ID

45023

Descrizione

Principal Investigator: Dawood Darbar, MD, PhD, Vanderbilt University Medical Center, Nashville, TN, USA MeSH: Atrial Fibrillation https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000439 The goal of this study was to identify genetic predictors of response to rate control therapy in patients with AF. We conducted a genome-wide association study (GWAS) focusing on subjects with a history of atrial fibrillation. Rate control therapy for AF uses a range of drugs (beta-adrenergic receptor blockers, calcium channel blockers, and digitalis) to depress conduction through the AV node, thereby preventing rapid rates and minimizing symptoms. In large groups of patients, such as the Vanderbilt AF Registry (a clinical and genetic repository with over 1200 patients with ECG-confirmed AF) from which these study subjects were drawn, approximately 5% display failure of aggressive AV nodal-blocking therapy to control ventricular rate. In these patients, interruption of the AV node by ablation and pacemaker implantation are necessary for adequate rate control. Study cases were individuals who underwent AV node ablation and pacemaker implantation after combined therapy with 3 AV nodal-blocking agents was ineffective in rate control. Controls for this study were individuals who met standardized rate-control efficacy criteria (as described in AFFIRM study, Wyse et al, NEJM 2002; PMID: 12466506) for optimal rate control with 2 or fewer AV nodal-blocking agents. Two additional groups were genotyped by RIKEN: An additional group of patients with AF as well as subjects undergoing cardiac surgery in whom AF did not occur post-operatively. All study participants were recruited and treated/evaluated at Vanderbilt University Medical Center. This study was conducted by the Pharmacogenomics of Arrhythmia Therapy subgroup of the Pharmacogenetics Research Network, a nationwide collaboration of scientists studying the genetic contributions to drug response variability. Genotyping was performed by the RIKEN research institute in Japan using the Illumina 610 Quad Beadchip platform.

collegamento

https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000439

Keywords

versioni (2)
  1. 21/07/22 21/07/22 - Simon Heim
  2. 12/10/22 12/10/22 - Adrian Schulz
Titolare del copyright

Dawood Darbar, MD, PhD, Vanderbilt University Medical Center, Nashville, TN, USA

Caricato su

21 luglio 2022

DOI

Per favore, per richiedere un accesso.

Licenza

Creative Commons BY 4.0
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dbGaP phs000439 PGRN-RIKEN: Rate Control Therapy in Patients with Atrial Fibrillation

Inglese

Eligibility Criteria

4 moduli  
Inclusion and exclusion criteria
Descrizione

Inclusion and exclusion criteria

Inclusion criteria for all AF subjects: Must be between 18 and 100 years old with a diagnosis of atrial fibrillation. Additionally, subject must have a family member with known AF.
Descrizione

Inclusion criteria for all AF subjects: Must be between 18 and 100 years old with a diagnosis of atrial fibrillation. Additionally, subject must have a family member with known AF.

Tipo di dati

boolean

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C1706256
UMLS CUI [1,3]
C0004238
UMLS CUI [1,4]
C0001779
UMLS CUI [1,5]
C0086282
UMLS CUI [1,6]
C0004238
Exclusion criteria for all AF subjects: New onset AF occurring within 3 months of CABG or valve surgery; AF occurring post heart transplant; Post allogeneic bone marrow transplant.
Descrizione

Exclusion criteria for all AF subjects: New onset AF occurring within 3 months of CABG or valve surgery; AF occurring post heart transplant; Post allogeneic bone marrow transplant.

Tipo di dati

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C1706256
UMLS CUI [1,3]
C0004238
UMLS CUI [1,4]
C1442461
UMLS CUI [1,5]
C0010055
UMLS CUI [1,6]
C2066019
UMLS CUI [2,1]
C0680251
UMLS CUI [2,2]
C1706256
UMLS CUI [2,3]
C0231290
UMLS CUI [2,4]
C0018823
UMLS CUI [3,1]
C0680251
UMLS CUI [3,2]
C1706256
UMLS CUI [3,3]
C0231290
UMLS CUI [3,4]
C0194037
Controls were defined as those subjects who satisfied the following criteria (AFFIRM) after treatment with 2 or fewer AV nodal-blocking agents: average heart rate (HR) ≤ 80 bpm at rest, in addition to either an average 24-hour HR ≤ 100 bpm and no maximal 24-hr HR > 110% of the predicted age-adjusted maximum exercise HR, or a HR ≤ 110 bpm during a 6-minute walk test.
Descrizione

Controls were defined as those subjects who satisfied the following criteria (AFFIRM) after treatment with 2 or fewer AV nodal-blocking agents: average heart rate (HR) ≤ 80 bpm at rest, in addition to either an average 24-hour HR ≤ 100 bpm and no maximal 24-hr HR > 110% of the predicted age-adjusted maximum exercise HR, or a HR ≤ 110 bpm during a 6-minute walk test.

Tipo di dati

boolean

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0009932
UMLS CUI [1,3]
C0087111
UMLS CUI [1,4]
C0013227
UMLS CUI [1,5]
C4523943
UMLS CUI [1,6]
C0018810
Cases were defined as those subjects who failed to satisfy the AFFIRM criteria after combined therapy with 3 AV nodal-blocking agents and required AV node ablation and pacemaker implantation.
Descrizione

Cases were defined as those subjects who failed to satisfy the AFFIRM criteria after combined therapy with 3 AV nodal-blocking agents and required AV node ablation and pacemaker implantation.

Tipo di dati

boolean

Alias
UMLS CUI [1,1]
C1706256
UMLS CUI [1,2]
C0087111
UMLS CUI [1,3]
C0013227
UMLS CUI [1,4]
C4523943
UMLS CUI [1,5]
C1514873
UMLS CUI [1,6]
C3275044
UMLS CUI [1,7]
C0189863
Criteria for post-op patients with no AF: All adult patients scheduled for elective cardiothoracic surgery who are capable of providing informed consent will be eligible for the study. Emergency patients or hemodynamically unstable patients for whom discussion of consent would delay surgery or who are incapable of providing consent will be excluded.
Descrizione

Criteria for post-op patients with no AF: All adult patients scheduled for elective cardiothoracic surgery who are capable of providing informed consent will be eligible for the study. Emergency patients or hemodynamically unstable patients for whom discussion of consent would delay surgery or who are incapable of providing consent will be excluded.

Tipo di dati

boolean

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C1549444
UMLS CUI [1,3]
C0004238
UMLS CUI [1,4]
C2242990
UMLS CUI [1,5]
C0085732
UMLS CUI [1,6]
C0021430
UMLS CUI [2,1]
C0680251
UMLS CUI [2,2]
C0021430
UMLS CUI [2,3]
C1640361
UMLS CUI [2,4]
C0543467
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Similar models

Eligibility Criteria

4 moduli
Name
genere
Description | Question | Decode (Coded Value)
Tipo di dati
Alias
Item Group
Inclusion and exclusion criteria
Inclusion criteria for all AF subjects: Must be between 18 and 100 years old with a diagnosis of atrial fibrillation. Additionally, subject must have a family member with known AF.
Item
Inclusion criteria for all AF subjects: Must be between 18 and 100 years old with a diagnosis of atrial fibrillation. Additionally, subject must have a family member with known AF.
boolean
C1512693 (UMLS CUI [1,1])
C1706256 (UMLS CUI [1,2])
C0004238 (UMLS CUI [1,3])
C0001779 (UMLS CUI [1,4])
C0086282 (UMLS CUI [1,5])
C0004238 (UMLS CUI [1,6])
Exclusion criteria for all AF subjects: New onset AF occurring within 3 months of CABG or valve surgery; AF occurring post heart transplant; Post allogeneic bone marrow transplant.
Item
Exclusion criteria for all AF subjects: New onset AF occurring within 3 months of CABG or valve surgery; AF occurring post heart transplant; Post allogeneic bone marrow transplant.
boolean
C0680251 (UMLS CUI [1,1])
C1706256 (UMLS CUI [1,2])
C0004238 (UMLS CUI [1,3])
C1442461 (UMLS CUI [1,4])
C0010055 (UMLS CUI [1,5])
C2066019 (UMLS CUI [1,6])
C0680251 (UMLS CUI [2,1])
C1706256 (UMLS CUI [2,2])
C0231290 (UMLS CUI [2,3])
C0018823 (UMLS CUI [2,4])
C0680251 (UMLS CUI [3,1])
C1706256 (UMLS CUI [3,2])
C0231290 (UMLS CUI [3,3])
C0194037 (UMLS CUI [3,4])
Controls were defined as those subjects who satisfied the following criteria (AFFIRM) after treatment with 2 or fewer AV nodal-blocking agents: average heart rate (HR) ≤ 80 bpm at rest, in addition to either an average 24-hour HR ≤ 100 bpm and no maximal 24-hr HR > 110% of the predicted age-adjusted maximum exercise HR, or a HR ≤ 110 bpm during a 6-minute walk test.
Item
Controls were defined as those subjects who satisfied the following criteria (AFFIRM) after treatment with 2 or fewer AV nodal-blocking agents: average heart rate (HR) ≤ 80 bpm at rest, in addition to either an average 24-hour HR ≤ 100 bpm and no maximal 24-hr HR > 110% of the predicted age-adjusted maximum exercise HR, or a HR ≤ 110 bpm during a 6-minute walk test.
boolean
C1512693 (UMLS CUI [1,1])
C0009932 (UMLS CUI [1,2])
C0087111 (UMLS CUI [1,3])
C0013227 (UMLS CUI [1,4])
C4523943 (UMLS CUI [1,5])
C0018810 (UMLS CUI [1,6])
Cases were defined as those subjects who failed to satisfy the AFFIRM criteria after combined therapy with 3 AV nodal-blocking agents and required AV node ablation and pacemaker implantation.
Item
Cases were defined as those subjects who failed to satisfy the AFFIRM criteria after combined therapy with 3 AV nodal-blocking agents and required AV node ablation and pacemaker implantation.
boolean
C1706256 (UMLS CUI [1,1])
C0087111 (UMLS CUI [1,2])
C0013227 (UMLS CUI [1,3])
C4523943 (UMLS CUI [1,4])
C1514873 (UMLS CUI [1,5])
C3275044 (UMLS CUI [1,6])
C0189863 (UMLS CUI [1,7])
Criteria for post-op patients with no AF: All adult patients scheduled for elective cardiothoracic surgery who are capable of providing informed consent will be eligible for the study. Emergency patients or hemodynamically unstable patients for whom discussion of consent would delay surgery or who are incapable of providing consent will be excluded.
Item
Criteria for post-op patients with no AF: All adult patients scheduled for elective cardiothoracic surgery who are capable of providing informed consent will be eligible for the study. Emergency patients or hemodynamically unstable patients for whom discussion of consent would delay surgery or who are incapable of providing consent will be excluded.
boolean
C1512693 (UMLS CUI [1,1])
C1549444 (UMLS CUI [1,2])
C0004238 (UMLS CUI [1,3])
C2242990 (UMLS CUI [1,4])
C0085732 (UMLS CUI [1,5])
C0021430 (UMLS CUI [1,6])
C0680251 (UMLS CUI [2,1])
C0021430 (UMLS CUI [2,2])
C1640361 (UMLS CUI [2,3])
C0543467 (UMLS CUI [2,4])
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