum, urine) as well as demographic, anthropometric, environmental, clinical, biochemical, physiological, and genetic data for understanding the genetic predictors of diseases of the heart, brain, kidney, and peripheral arteries. *Family Blood Pressure Program (FBPP):* GENOA's parent program, the FBPP, is an unprecedented collaboration to identify genes influencing blood pressure (BP) levels, hypertension, and its target-organ damage. This program has conducted over 21,000 physical examinations, assembled a shared database of several hundred BP and hypertension-related phenotypic measurements, completed genome-wide linkage analyses for BP, hypertension, and hypertension associated risk factors and complications, and published over 130 manuscripts on program findings. The FBPP emerged from what was initially funded as four independent networks of investigators (HyperGEN, GenNet, SAPPHIRe and GENOA) competing to identify genetic determinants of hypertension in multiple ethnic groups. Realizing the greater likelihood of success through collaboration, the investigators began working together during the first funding cycle (1995-2000) and formalized this arrangement in the second cycle (2000-2005), creating a single confederation with program-wide and network-specific goals.

Link

dbGaP study = phs000379

Stichworte

Versionen (2)
  1. 22.08.22 22.08.22 - Niko Möller-Grell
  2. 12.10.22 12.10.22 - Adrian Schulz
Rechteinhaber

Sharon Kardia, PhD, University of Michigan, Department of Epidemiology, Ann Arbor, MI, USA

Hochgeladen am

12. Oktober 2022

DOI

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Lizenz

Creative Commons BY 4.0
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dbGaP phs000379 Genetic Epidemiology Network of Arteriopathy (GENOA)

Englisch

Eligibility Criteria

1 Formulare  
  1. StudyEvent: SEV1
    1. Eligibility Criteria
Inclusion and exclusion criteria
Beschreibung

Inclusion and exclusion criteria

Two GENOA cohorts were originally ascertained (1995-2000) through sibships in which at least 2 siblings had essential hypertension diagnosed prior to age 60 years. All siblings in the sibship were invited to participate, both normotensive and hypertensive. These include non-Hispanic White Americans from Rochester, MN (n =1583 at the 1st exam) and African Americans from Jackson, MS (N=1854 at the 1st exam). During the second exam (2000-2005), approximately 80% of participants were re-recruited.
Beschreibung

Elig.phs000379.v1.p1.1

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0205448
UMLS CUI [1,2]
C0037047
UMLS CUI [1,3]
C0085580
Individuals in GENOA belong to sibships identified in which at least two siblings had essential hypertension diagnosed prior to 60 years of age. *After identification of the initial pairs of hypertensive siblings, *all siblings* in the sibship were invited to participate regardless of hypertension status.*
Beschreibung

Elig.phs000379.v1.p1.2

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0205448
UMLS CUI [1,2]
C0037047
UMLS CUI [1,3]
C0085580
*Hypertension case definition:* Essential hypertension diagnosed prior to age 60 years of age, defined as: 1) average of the last 2 out of 3 systolic BP readings ≥ 140mmHg, or 2) an average of the last 2 out of 3 diastolic BP readings ≥ 90 mmHg, or 3) previous diagnosis of hypertension and antihypertensive medication prescribed by a physician to be taken daily during the last month.
Beschreibung

Elig.phs000379.v1.p1.3

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0085580
*Exclusion criteria:* Pregnancy or breast feeding, Type I diabetes mellitus (juvenile onset, insulin dependent), diagnosis of hypertension ≥ 60 yrs of age, or secondary causes of hypertension including but not limited to prior knowledge of renal parenchymal disease or serum creatinine ≥ 2.5 mg/dL, renal vascular disease, primary aldosteronism, pheochromocytoma, coarctation of aorta, hypertension associated with current use of oral contraceptive agents, prescription or non-prescription drugs, or active alcohol abuse.
Beschreibung

Elig.phs000379.v1.p1.4

Datentyp

boolean

Alias
UMLS CUI [1,1]
C0032961
UMLS CUI [2,1]
C0006147
UMLS CUI [3,1]
C0011854
UMLS CUI [4,1]
C0155616
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Eligibility Criteria

1 Formulare
  1. StudyEvent: SEV1
    1. Eligibility Criteria
Name
Typ
Description | Question | Decode (Coded Value)
Datentyp
Alias
Item Group
Inclusion and exclusion criteria
Elig.phs000379.v1.p1.1
Item
Two GENOA cohorts were originally ascertained (1995-2000) through sibships in which at least 2 siblings had essential hypertension diagnosed prior to age 60 years. All siblings in the sibship were invited to participate, both normotensive and hypertensive. These include non-Hispanic White Americans from Rochester, MN (n =1583 at the 1st exam) and African Americans from Jackson, MS (N=1854 at the 1st exam). During the second exam (2000-2005), approximately 80% of participants were re-recruited.
boolean
C0205448 (UMLS CUI [1,1])
C0037047 (UMLS CUI [1,2])
C0085580 (UMLS CUI [1,3])
Elig.phs000379.v1.p1.2
Item
Individuals in GENOA belong to sibships identified in which at least two siblings had essential hypertension diagnosed prior to 60 years of age. *After identification of the initial pairs of hypertensive siblings, *all siblings* in the sibship were invited to participate regardless of hypertension status.*
boolean
C0205448 (UMLS CUI [1,1])
C0037047 (UMLS CUI [1,2])
C0085580 (UMLS CUI [1,3])
Elig.phs000379.v1.p1.3
Item
*Hypertension case definition:* Essential hypertension diagnosed prior to age 60 years of age, defined as: 1) average of the last 2 out of 3 systolic BP readings ≥ 140mmHg, or 2) an average of the last 2 out of 3 diastolic BP readings ≥ 90 mmHg, or 3) previous diagnosis of hypertension and antihypertensive medication prescribed by a physician to be taken daily during the last month.
boolean
C0085580 (UMLS CUI [1,1])
Elig.phs000379.v1.p1.4
Item
*Exclusion criteria:* Pregnancy or breast feeding, Type I diabetes mellitus (juvenile onset, insulin dependent), diagnosis of hypertension ≥ 60 yrs of age, or secondary causes of hypertension including but not limited to prior knowledge of renal parenchymal disease or serum creatinine ≥ 2.5 mg/dL, renal vascular disease, primary aldosteronism, pheochromocytoma, coarctation of aorta, hypertension associated with current use of oral contraceptive agents, prescription or non-prescription drugs, or active alcohol abuse.
boolean
C0032961 (UMLS CUI [1,1])
C0006147 (UMLS CUI [2,1])
C0011854 (UMLS CUI [3,1])
C0155616 (UMLS CUI [4,1])
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