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ID

45157

Description

Principal Investigator: Alan Shuldiner, MD, University of Maryland Baltimore, Baltimore, MD, USA MeSH: Pharmacogenomics,Clopidogrel,Platelets https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000391 CHD is the leading cause of death in the United States. One of the most common ways to prevent CHD is to take an anti-platelet agent, which lessens platelet aggregation. Two of the most common anti-platelet agents are aspirin and clopidogrel. However, up to 25% to 30% of people do not respond to these medications. Evidence indicates that treatment response may be related to genetics. The purpose of this study is to determine specific gene variants that predict response to aspirin and clopidogrel therapy. This study is part of a larger group of studies called the Pharmacogenomics Research Network (PGRN). Participants are from the Old Order Amish of Lancaster, Pennsylvania. They are well suited for genetic studies because they are a homogenous, closed, founder population. Participants received 300 mg of clopidogrel on the first day, then 75 mg of clopidogrel per day for the next 6 days. On the last day of clopidogrel treatment, participants took a single dose of 324 mg aspirin. Participants underwent platelet function tests before and after clopidogrel alone, and then again after taking clopidogrel plus aspirin. Using the gene variation profiles across the genome, researchers analyzed which variants correspond to treatment response.

Lien

dbGaP study = phs000391

Mots-clés

Versions (2)
  1. 02/09/2022 02/09/2022 - Niko Möller-Grell
  2. 12/10/2022 12/10/2022 - Adrian Schulz
Détendeur de droits

Alan Shuldiner, MD, University of Maryland Baltimore, Baltimore, MD, USA

Téléchargé le

12 octobre 2022

DOI

Pour une demande vous connecter.

Licence

Creative Commons BY 4.0
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    dbGaP phs000391 Pharmacogenomics of Anti-Platelet Intervention (PAPI) Study

    Anglais

    Subject ID, age, sex, body mass index, systolic and diastolic blood pressure, waist circumference, fasting triglycerides, total cholesterol, LHD, HDL, baseline whole blood max aggregation of ADP, of arachidonic acid, and collagen 1, post plavix/pre aspirin whole blood max aggregation of ADP, of arachadonic acid, and collagen 1, baseline platelet rich plasma max aggregation of ADP, of collagen 2, of Epi, and arachadonic acid, post plavix/pre aspirin platelet rich plasma max aggregation of ADP, of Epi, and arachadonic acid, post plavix/post aspirin platelet rich plasma max aggregation of ADP, of collagen 2, of Epi, of arachadonic acid obtained from participants involved in the "Determining Genetic Role in Treatment Response to Anti-Platelet Interventions (The PAPI Study)" project.

    4 Formulaires  
    pht002996
    Description

    pht002996

    De-identified subject ID
    Description

    Assigned

    Type de données

    string

    Alias
    UMLS CUI [1,1]
    C4684638
    UMLS CUI [1,2]
    C2348585
    Age participant began study (clinic visit 1)
    Description

    Collected at consent visit

    Type de données

    text

    Unités de mesure
    • Years
    Alias
    UMLS CUI [1,1]
    C0001779
    UMLS CUI [1,2]
    C0439659
    UMLS CUI [1,3]
    C5418626
    Years
    Gender of participant
    Description

    Collected at consent visit

    Type de données

    text

    Alias
    UMLS CUI [1,1]
    C0079399
    Body mass index of participant, calculated from measured height and weight
    Description

    Collected at first clinic visit

    Type de données

    text

    Unités de mesure
    • kg/m2
    Alias
    UMLS CUI [1,1]
    C1305855
    kg/m2
    Systolic blood pressure of participant, calculated from three measurements
    Description

    Collected at first clinic visit

    Type de données

    text

    Unités de mesure
    • mmHg
    Alias
    UMLS CUI [1,1]
    C0871470
    mmHg
    Diastolic blood pressure of participant, calculated from three measurements
    Description

    Collected at first clinic visit

    Type de données

    text

    Unités de mesure
    • mmHg
    Alias
    UMLS CUI [1,1]
    C0428883
    mmHg
    Waist circumference of participant
    Description

    Collected at first clinic visit

    Type de données

    float

    Unités de mesure
    • cm
    Alias
    UMLS CUI [1,1]
    C0455829
    cm
    Fasting triglycerides, measured by Quest diagnostics
    Description

    Collected at first clinic visit

    Type de données

    text

    Unités de mesure
    • mg/dl
    Alias
    UMLS CUI [1,1]
    C0583331
    mg/dl
    Fasting total cholesterol, measured by Quest diagnostics
    Description

    Collected at first clinic visit

    Type de données

    text

    Unités de mesure
    • mg/dl
    Alias
    UMLS CUI [1,1]
    C0543421
    mg/dl
    Fasting hdl cholesterol, measured by Quest diagnostics
    Description

    Collected at first clinic visit

    Type de données

    text

    Unités de mesure
    • mg/dl
    Alias
    UMLS CUI [1,1]
    C1318353
    mg/dl
    Fasting ldl cholesterol, measured by Quest diagnostics
    Description

    Collected at first clinic visit

    Type de données

    text

    Unités de mesure
    • mg/dl
    Alias
    UMLS CUI [1,1]
    C0582830
    mg/dl
    Baseline whole blood max aggregation of ADP 20 ug/ml
    Description

    Collected at first clinic visit

    Type de données

    text

    Unités de mesure
    • ohms
    Alias
    UMLS CUI [1,1]
    C1978977
    ohms
    Baseline whole blood max aggregation of arachidonic acid
    Description

    Collected at first clinic visit

    Type de données

    text

    Unités de mesure
    • ohms
    Alias
    UMLS CUI [1,1]
    C1268820
    ohms
    Baseline whole blood max aggregation of collagen 1 ug/ml
    Description

    Collected at first clinic visit

    Type de données

    text

    Unités de mesure
    • ohms
    Alias
    UMLS CUI [1,1]
    C0369863
    ohms
    Post plavix/pre aspirin whole blood max aggregation of ADP 20 ug/ml
    Description

    Collected at second clinic visit

    Type de données

    text

    Unités de mesure
    • ohms
    Alias
    UMLS CUI [1,1]
    C0231290
    UMLS CUI [1,2]
    C3469597
    UMLS CUI [1,3]
    C0633084
    UMLS CUI [1,4]
    C1978977
    UMLS CUI [1,5]
    C0439565
    UMLS CUI [1,6]
    C0004057
    UMLS CUI [1,7]
    C1978977
    ohms
    Post plavix/pre aspirin whole blood max aggregation of arachidonic acid
    Description

    Collected at second clinic visit

    Type de données

    text

    Unités de mesure
    • ohms
    Alias
    UMLS CUI [1,1]
    C0231290
    UMLS CUI [1,2]
    C3469597
    UMLS CUI [1,3]
    C0633084
    UMLS CUI [1,4]
    C0439565
    UMLS CUI [1,5]
    C0004057
    UMLS CUI [1,6]
    C1268820
    ohms
    Post plavix/pre aspirin whole blood max aggregation of collagen 1 ug/ml
    Description

    Collected at second clinic visit

    Type de données

    text

    Unités de mesure
    • ohms
    Alias
    UMLS CUI [1,1]
    C0231290
    UMLS CUI [1,2]
    C3469597
    UMLS CUI [1,3]
    C0633084
    UMLS CUI [1,4]
    C0439565
    UMLS CUI [1,5]
    C0004057
    UMLS CUI [1,6]
    C0369863
    ohms
    Post plavix/post aspirin whole blood max aggregation of ADP 20 ug/ml
    Description

    Collected at second clinic visit

    Type de données

    text

    Unités de mesure
    • ohms
    Alias
    UMLS CUI [1,1]
    C0231290
    UMLS CUI [1,2]
    C3469597
    UMLS CUI [1,3]
    C0633084
    UMLS CUI [1,4]
    C0231290
    UMLS CUI [1,5]
    C3469597
    UMLS CUI [1,6]
    C0004057
    UMLS CUI [1,7]
    C1978977
    ohms
    Post plavix/post aspirin whole blood max aggregation of arachidonic acid
    Description

    Collected at second clinic visit

    Type de données

    text

    Unités de mesure
    • ohms
    Alias
    UMLS CUI [1,1]
    C0231290
    UMLS CUI [1,2]
    C3469597
    UMLS CUI [1,3]
    C0633084
    UMLS CUI [1,4]
    C0231290
    UMLS CUI [1,5]
    C3469597
    UMLS CUI [1,6]
    C0004057
    UMLS CUI [1,7]
    C1268820
    ohms
    Post plavix/post aspirin whole blood max aggregation of collagen 1 ug/ml
    Description

    Collected at second clinic visit

    Type de données

    text

    Unités de mesure
    • ohms
    Alias
    UMLS CUI [1,1]
    C0231290
    UMLS CUI [1,2]
    C3469597
    UMLS CUI [1,3]
    C0633084
    UMLS CUI [1,4]
    C0231290
    UMLS CUI [1,5]
    C3469597
    UMLS CUI [1,6]
    C0004057
    UMLS CUI [1,7]
    C0369863
    ohms
    Baseline platelet rich plasma max aggregation of ADP 20 ug/ml
    Description

    Collected at first clinic visit

    Type de données

    text

    Unités de mesure
    • %
    Alias
    UMLS CUI [1,1]
    C1978977
    %
    Baseline platelet rich plasma max aggregation of collagen 2 ug/ml
    Description

    Collected at first clinic visit

    Type de données

    text

    Unités de mesure
    • %
    Alias
    UMLS CUI [1,1]
    C5177543
    %
    Baseline platelet rich plasma max aggregation of Epi
    Description

    Collected at first clinic visit

    Type de données

    text

    Unités de mesure
    • %
    Alias
    UMLS CUI [1,1]
    C5177548
    %
    Baseline platelet rich plasma max aggregation of arachidonic acid
    Description

    Collected at first clinic visit

    Type de données

    text

    Unités de mesure
    • %
    Alias
    UMLS CUI [1,1]
    C5177539
    %
    Post plavix/pre aspirin platelet rich plasma max aggregation of ADP 20 ug/ml
    Description

    Collected at second clinic visit

    Type de données

    text

    Unités de mesure
    • %
    Alias
    UMLS CUI [1,1]
    C0231290
    UMLS CUI [1,2]
    C3469597
    UMLS CUI [1,3]
    C0633084
    UMLS CUI [1,4]
    C0439565
    UMLS CUI [1,5]
    C0004057
    UMLS CUI [1,6]
    C5177535
    %
    Post plavix/pre aspirin platelet rich plasma max aggregation of collagen 2 ug/ml
    Description

    Collected at second clinic visit

    Type de données

    text

    Unités de mesure
    • %
    Alias
    UMLS CUI [1,1]
    C0231290
    UMLS CUI [1,2]
    C3469597
    UMLS CUI [1,3]
    C0633084
    UMLS CUI [1,4]
    C0439565
    UMLS CUI [1,5]
    C0004057
    UMLS CUI [1,6]
    C5177543
    %
    Post plavix/pre aspirin platelet rich plasma max aggregation of Epi
    Description

    Collected at second clinic visit

    Type de données

    text

    Unités de mesure
    • %
    Alias
    UMLS CUI [1,1]
    C0231290
    UMLS CUI [1,2]
    C3469597
    UMLS CUI [1,3]
    C0633084
    UMLS CUI [1,4]
    C0439565
    UMLS CUI [1,5]
    C0004057
    UMLS CUI [1,6]
    C5177548
    %
    Post plavix/pre aspirin platelet rich plasma max aggregation of arachidonic acid
    Description

    Collected at second clinic visit

    Type de données

    text

    Unités de mesure
    • %
    Alias
    UMLS CUI [1,1]
    C0231290
    UMLS CUI [1,2]
    C3469597
    UMLS CUI [1,3]
    C0633084
    UMLS CUI [1,4]
    C0439565
    UMLS CUI [1,5]
    C0004057
    UMLS CUI [1,6]
    C5177539
    %
    Post plavix/post aspirin platelet rich plasma max aggregation of ADP 20 ug/ml
    Description

    Collected at second clinic visit

    Type de données

    text

    Unités de mesure
    • %
    Alias
    UMLS CUI [1,1]
    C0231290
    UMLS CUI [1,2]
    C3469597
    UMLS CUI [1,3]
    C0633084
    UMLS CUI [1,4]
    C0231290
    UMLS CUI [1,5]
    C3469597
    UMLS CUI [1,6]
    C0004057
    UMLS CUI [1,7]
    C1978977
    %
    Post plavix/post aspirin platelet rich plasma max aggregation of collagen 2 ug/ml
    Description

    Collected at second clinic visit

    Type de données

    text

    Unités de mesure
    • %
    Alias
    UMLS CUI [1,1]
    C0231290
    UMLS CUI [1,2]
    C3469597
    UMLS CUI [1,3]
    C0633084
    UMLS CUI [1,4]
    C0231290
    UMLS CUI [1,5]
    C3469597
    UMLS CUI [1,6]
    C0004057
    UMLS CUI [1,7]
    C5177543
    %
    Post plavix/post aspirin platelet rich plasma max aggregation of Epi
    Description

    Collected at second clinic visit

    Type de données

    text

    Unités de mesure
    • %
    Alias
    UMLS CUI [1,1]
    C0231290
    UMLS CUI [1,2]
    C3469597
    UMLS CUI [1,3]
    C0633084
    UMLS CUI [1,4]
    C0231290
    UMLS CUI [1,5]
    C3469597
    UMLS CUI [1,6]
    C0004057
    UMLS CUI [1,7]
    C5177548
    %
    Post plavix/post aspirin platelet rich plasma max aggregation of arachidonic acid
    Description

    Collected at second clinic visit

    Type de données

    text

    Unités de mesure
    • %
    Alias
    UMLS CUI [1,1]
    C0231290
    UMLS CUI [1,2]
    C3469597
    UMLS CUI [1,3]
    C0633084
    UMLS CUI [1,4]
    C0231290
    UMLS CUI [1,5]
    C3469597
    UMLS CUI [1,6]
    C0004057
    UMLS CUI [1,7]
    C5177539
    %
    Retour au début de la page

    Similar models

    Subject ID, age, sex, body mass index, systolic and diastolic blood pressure, waist circumference, fasting triglycerides, total cholesterol, LHD, HDL, baseline whole blood max aggregation of ADP, of arachidonic acid, and collagen 1, post plavix/pre aspirin whole blood max aggregation of ADP, of arachadonic acid, and collagen 1, baseline platelet rich plasma max aggregation of ADP, of collagen 2, of Epi, and arachadonic acid, post plavix/pre aspirin platelet rich plasma max aggregation of ADP, of Epi, and arachadonic acid, post plavix/post aspirin platelet rich plasma max aggregation of ADP, of collagen 2, of Epi, of arachadonic acid obtained from participants involved in the "Determining Genetic Role in Treatment Response to Anti-Platelet Interventions (The PAPI Study)" project.

    4 Formulaires
    Name
    Type
    Description | Question | Decode (Coded Value)
    Type de données
    Alias
    Item Group
    pht002996
    SUBJID
    Item
    De-identified subject ID
    string
    C4684638 (UMLS CUI [1,1])
    C2348585 (UMLS CUI [1,2])
    AGE
    Item
    Age participant began study (clinic visit 1)
    text
    C0001779 (UMLS CUI [1,1])
    C0439659 (UMLS CUI [1,2])
    C5418626 (UMLS CUI [1,3])
    Item
    Gender of participant
    text
    C0079399 (UMLS CUI [1,1])
    SEX
    Code List
    Gender of participant
    CL Item
    Male (1)
    CL Item
    Female (2)
    BodyMassIndex
    Item
    Body mass index of participant, calculated from measured height and weight
    text
    C1305855 (UMLS CUI [1,1])
    SystolicBloodPressure
    Item
    Systolic blood pressure of participant, calculated from three measurements
    text
    C0871470 (UMLS CUI [1,1])
    DiastolicBloodPressure
    Item
    Diastolic blood pressure of participant, calculated from three measurements
    text
    C0428883 (UMLS CUI [1,1])
    waistCircumference
    Item
    Waist circumference of participant
    float
    C0455829 (UMLS CUI [1,1])
    fastingTriglycerides
    Item
    Fasting triglycerides, measured by Quest diagnostics
    text
    C0583331 (UMLS CUI [1,1])
    fastingTotalCholesterol
    Item
    Fasting total cholesterol, measured by Quest diagnostics
    text
    C0543421 (UMLS CUI [1,1])
    fastingHDLCholesterol
    Item
    Fasting hdl cholesterol, measured by Quest diagnostics
    text
    C1318353 (UMLS CUI [1,1])
    fastingLDLCholesterol
    Item
    Fasting ldl cholesterol, measured by Quest diagnostics
    text
    C0582830 (UMLS CUI [1,1])
    preMaxAggrWholeBloodADP20
    Item
    Baseline whole blood max aggregation of ADP 20 ug/ml
    text
    C1978977 (UMLS CUI [1,1])
    preMaxAggrWholeBloodAA
    Item
    Baseline whole blood max aggregation of arachidonic acid
    text
    C1268820 (UMLS CUI [1,1])
    preMaxAggrWholeBloodColl1
    Item
    Baseline whole blood max aggregation of collagen 1 ug/ml
    text
    C0369863 (UMLS CUI [1,1])
    cv2MaxAggrWholeBloodADP20
    Item
    Post plavix/pre aspirin whole blood max aggregation of ADP 20 ug/ml
    text
    C0231290 (UMLS CUI [1,1])
    C3469597 (UMLS CUI [1,2])
    C0633084 (UMLS CUI [1,3])
    C1978977 (UMLS CUI [1,4])
    C0439565 (UMLS CUI [1,5])
    C0004057 (UMLS CUI [1,6])
    C1978977 (UMLS CUI [1,7])
    cv2MaxAggrWholeBloodAA
    Item
    Post plavix/pre aspirin whole blood max aggregation of arachidonic acid
    text
    C0231290 (UMLS CUI [1,1])
    C3469597 (UMLS CUI [1,2])
    C0633084 (UMLS CUI [1,3])
    C0439565 (UMLS CUI [1,4])
    C0004057 (UMLS CUI [1,5])
    C1268820 (UMLS CUI [1,6])
    cv2MaxAggrWholeBloodColl1
    Item
    Post plavix/pre aspirin whole blood max aggregation of collagen 1 ug/ml
    text
    C0231290 (UMLS CUI [1,1])
    C3469597 (UMLS CUI [1,2])
    C0633084 (UMLS CUI [1,3])
    C0439565 (UMLS CUI [1,4])
    C0004057 (UMLS CUI [1,5])
    C0369863 (UMLS CUI [1,6])
    cv3MaxAggrWholeBloodADP20
    Item
    Post plavix/post aspirin whole blood max aggregation of ADP 20 ug/ml
    text
    C0231290 (UMLS CUI [1,1])
    C3469597 (UMLS CUI [1,2])
    C0633084 (UMLS CUI [1,3])
    C0231290 (UMLS CUI [1,4])
    C3469597 (UMLS CUI [1,5])
    C0004057 (UMLS CUI [1,6])
    C1978977 (UMLS CUI [1,7])
    cv3MaxAggrWholeBloodAA
    Item
    Post plavix/post aspirin whole blood max aggregation of arachidonic acid
    text
    C0231290 (UMLS CUI [1,1])
    C3469597 (UMLS CUI [1,2])
    C0633084 (UMLS CUI [1,3])
    C0231290 (UMLS CUI [1,4])
    C3469597 (UMLS CUI [1,5])
    C0004057 (UMLS CUI [1,6])
    C1268820 (UMLS CUI [1,7])
    cv3MaxAggrWholeBloodColl1
    Item
    Post plavix/post aspirin whole blood max aggregation of collagen 1 ug/ml
    text
    C0231290 (UMLS CUI [1,1])
    C3469597 (UMLS CUI [1,2])
    C0633084 (UMLS CUI [1,3])
    C0231290 (UMLS CUI [1,4])
    C3469597 (UMLS CUI [1,5])
    C0004057 (UMLS CUI [1,6])
    C0369863 (UMLS CUI [1,7])
    preMaxAggrPRPADP20
    Item
    Baseline platelet rich plasma max aggregation of ADP 20 ug/ml
    text
    C1978977 (UMLS CUI [1,1])
    preMaxAggrPRPColl2
    Item
    Baseline platelet rich plasma max aggregation of collagen 2 ug/ml
    text
    C5177543 (UMLS CUI [1,1])
    preMaxAggrPRPEpi
    Item
    Baseline platelet rich plasma max aggregation of Epi
    text
    C5177548 (UMLS CUI [1,1])
    preMaxAggrPRPAA
    Item
    Baseline platelet rich plasma max aggregation of arachidonic acid
    text
    C5177539 (UMLS CUI [1,1])
    cv2MaxAggrPRPADP20
    Item
    Post plavix/pre aspirin platelet rich plasma max aggregation of ADP 20 ug/ml
    text
    C0231290 (UMLS CUI [1,1])
    C3469597 (UMLS CUI [1,2])
    C0633084 (UMLS CUI [1,3])
    C0439565 (UMLS CUI [1,4])
    C0004057 (UMLS CUI [1,5])
    C5177535 (UMLS CUI [1,6])
    cv2MaxAggrPRPColl2
    Item
    Post plavix/pre aspirin platelet rich plasma max aggregation of collagen 2 ug/ml
    text
    C0231290 (UMLS CUI [1,1])
    C3469597 (UMLS CUI [1,2])
    C0633084 (UMLS CUI [1,3])
    C0439565 (UMLS CUI [1,4])
    C0004057 (UMLS CUI [1,5])
    C5177543 (UMLS CUI [1,6])
    cv2MaxAggrPRPEpi
    Item
    Post plavix/pre aspirin platelet rich plasma max aggregation of Epi
    text
    C0231290 (UMLS CUI [1,1])
    C3469597 (UMLS CUI [1,2])
    C0633084 (UMLS CUI [1,3])
    C0439565 (UMLS CUI [1,4])
    C0004057 (UMLS CUI [1,5])
    C5177548 (UMLS CUI [1,6])
    cv2MaxAggrPRPAA
    Item
    Post plavix/pre aspirin platelet rich plasma max aggregation of arachidonic acid
    text
    C0231290 (UMLS CUI [1,1])
    C3469597 (UMLS CUI [1,2])
    C0633084 (UMLS CUI [1,3])
    C0439565 (UMLS CUI [1,4])
    C0004057 (UMLS CUI [1,5])
    C5177539 (UMLS CUI [1,6])
    cv3MaxAggrPRPADP20
    Item
    Post plavix/post aspirin platelet rich plasma max aggregation of ADP 20 ug/ml
    text
    C0231290 (UMLS CUI [1,1])
    C3469597 (UMLS CUI [1,2])
    C0633084 (UMLS CUI [1,3])
    C0231290 (UMLS CUI [1,4])
    C3469597 (UMLS CUI [1,5])
    C0004057 (UMLS CUI [1,6])
    C1978977 (UMLS CUI [1,7])
    cv3MaxAggrPRPColl2
    Item
    Post plavix/post aspirin platelet rich plasma max aggregation of collagen 2 ug/ml
    text
    C0231290 (UMLS CUI [1,1])
    C3469597 (UMLS CUI [1,2])
    C0633084 (UMLS CUI [1,3])
    C0231290 (UMLS CUI [1,4])
    C3469597 (UMLS CUI [1,5])
    C0004057 (UMLS CUI [1,6])
    C5177543 (UMLS CUI [1,7])
    cv3MaxAggrPRPEpi
    Item
    Post plavix/post aspirin platelet rich plasma max aggregation of Epi
    text
    C0231290 (UMLS CUI [1,1])
    C3469597 (UMLS CUI [1,2])
    C0633084 (UMLS CUI [1,3])
    C0231290 (UMLS CUI [1,4])
    C3469597 (UMLS CUI [1,5])
    C0004057 (UMLS CUI [1,6])
    C5177548 (UMLS CUI [1,7])
    cv3MaxAggrPRPAA
    Item
    Post plavix/post aspirin platelet rich plasma max aggregation of arachidonic acid
    text
    C0231290 (UMLS CUI [1,1])
    C3469597 (UMLS CUI [1,2])
    C0633084 (UMLS CUI [1,3])
    C0231290 (UMLS CUI [1,4])
    C3469597 (UMLS CUI [1,5])
    C0004057 (UMLS CUI [1,6])
    C5177539 (UMLS CUI [1,7])
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