ID

45157

Descrição

Principal Investigator: Alan Shuldiner, MD, University of Maryland Baltimore, Baltimore, MD, USA MeSH: Pharmacogenomics,Clopidogrel,Platelets https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000391 CHD is the leading cause of death in the United States. One of the most common ways to prevent CHD is to take an anti-platelet agent, which lessens platelet aggregation. Two of the most common anti-platelet agents are aspirin and clopidogrel. However, up to 25% to 30% of people do not respond to these medications. Evidence indicates that treatment response may be related to genetics. The purpose of this study is to determine specific gene variants that predict response to aspirin and clopidogrel therapy. This study is part of a larger group of studies called the Pharmacogenomics Research Network (PGRN). Participants are from the Old Order Amish of Lancaster, Pennsylvania. They are well suited for genetic studies because they are a homogenous, closed, founder population. Participants received 300 mg of clopidogrel on the first day, then 75 mg of clopidogrel per day for the next 6 days. On the last day of clopidogrel treatment, participants took a single dose of 324 mg aspirin. Participants underwent platelet function tests before and after clopidogrel alone, and then again after taking clopidogrel plus aspirin. Using the gene variation profiles across the genome, researchers analyzed which variants correspond to treatment response.

Link

dbGaP study = phs000391

Palavras-chave

Versões (2)
  1. 02/09/2022 02/09/2022 - Niko Möller-Grell
  2. 12/10/2022 12/10/2022 - Adrian Schulz
Titular dos direitos

Alan Shuldiner, MD, University of Maryland Baltimore, Baltimore, MD, USA

Transferido a

12 de outubro de 2022

DOI

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Licença

Creative Commons BY 4.0
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dbGaP phs000391 Pharmacogenomics of Anti-Platelet Intervention (PAPI) Study

Inglês

Subject ID, age, sex, body mass index, systolic and diastolic blood pressure, waist circumference, fasting triglycerides, total cholesterol, LHD, HDL, baseline whole blood max aggregation of ADP, of arachidonic acid, and collagen 1, post plavix/pre aspirin whole blood max aggregation of ADP, of arachadonic acid, and collagen 1, baseline platelet rich plasma max aggregation of ADP, of collagen 2, of Epi, and arachadonic acid, post plavix/pre aspirin platelet rich plasma max aggregation of ADP, of Epi, and arachadonic acid, post plavix/post aspirin platelet rich plasma max aggregation of ADP, of collagen 2, of Epi, of arachadonic acid obtained from participants involved in the "Determining Genetic Role in Treatment Response to Anti-Platelet Interventions (The PAPI Study)" project.

4 Formulários  
pht002996
Descrição

pht002996

De-identified subject ID
Descrição

Assigned

Tipo de dados

string

Alias
UMLS CUI [1,1]
C4684638
UMLS CUI [1,2]
C2348585
Age participant began study (clinic visit 1)
Descrição

Collected at consent visit

Tipo de dados

text

Unidades de medida
  • Years
Alias
UMLS CUI [1,1]
C0001779
UMLS CUI [1,2]
C0439659
UMLS CUI [1,3]
C5418626
Years
Gender of participant
Descrição

Collected at consent visit

Tipo de dados

text

Alias
UMLS CUI [1,1]
C0079399
Body mass index of participant, calculated from measured height and weight
Descrição

Collected at first clinic visit

Tipo de dados

text

Unidades de medida
  • kg/m2
Alias
UMLS CUI [1,1]
C1305855
kg/m2
Systolic blood pressure of participant, calculated from three measurements
Descrição

Collected at first clinic visit

Tipo de dados

text

Unidades de medida
  • mmHg
Alias
UMLS CUI [1,1]
C0871470
mmHg
Diastolic blood pressure of participant, calculated from three measurements
Descrição

Collected at first clinic visit

Tipo de dados

text

Unidades de medida
  • mmHg
Alias
UMLS CUI [1,1]
C0428883
mmHg
Waist circumference of participant
Descrição

Collected at first clinic visit

Tipo de dados

float

Unidades de medida
  • cm
Alias
UMLS CUI [1,1]
C0455829
cm
Fasting triglycerides, measured by Quest diagnostics
Descrição

Collected at first clinic visit

Tipo de dados

text

Unidades de medida
  • mg/dl
Alias
UMLS CUI [1,1]
C0583331
mg/dl
Fasting total cholesterol, measured by Quest diagnostics
Descrição

Collected at first clinic visit

Tipo de dados

text

Unidades de medida
  • mg/dl
Alias
UMLS CUI [1,1]
C0543421
mg/dl
Fasting hdl cholesterol, measured by Quest diagnostics
Descrição

Collected at first clinic visit

Tipo de dados

text

Unidades de medida
  • mg/dl
Alias
UMLS CUI [1,1]
C1318353
mg/dl
Fasting ldl cholesterol, measured by Quest diagnostics
Descrição

Collected at first clinic visit

Tipo de dados

text

Unidades de medida
  • mg/dl
Alias
UMLS CUI [1,1]
C0582830
mg/dl
Baseline whole blood max aggregation of ADP 20 ug/ml
Descrição

Collected at first clinic visit

Tipo de dados

text

Unidades de medida
  • ohms
Alias
UMLS CUI [1,1]
C1978977
ohms
Baseline whole blood max aggregation of arachidonic acid
Descrição

Collected at first clinic visit

Tipo de dados

text

Unidades de medida
  • ohms
Alias
UMLS CUI [1,1]
C1268820
ohms
Baseline whole blood max aggregation of collagen 1 ug/ml
Descrição

Collected at first clinic visit

Tipo de dados

text

Unidades de medida
  • ohms
Alias
UMLS CUI [1,1]
C0369863
ohms
Post plavix/pre aspirin whole blood max aggregation of ADP 20 ug/ml
Descrição

Collected at second clinic visit

Tipo de dados

text

Unidades de medida
  • ohms
Alias
UMLS CUI [1,1]
C0231290
UMLS CUI [1,2]
C3469597
UMLS CUI [1,3]
C0633084
UMLS CUI [1,4]
C1978977
UMLS CUI [1,5]
C0439565
UMLS CUI [1,6]
C0004057
UMLS CUI [1,7]
C1978977
ohms
Post plavix/pre aspirin whole blood max aggregation of arachidonic acid
Descrição

Collected at second clinic visit

Tipo de dados

text

Unidades de medida
  • ohms
Alias
UMLS CUI [1,1]
C0231290
UMLS CUI [1,2]
C3469597
UMLS CUI [1,3]
C0633084
UMLS CUI [1,4]
C0439565
UMLS CUI [1,5]
C0004057
UMLS CUI [1,6]
C1268820
ohms
Post plavix/pre aspirin whole blood max aggregation of collagen 1 ug/ml
Descrição

Collected at second clinic visit

Tipo de dados

text

Unidades de medida
  • ohms
Alias
UMLS CUI [1,1]
C0231290
UMLS CUI [1,2]
C3469597
UMLS CUI [1,3]
C0633084
UMLS CUI [1,4]
C0439565
UMLS CUI [1,5]
C0004057
UMLS CUI [1,6]
C0369863
ohms
Post plavix/post aspirin whole blood max aggregation of ADP 20 ug/ml
Descrição

Collected at second clinic visit

Tipo de dados

text

Unidades de medida
  • ohms
Alias
UMLS CUI [1,1]
C0231290
UMLS CUI [1,2]
C3469597
UMLS CUI [1,3]
C0633084
UMLS CUI [1,4]
C0231290
UMLS CUI [1,5]
C3469597
UMLS CUI [1,6]
C0004057
UMLS CUI [1,7]
C1978977
ohms
Post plavix/post aspirin whole blood max aggregation of arachidonic acid
Descrição

Collected at second clinic visit

Tipo de dados

text

Unidades de medida
  • ohms
Alias
UMLS CUI [1,1]
C0231290
UMLS CUI [1,2]
C3469597
UMLS CUI [1,3]
C0633084
UMLS CUI [1,4]
C0231290
UMLS CUI [1,5]
C3469597
UMLS CUI [1,6]
C0004057
UMLS CUI [1,7]
C1268820
ohms
Post plavix/post aspirin whole blood max aggregation of collagen 1 ug/ml
Descrição

Collected at second clinic visit

Tipo de dados

text

Unidades de medida
  • ohms
Alias
UMLS CUI [1,1]
C0231290
UMLS CUI [1,2]
C3469597
UMLS CUI [1,3]
C0633084
UMLS CUI [1,4]
C0231290
UMLS CUI [1,5]
C3469597
UMLS CUI [1,6]
C0004057
UMLS CUI [1,7]
C0369863
ohms
Baseline platelet rich plasma max aggregation of ADP 20 ug/ml
Descrição

Collected at first clinic visit

Tipo de dados

text

Unidades de medida
  • %
Alias
UMLS CUI [1,1]
C1978977
%
Baseline platelet rich plasma max aggregation of collagen 2 ug/ml
Descrição

Collected at first clinic visit

Tipo de dados

text

Unidades de medida
  • %
Alias
UMLS CUI [1,1]
C5177543
%
Baseline platelet rich plasma max aggregation of Epi
Descrição

Collected at first clinic visit

Tipo de dados

text

Unidades de medida
  • %
Alias
UMLS CUI [1,1]
C5177548
%
Baseline platelet rich plasma max aggregation of arachidonic acid
Descrição

Collected at first clinic visit

Tipo de dados

text

Unidades de medida
  • %
Alias
UMLS CUI [1,1]
C5177539
%
Post plavix/pre aspirin platelet rich plasma max aggregation of ADP 20 ug/ml
Descrição

Collected at second clinic visit

Tipo de dados

text

Unidades de medida
  • %
Alias
UMLS CUI [1,1]
C0231290
UMLS CUI [1,2]
C3469597
UMLS CUI [1,3]
C0633084
UMLS CUI [1,4]
C0439565
UMLS CUI [1,5]
C0004057
UMLS CUI [1,6]
C5177535
%
Post plavix/pre aspirin platelet rich plasma max aggregation of collagen 2 ug/ml
Descrição

Collected at second clinic visit

Tipo de dados

text

Unidades de medida
  • %
Alias
UMLS CUI [1,1]
C0231290
UMLS CUI [1,2]
C3469597
UMLS CUI [1,3]
C0633084
UMLS CUI [1,4]
C0439565
UMLS CUI [1,5]
C0004057
UMLS CUI [1,6]
C5177543
%
Post plavix/pre aspirin platelet rich plasma max aggregation of Epi
Descrição

Collected at second clinic visit

Tipo de dados

text

Unidades de medida
  • %
Alias
UMLS CUI [1,1]
C0231290
UMLS CUI [1,2]
C3469597
UMLS CUI [1,3]
C0633084
UMLS CUI [1,4]
C0439565
UMLS CUI [1,5]
C0004057
UMLS CUI [1,6]
C5177548
%
Post plavix/pre aspirin platelet rich plasma max aggregation of arachidonic acid
Descrição

Collected at second clinic visit

Tipo de dados

text

Unidades de medida
  • %
Alias
UMLS CUI [1,1]
C0231290
UMLS CUI [1,2]
C3469597
UMLS CUI [1,3]
C0633084
UMLS CUI [1,4]
C0439565
UMLS CUI [1,5]
C0004057
UMLS CUI [1,6]
C5177539
%
Post plavix/post aspirin platelet rich plasma max aggregation of ADP 20 ug/ml
Descrição

Collected at second clinic visit

Tipo de dados

text

Unidades de medida
  • %
Alias
UMLS CUI [1,1]
C0231290
UMLS CUI [1,2]
C3469597
UMLS CUI [1,3]
C0633084
UMLS CUI [1,4]
C0231290
UMLS CUI [1,5]
C3469597
UMLS CUI [1,6]
C0004057
UMLS CUI [1,7]
C1978977
%
Post plavix/post aspirin platelet rich plasma max aggregation of collagen 2 ug/ml
Descrição

Collected at second clinic visit

Tipo de dados

text

Unidades de medida
  • %
Alias
UMLS CUI [1,1]
C0231290
UMLS CUI [1,2]
C3469597
UMLS CUI [1,3]
C0633084
UMLS CUI [1,4]
C0231290
UMLS CUI [1,5]
C3469597
UMLS CUI [1,6]
C0004057
UMLS CUI [1,7]
C5177543
%
Post plavix/post aspirin platelet rich plasma max aggregation of Epi
Descrição

Collected at second clinic visit

Tipo de dados

text

Unidades de medida
  • %
Alias
UMLS CUI [1,1]
C0231290
UMLS CUI [1,2]
C3469597
UMLS CUI [1,3]
C0633084
UMLS CUI [1,4]
C0231290
UMLS CUI [1,5]
C3469597
UMLS CUI [1,6]
C0004057
UMLS CUI [1,7]
C5177548
%
Post plavix/post aspirin platelet rich plasma max aggregation of arachidonic acid
Descrição

Collected at second clinic visit

Tipo de dados

text

Unidades de medida
  • %
Alias
UMLS CUI [1,1]
C0231290
UMLS CUI [1,2]
C3469597
UMLS CUI [1,3]
C0633084
UMLS CUI [1,4]
C0231290
UMLS CUI [1,5]
C3469597
UMLS CUI [1,6]
C0004057
UMLS CUI [1,7]
C5177539
%
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Similar models

Subject ID, age, sex, body mass index, systolic and diastolic blood pressure, waist circumference, fasting triglycerides, total cholesterol, LHD, HDL, baseline whole blood max aggregation of ADP, of arachidonic acid, and collagen 1, post plavix/pre aspirin whole blood max aggregation of ADP, of arachadonic acid, and collagen 1, baseline platelet rich plasma max aggregation of ADP, of collagen 2, of Epi, and arachadonic acid, post plavix/pre aspirin platelet rich plasma max aggregation of ADP, of Epi, and arachadonic acid, post plavix/post aspirin platelet rich plasma max aggregation of ADP, of collagen 2, of Epi, of arachadonic acid obtained from participants involved in the "Determining Genetic Role in Treatment Response to Anti-Platelet Interventions (The PAPI Study)" project.

4 Formulários
Name
Tipo
Description | Question | Decode (Coded Value)
Tipo de dados
Alias
Item Group
pht002996
SUBJID
Item
De-identified subject ID
string
C4684638 (UMLS CUI [1,1])
C2348585 (UMLS CUI [1,2])
AGE
Item
Age participant began study (clinic visit 1)
text
C0001779 (UMLS CUI [1,1])
C0439659 (UMLS CUI [1,2])
C5418626 (UMLS CUI [1,3])
Item
Gender of participant
text
C0079399 (UMLS CUI [1,1])
SEX
Code List
Gender of participant
CL Item
Male (1)
CL Item
Female (2)
BodyMassIndex
Item
Body mass index of participant, calculated from measured height and weight
text
C1305855 (UMLS CUI [1,1])
SystolicBloodPressure
Item
Systolic blood pressure of participant, calculated from three measurements
text
C0871470 (UMLS CUI [1,1])
DiastolicBloodPressure
Item
Diastolic blood pressure of participant, calculated from three measurements
text
C0428883 (UMLS CUI [1,1])
waistCircumference
Item
Waist circumference of participant
float
C0455829 (UMLS CUI [1,1])
fastingTriglycerides
Item
Fasting triglycerides, measured by Quest diagnostics
text
C0583331 (UMLS CUI [1,1])
fastingTotalCholesterol
Item
Fasting total cholesterol, measured by Quest diagnostics
text
C0543421 (UMLS CUI [1,1])
fastingHDLCholesterol
Item
Fasting hdl cholesterol, measured by Quest diagnostics
text
C1318353 (UMLS CUI [1,1])
fastingLDLCholesterol
Item
Fasting ldl cholesterol, measured by Quest diagnostics
text
C0582830 (UMLS CUI [1,1])
preMaxAggrWholeBloodADP20
Item
Baseline whole blood max aggregation of ADP 20 ug/ml
text
C1978977 (UMLS CUI [1,1])
preMaxAggrWholeBloodAA
Item
Baseline whole blood max aggregation of arachidonic acid
text
C1268820 (UMLS CUI [1,1])
preMaxAggrWholeBloodColl1
Item
Baseline whole blood max aggregation of collagen 1 ug/ml
text
C0369863 (UMLS CUI [1,1])
cv2MaxAggrWholeBloodADP20
Item
Post plavix/pre aspirin whole blood max aggregation of ADP 20 ug/ml
text
C0231290 (UMLS CUI [1,1])
C3469597 (UMLS CUI [1,2])
C0633084 (UMLS CUI [1,3])
C1978977 (UMLS CUI [1,4])
C0439565 (UMLS CUI [1,5])
C0004057 (UMLS CUI [1,6])
C1978977 (UMLS CUI [1,7])
cv2MaxAggrWholeBloodAA
Item
Post plavix/pre aspirin whole blood max aggregation of arachidonic acid
text
C0231290 (UMLS CUI [1,1])
C3469597 (UMLS CUI [1,2])
C0633084 (UMLS CUI [1,3])
C0439565 (UMLS CUI [1,4])
C0004057 (UMLS CUI [1,5])
C1268820 (UMLS CUI [1,6])
cv2MaxAggrWholeBloodColl1
Item
Post plavix/pre aspirin whole blood max aggregation of collagen 1 ug/ml
text
C0231290 (UMLS CUI [1,1])
C3469597 (UMLS CUI [1,2])
C0633084 (UMLS CUI [1,3])
C0439565 (UMLS CUI [1,4])
C0004057 (UMLS CUI [1,5])
C0369863 (UMLS CUI [1,6])
cv3MaxAggrWholeBloodADP20
Item
Post plavix/post aspirin whole blood max aggregation of ADP 20 ug/ml
text
C0231290 (UMLS CUI [1,1])
C3469597 (UMLS CUI [1,2])
C0633084 (UMLS CUI [1,3])
C0231290 (UMLS CUI [1,4])
C3469597 (UMLS CUI [1,5])
C0004057 (UMLS CUI [1,6])
C1978977 (UMLS CUI [1,7])
cv3MaxAggrWholeBloodAA
Item
Post plavix/post aspirin whole blood max aggregation of arachidonic acid
text
C0231290 (UMLS CUI [1,1])
C3469597 (UMLS CUI [1,2])
C0633084 (UMLS CUI [1,3])
C0231290 (UMLS CUI [1,4])
C3469597 (UMLS CUI [1,5])
C0004057 (UMLS CUI [1,6])
C1268820 (UMLS CUI [1,7])
cv3MaxAggrWholeBloodColl1
Item
Post plavix/post aspirin whole blood max aggregation of collagen 1 ug/ml
text
C0231290 (UMLS CUI [1,1])
C3469597 (UMLS CUI [1,2])
C0633084 (UMLS CUI [1,3])
C0231290 (UMLS CUI [1,4])
C3469597 (UMLS CUI [1,5])
C0004057 (UMLS CUI [1,6])
C0369863 (UMLS CUI [1,7])
preMaxAggrPRPADP20
Item
Baseline platelet rich plasma max aggregation of ADP 20 ug/ml
text
C1978977 (UMLS CUI [1,1])
preMaxAggrPRPColl2
Item
Baseline platelet rich plasma max aggregation of collagen 2 ug/ml
text
C5177543 (UMLS CUI [1,1])
preMaxAggrPRPEpi
Item
Baseline platelet rich plasma max aggregation of Epi
text
C5177548 (UMLS CUI [1,1])
preMaxAggrPRPAA
Item
Baseline platelet rich plasma max aggregation of arachidonic acid
text
C5177539 (UMLS CUI [1,1])
cv2MaxAggrPRPADP20
Item
Post plavix/pre aspirin platelet rich plasma max aggregation of ADP 20 ug/ml
text
C0231290 (UMLS CUI [1,1])
C3469597 (UMLS CUI [1,2])
C0633084 (UMLS CUI [1,3])
C0439565 (UMLS CUI [1,4])
C0004057 (UMLS CUI [1,5])
C5177535 (UMLS CUI [1,6])
cv2MaxAggrPRPColl2
Item
Post plavix/pre aspirin platelet rich plasma max aggregation of collagen 2 ug/ml
text
C0231290 (UMLS CUI [1,1])
C3469597 (UMLS CUI [1,2])
C0633084 (UMLS CUI [1,3])
C0439565 (UMLS CUI [1,4])
C0004057 (UMLS CUI [1,5])
C5177543 (UMLS CUI [1,6])
cv2MaxAggrPRPEpi
Item
Post plavix/pre aspirin platelet rich plasma max aggregation of Epi
text
C0231290 (UMLS CUI [1,1])
C3469597 (UMLS CUI [1,2])
C0633084 (UMLS CUI [1,3])
C0439565 (UMLS CUI [1,4])
C0004057 (UMLS CUI [1,5])
C5177548 (UMLS CUI [1,6])
cv2MaxAggrPRPAA
Item
Post plavix/pre aspirin platelet rich plasma max aggregation of arachidonic acid
text
C0231290 (UMLS CUI [1,1])
C3469597 (UMLS CUI [1,2])
C0633084 (UMLS CUI [1,3])
C0439565 (UMLS CUI [1,4])
C0004057 (UMLS CUI [1,5])
C5177539 (UMLS CUI [1,6])
cv3MaxAggrPRPADP20
Item
Post plavix/post aspirin platelet rich plasma max aggregation of ADP 20 ug/ml
text
C0231290 (UMLS CUI [1,1])
C3469597 (UMLS CUI [1,2])
C0633084 (UMLS CUI [1,3])
C0231290 (UMLS CUI [1,4])
C3469597 (UMLS CUI [1,5])
C0004057 (UMLS CUI [1,6])
C1978977 (UMLS CUI [1,7])
cv3MaxAggrPRPColl2
Item
Post plavix/post aspirin platelet rich plasma max aggregation of collagen 2 ug/ml
text
C0231290 (UMLS CUI [1,1])
C3469597 (UMLS CUI [1,2])
C0633084 (UMLS CUI [1,3])
C0231290 (UMLS CUI [1,4])
C3469597 (UMLS CUI [1,5])
C0004057 (UMLS CUI [1,6])
C5177543 (UMLS CUI [1,7])
cv3MaxAggrPRPEpi
Item
Post plavix/post aspirin platelet rich plasma max aggregation of Epi
text
C0231290 (UMLS CUI [1,1])
C3469597 (UMLS CUI [1,2])
C0633084 (UMLS CUI [1,3])
C0231290 (UMLS CUI [1,4])
C3469597 (UMLS CUI [1,5])
C0004057 (UMLS CUI [1,6])
C5177548 (UMLS CUI [1,7])
cv3MaxAggrPRPAA
Item
Post plavix/post aspirin platelet rich plasma max aggregation of arachidonic acid
text
C0231290 (UMLS CUI [1,1])
C3469597 (UMLS CUI [1,2])
C0633084 (UMLS CUI [1,3])
C0231290 (UMLS CUI [1,4])
C3469597 (UMLS CUI [1,5])
C0004057 (UMLS CUI [1,6])
C5177539 (UMLS CUI [1,7])
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