ID
45150
Beskrivning
Principal Investigator: Sudha K. Iyengar, PhD, Case Western Reserve University, Cleveland, OH, USA MeSH: Diabetes Mellitus,Kidney Diseases,Diabetic Nephropathies https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000333 The Family Investigation of Nephropathy and Diabetes (FIND) is a multicenter study designed to identify genetic determinants of diabetic kidney disease. Study subjects were recruited from eleven centers and in many ethnic groups throughout the United States. A genome-wide association study (GWAS) was conducted with the Affymetrix 6.0 chip. Subjects (index cases) with diabetes and kidney disease were initially recruited, and their parents and siblings were invited to participate. Genetic material from these participants was used to genotype markers throughout the genome. For association-based testing, a case-control design was implemented with study subjects selected primarily from the index cases of the families. Unrelated controls were selected from families where a case was not already selected. Several study sites also contributed non-FIND subjects, both cases and controls (consent forms for the release of FIND and non-FIND subjects/samples are included in this dbGaP release). Cases were selected if they met study criteria for diabetic nephropathy or met inclusion criteria based on elevated serum creatinine levels and abnormal urine protein excretion. Similarly, controls were long-term diabetics with otherwise normal kidney function. See inclusion/exclusion criteria section for a detailed description for the FIND study as a whole and this GWAS. The goal of the FIND study is to identify genes that influence susceptibility to diabetic kidney disease, leading to a better understanding of how kidney disease develops. In the long run, this may lead to improved treatment and prevention of diabetic kidney disease.
Länk
Nyckelord
Versioner (2)
- 2022-09-10 2022-09-10 - Simon Heim
- 2022-10-12 2022-10-12 - Adrian Schulz
Rättsinnehavare
Sudha K. Iyengar, PhD, Case Western Reserve University, Cleveland, OH, USA
Uppladdad den
12 oktober 2022
DOI
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Licens
Creative Commons BY 4.0
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dbGaP phs000333 Family Investigation of Nephropathy and Diabetes (FIND) Study
Sample ID and subject ID of participants involved in the Family Investigation of Nephropathy and Diabetes [FIND] project and affected or not affected with diabetic kidney disease.
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, consent group, and affection status of participants involved in the Family Investigation of Nephropathy and Diabetes [FIND] project and affected or not affected with diabetic kidney disease.
- Subject ID, family ID, father and mother IDs, and sex of participants involved in the Family Investigation of Nephropathy and Diabetes [FIND] project and affected or not affected with diabetic kidney disease.
- Sample ID and subject ID of participants involved in the Family Investigation of Nephropathy and Diabetes [FIND] project and affected or not affected with diabetic kidney disease.
- Sociodemographic data including sex, race, age, and subject ID, medical history of participant's laboratory tests including creatinine ratio, glomerular filtration rate, serum creatinine, urine albumin excretion, urine creatinine excretion, urine protein excretion, laboratory tests of albumin-to-creatinine ratio, glomerular filtration rate, hemoglobin A1c, protein-to-creatinine ratio, serum creatinine, urine albumin excretion, urine creatinine excretion, urine protein excretion, health status including diabetes, high blood pressure, kidney failure, leg amputation, retinopathy, anthropometry, and ACE inhibitors or insulin administration of participants involved in the Family Investigation of Nephropathy and Diabetes [FIND] project and affected or not affected with diabetic kidney disease.
- Sample ID, tumor status, body site where from sample was collected, histological type of samples where from DNA was extracted obtained from participants involved in the Family Investigation of Nephropathy and Diabetes [FIND] project and affected or not affected with diabetic kidney disease.
Similar models
Sample ID and subject ID of participants involved in the Family Investigation of Nephropathy and Diabetes [FIND] project and affected or not affected with diabetic kidney disease.
- StudyEvent: SEV1
- Eligibility Criteria
- Subject ID, consent group, and affection status of participants involved in the Family Investigation of Nephropathy and Diabetes [FIND] project and affected or not affected with diabetic kidney disease.
- Subject ID, family ID, father and mother IDs, and sex of participants involved in the Family Investigation of Nephropathy and Diabetes [FIND] project and affected or not affected with diabetic kidney disease.
- Sample ID and subject ID of participants involved in the Family Investigation of Nephropathy and Diabetes [FIND] project and affected or not affected with diabetic kidney disease.
- Sociodemographic data including sex, race, age, and subject ID, medical history of participant's laboratory tests including creatinine ratio, glomerular filtration rate, serum creatinine, urine albumin excretion, urine creatinine excretion, urine protein excretion, laboratory tests of albumin-to-creatinine ratio, glomerular filtration rate, hemoglobin A1c, protein-to-creatinine ratio, serum creatinine, urine albumin excretion, urine creatinine excretion, urine protein excretion, health status including diabetes, high blood pressure, kidney failure, leg amputation, retinopathy, anthropometry, and ACE inhibitors or insulin administration of participants involved in the Family Investigation of Nephropathy and Diabetes [FIND] project and affected or not affected with diabetic kidney disease.
- Sample ID, tumor status, body site where from sample was collected, histological type of samples where from DNA was extracted obtained from participants involved in the Family Investigation of Nephropathy and Diabetes [FIND] project and affected or not affected with diabetic kidney disease.