ID

45041

Description

Principal Investigator: Kari Stefansson, MD, PhD, deCODE Genetics, Inc., Reykjavik, Iceland MeSH: Tobacco Use Disorder https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000393 A genome-wide association study on smoking behavior and nicotine dependence in Icelandic smokers, assessed by the number of cigarettes smoked per day, smoking initiation and degree of dependence on nicotine. The number of cigarettes smoked per day was ascertained through questionnaires given to individuals participating in multiple disease projects at deCODE Genetics (n=16,483). Smoking initiation was analyzed by comparing those that have ever smoked (n=16,483) versus those that have never smoked (n=21,667). The nicotine dependence analysis included 3,435 nicotine dependent cases (score 4 or higher on Fagerstrom Test for Nicotine Dependence (FTND) or endorsement of at least three of the seven Diagnostic and Statistical Manual of Mental Disorders 4th edition (DSM-IV) criteria) and 3,344 low-quantity smokers as controls.

Link

https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000393

Keywords

Tobacco Use Disorder

7/31/22 7/31/22 - Simon Heim
10/12/22 10/12/22 - Adrian Schulz

Copyright Holder

Kari Stefansson, MD, PhD, deCODE Genetics, Inc., Reykjavik, Iceland

Uploaded on

July 31, 2022

DOI

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License

Creative Commons BY 4.0

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dbGaP phs000393 Genes Contributing to Nicotine Dependence in Humans

model
Details

Eligibility Criteria

StudyEvent: SEV1
1. Eligibility Criteria
2. This table contains the summary level phenotype data for 3 separate analyses: 1) Number of cigarettes smoked per day, 2) Smoking initiation over cases and controls, and 3) Nicotine dependence over cases and controls.

Inclusion and exclusion criteria

Description

Inclusion and exclusion criteria

Individuals showing low genotype yield were excluded from the analysis (<98% call rate).

Description

Individuals showing low genotype yield were excluded from the analysis (<98% call rate).

Data type

boolean

Alias

UMLS CUI [1,1]: C0680251

UMLS CUI [1,2]: C1285573

Yes

No

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Eligibility Criteria

StudyEvent: SEV1
1. Eligibility Criteria
2. This table contains the summary level phenotype data for 3 separate analyses: 1) Number of cigarettes smoked per day, 2) Smoking initiation over cases and controls, and 3) Nicotine dependence over cases and controls.

Name

Type

Description | Question | Decode (Coded Value)

Data type

Alias

Item Group

Inclusion and exclusion criteria

Individuals showing low genotype yield were excluded from the analysis (<98% call rate).

Item

Individuals showing low genotype yield were excluded from the analysis (<98% call rate).

boolean

C0680251 (UMLS CUI [1,1])
C1285573 (UMLS CUI [1,2])

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