ID

45141

Descripción

Principal Investigator: Stephen Rich, PhD, University of Virginia, Charlottesville, VA, USA MeSH: Myocardial Infarction,Brain Ischemia https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000398 The NHLBI "Grand Opportunity" Exome Sequencing Project (GO-ESP), a signature project of the NHLBI Recovery Act investment, was designed to identify genetic variants in coding regions (exons) of the human genome (the "exome") that are associated with heart, lung and blood diseases. These and related diseases that are of high impact to public health and individuals from diverse racial and ethnic groups will be studied. These data may help researchers understand the causes of disease, contributing to better ways to prevent, diagnose, and treat diseases, as well as determine whether to tailor prevention and treatments to specific populations. This could lead to more effective treatments and reduce the likelihood of side effects. GO-ESP is comprised of five collaborative components: 3 cohort consortia - HeartGO, LungGO, and WHISP - and 2 sequencing centers - BroadGO and SeattleGO. HeartGO is a consortium of six well-phenotyped NHLBI cohorts: Atherosclerosis Risk in Communities (ARIC) study, the Coronary Artery Risk Development in Young Adults (CARDIA) study, the Cardiovascular Health Study, the Framingham Heart Study, the Jackson Heart Study, and the Multi-Ethnic Study of Atherosclerosis. Together, these cohorts have provided DNA and phenotype datasets from a diverse cohort of individuals of African-American, Caucasian, Asian, and Hispanic ancestry to be made available for use by qualified investigators in dbGaP. HeartGO investigators will conduct genotype-phenotype analyses for phenotypes related not only to heart disease but with other variables that will be contributed to dbGaP. The HeartGO dataset provides investigators with genotype-phenotype analytic opportunities for traits not only related to heart disease but also associated with ancillary variables that will be contributed to dbGaP, including disease endpoints, risk factors, biomarkers, and subclinical disease measures. The phenotypes planned for investigation as part of the GO-ESP HeartGO project include early-onset myocardial infarction (EOMI), low density lipoprotein (LDL) cholesterol, body mass index/type 2 diabetes (BMI/T2D), blood pressure and ischemic stroke. Results of the proposed analyses as well as relevant replication/follow-up analyses will be reported in peer-reviewed journals. This study phs000398 contains the Atherosclerosis Risk in Communities (ARIC) subset of GO-ESP/Heart-GO. Additional GO-ESP data is also available via dbGaP.

Link

dbGaP study=phs000398

Palabras clave

Versiones (2)
  1. 2/10/22 2/10/22 - Chiara Middel
  2. 12/10/22 12/10/22 - Adrian Schulz
Titular de derechos de autor

Stephen Rich, PhD, University of Virginia, Charlottesville, VA, USA

Subido en

12 de octubre de 2022

DOI

Para solicitar uno, por favor iniciar sesión.

Licencia

Creative Commons BY 4.0
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dbGaP phs000398 NHLBI GO-ESP: Heart Cohorts Exome Sequencing Project (ARIC)

Inglés

Sociodemographic data including subject ID, sex, race, study site, study cohort, and age, family history of stroke, systolic and diastolic blood pressure, anthropometric data including BMI, body weight, body height, and waist in centimeters, laboratory measurement of blood including eosinophils, basophils, platelet count, red blood count, neutrophils, monocytes, lymphocytes, hematocrit, hemoglobin, Factor VIII, fasting glucose, fasting insulin, ICAM1 level, IL6 level, cystatin C, Digoxin, total cholesterol, triglycerides, HDL, LDL, C-reactive protein, Factor VII level, and Fibrinogen, uric acid, urinary albumin, and urinary creatinine, EKG including HR, PR, QRS, QT, and RR interval measurement, status of myocardial infraction, angioplasty, atrial fibrillation, atrioventricular block, hypertension, left ventricular hypertrophy, gout, and type 2 diabetes, coronary artery calcium Agatston and Framingham Risk Score, intimal-medial thickness, Wolf-Parkinson-White syndrome, treatment with medications, and smoking status of participants involved in the "National Heart Lung and Blood Institute (NHLBI) GO-ESP: Heart Cohorts Component of the Exome Sequencing Project (ARIC)" project.

4 formularios  
  1. StudyEvent: SEV1
    1. Eligibility Criteria
    2. Subject ID, subject source, subject source ID, and consent group of participants involved in the "National Heart Lung and Blood Institute (NHLBI) GO-ESP: Heart Cohorts Component of the Exome Sequencing Project (ARIC)" project.
    3. Sample ID, subject ID, and using of samples obtained from participants involved in the "National Heart Lung and Blood Institute (NHLBI) GO-ESP: Heart Cohorts Component of the Exome Sequencing Project (ARIC)" project.
    4. Sociodemographic data including subject ID, sex, race, study site, study cohort, and age, family history of stroke, systolic and diastolic blood pressure, anthropometric data including BMI, body weight, body height, and waist in centimeters, laboratory measurement of blood including eosinophils, basophils, platelet count, red blood count, neutrophils, monocytes, lymphocytes, hematocrit, hemoglobin, Factor VIII, fasting glucose, fasting insulin, ICAM1 level, IL6 level, cystatin C, Digoxin, total cholesterol, triglycerides, HDL, LDL, C-reactive protein, Factor VII level, and Fibrinogen, uric acid, urinary albumin, and urinary creatinine, EKG including HR, PR, QRS, QT, and RR interval measurement, status of myocardial infraction, angioplasty, atrial fibrillation, atrioventricular block, hypertension, left ventricular hypertrophy, gout, and type 2 diabetes, coronary artery calcium Agatston and Framingham Risk Score, intimal-medial thickness, Wolf-Parkinson-White syndrome, treatment with medications, and smoking status of participants involved in the "National Heart Lung and Blood Institute (NHLBI) GO-ESP: Heart Cohorts Component of the Exome Sequencing Project (ARIC)" project.
pht002467
Descripción

pht002467

Cohort name
Descripción

ESP_COHORT

Tipo de datos

string

Alias
UMLS CUI [1,1]
C0599755
UMLS CUI [1,2]
C0027365
De-identified subject ID
Descripción

SUBJID

Tipo de datos

string

Alias
UMLS CUI [1,1]
C2348585
UMLS CUI [1,2]
C4684638
Values: EOMI_Case (Early MI case); EOMI_Control (Early MI control); LDL_High; LDL_Low
Descripción

ESP_PHENOTYPE

Tipo de datos

string

Alias
UMLS CUI [1,1]
C0027051
UMLS CUI [1,2]
C0814120
UMLS CUI [1,3]
C1698493
UMLS CUI [2,1]
C0027051
UMLS CUI [2,2]
C0814120
UMLS CUI [2,3]
C0009932
UMLS CUI [3,1]
C4747855
UMLS CUI [4,1]
C3807409
Information from quality control analysis
Descripción

SAMPLE_QC_INFO

Tipo de datos

string

Alias
UMLS CUI [1,1]
C0034378
Information about known duplicates and related
Descripción

DUP_RELATED_INFO

Tipo de datos

string

Alias
UMLS CUI [1,1]
C0205309
UMLS CUI [1,2]
C0205173
Values: European American; African American
Descripción

ESP_RACE

Tipo de datos

string

Alias
UMLS CUI [1,1]
C0085756
UMLS CUI [2,1]
C0043157
Values: Male; Female
Descripción

ESP_SEX

Tipo de datos

string

Alias
UMLS CUI [1,1]
C0086582
UMLS CUI [2,1]
C0086287
Clinic or field center within cohort
Descripción

ESP_STUDY_SITE

Tipo de datos

string

Alias
UMLS CUI [1,1]
C0442592
UMLS CUI [1,2]
C0332285
UMLS CUI [1,3]
C0599755
Age in years at baseline
Descripción

ESP_AGE_BASELINE

Tipo de datos

text

Unidades de medida
  • Years
Alias
UMLS CUI [1,1]
C0001779
UMLS CUI [1,2]
C1442488
Years
MI status at baseline [ 0=No, 1=Yes]
Descripción

ESP_MI_BASELINE

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0027051
UMLS CUI [1,2]
C1442488
0/1 - to indicate that an MI occurred during study follow up. 0 - if no MI during study follow up. 1 - if an adjudicated MI occurred during study follow up (even if baseline MI status was 1).
Descripción

ESP_MI_DURING_FOLLOWUP

Tipo de datos

text

Alias
UMLS CUI [1,1]
C1298908
UMLS CUI [1,2]
C0027051
UMLS CUI [1,3]
C0347984
UMLS CUI [1,4]
C1522577
UMLS CUI [2,1]
C0027051
UMLS CUI [2,2]
C0347984
UMLS CUI [2,3]
C1522577
Time to event variable for MI. Time (in days) from start of study to MI for event that occurred during study follow up; and follow up time for those that did not have an MI during study follow up.
Descripción

ESP_MI_TTE_OR_CENSOR

Tipo de datos

text

Unidades de medida
  • Days
Alias
UMLS CUI [1,1]
C0040223
UMLS CUI [1,2]
C1720302
UMLS CUI [1,3]
C0027051
UMLS CUI [1,4]
C0347984
UMLS CUI [1,5]
C1522577
UMLS CUI [2,1]
C0040223
UMLS CUI [2,2]
C1522577
UMLS CUI [2,3]
C1298908
UMLS CUI [2,4]
C0027051
Days
Framingham Risk Score predicted prob. calculated at baseline (was not calculated for those with baseline history of MI)
Descripción

ESP_FRS_CHDPROB_BASELINE

Tipo de datos

text

Alias
UMLS CUI [1,1]
C5442395
UMLS CUI [1,2]
C1442488
Baseline BMI in kg/m2
Descripción

ESP_BMI_BASELINE

Tipo de datos

text

Unidades de medida
  • kg/m2
Alias
UMLS CUI [1,1]
C1305855
UMLS CUI [1,2]
C1442488
kg/m2
Type 2 diabetes status at baseline [ 0=No, 1=Yes]
Descripción

ESP_T2DIABETES_BASELINE

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0011860
UMLS CUI [1,2]
C1442488
Weight in kg. at baseline
Descripción

ESP_WEIGHT_BASELINE

Tipo de datos

text

Unidades de medida
  • kg
Alias
UMLS CUI [1,1]
C0005910
UMLS CUI [1,2]
C1442488
kg
Waist in cm at baseline
Descripción

ESP_WAIST_BASELINE

Tipo de datos

text

Unidades de medida
  • cm
Alias
UMLS CUI [1,1]
C0455829
UMLS CUI [1,2]
C1442488
cm
Waist to hip ratio at baseline
Descripción

ESP_WHR_BASELINE

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0205682
UMLS CUI [1,2]
C1442488
Standing height in cm at baseline
Descripción

ESP_HEIGHT_BASELINE

Tipo de datos

text

Unidades de medida
  • cm
Alias
UMLS CUI [1,1]
C0005890
UMLS CUI [1,2]
C1442488
cm
Baseline calculated LDL in mg/dL (missing where trigs>400)
Descripción

ESP_LDL_BASELINE

Tipo de datos

text

Unidades de medida
  • mg/dL
Alias
UMLS CUI [1,1]
C0428474
UMLS CUI [1,2]
C1442488
mg/dL
HDL level in mg/dL at baseline
Descripción

ESP_HDL_BASELINE

Tipo de datos

text

Unidades de medida
  • mg/dL
Alias
UMLS CUI [1,1]
C0428472
UMLS CUI [1,2]
C1442488
mg/dL
Triglycerides at baseline in mg/dL
Descripción

ESP_TRIGS_BASELINE

Tipo de datos

text

Unidades de medida
  • mg/dL
Alias
UMLS CUI [1,1]
C0202236
UMLS CUI [1,2]
C1442488
mg/dL
Total cholesterol at baseline in mg/dL
Descripción

ESP_TOTCHOL_BASELINE

Tipo de datos

text

Unidades de medida
  • mg/dL
Alias
UMLS CUI [1,1]
C1445957
UMLS CUI [1,2]
C1442488
mg/dL
Any lipid lowering med (statin or other) at baseline
Descripción

ESP_LIPID_MED_BASELINE

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0585943
UMLS CUI [1,2]
C1442488
Systolic blood pressure at baseline (avg. of 2 measurements), in mm Hg
Descripción

ESP_SBP_BASELINE

Tipo de datos

text

Unidades de medida
  • mm Hg
Alias
UMLS CUI [1,1]
C0871470
UMLS CUI [1,2]
C1442488
mm Hg
Diastolic blood pressure at baseline (avg. of 2 measurements), in mm Hg
Descripción

ESP_DBP_BASELINE

Tipo de datos

text

Unidades de medida
  • mm Hg
Alias
UMLS CUI [1,1]
C0428883
UMLS CUI [1,2]
C1442488
mm Hg
Physician diagnosed hypertension status at baseline [ 0=No, 1=Yes]
Descripción

ESP_HTN_STATUS_BASELINE

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0020538
UMLS CUI [1,2]
C1442488
Hypertension med status (any) at baseline [ 0=No, 1=Yes]
Descripción

ESP_HTN_MED_BASELINE

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0684167
UMLS CUI [1,2]
C1442488
Stroke status at baseline [ 0=No, 1=Yes]
Descripción

ESP_STROKE_BASELINE

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0038454
UMLS CUI [1,2]
C0449438
UMLS CUI [1,3]
C1442488
0/1 - to indicate that a stroke occurred during study follow up. 0 - if no stroke during study follow up. 1 - if an adjudicated stroke occurred during study follow up (even if baseline stroke status was 1).
Descripción

ESP_STROKE_DURING_FOLLOWUP

Tipo de datos

text

Alias
UMLS CUI [1,1]
C1298908
UMLS CUI [1,2]
C0038454
UMLS CUI [1,3]
C0347984
UMLS CUI [1,4]
C1522577
UMLS CUI [2,1]
C0038454
UMLS CUI [2,2]
C0347984
UMLS CUI [2,3]
C1522577
Time to event variable for stroke. Time (in days) from start of study to stroke for event that occurred during study follow up; and follow up time for those that did not have an stroke during study follow up.
Descripción

ESP_STROKE_TTE_OR_CENSOR

Tipo de datos

text

Unidades de medida
  • Days
Alias
UMLS CUI [1,1]
C0040223
UMLS CUI [1,2]
C1720302
UMLS CUI [1,3]
C0038454
UMLS CUI [2,1]
C1522577
UMLS CUI [2,2]
C0040223
UMLS CUI [2,3]
C1298908
UMLS CUI [2,4]
C0038454
Days
Incident stroke subtype (Lacune or LVAth). Subtype is available only on a subset of samples, so will be missing for some with non-missing age at incident stroke
Descripción

ESP_INC_STROKE_SUBTYPE

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0449560
UMLS CUI [1,2]
C0038454
Family history (first degree relatives) of stroke at baseline [ 0=No, 1=Yes]
Descripción

ESP_STROKE_FAMHX_BASELINE

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0241889
UMLS CUI [1,2]
C0559159
UMLS CUI [1,3]
C1442488
Current smoking status at baseline [ 0=No, 1=Yes]
Descripción

ESP_CURRENT_SMOKER_BASELINE

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0521116
UMLS CUI [1,2]
C3496610
UMLS CUI [1,3]
C1442488
Former smoking status at baseline [ 0=No, 1=Yes]
Descripción

ESP_FORMER_SMOKER_BASELINE

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0205156
UMLS CUI [1,2]
C1519386
UMLS CUI [1,3]
C1442488
Age at menarche
Descripción

ESP_AGE_AT_MENARCHE

Tipo de datos

text

Unidades de medida
  • Years
Alias
UMLS CUI [1,1]
C1314691
Years
Age categories for menarche
Descripción

ESP_AGE_AT_MENARCHE_CAT

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0001779
UMLS CUI [1,2]
C0683312
UMLS CUI [1,3]
C1314691
Atrial fibrillation at baseline [ 0=No, 1=Yes]
Descripción

ESP_AFIB_BASELINE

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0004238
UMLS CUI [1,2]
C1442488
0/1 - to indicate that an afib occurred during study follow up. 0 - if no afib during study follow up. 1 - if an adjudicated afib occurred during study follow up.
Descripción

ESP_AFIB_DURING_FOLLOWUP

Tipo de datos

text

Alias
UMLS CUI [1,1]
C1298908
UMLS CUI [1,2]
C0004238
UMLS CUI [1,3]
C0347984
UMLS CUI [1,4]
C1522577
UMLS CUI [2,1]
C0004238
UMLS CUI [2,2]
C0347984
UMLS CUI [2,3]
C1522577
Time to event variable for afib. Time (in days) from start of study to afib for event that occurred during study follow up; and follow up time for those that did not have an afib during study follow up.
Descripción

ESP_AFIB_TTE_OR_CENSOR

Tipo de datos

text

Unidades de medida
  • Days
Alias
UMLS CUI [1,1]
C0040223
UMLS CUI [1,2]
C1720302
UMLS CUI [1,3]
C0004238
UMLS CUI [2,1]
C0040223
UMLS CUI [2,2]
C1522577
Days
Blood fasting insulin at baseline in uU/mL. (Note that there are some extreme outliers)
Descripción

ESP_FASTINSULIN_BASELINE

Tipo de datos

text

Unidades de medida
  • uU/mL
Alias
UMLS CUI [1,1]
C0015663
UMLS CUI [1,2]
C0021641
UMLS CUI [1,3]
C1442488
uU/mL
Blood fasting glucose at baseline in mg/dL
Descripción

ESP_FASTGLUCOSE_BASELINE

Tipo de datos

text

Unidades de medida
  • mg/dL
Alias
UMLS CUI [1,1]
C0428568
UMLS CUI [1,2]
C1442488
mg/dL
Fibrinogen level in mg/dL at first designated visit (may not be baseline)
Descripción

ESP_FIBRINOGEN

Tipo de datos

text

Unidades de medida
  • mg/dL
Alias
UMLS CUI [1,1]
C0016006
UMLS CUI [1,2]
C1524084
UMLS CUI [1,3]
C0545082
mg/dL
Age in years at Fibrinogen measurement
Descripción

ESP_AGE_AT_FIBRINOGEN

Tipo de datos

text

Unidades de medida
  • Years
Alias
UMLS CUI [1,1]
C0001779
UMLS CUI [1,2]
C0337428
Years
Factor VII level in % at designated visit (may not be baseline)
Descripción

ESP_FACTORVII

Tipo de datos

text

Unidades de medida
  • %
Alias
UMLS CUI [1,1]
C0427593
UMLS CUI [1,2]
C1524084
UMLS CUI [1,3]
C0545082
%
Age in years at Factor VII measurement
Descripción

ESP_AGE_AT_FACTORVII

Tipo de datos

text

Unidades de medida
  • Years
Alias
UMLS CUI [1,1]
C0001779
UMLS CUI [1,2]
C0427593
UMLS CUI [1,3]
C0242485
Years
Factor VIII level in % at designated visit (may not be baseline)
Descripción

ESP_FACTORVIII

Tipo de datos

text

Unidades de medida
  • %
Alias
UMLS CUI [1,1]
C2825857
UMLS CUI [1,2]
C1524084
UMLS CUI [1,3]
C0545082
%
Age in years at Factor VIII measurement
Descripción

ESP_AGE_AT_FACTORVIII

Tipo de datos

text

Unidades de medida
  • Years
Alias
UMLS CUI [1,1]
C0001779
UMLS CUI [1,2]
C2825857
Years
VWF level in % at designated visit (may not be baseline)
Descripción

ESP_vWF

Tipo de datos

text

Unidades de medida
  • %
Alias
UMLS CUI [1,1]
C0427585
UMLS CUI [1,2]
C1524084
UMLS CUI [1,3]
C0545082
%
Age in years at visit of hemostatic factors measurement
Descripción

ESP_AGE_AT_vWF

Tipo de datos

text

Unidades de medida
  • Years
Alias
UMLS CUI [1,1]
C0001779
UMLS CUI [1,2]
C0019116
UMLS CUI [1,3]
C0242485
Years
C-reactive protein level in mg/L at designated visit (may not be baseline)
Descripción

ESP_CRP

Tipo de datos

text

Unidades de medida
  • mg/L
Alias
UMLS CUI [1,1]
C0201657
UMLS CUI [1,2]
C1524084
UMLS CUI [1,3]
C0545082
mg/L
Age in years at CRP measurement
Descripción

ESP_AGE_AT_CRP

Tipo de datos

text

Unidades de medida
  • Years
Alias
UMLS CUI [1,1]
C0001779
UMLS CUI [1,2]
C0201657
Years
IL6 level in pg/mL at designated visit (may not be baseline)
Descripción

ESP_IL6

Tipo de datos

text

Unidades de medida
  • pg/mL
Alias
UMLS CUI [1,1]
C0919829
UMLS CUI [1,2]
C1524084
UMLS CUI [1,3]
C0545082
pg/mL
Age in years at IL6 measurement
Descripción

ESP_AGE_AT_IL6

Tipo de datos

text

Unidades de medida
  • Years
Alias
UMLS CUI [1,1]
C0001779
UMLS CUI [1,2]
C0919829
Years
ICAM1 level in ng/mL at designated visit (may not be baseline)
Descripción

ESP_ICAM1

Tipo de datos

text

Unidades de medida
  • ng/mL
Alias
UMLS CUI [1,1]
C4084871
UMLS CUI [1,2]
C1524084
UMLS CUI [1,3]
C0545082
ng/mL
Age in years at ICAM1 measurement
Descripción

ESP_AGE_AT_ICAM1

Tipo de datos

text

Unidades de medida
  • Years
Alias
UMLS CUI [1,1]
C0001779
UMLS CUI [1,2]
C4084871
Years
P-selectin level at designated visit (may not be baseline)
Descripción

ESP_PSELECTIN

Tipo de datos

text

Alias
UMLS CUI [1,1]
C3890352
UMLS CUI [1,2]
C1524084
UMLS CUI [1,3]
C0545082
Age in years at P-selectin measurement
Descripción

ESP_AGE_AT_PSELECTIN

Tipo de datos

text

Unidades de medida
  • Years
Alias
UMLS CUI [1,1]
C0001779
UMLS CUI [1,2]
C3890352
Years
White blood count in x1,000/cubic mm at designated visit (may not be baseline)
Descripción

ESP_WBC

Tipo de datos

text

Unidades de medida
  • x1000/cubic mm
Alias
UMLS CUI [1,1]
C0023508
UMLS CUI [1,2]
C1524084
UMLS CUI [1,3]
C0545082
x1000/cubic mm
Age in years at WBC measurement
Descripción

ESP_AGE_AT_WBC

Tipo de datos

text

Unidades de medida
  • Years
Alias
UMLS CUI [1,1]
C0001779
UMLS CUI [1,2]
C0023508
Years
Hemoglobin at designated visit (may not be baseline) in g/dl
Descripción

ESP_HEMOGLOBIN

Tipo de datos

text

Unidades de medida
  • g/dl
Alias
UMLS CUI [1,1]
C0518015
UMLS CUI [1,2]
C1524084
UMLS CUI [1,3]
C0545082
g/dl
Age in years at hemoglobin measurement
Descripción

ESP_AGE_AT_HEMOGLOBIN

Tipo de datos

text

Unidades de medida
  • Years
Alias
UMLS CUI [1,1]
C0001779
UMLS CUI [1,2]
C0518015
Years
Hematocrit at designated visit (may not be baseline) in %
Descripción

ESP_HEMATOCRIT

Tipo de datos

text

Unidades de medida
  • %
Alias
UMLS CUI [1,1]
C0518014
UMLS CUI [1,2]
C1524084
UMLS CUI [1,3]
C0545082
%
Age in years at hematocrit measurement
Descripción

ESP_AGE_AT_HEMATOCRIT

Tipo de datos

text

Unidades de medida
  • Years
Alias
UMLS CUI [1,1]
C0001779
UMLS CUI [1,2]
C0518014
Years
Platelet count at designated visit (may not be baseline) in x 1000/cubic mm
Descripción

ESP_PLATELET_COUNT

Tipo de datos

text

Unidades de medida
  • x1000/cubic mm
Alias
UMLS CUI [1,1]
C0032181
UMLS CUI [1,2]
C1524084
UMLS CUI [1,3]
C0545082
x1000/cubic mm
Age in years at platelet count measurement
Descripción

ESP_AGE_AT_PLATELET_COUNT

Tipo de datos

text

Unidades de medida
  • Years
Alias
UMLS CUI [1,1]
C0001779
UMLS CUI [1,2]
C0032181
Years
Mean corpuscular volume in femtoliters at designated visit (may not be baseline)
Descripción

ESP_MEAN_CORPUSCULAR_VOLUME

Tipo de datos

text

Alias
UMLS CUI [1,1]
C1948043
UMLS CUI [1,2]
C1524084
UMLS CUI [1,3]
C0545082
Age in years at mean corpuscular volume measurement
Descripción

ESP_AGE_AT_MCV

Tipo de datos

text

Unidades de medida
  • Years
Alias
UMLS CUI [1,1]
C0001779
UMLS CUI [1,2]
C1948043
Years
Red blood cell count in million cells per microliter at designated visit (may not be baseline)
Descripción

ESP_RED_BLOOD_COUNT

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0014772
UMLS CUI [1,2]
C1524084
UMLS CUI [1,3]
C0545082
Age in years at red blood cell count measurement
Descripción

ESP_AGE_AT_RBC

Tipo de datos

text

Unidades de medida
  • Years
Alias
UMLS CUI [1,1]
C0001779
UMLS CUI [1,2]
C0014772
Years
Neutrophils in absolute numbers at designated visit (may not be baseline).
Descripción

ESP_NEUTROPHILS

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0200633
UMLS CUI [1,2]
C1524084
UMLS CUI [1,3]
C0545082
Monocytes in absolute numbers at designated visit (may not be baseline).
Descripción

ESP_MONOCYTES

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0200637
UMLS CUI [1,2]
C1524084
UMLS CUI [1,3]
C0545082
Lymphocytes in absolute numbers at designated visit (may not be baseline).
Descripción

ESP_LYMPHOCYTES

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0200635
UMLS CUI [1,2]
C1524084
UMLS CUI [1,3]
C0545082
Eosinophils in absolute numbers at designated visit (may not be baseline).
Descripción

ESP_EOSINOPHILS

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0200638
UMLS CUI [1,2]
C1524084
UMLS CUI [1,3]
C0545082
Basophils in absolute numbers at designated visit (may not be baseline)
Descripción

ESP_BASOPHILS

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0200641
UMLS CUI [1,2]
C1524084
UMLS CUI [1,3]
C0545082
Age in years at secondary blood count measurements (MCV, RBC, Neutrophils, Monocytes, Lymphocytes, Eosinophils, Basophils)
Descripción

ESP_AGE_AT_SECONDARY_BLOOD_COUNT

Tipo de datos

text

Unidades de medida
  • Years
Alias
UMLS CUI [1,1]
C0001779
UMLS CUI [1,2]
C0009555
Years
Baseline angioplasty status [ 0=No, 1=Yes]
Descripción

ESP_ANGIOPLASTY_BASELINE

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0162577
UMLS CUI [1,2]
C0449438
UMLS CUI [1,3]
C1442488
Baseline CABG status [ 0=No, 1=Yes]
Descripción

ESP_CABG_BASELINE

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0010055
UMLS CUI [1,2]
C0449438
UMLS CUI [1,3]
C1442488
Coronary artery calcium Agatston total score
Descripción

ESP_CAC_AGATSTON_SCORE

Tipo de datos

text

Alias
UMLS CUI [1,1]
C1956346
UMLS CUI [1,2]
C1533591
UMLS CUI [1,3]
C0449820
Age in years at CAC Agatston score measurement
Descripción

ESP_AGE_AT_CAC

Tipo de datos

text

Unidades de medida
  • Years
Alias
UMLS CUI [1,1]
C0001779
UMLS CUI [1,2]
C1533591
UMLS CUI [1,3]
C0449820
UMLS CUI [1,4]
C0242485
Years
Average far wall thickness of the right and left common carotid mean IMT values, using as many views as are available for a given study
Descripción

ESP_IMT_MEANMEAN_FARWALL_CCA

Tipo de datos

text

Alias
UMLS CUI [1,1]
C1510992
UMLS CUI [1,2]
C0226086
UMLS CUI [1,3]
C0226087
UMLS CUI [1,4]
C3517541
Average far wall thickness of the right and left internal carotid maximum IMT values, using as many views as are available for a given study
Descripción

ESP_IMT_MEANMEAN_FARWALL_ICA

Tipo de datos

text

Alias
UMLS CUI [1,1]
C1510992
UMLS CUI [1,2]
C0226086
UMLS CUI [1,3]
C0226087
UMLS CUI [1,4]
C3517541
Presence of any plaque, as determined by IMT at designated visit (may not be baseline).
Descripción

ESP_IMT_ANYPLAQUE

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0150312
UMLS CUI [1,2]
C2936350
UMLS CUI [1,3]
C3517541
UMLS CUI [1,4]
C1524084
UMLS CUI [1,5]
C0545082
Age in years at IMT measurement
Descripción

ESP_AGE_AT_IMT

Tipo de datos

text

Unidades de medida
  • Years
Alias
UMLS CUI [1,1]
C0001779
UMLS CUI [1,2]
C3517541
Years
QRS interval from EKG at designated visit (may not be baseline)
Descripción

ESP_EKG_QRS

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0429025
UMLS CUI [1,2]
C1524084
UMLS CUI [1,3]
C0545082
RR interval from EKG at designated visit (may not be baseline)
Descripción

ESP_EKG_RR

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0489636
UMLS CUI [1,2]
C1524084
UMLS CUI [1,3]
C0545082
QT interval from EKG at designated visit (may not be baseline)
Descripción

ESP_EKG_QT

Tipo de datos

text

Alias
UMLS CUI [1,1]
C1287082
UMLS CUI [1,2]
C1524084
UMLS CUI [1,3]
C0545082
PR interval from EKG at designated visit (may not be baseline)
Descripción

ESP_EKG_PR

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0429087
UMLS CUI [1,2]
C1524084
UMLS CUI [1,3]
C0545082
HR interval from EKG at designated visit (may not be baseline)
Descripción

ESP_EKG_HR

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0522055
UMLS CUI [1,2]
C1524084
UMLS CUI [1,3]
C0545082
Left ventricular hypertrophy status at baseline [ 0=No, 1=Yes]
Descripción

ESP_LVH_AT_EKG

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0149721
UMLS CUI [1,2]
C0449438
UMLS CUI [1,3]
C1442488
Atrial flutter at EKG
Descripción

ESP_AFLUT_AT_EKG

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0004239
UMLS CUI [1,2]
C0438154
Wolf-Parkinson-White pattern
Descripción

ESP_WPW_AT_EKG

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0043202
Second degree AV block
Descripción

ESP_AVBLOCK2_AT_EKG

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0264906
Third degree AV block
Descripción

ESP_AVBLOCK3_AT_EKG

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0151517
Cornell voltage for EKG measurement, for EKG group.
Descripción

ESP_CORNELL_VOLTAGE_EKG

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0438154
UMLS CUI [1,2]
C0598352
Pacer at EKG
Descripción

ESP_PACER_EKG

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0030163
UMLS CUI [1,2]
C0438154
Digoxin, for EKG group
Descripción

ESP_DIGOXIN_EKG

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0012265
Dihydropyridine calcium channel blockers
Descripción

ESP_DIHYDRO_CALCIUM_CHANNEL_BLOC

Tipo de datos

text

Alias
UMLS CUI [1,1]
C2945601
Non-dihydropyridine calcium channel blockers, for EKG group.
Descripción

ESP_NONDIHYDRO_CALCIUM_CHANNEL_B

Tipo de datos

text

Alias
UMLS CUI [1,1]
C1298908
UMLS CUI [1,2]
C2945601
UMLS CUI [1,3]
C0006684
Any Calc Channel blocker (only for ARIC - other HeartGO cohorts have this broken down by Dihydro versus Non-Dihydro)
Descripción

ESP_CALCIUM_CHANNEL_BLOCKERS_EKG

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0006684
Betablockers, for EKG group.
Descripción

ESP_BETA_BLOCKERS_EKG

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0304516
Age in years at EKG measurement
Descripción

ESP_AGE_AT_EKG

Tipo de datos

text

Unidades de medida
  • Years
Alias
UMLS CUI [1,1]
C0001779
UMLS CUI [1,2]
C0430456
Years
Raw cystatin C (mg/L)
Descripción

ESP_SERUM_CYSTATINC

Tipo de datos

text

Unidades de medida
  • mg/L
Alias
UMLS CUI [1,1]
C1619716
mg/L
Age in years at serum cystatin c measurement
Descripción

ESP_AGE_AT_SERUM_CYSTATINC

Tipo de datos

text

Unidades de medida
  • Years
Alias
UMLS CUI [1,1]
C0001779
UMLS CUI [1,2]
C1619716
Years
Uric acid in mg/dL
Descripción

ESP_URIC_ACID

Tipo de datos

text

Unidades de medida
  • mg/dL
Alias
UMLS CUI [1,1]
C0202239
mg/dL
Age in years at uric acid measurement
Descripción

ESP_AGE_AT_URIC_ACID

Tipo de datos

text

Unidades de medida
  • Years
Alias
UMLS CUI [1,1]
C0001779
UMLS CUI [1,2]
C0202239
Years
Raw urinary albumin. Note: Users need to confirm units are the same across cohorts
Descripción

ESP_URINARY_ALBUMIN

Tipo de datos

text

Alias
UMLS CUI [1,1]
C1524119
UMLS CUI [1,2]
C0201838
Age in years at urinary albumin measurement
Descripción

ESP_AGE_AT_URINARY_ALBUMIN

Tipo de datos

text

Unidades de medida
  • Years
Alias
UMLS CUI [1,1]
C0001779
UMLS CUI [1,2]
C1524119
UMLS CUI [1,3]
C0201838
Years
Raw urinary creatinine in mg/dL
Descripción

ESP_URINARY_CREATININE

Tipo de datos

text

Unidades de medida
  • mg/dL
Alias
UMLS CUI [1,1]
C1524119
UMLS CUI [1,2]
C0201975
mg/dL
Age in years at urinary creatinine measurement
Descripción

ESP_AGE_AT_URINARY_CREATININE

Tipo de datos

text

Unidades de medida
  • Years
Alias
UMLS CUI [1,1]
C0001779
UMLS CUI [1,2]
C1524119
UMLS CUI [1,3]
C0201975
Years
May be MD-reported, self-reported, or abstracted from patients taking allopurinol. Ever had gout through study.
Descripción

ESP_GOUT

Tipo de datos

text

Alias
UMLS CUI [1,1]
C0031831
UMLS CUI [1,2]
C0018099
UMLS CUI [1,3]
C4319718
UMLS CUI [2,1]
C2700446
UMLS CUI [2,2]
C0018099
UMLS CUI [3,1]
C1524063
UMLS CUI [3,2]
C0002144
UMLS CUI [3,3]
C0018099
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Similar models

Sociodemographic data including subject ID, sex, race, study site, study cohort, and age, family history of stroke, systolic and diastolic blood pressure, anthropometric data including BMI, body weight, body height, and waist in centimeters, laboratory measurement of blood including eosinophils, basophils, platelet count, red blood count, neutrophils, monocytes, lymphocytes, hematocrit, hemoglobin, Factor VIII, fasting glucose, fasting insulin, ICAM1 level, IL6 level, cystatin C, Digoxin, total cholesterol, triglycerides, HDL, LDL, C-reactive protein, Factor VII level, and Fibrinogen, uric acid, urinary albumin, and urinary creatinine, EKG including HR, PR, QRS, QT, and RR interval measurement, status of myocardial infraction, angioplasty, atrial fibrillation, atrioventricular block, hypertension, left ventricular hypertrophy, gout, and type 2 diabetes, coronary artery calcium Agatston and Framingham Risk Score, intimal-medial thickness, Wolf-Parkinson-White syndrome, treatment with medications, and smoking status of participants involved in the "National Heart Lung and Blood Institute (NHLBI) GO-ESP: Heart Cohorts Component of the Exome Sequencing Project (ARIC)" project.

4 formularios
  1. StudyEvent: SEV1
    1. Eligibility Criteria
    2. Subject ID, subject source, subject source ID, and consent group of participants involved in the "National Heart Lung and Blood Institute (NHLBI) GO-ESP: Heart Cohorts Component of the Exome Sequencing Project (ARIC)" project.
    3. Sample ID, subject ID, and using of samples obtained from participants involved in the "National Heart Lung and Blood Institute (NHLBI) GO-ESP: Heart Cohorts Component of the Exome Sequencing Project (ARIC)" project.
    4. Sociodemographic data including subject ID, sex, race, study site, study cohort, and age, family history of stroke, systolic and diastolic blood pressure, anthropometric data including BMI, body weight, body height, and waist in centimeters, laboratory measurement of blood including eosinophils, basophils, platelet count, red blood count, neutrophils, monocytes, lymphocytes, hematocrit, hemoglobin, Factor VIII, fasting glucose, fasting insulin, ICAM1 level, IL6 level, cystatin C, Digoxin, total cholesterol, triglycerides, HDL, LDL, C-reactive protein, Factor VII level, and Fibrinogen, uric acid, urinary albumin, and urinary creatinine, EKG including HR, PR, QRS, QT, and RR interval measurement, status of myocardial infraction, angioplasty, atrial fibrillation, atrioventricular block, hypertension, left ventricular hypertrophy, gout, and type 2 diabetes, coronary artery calcium Agatston and Framingham Risk Score, intimal-medial thickness, Wolf-Parkinson-White syndrome, treatment with medications, and smoking status of participants involved in the "National Heart Lung and Blood Institute (NHLBI) GO-ESP: Heart Cohorts Component of the Exome Sequencing Project (ARIC)" project.
Name
Tipo
Description | Question | Decode (Coded Value)
Tipo de datos
Alias
Item Group
pht002467
ESP_COHORT
Item
Cohort name
string
C0599755 (UMLS CUI [1,1])
C0027365 (UMLS CUI [1,2])
SUBJID
Item
De-identified subject ID
string
C2348585 (UMLS CUI [1,1])
C4684638 (UMLS CUI [1,2])
ESP_PHENOTYPE
Item
Values: EOMI_Case (Early MI case); EOMI_Control (Early MI control); LDL_High; LDL_Low
string
C0027051 (UMLS CUI [1,1])
C0814120 (UMLS CUI [1,2])
C1698493 (UMLS CUI [1,3])
C0027051 (UMLS CUI [2,1])
C0814120 (UMLS CUI [2,2])
C0009932 (UMLS CUI [2,3])
C4747855 (UMLS CUI [3,1])
C3807409 (UMLS CUI [4,1])
SAMPLE_QC_INFO
Item
Information from quality control analysis
string
C0034378 (UMLS CUI [1,1])
DUP_RELATED_INFO
Item
Information about known duplicates and related
string
C0205309 (UMLS CUI [1,1])
C0205173 (UMLS CUI [1,2])
ESP_RACE
Item
Values: European American; African American
string
C0085756 (UMLS CUI [1,1])
C0043157 (UMLS CUI [2,1])
ESP_SEX
Item
Values: Male; Female
string
C0086582 (UMLS CUI [1,1])
C0086287 (UMLS CUI [2,1])
ESP_STUDY_SITE
Item
Clinic or field center within cohort
string
C0442592 (UMLS CUI [1,1])
C0332285 (UMLS CUI [1,2])
C0599755 (UMLS CUI [1,3])
ESP_AGE_BASELINE
Item
Age in years at baseline
text
C0001779 (UMLS CUI [1,1])
C1442488 (UMLS CUI [1,2])
Item
MI status at baseline [ 0=No, 1=Yes]
text
C0027051 (UMLS CUI [1,1])
C1442488 (UMLS CUI [1,2])
ESP_MI_BASELINE
Code List
MI status at baseline [ 0=No, 1=Yes]
CL Item
No (0)
CL Item
Yes (1)
Item
0/1 - to indicate that an MI occurred during study follow up. 0 - if no MI during study follow up. 1 - if an adjudicated MI occurred during study follow up (even if baseline MI status was 1).
text
C1298908 (UMLS CUI [1,1])
C0027051 (UMLS CUI [1,2])
C0347984 (UMLS CUI [1,3])
C1522577 (UMLS CUI [1,4])
C0027051 (UMLS CUI [2,1])
C0347984 (UMLS CUI [2,2])
C1522577 (UMLS CUI [2,3])
ESP_MI_DURING_FOLLOWUP
Code List
0/1 - to indicate that an MI occurred during study follow up. 0 - if no MI during study follow up. 1 - if an adjudicated MI occurred during study follow up (even if baseline MI status was 1).
CL Item
No (0)
CL Item
Yes (1)
ESP_MI_TTE_OR_CENSOR
Item
Time to event variable for MI. Time (in days) from start of study to MI for event that occurred during study follow up; and follow up time for those that did not have an MI during study follow up.
text
C0040223 (UMLS CUI [1,1])
C1720302 (UMLS CUI [1,2])
C0027051 (UMLS CUI [1,3])
C0347984 (UMLS CUI [1,4])
C1522577 (UMLS CUI [1,5])
C0040223 (UMLS CUI [2,1])
C1522577 (UMLS CUI [2,2])
C1298908 (UMLS CUI [2,3])
C0027051 (UMLS CUI [2,4])
ESP_FRS_CHDPROB_BASELINE
Item
Framingham Risk Score predicted prob. calculated at baseline (was not calculated for those with baseline history of MI)
text
C5442395 (UMLS CUI [1,1])
C1442488 (UMLS CUI [1,2])
ESP_BMI_BASELINE
Item
Baseline BMI in kg/m2
text
C1305855 (UMLS CUI [1,1])
C1442488 (UMLS CUI [1,2])
Item
Type 2 diabetes status at baseline [ 0=No, 1=Yes]
text
C0011860 (UMLS CUI [1,1])
C1442488 (UMLS CUI [1,2])
ESP_T2DIABETES_BASELINE
Code List
Type 2 diabetes status at baseline [ 0=No, 1=Yes]
CL Item
No (0)
CL Item
Yes (1)
ESP_WEIGHT_BASELINE
Item
Weight in kg. at baseline
text
C0005910 (UMLS CUI [1,1])
C1442488 (UMLS CUI [1,2])
ESP_WAIST_BASELINE
Item
Waist in cm at baseline
text
C0455829 (UMLS CUI [1,1])
C1442488 (UMLS CUI [1,2])
ESP_WHR_BASELINE
Item
Waist to hip ratio at baseline
text
C0205682 (UMLS CUI [1,1])
C1442488 (UMLS CUI [1,2])
ESP_HEIGHT_BASELINE
Item
Standing height in cm at baseline
text
C0005890 (UMLS CUI [1,1])
C1442488 (UMLS CUI [1,2])
ESP_LDL_BASELINE
Item
Baseline calculated LDL in mg/dL (missing where trigs>400)
text
C0428474 (UMLS CUI [1,1])
C1442488 (UMLS CUI [1,2])
ESP_HDL_BASELINE
Item
HDL level in mg/dL at baseline
text
C0428472 (UMLS CUI [1,1])
C1442488 (UMLS CUI [1,2])
ESP_TRIGS_BASELINE
Item
Triglycerides at baseline in mg/dL
text
C0202236 (UMLS CUI [1,1])
C1442488 (UMLS CUI [1,2])
ESP_TOTCHOL_BASELINE
Item
Total cholesterol at baseline in mg/dL
text
C1445957 (UMLS CUI [1,1])
C1442488 (UMLS CUI [1,2])
Item
Any lipid lowering med (statin or other) at baseline
text
C0585943 (UMLS CUI [1,1])
C1442488 (UMLS CUI [1,2])
ESP_LIPID_MED_BASELINE
Code List
Any lipid lowering med (statin or other) at baseline
CL Item
No (0)
CL Item
Yes (1)
ESP_SBP_BASELINE
Item
Systolic blood pressure at baseline (avg. of 2 measurements), in mm Hg
text
C0871470 (UMLS CUI [1,1])
C1442488 (UMLS CUI [1,2])
ESP_DBP_BASELINE
Item
Diastolic blood pressure at baseline (avg. of 2 measurements), in mm Hg
text
C0428883 (UMLS CUI [1,1])
C1442488 (UMLS CUI [1,2])
Item
Physician diagnosed hypertension status at baseline [ 0=No, 1=Yes]
text
C0020538 (UMLS CUI [1,1])
C1442488 (UMLS CUI [1,2])
ESP_HTN_STATUS_BASELINE
Code List
Physician diagnosed hypertension status at baseline [ 0=No, 1=Yes]
CL Item
No (0)
CL Item
Yes (1)
Item
Hypertension med status (any) at baseline [ 0=No, 1=Yes]
text
C0684167 (UMLS CUI [1,1])
C1442488 (UMLS CUI [1,2])
ESP_HTN_MED_BASELINE
Code List
Hypertension med status (any) at baseline [ 0=No, 1=Yes]
CL Item
No (0)
CL Item
Yes (1)
Item
Stroke status at baseline [ 0=No, 1=Yes]
text
C0038454 (UMLS CUI [1,1])
C0449438 (UMLS CUI [1,2])
C1442488 (UMLS CUI [1,3])
ESP_STROKE_BASELINE
Code List
Stroke status at baseline [ 0=No, 1=Yes]
CL Item
No (0)
CL Item
Yes (1)
Item
0/1 - to indicate that a stroke occurred during study follow up. 0 - if no stroke during study follow up. 1 - if an adjudicated stroke occurred during study follow up (even if baseline stroke status was 1).
text
C1298908 (UMLS CUI [1,1])
C0038454 (UMLS CUI [1,2])
C0347984 (UMLS CUI [1,3])
C1522577 (UMLS CUI [1,4])
C0038454 (UMLS CUI [2,1])
C0347984 (UMLS CUI [2,2])
C1522577 (UMLS CUI [2,3])
ESP_STROKE_DURING_FOLLOWUP
Code List
0/1 - to indicate that a stroke occurred during study follow up. 0 - if no stroke during study follow up. 1 - if an adjudicated stroke occurred during study follow up (even if baseline stroke status was 1).
CL Item
No (0)
CL Item
Yes (1)
ESP_STROKE_TTE_OR_CENSOR
Item
Time to event variable for stroke. Time (in days) from start of study to stroke for event that occurred during study follow up; and follow up time for those that did not have an stroke during study follow up.
text
C0040223 (UMLS CUI [1,1])
C1720302 (UMLS CUI [1,2])
C0038454 (UMLS CUI [1,3])
C1522577 (UMLS CUI [2,1])
C0040223 (UMLS CUI [2,2])
C1298908 (UMLS CUI [2,3])
C0038454 (UMLS CUI [2,4])
ESP_INC_STROKE_SUBTYPE
Item
Incident stroke subtype (Lacune or LVAth). Subtype is available only on a subset of samples, so will be missing for some with non-missing age at incident stroke
text
C0449560 (UMLS CUI [1,1])
C0038454 (UMLS CUI [1,2])
Item
Family history (first degree relatives) of stroke at baseline [ 0=No, 1=Yes]
text
C0241889 (UMLS CUI [1,1])
C0559159 (UMLS CUI [1,2])
C1442488 (UMLS CUI [1,3])
ESP_STROKE_FAMHX_BASELINE
Code List
Family history (first degree relatives) of stroke at baseline [ 0=No, 1=Yes]
CL Item
No (0)
CL Item
Yes (1)
Item
Current smoking status at baseline [ 0=No, 1=Yes]
text
C0521116 (UMLS CUI [1,1])
C3496610 (UMLS CUI [1,2])
C1442488 (UMLS CUI [1,3])
ESP_CURRENT_SMOKER_BASELINE
Code List
Current smoking status at baseline [ 0=No, 1=Yes]
CL Item
No (0)
CL Item
Yes (1)
Item
Former smoking status at baseline [ 0=No, 1=Yes]
text
C0205156 (UMLS CUI [1,1])
C1519386 (UMLS CUI [1,2])
C1442488 (UMLS CUI [1,3])
ESP_FORMER_SMOKER_BASELINE
Code List
Former smoking status at baseline [ 0=No, 1=Yes]
CL Item
No (0)
CL Item
Yes (1)
ESP_AGE_AT_MENARCHE
Item
Age at menarche
text
C1314691 (UMLS CUI [1,1])
Item
Age categories for menarche
text
C0001779 (UMLS CUI [1,1])
C0683312 (UMLS CUI [1,2])
C1314691 (UMLS CUI [1,3])
ESP_AGE_AT_MENARCHE_CAT
Code List
Age categories for menarche
CL Item
9 OR LESS (1)
CL Item
10 (2)
CL Item
11 (3)
CL Item
12 (4)
CL Item
13 (5)
CL Item
14 (6)
CL Item
15 (7)
CL Item
16 (8)
CL Item
17 OR OLDER (9)
Item
Atrial fibrillation at baseline [ 0=No, 1=Yes]
text
C0004238 (UMLS CUI [1,1])
C1442488 (UMLS CUI [1,2])
ESP_AFIB_BASELINE
Code List
Atrial fibrillation at baseline [ 0=No, 1=Yes]
CL Item
No (0)
CL Item
Yes (1)
Item
0/1 - to indicate that an afib occurred during study follow up. 0 - if no afib during study follow up. 1 - if an adjudicated afib occurred during study follow up.
text
C1298908 (UMLS CUI [1,1])
C0004238 (UMLS CUI [1,2])
C0347984 (UMLS CUI [1,3])
C1522577 (UMLS CUI [1,4])
C0004238 (UMLS CUI [2,1])
C0347984 (UMLS CUI [2,2])
C1522577 (UMLS CUI [2,3])
ESP_AFIB_DURING_FOLLOWUP
Code List
0/1 - to indicate that an afib occurred during study follow up. 0 - if no afib during study follow up. 1 - if an adjudicated afib occurred during study follow up.
CL Item
No (0)
CL Item
Yes (1)
ESP_AFIB_TTE_OR_CENSOR
Item
Time to event variable for afib. Time (in days) from start of study to afib for event that occurred during study follow up; and follow up time for those that did not have an afib during study follow up.
text
C0040223 (UMLS CUI [1,1])
C1720302 (UMLS CUI [1,2])
C0004238 (UMLS CUI [1,3])
C0040223 (UMLS CUI [2,1])
C1522577 (UMLS CUI [2,2])
ESP_FASTINSULIN_BASELINE
Item
Blood fasting insulin at baseline in uU/mL. (Note that there are some extreme outliers)
text
C0015663 (UMLS CUI [1,1])
C0021641 (UMLS CUI [1,2])
C1442488 (UMLS CUI [1,3])
ESP_FASTGLUCOSE_BASELINE
Item
Blood fasting glucose at baseline in mg/dL
text
C0428568 (UMLS CUI [1,1])
C1442488 (UMLS CUI [1,2])
ESP_FIBRINOGEN
Item
Fibrinogen level in mg/dL at first designated visit (may not be baseline)
text
C0016006 (UMLS CUI [1,1])
C1524084 (UMLS CUI [1,2])
C0545082 (UMLS CUI [1,3])
ESP_AGE_AT_FIBRINOGEN
Item
Age in years at Fibrinogen measurement
text
C0001779 (UMLS CUI [1,1])
C0337428 (UMLS CUI [1,2])
ESP_FACTORVII
Item
Factor VII level in % at designated visit (may not be baseline)
text
C0427593 (UMLS CUI [1,1])
C1524084 (UMLS CUI [1,2])
C0545082 (UMLS CUI [1,3])
ESP_AGE_AT_FACTORVII
Item
Age in years at Factor VII measurement
text
C0001779 (UMLS CUI [1,1])
C0427593 (UMLS CUI [1,2])
C0242485 (UMLS CUI [1,3])
ESP_FACTORVIII
Item
Factor VIII level in % at designated visit (may not be baseline)
text
C2825857 (UMLS CUI [1,1])
C1524084 (UMLS CUI [1,2])
C0545082 (UMLS CUI [1,3])
ESP_AGE_AT_FACTORVIII
Item
Age in years at Factor VIII measurement
text
C0001779 (UMLS CUI [1,1])
C2825857 (UMLS CUI [1,2])
ESP_vWF
Item
VWF level in % at designated visit (may not be baseline)
text
C0427585 (UMLS CUI [1,1])
C1524084 (UMLS CUI [1,2])
C0545082 (UMLS CUI [1,3])
ESP_AGE_AT_vWF
Item
Age in years at visit of hemostatic factors measurement
text
C0001779 (UMLS CUI [1,1])
C0019116 (UMLS CUI [1,2])
C0242485 (UMLS CUI [1,3])
ESP_CRP
Item
C-reactive protein level in mg/L at designated visit (may not be baseline)
text
C0201657 (UMLS CUI [1,1])
C1524084 (UMLS CUI [1,2])
C0545082 (UMLS CUI [1,3])
ESP_AGE_AT_CRP
Item
Age in years at CRP measurement
text
C0001779 (UMLS CUI [1,1])
C0201657 (UMLS CUI [1,2])
ESP_IL6
Item
IL6 level in pg/mL at designated visit (may not be baseline)
text
C0919829 (UMLS CUI [1,1])
C1524084 (UMLS CUI [1,2])
C0545082 (UMLS CUI [1,3])
ESP_AGE_AT_IL6
Item
Age in years at IL6 measurement
text
C0001779 (UMLS CUI [1,1])
C0919829 (UMLS CUI [1,2])
ESP_ICAM1
Item
ICAM1 level in ng/mL at designated visit (may not be baseline)
text
C4084871 (UMLS CUI [1,1])
C1524084 (UMLS CUI [1,2])
C0545082 (UMLS CUI [1,3])
ESP_AGE_AT_ICAM1
Item
Age in years at ICAM1 measurement
text
C0001779 (UMLS CUI [1,1])
C4084871 (UMLS CUI [1,2])
ESP_PSELECTIN
Item
P-selectin level at designated visit (may not be baseline)
text
C3890352 (UMLS CUI [1,1])
C1524084 (UMLS CUI [1,2])
C0545082 (UMLS CUI [1,3])
ESP_AGE_AT_PSELECTIN
Item
Age in years at P-selectin measurement
text
C0001779 (UMLS CUI [1,1])
C3890352 (UMLS CUI [1,2])
ESP_WBC
Item
White blood count in x1,000/cubic mm at designated visit (may not be baseline)
text
C0023508 (UMLS CUI [1,1])
C1524084 (UMLS CUI [1,2])
C0545082 (UMLS CUI [1,3])
ESP_AGE_AT_WBC
Item
Age in years at WBC measurement
text
C0001779 (UMLS CUI [1,1])
C0023508 (UMLS CUI [1,2])
ESP_HEMOGLOBIN
Item
Hemoglobin at designated visit (may not be baseline) in g/dl
text
C0518015 (UMLS CUI [1,1])
C1524084 (UMLS CUI [1,2])
C0545082 (UMLS CUI [1,3])
ESP_AGE_AT_HEMOGLOBIN
Item
Age in years at hemoglobin measurement
text
C0001779 (UMLS CUI [1,1])
C0518015 (UMLS CUI [1,2])
ESP_HEMATOCRIT
Item
Hematocrit at designated visit (may not be baseline) in %
text
C0518014 (UMLS CUI [1,1])
C1524084 (UMLS CUI [1,2])
C0545082 (UMLS CUI [1,3])
ESP_AGE_AT_HEMATOCRIT
Item
Age in years at hematocrit measurement
text
C0001779 (UMLS CUI [1,1])
C0518014 (UMLS CUI [1,2])
ESP_PLATELET_COUNT
Item
Platelet count at designated visit (may not be baseline) in x 1000/cubic mm
text
C0032181 (UMLS CUI [1,1])
C1524084 (UMLS CUI [1,2])
C0545082 (UMLS CUI [1,3])
ESP_AGE_AT_PLATELET_COUNT
Item
Age in years at platelet count measurement
text
C0001779 (UMLS CUI [1,1])
C0032181 (UMLS CUI [1,2])
ESP_MEAN_CORPUSCULAR_VOLUME
Item
Mean corpuscular volume in femtoliters at designated visit (may not be baseline)
text
C1948043 (UMLS CUI [1,1])
C1524084 (UMLS CUI [1,2])
C0545082 (UMLS CUI [1,3])
ESP_AGE_AT_MCV
Item
Age in years at mean corpuscular volume measurement
text
C0001779 (UMLS CUI [1,1])
C1948043 (UMLS CUI [1,2])
ESP_RED_BLOOD_COUNT
Item
Red blood cell count in million cells per microliter at designated visit (may not be baseline)
text
C0014772 (UMLS CUI [1,1])
C1524084 (UMLS CUI [1,2])
C0545082 (UMLS CUI [1,3])
ESP_AGE_AT_RBC
Item
Age in years at red blood cell count measurement
text
C0001779 (UMLS CUI [1,1])
C0014772 (UMLS CUI [1,2])
ESP_NEUTROPHILS
Item
Neutrophils in absolute numbers at designated visit (may not be baseline).
text
C0200633 (UMLS CUI [1,1])
C1524084 (UMLS CUI [1,2])
C0545082 (UMLS CUI [1,3])
ESP_MONOCYTES
Item
Monocytes in absolute numbers at designated visit (may not be baseline).
text
C0200637 (UMLS CUI [1,1])
C1524084 (UMLS CUI [1,2])
C0545082 (UMLS CUI [1,3])
ESP_LYMPHOCYTES
Item
Lymphocytes in absolute numbers at designated visit (may not be baseline).
text
C0200635 (UMLS CUI [1,1])
C1524084 (UMLS CUI [1,2])
C0545082 (UMLS CUI [1,3])
ESP_EOSINOPHILS
Item
Eosinophils in absolute numbers at designated visit (may not be baseline).
text
C0200638 (UMLS CUI [1,1])
C1524084 (UMLS CUI [1,2])
C0545082 (UMLS CUI [1,3])
ESP_BASOPHILS
Item
Basophils in absolute numbers at designated visit (may not be baseline)
text
C0200641 (UMLS CUI [1,1])
C1524084 (UMLS CUI [1,2])
C0545082 (UMLS CUI [1,3])
ESP_AGE_AT_SECONDARY_BLOOD_COUNT
Item
Age in years at secondary blood count measurements (MCV, RBC, Neutrophils, Monocytes, Lymphocytes, Eosinophils, Basophils)
text
C0001779 (UMLS CUI [1,1])
C0009555 (UMLS CUI [1,2])
Item
Baseline angioplasty status [ 0=No, 1=Yes]
text
C0162577 (UMLS CUI [1,1])
C0449438 (UMLS CUI [1,2])
C1442488 (UMLS CUI [1,3])
ESP_ANGIOPLASTY_BASELINE
Code List
Baseline angioplasty status [ 0=No, 1=Yes]
CL Item
No (0)
CL Item
Yes (1)
Item
Baseline CABG status [ 0=No, 1=Yes]
text
C0010055 (UMLS CUI [1,1])
C0449438 (UMLS CUI [1,2])
C1442488 (UMLS CUI [1,3])
ESP_CABG_BASELINE
Code List
Baseline CABG status [ 0=No, 1=Yes]
CL Item
No (0)
CL Item
Yes (1)
ESP_CAC_AGATSTON_SCORE
Item
Coronary artery calcium Agatston total score
text
C1956346 (UMLS CUI [1,1])
C1533591 (UMLS CUI [1,2])
C0449820 (UMLS CUI [1,3])
ESP_AGE_AT_CAC
Item
Age in years at CAC Agatston score measurement
text
C0001779 (UMLS CUI [1,1])
C1533591 (UMLS CUI [1,2])
C0449820 (UMLS CUI [1,3])
C0242485 (UMLS CUI [1,4])
ESP_IMT_MEANMEAN_FARWALL_CCA
Item
Average far wall thickness of the right and left common carotid mean IMT values, using as many views as are available for a given study
text
C1510992 (UMLS CUI [1,1])
C0226086 (UMLS CUI [1,2])
C0226087 (UMLS CUI [1,3])
C3517541 (UMLS CUI [1,4])
ESP_IMT_MEANMEAN_FARWALL_ICA
Item
Average far wall thickness of the right and left internal carotid maximum IMT values, using as many views as are available for a given study
text
C1510992 (UMLS CUI [1,1])
C0226086 (UMLS CUI [1,2])
C0226087 (UMLS CUI [1,3])
C3517541 (UMLS CUI [1,4])
Item
Presence of any plaque, as determined by IMT at designated visit (may not be baseline).
text
C0150312 (UMLS CUI [1,1])
C2936350 (UMLS CUI [1,2])
C3517541 (UMLS CUI [1,3])
C1524084 (UMLS CUI [1,4])
C0545082 (UMLS CUI [1,5])
ESP_IMT_ANYPLAQUE
Code List
Presence of any plaque, as determined by IMT at designated visit (may not be baseline).
CL Item
No (0)
CL Item
Yes (1)
ESP_AGE_AT_IMT
Item
Age in years at IMT measurement
text
C0001779 (UMLS CUI [1,1])
C3517541 (UMLS CUI [1,2])
ESP_EKG_QRS
Item
QRS interval from EKG at designated visit (may not be baseline)
text
C0429025 (UMLS CUI [1,1])
C1524084 (UMLS CUI [1,2])
C0545082 (UMLS CUI [1,3])
ESP_EKG_RR
Item
RR interval from EKG at designated visit (may not be baseline)
text
C0489636 (UMLS CUI [1,1])
C1524084 (UMLS CUI [1,2])
C0545082 (UMLS CUI [1,3])
ESP_EKG_QT
Item
QT interval from EKG at designated visit (may not be baseline)
text
C1287082 (UMLS CUI [1,1])
C1524084 (UMLS CUI [1,2])
C0545082 (UMLS CUI [1,3])
ESP_EKG_PR
Item
PR interval from EKG at designated visit (may not be baseline)
text
C0429087 (UMLS CUI [1,1])
C1524084 (UMLS CUI [1,2])
C0545082 (UMLS CUI [1,3])
ESP_EKG_HR
Item
HR interval from EKG at designated visit (may not be baseline)
text
C0522055 (UMLS CUI [1,1])
C1524084 (UMLS CUI [1,2])
C0545082 (UMLS CUI [1,3])
ESP_LVH_AT_EKG
Item
Left ventricular hypertrophy status at baseline [ 0=No, 1=Yes]
text
C0149721 (UMLS CUI [1,1])
C0449438 (UMLS CUI [1,2])
C1442488 (UMLS CUI [1,3])
ESP_AFLUT_AT_EKG
Item
Atrial flutter at EKG
text
C0004239 (UMLS CUI [1,1])
C0438154 (UMLS CUI [1,2])
ESP_WPW_AT_EKG
Item
Wolf-Parkinson-White pattern
text
C0043202 (UMLS CUI [1,1])
ESP_AVBLOCK2_AT_EKG
Item
Second degree AV block
text
C0264906 (UMLS CUI [1,1])
ESP_AVBLOCK3_AT_EKG
Item
Third degree AV block
text
C0151517 (UMLS CUI [1,1])
Item
Cornell voltage for EKG measurement, for EKG group.
text
C0438154 (UMLS CUI [1,1])
C0598352 (UMLS CUI [1,2])
ESP_CORNELL_VOLTAGE_EKG
Code List
Cornell voltage for EKG measurement, for EKG group.
CL Item
No (0)
CL Item
Yes (1)
Item
Pacer at EKG
text
C0030163 (UMLS CUI [1,1])
C0438154 (UMLS CUI [1,2])
ESP_PACER_EKG
Code List
Pacer at EKG
CL Item
No (0)
CL Item
Yes (1)
Item
Digoxin, for EKG group
text
C0012265 (UMLS CUI [1,1])
ESP_DIGOXIN_EKG
Code List
Digoxin, for EKG group
CL Item
No (0)
CL Item
Yes (1)
Item
Dihydropyridine calcium channel blockers
text
C2945601 (UMLS CUI [1,1])
ESP_DIHYDRO_CALCIUM_CHANNEL_BLOC
Code List
Dihydropyridine calcium channel blockers
CL Item
No (0)
CL Item
Yes (1)
Item
Non-dihydropyridine calcium channel blockers, for EKG group.
text
C1298908 (UMLS CUI [1,1])
C2945601 (UMLS CUI [1,2])
C0006684 (UMLS CUI [1,3])
ESP_NONDIHYDRO_CALCIUM_CHANNEL_B
Code List
Non-dihydropyridine calcium channel blockers, for EKG group.
CL Item
No (0)
CL Item
Yes (1)
Item
Any Calc Channel blocker (only for ARIC - other HeartGO cohorts have this broken down by Dihydro versus Non-Dihydro)
text
C0006684 (UMLS CUI [1,1])
ESP_CALCIUM_CHANNEL_BLOCKERS_EKG
Code List
Any Calc Channel blocker (only for ARIC - other HeartGO cohorts have this broken down by Dihydro versus Non-Dihydro)
CL Item
No (0)
CL Item
Yes (1)
Item
Betablockers, for EKG group.
text
C0304516 (UMLS CUI [1,1])
ESP_BETA_BLOCKERS_EKG
Code List
Betablockers, for EKG group.
CL Item
No (0)
CL Item
Yes (1)
ESP_AGE_AT_EKG
Item
Age in years at EKG measurement
text
C0001779 (UMLS CUI [1,1])
C0430456 (UMLS CUI [1,2])
ESP_SERUM_CYSTATINC
Item
Raw cystatin C (mg/L)
text
C1619716 (UMLS CUI [1,1])
ESP_AGE_AT_SERUM_CYSTATINC
Item
Age in years at serum cystatin c measurement
text
C0001779 (UMLS CUI [1,1])
C1619716 (UMLS CUI [1,2])
ESP_URIC_ACID
Item
Uric acid in mg/dL
text
C0202239 (UMLS CUI [1,1])
ESP_AGE_AT_URIC_ACID
Item
Age in years at uric acid measurement
text
C0001779 (UMLS CUI [1,1])
C0202239 (UMLS CUI [1,2])
ESP_URINARY_ALBUMIN
Item
Raw urinary albumin. Note: Users need to confirm units are the same across cohorts
text
C1524119 (UMLS CUI [1,1])
C0201838 (UMLS CUI [1,2])
ESP_AGE_AT_URINARY_ALBUMIN
Item
Age in years at urinary albumin measurement
text
C0001779 (UMLS CUI [1,1])
C1524119 (UMLS CUI [1,2])
C0201838 (UMLS CUI [1,3])
ESP_URINARY_CREATININE
Item
Raw urinary creatinine in mg/dL
text
C1524119 (UMLS CUI [1,1])
C0201975 (UMLS CUI [1,2])
ESP_AGE_AT_URINARY_CREATININE
Item
Age in years at urinary creatinine measurement
text
C0001779 (UMLS CUI [1,1])
C1524119 (UMLS CUI [1,2])
C0201975 (UMLS CUI [1,3])
Item
May be MD-reported, self-reported, or abstracted from patients taking allopurinol. Ever had gout through study.
text
C0031831 (UMLS CUI [1,1])
C0018099 (UMLS CUI [1,2])
C4319718 (UMLS CUI [1,3])
C2700446 (UMLS CUI [2,1])
C0018099 (UMLS CUI [2,2])
C1524063 (UMLS CUI [3,1])
C0002144 (UMLS CUI [3,2])
C0018099 (UMLS CUI [3,3])
ESP_GOUT
Code List
May be MD-reported, self-reported, or abstracted from patients taking allopurinol. Ever had gout through study.
CL Item
No (0)
CL Item
Yes (1)
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