ID
45163
Beschreibung
Principal Investigator: Dwight Stambolian, University of Pennsylvania, Philadelphia, PA, USA MeSH: Refractive Errors,Astigmatism,Myopia,Hyperopia https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000303 KORA ("Kooperative Gesundheitsforschung in der Region Augsburg" which translates as "Cooperative Health Research in the Region of Augsburg") is a population based study of adults randomly selected from 430,000 inhabitants living in Augsburg and 16 surrounding counties in Germany. The collection was done in 4 separate groups from 1984-2001 (S1-S4). One of the KORA groups, S3/F3, will be utilized for our GWAS because it is the only group with refractive error (RE) measurements. Consequent to informed consent, each of the surveys sampled subjects from ten strata according to age (range 25-74 years) and sex (equal ratio) with a minimum stratum size of 400 subjects. In the KORA S3 study 4,856 subjects were studied between 1994 and 1995, and 3,006 individuals from S3 returned for follow up between 2003 and 2005 (S3/F3). For this refractive error study, we are including 1,981 subjects from S3/F3 (mean age 55.7, range 35-84). For each subject, eyeglass prescriptions were measured in addition to an evaluation by the Nikon Retinomax. Subjects with predisposing medical conditions, i.e., connective tissue disorders, and ocular conditions i.e., cataract and corneal opacities, that might predispose them to refractive error will not be included for genotyping. Whole genome association genotyping will be performed to determine common alleles that contribute to the variation of the quantitative trait of refractive error.
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Stichworte
Versionen (2)
- 8/25/22 8/25/22 - Simon Heim
- 10/12/22 10/12/22 - Adrian Schulz
Rechteinhaber
Dwight Stambolian, University of Pennsylvania, Philadelphia, PA, USA
Hochgeladen am
October 12, 2022
DOI
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Lizenz
Creative Commons BY 4.0
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dbGaP phs000303 Genetic Epidemiology of Refractive Error in the KORA Study
Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- This data table contains a listing of subjects, subject consent groups, and mapping of subject IDs to the subject IDs of the source repository (KORA).
- The data table contains mapping of study subject IDs to sample IDs, and sample IDs to sample IDs of the source repository (KORA).
- This is a subject phenotype table including sociodemography variables, i.e., sex, years of education and age, and optical measurements, such as axis, sphere, cylinder, refractive error, and spherical equivalent.
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Eligibility Criteria
- StudyEvent: SEV1
- Eligibility Criteria
- This data table contains a listing of subjects, subject consent groups, and mapping of subject IDs to the subject IDs of the source repository (KORA).
- The data table contains mapping of study subject IDs to sample IDs, and sample IDs to sample IDs of the source repository (KORA).
- This is a subject phenotype table including sociodemography variables, i.e., sex, years of education and age, and optical measurements, such as axis, sphere, cylinder, refractive error, and spherical equivalent.
C0086543 (UMLS CUI [1,2])
C0024437 (UMLS CUI [1,3])
C0035334 (UMLS CUI [1,4])
C0242225 (UMLS CUI [1,5])
C0262477 (UMLS CUI [1,6])
C1744681 (UMLS CUI [1,7])
C2095814 (UMLS CUI [1,8])
C0336564 (UMLS CUI [1,9])
C4699186 (UMLS CUI [1,10])