ID

45038

Beskrivning

Principal Investigator: Thomas Quertermous, Stanford University, Palo Alto, CA, USA MeSH: https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000423 ADVANCE (Atherosclerotic Disease, VAscular functioN, and genetiC Epidemiology) is a large epidemiological study of genetic and non-genetic determinants of coronary artery disease (CAD) that started in 2000 as a collaborative effort between researchers at Stanford University and Kaiser Permanente of Northern California. The overarching goal of the study is to improve our ability to prevent, diagnose and treat CAD. The initial study included recruitment of over 3600 subjects (including 1873 subjects with incident clinically significant coronary disease and 1745 control subjects) from multiple race/ethnic backgrounds. A subset of ~ 500 subjects with very early onset coronary disease (men 45 and women 55) and ~ 500 similar aged controls were genotyped using the Illumina 550K platform as part of an NIH funded effort within the STAMPEED consortium.

Länk

https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000423

Nyckelord

Versioner (3)
  1. 2022-07-29 2022-07-29 - Simon Heim
  2. 2022-10-12 2022-10-12 - Adrian Schulz
  3. 2025-01-29 2025-01-29 - Akane Nishihara
Rättsinnehavare

Thomas Quertermous, Stanford University, Palo Alto, CA, USA

Uppladdad den

29 juli 2022

DOI

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Licens

Creative Commons BY 4.0
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dbGaP phs000423 GWAS for Early Onset Coronary Disease (ADVANCE)

Engelsk

Eligibility Criteria

1 Formulär  
  1. StudyEvent: SEV1
    1. Eligibility Criteria
Inclusion and exclusion criteria
Beskrivning

Inclusion and exclusion criteria

**Cases**
Beskrivning

Cases

Datatyp

boolean

*Inclusion*
Beskrivning

Inclusion

Datatyp

boolean

Evidence in the electronic databases of any of the following in the time period 1/1/1999-12/31/2003: a rise in cardiac enzymes with a discharge diagnosis of CAD, a coronary revascularization procedure, or a diagnosis of angina with a coronary angiogram documenting at least one stenosis > 50%.
Beskrivning

Evidence in the electronic databases of any of the following in the time period 1/1/1999-12/31/2003: a rise in cardiac enzymes with a discharge diagnosis of CAD, a coronary revascularization procedure, or a diagnosis of angina with a coronary angiogram documenting at least one stenosis > 50%.

Datatyp

boolean

Alias
UMLS CUI [1,1]
C1706256
UMLS CUI [1,2]
C1512693
UMLS CUI [1,3]
C0455539
Age on date of first hospitalization for qualifying event: 18 to 45 for males, 18 to 55 for females
Beskrivning

Age on date of first hospitalization for qualifying event: 18 to 45 for males, 18 to 55 for females

Datatyp

boolean

Alias
UMLS CUI [1,1]
C1706256
UMLS CUI [1,2]
C1512693
UMLS CUI [1,3]
C0001779
*Exclusion*
Beskrivning

Exclusion

Datatyp

boolean

Evidence in the electronic databases (going back to 01/01/1996) of any of the following: CAD related diagnosis at anytime prior to the date of hospitalization, cancer, cirrhosis, renal failure, a bone marrow or organ transplant, entry in "no contact list", no assigned PCP, and remote distance from the study clinics.
Beskrivning

Evidence in the electronic databases (going back to 01/01/1996) of any of the following: CAD related diagnosis at anytime prior to the date of hospitalization, cancer, cirrhosis, renal failure, a bone marrow or organ transplant, entry in "no contact list", no assigned PCP, and remote distance from the study clinics.

Datatyp

boolean

Alias
UMLS CUI [1,1]
C1706256
UMLS CUI [1,2]
C0680251
UMLS CUI [1,3]
C0010068
UMLS CUI [1,4]
C0006826
UMLS CUI [1,5]
C1623038
UMLS CUI [1,6]
C0035078
UMLS CUI [1,7]
C0029216
UMLS CUI [1,8]
C0005961
A report during a screening interview of an inability to speak and write English, or any of the above exclusion criteria except a history of CAD prior to membership in KPNC.
Beskrivning

A report during a screening interview of an inability to speak and write English, or any of the above exclusion criteria except a history of CAD prior to membership in KPNC.

Datatyp

boolean

Alias
UMLS CUI [1,1]
C1706256
UMLS CUI [1,2]
C0680251
UMLS CUI [1,3]
C2984077
UMLS CUI [1,4]
C0564215
UMLS CUI [1,5]
C0584993
UMLS CUI [1,6]
C0376245
**Controls**
Beskrivning

Controls

Datatyp

boolean

*Young Controls from Kaiser*
Beskrivning

Young Controls from Kaiser

Datatyp

boolean

*Inclusion*
Beskrivning

Inclusion

Datatyp

boolean

Membership in KPNC continuously since 1/1/1998
Beskrivning

Membership in KPNC continuously since 1/1/1998

Datatyp

boolean

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0009932
UMLS CUI [1,3]
C0680038
Age on 6/30/2003 between 30 and 45 years for males and 30 and 55 years for females
Beskrivning

Age on 6/30/2003 between 30 and 45 years for males and 30 and 55 years for females

Datatyp

boolean

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0009932
UMLS CUI [1,3]
C0001779
Living in Oakland, San Francisco, Berkeley, Emeryville, Piedmont, Richmond or Albany, California
Beskrivning

Living in Oakland, San Francisco, Berkeley, Emeryville, Piedmont, Richmond or Albany, California

Datatyp

boolean

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0009932
UMLS CUI [1,3]
C2316883
*Exclusion*
Beskrivning

Exclusion

Datatyp

boolean

Evidence in the electronic databases (going back to 01/01/1996) of any of the following: atherosclerotic vascular disease (including CAD, CHF, stroke, PVD, cerebrovascular disease, and vascular disease not otherwise specified), HIV, dementia, cancer, cirrhosis, renal failure, entry in "no contact list", no assigned PCP, and remote distance from the study clinics.
Beskrivning

Evidence in the electronic databases (going back to 01/01/1996) of any of the following: atherosclerotic vascular disease (including CAD, CHF, stroke, PVD, cerebrovascular disease, and vascular disease not otherwise specified), HIV, dementia, cancer, cirrhosis, renal failure, entry in "no contact list", no assigned PCP, and remote distance from the study clinics.

Datatyp

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0009932
UMLS CUI [1,3]
C0010068
UMLS CUI [1,4]
C0019682
UMLS CUI [1,5]
C0497327
UMLS CUI [1,6]
C0006826
UMLS CUI [1,7]
C1623038
UMLS CUI [1,8]
C0035078
UMLS CUI [1,9]
C5549095
UMLS CUI [1,10]
C3846158
A report during a screening interview an inability to speak and write English, or of any of the above exclusion criteria at any time.
Beskrivning

A report during a screening interview an inability to speak and write English, or of any of the above exclusion criteria at any time.

Datatyp

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0009932
UMLS CUI [1,3]
C2984077
UMLS CUI [1,4]
C0564215
UMLS CUI [1,5]
C0584993
UMLS CUI [1,6]
C0376245
*Young Controls from CARDIA*
Beskrivning

Young Controls from CARDIA

Datatyp

boolean

*Inclusion*
Beskrivning

Inclusion

Datatyp

boolean

Participants in the CARDIA study with white/European and African American ancestry originally recruited in the Oakland KPNC field center in 1985-86 who completed the year 15 examination in 2000-2001 and had adequate samples of DNA.
Beskrivning

Participants in the CARDIA study with white/European and African American ancestry originally recruited in the Oakland KPNC field center in 1985-86 who completed the year 15 examination in 2000-2001 and had adequate samples of DNA.

Datatyp

boolean

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0009932
UMLS CUI [1,3]
C0239307
UMLS CUI [1,4]
C0085756
UMLS CUI [1,5]
C0205411
UMLS CUI [1,6]
C0444245
*Exclusion*
Beskrivning

Exclusion

Datatyp

boolean

A personal history of clinically significant CAD or documented CAD by CARDIA investigators
Beskrivning

A personal history of clinically significant CAD or documented CAD by CARDIA investigators

Datatyp

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0009932
UMLS CUI [1,3]
C1956346
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Similar models

Eligibility Criteria

1 Formulär
  1. StudyEvent: SEV1
    1. Eligibility Criteria
Name
Typ
Description | Question | Decode (Coded Value)
Datatyp
Alias
Item Group
Inclusion and exclusion criteria
Cases
Item
**Cases**
boolean
Inclusion
Item
*Inclusion*
boolean
Evidence in the electronic databases of any of the following in the time period 1/1/1999-12/31/2003: a rise in cardiac enzymes with a discharge diagnosis of CAD, a coronary revascularization procedure, or a diagnosis of angina with a coronary angiogram documenting at least one stenosis > 50%.
Item
Evidence in the electronic databases of any of the following in the time period 1/1/1999-12/31/2003: a rise in cardiac enzymes with a discharge diagnosis of CAD, a coronary revascularization procedure, or a diagnosis of angina with a coronary angiogram documenting at least one stenosis > 50%.
boolean
C1706256 (UMLS CUI [1,1])
C1512693 (UMLS CUI [1,2])
C0455539 (UMLS CUI [1,3])
Age on date of first hospitalization for qualifying event: 18 to 45 for males, 18 to 55 for females
Item
Age on date of first hospitalization for qualifying event: 18 to 45 for males, 18 to 55 for females
boolean
C1706256 (UMLS CUI [1,1])
C1512693 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
Exclusion
Item
*Exclusion*
boolean
Evidence in the electronic databases (going back to 01/01/1996) of any of the following: CAD related diagnosis at anytime prior to the date of hospitalization, cancer, cirrhosis, renal failure, a bone marrow or organ transplant, entry in "no contact list", no assigned PCP, and remote distance from the study clinics.
Item
Evidence in the electronic databases (going back to 01/01/1996) of any of the following: CAD related diagnosis at anytime prior to the date of hospitalization, cancer, cirrhosis, renal failure, a bone marrow or organ transplant, entry in "no contact list", no assigned PCP, and remote distance from the study clinics.
boolean
C1706256 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
C0010068 (UMLS CUI [1,3])
C0006826 (UMLS CUI [1,4])
C1623038 (UMLS CUI [1,5])
C0035078 (UMLS CUI [1,6])
C0029216 (UMLS CUI [1,7])
C0005961 (UMLS CUI [1,8])
A report during a screening interview of an inability to speak and write English, or any of the above exclusion criteria except a history of CAD prior to membership in KPNC.
Item
A report during a screening interview of an inability to speak and write English, or any of the above exclusion criteria except a history of CAD prior to membership in KPNC.
boolean
C1706256 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
C2984077 (UMLS CUI [1,3])
C0564215 (UMLS CUI [1,4])
C0584993 (UMLS CUI [1,5])
C0376245 (UMLS CUI [1,6])
Controls
Item
**Controls**
boolean
Young Controls from Kaiser
Item
*Young Controls from Kaiser*
boolean
Inclusion
Item
*Inclusion*
boolean
Membership in KPNC continuously since 1/1/1998
Item
Membership in KPNC continuously since 1/1/1998
boolean
C1512693 (UMLS CUI [1,1])
C0009932 (UMLS CUI [1,2])
C0680038 (UMLS CUI [1,3])
Age on 6/30/2003 between 30 and 45 years for males and 30 and 55 years for females
Item
Age on 6/30/2003 between 30 and 45 years for males and 30 and 55 years for females
boolean
C1512693 (UMLS CUI [1,1])
C0009932 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
Living in Oakland, San Francisco, Berkeley, Emeryville, Piedmont, Richmond or Albany, California
Item
Living in Oakland, San Francisco, Berkeley, Emeryville, Piedmont, Richmond or Albany, California
boolean
C1512693 (UMLS CUI [1,1])
C0009932 (UMLS CUI [1,2])
C2316883 (UMLS CUI [1,3])
Exclusion
Item
*Exclusion*
boolean
Evidence in the electronic databases (going back to 01/01/1996) of any of the following: atherosclerotic vascular disease (including CAD, CHF, stroke, PVD, cerebrovascular disease, and vascular disease not otherwise specified), HIV, dementia, cancer, cirrhosis, renal failure, entry in "no contact list", no assigned PCP, and remote distance from the study clinics.
Item
Evidence in the electronic databases (going back to 01/01/1996) of any of the following: atherosclerotic vascular disease (including CAD, CHF, stroke, PVD, cerebrovascular disease, and vascular disease not otherwise specified), HIV, dementia, cancer, cirrhosis, renal failure, entry in "no contact list", no assigned PCP, and remote distance from the study clinics.
boolean
C0680251 (UMLS CUI [1,1])
C0009932 (UMLS CUI [1,2])
C0010068 (UMLS CUI [1,3])
C0019682 (UMLS CUI [1,4])
C0497327 (UMLS CUI [1,5])
C0006826 (UMLS CUI [1,6])
C1623038 (UMLS CUI [1,7])
C0035078 (UMLS CUI [1,8])
C5549095 (UMLS CUI [1,9])
C3846158 (UMLS CUI [1,10])
A report during a screening interview an inability to speak and write English, or of any of the above exclusion criteria at any time.
Item
A report during a screening interview an inability to speak and write English, or of any of the above exclusion criteria at any time.
boolean
C0680251 (UMLS CUI [1,1])
C0009932 (UMLS CUI [1,2])
C2984077 (UMLS CUI [1,3])
C0564215 (UMLS CUI [1,4])
C0584993 (UMLS CUI [1,5])
C0376245 (UMLS CUI [1,6])
Young Controls from CARDIA
Item
*Young Controls from CARDIA*
boolean
Inclusion
Item
*Inclusion*
boolean
Participants in the CARDIA study with white/European and African American ancestry originally recruited in the Oakland KPNC field center in 1985-86 who completed the year 15 examination in 2000-2001 and had adequate samples of DNA.
Item
Participants in the CARDIA study with white/European and African American ancestry originally recruited in the Oakland KPNC field center in 1985-86 who completed the year 15 examination in 2000-2001 and had adequate samples of DNA.
boolean
C1512693 (UMLS CUI [1,1])
C0009932 (UMLS CUI [1,2])
C0239307 (UMLS CUI [1,3])
C0085756 (UMLS CUI [1,4])
C0205411 (UMLS CUI [1,5])
C0444245 (UMLS CUI [1,6])
Exclusion
Item
*Exclusion*
boolean
A personal history of clinically significant CAD or documented CAD by CARDIA investigators
Item
A personal history of clinically significant CAD or documented CAD by CARDIA investigators
boolean
C0680251 (UMLS CUI [1,1])
C0009932 (UMLS CUI [1,2])
C1956346 (UMLS CUI [1,3])
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