ID
45152
Beskrivning
Principal Investigator: Maria Teresa Landi, Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA MeSH: Lung Neoplasms,Smoking https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000336 Three genetic loci for lung cancer risk have been identified by genome-wide association studies (GWAS), but inherited susceptibility to specific histologic types of lung cancer is not well established. We conducted a GWAS of lung cancer and its major histologic types genotyping 515,922 single nucleotide polymorphisms (SNPs) in 5,739 incident lung cancer cases and 5,848 controls from one population-based case-control study and three cohort studies. Results were combined with summary data from 10 additional studies for a total of 13,300 cases and 19,666 controls of European descent. Four studies also provided histology data for replication resulting in 3,333 adenocarcinomas (AD), 2,589 squamous cell carcinomas (SQ), and 1,418 small cell carcinomas (SC). In analyses by histology, rs2736100 (*TERT*) on chromosome 5p15.33, was associated with risk of adenocarcinoma (OR=1.23, 95%CI=1.13-1.33, P=3.02x10sup-7/sup), but not other histologic types (OR=1.01, P=0.84, and OR=1.00, P=0.93, for SQ and SC, respectively). This finding was confirmed in each replication study and overall meta-analysis (OR=1.24, 95%CI=1.17-1.31, P=3.74x10sup-14/sup for AD and OR=0.99, P=0.69 and OR=0.97, P=0.48, for SQ and SC, respectively). Other previously reported association signals on 15q25 and 6p21 were also refined, but no additional loci reached genome-wide significance. In conclusion, a lung cancer GWAS identified a distinct hereditary contribution to adenocarcinoma. *Note: The lung study dataset to be released to dbGaP and caBIG excludes 47 individuals from the PLCO cohort who consented to participate only in cancer research projects and 22 individuals because of updated QC. Thus, the released dataset is derived from 11517 subjects, 5699 cases and 5818 controls. After the updated QC, the dataset to be released to dbGaP and caBIG includes 506062 SNPs.*
Länk
Nyckelord
Versioner (2)
- 2022-09-10 2022-09-10 - Simon Heim
- 2022-10-12 2022-10-12 - Adrian Schulz
Rättsinnehavare
Maria Teresa Landi, Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Uppladdad den
12 oktober 2022
DOI
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Licens
Creative Commons BY 4.0
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dbGaP phs000336 DCEG Lung Cancer Study
Subject ID, affection status, gender, age at diagnosis, and principal components for population stratification contain "the Environment and Genetics in Lung Cancer Etiology (EAGLE)," "the Prostate, Lung, Colon, Ovary Screening Trial (PLCO)," "the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC)," and "the Cancer Prevention Study II Nutrition Cohort (CPS-II)" cohorts of intact or affected with lung cancer including adenocarcinomas, squamous cell carcinomas, and small cell carcinomas participants.
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, consent groups, and affection status of intact or affected with lung cancer including adenocarcinomas, squamous cell carcinomas, and small cell carcinomas participants.
- Sample ID and subject ID of intact or affected with lung cancer including adenocarcinomas, squamous cell carcinomas, and small cell carcinomas participants.
- Subject ID, affection status, gender, age at diagnosis, and principal components for population stratification contain "the Environment and Genetics in Lung Cancer Etiology (EAGLE)," "the Prostate, Lung, Colon, Ovary Screening Trial (PLCO)," "the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC)," and "the Cancer Prevention Study II Nutrition Cohort (CPS-II)" cohorts of intact or affected with lung cancer including adenocarcinomas, squamous cell carcinomas, and small cell carcinomas participants.
Similar models
Subject ID, affection status, gender, age at diagnosis, and principal components for population stratification contain "the Environment and Genetics in Lung Cancer Etiology (EAGLE)," "the Prostate, Lung, Colon, Ovary Screening Trial (PLCO)," "the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC)," and "the Cancer Prevention Study II Nutrition Cohort (CPS-II)" cohorts of intact or affected with lung cancer including adenocarcinomas, squamous cell carcinomas, and small cell carcinomas participants.
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, consent groups, and affection status of intact or affected with lung cancer including adenocarcinomas, squamous cell carcinomas, and small cell carcinomas participants.
- Sample ID and subject ID of intact or affected with lung cancer including adenocarcinomas, squamous cell carcinomas, and small cell carcinomas participants.
- Subject ID, affection status, gender, age at diagnosis, and principal components for population stratification contain "the Environment and Genetics in Lung Cancer Etiology (EAGLE)," "the Prostate, Lung, Colon, Ovary Screening Trial (PLCO)," "the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC)," and "the Cancer Prevention Study II Nutrition Cohort (CPS-II)" cohorts of intact or affected with lung cancer including adenocarcinomas, squamous cell carcinomas, and small cell carcinomas participants.
C2348585 (UMLS CUI [1,2])
C0001779 (UMLS CUI [2,1])
C0021822 (UMLS CUI [2,2])
C3258049 (UMLS CUI [1,2])
C3258049 (UMLS CUI [1,2])
C3258049 (UMLS CUI [1,2])
C3258049 (UMLS CUI [1,2])
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