ID

45015

Description

Principal Investigator: James Versalovic, MD, PhD, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA MeSH: Irritable Bowel Syndrome,Digestive System Diseases,Abdominal Pain https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000265 This project explores the nature of the human intestinal microbiome in healthy children and children with recurrent abdominal pain. The overall goal is to obtain a robust knowledge-base of the intestinal microbiome in children without evidence of pain or gastrointestinal disease, children with functional abdominal pain, and children with abdominal pain and changes in bowel habits (irritable bowel syndrome). Multiple strategies have been deployed to navigate and understand the nature of the intestinal microbiome in childhood. These strategies include 454 pyrosequencing-based strategies to sequence 16S rRNA genes and understand the detailed composition of microbes in healthy and disease groups. Microarray-based hybridization with the PhyloChip and quantitative real-time PCR (qPCR) probes are being applied as complementary strategies to gain an understanding of the intestinal microbiome from various perspectives. Data collected and analyzed during the HMP UH2 and UH3 Demo project, from a set of healthy and IBS children may enable the identification of core microbiomes in children in addition to variable components that may distinguish healthy from diseased pediatric states. We are currently analyzing the dataset for the presence of disease-specific signatures in the human microbiome, and correlating these microbial signatures with pediatric health or IBS disease status. This study explores the nature of core and variable human microbiomes in pre-adolescent healthy children and children with recurrent abdominal pain.

Link

https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000265

Keywords

Versions (2)
  1. 7/13/22 7/13/22 - Dr. Christian Niklas
  2. 10/12/22 10/12/22 - Adrian Schulz
Copyright Holder

James Versalovic, MD, PhD, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA

Uploaded on

July 13, 2022

DOI

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License

Creative Commons BY 4.0
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dbGaP phs000265 The Human Gut Microbiome and Recurrent Abdominal Pain in Children

English

Eligibility Criteria

5 forms  
Inclusion and exclusion criteria
Description

Inclusion and exclusion criteria

*Inclusion Criteria:*
Description

Inclusion Criteria

Data type

boolean

Alias
UMLS CUI [1,1]
C1512693
Children aged 7-12 years of age who either have IBS or FAP or are healthy without complaints (Controls).
Description

Children aged 7-12 years of age who either have IBS or FAP or are healthy without complaints (Controls)

Data type

boolean

Alias
UMLS CUI [1,1]
C1706256
UMLS CUI [1,2]
C1512693
UMLS CUI [1,3]
C0001779
UMLS CUI [1,4]
C0022104
UMLS CUI [1,5]
C0000737
UMLS CUI [1,6]
C3898900
UMLS CUI [2,1]
C1512693
UMLS CUI [2,2]
C0009932
UMLS CUI [2,3]
C0332288
UMLS CUI [2,4]
C0871764
IBS:
Description

IBS

Data type

boolean

Alias
UMLS CUI [1,1]
C1706256
UMLS CUI [1,2]
C1512693
UMLS CUI [1,3]
C0022104
Minimum of 1 healthcare visit for abdominal pain.
Description

Minimum of 1 healthcare visit for abdominal pain.

Data type

boolean

Alias
UMLS CUI [1,1]
C1706256
UMLS CUI [1,2]
C1512693
UMLS CUI [1,3]
C1524031
UMLS CUI [1,4]
C0205447
UMLS CUI [1,5]
C0086388
UMLS CUI [1,6]
C0545082
UMLS CUI [1,7]
C0566251
UMLS CUI [1,8]
C0000737
Minimum number of pain episodes of at least once per month, for three consecutive months within the year prior to enrolling in study.
Description

Minimum number of pain episodes of at least once per month, for three consecutive months within the year prior to enrolling in study.

Data type

boolean

Alias
UMLS CUI [1,1]
C1706256
UMLS CUI [1,2]
C1512693
UMLS CUI [1,3]
C1524031
UMLS CUI [1,4]
C4086638
UMLS CUI [1,5]
C0030193
UMLS CUI [1,6]
C3845349
UMLS CUI [1,7]
C0347984
UMLS CUI [1,8]
C1442461
UMLS CUI [1,9]
C1707491
UMLS CUI [1,10]
C0872291
UMLS CUI [1,11]
C0205156
UMLS CUI [1,12]
C4082117
Pain episodes have been severe enough to cause functional impairment; or have prompted medication use; or have been rated moderate to severe (≥ 3/10).
Description

Pain episodes have been severe enough to cause functional impairment; or have prompted medication use; or have been rated moderate to severe

Data type

boolean

Alias
UMLS CUI [1,1]
C1706256
UMLS CUI [1,2]
C1512693
UMLS CUI [1,3]
C0030193
UMLS CUI [1,4]
C0678227
UMLS CUI [1,5]
C4062321
UMLS CUI [2,1]
C1512693
UMLS CUI [2,2]
C0030193
UMLS CUI [2,3]
C0205263
UMLS CUI [2,4]
C0240320
UMLS CUI [3,1]
C1706256
UMLS CUI [3,2]
C1512693
UMLS CUI [3,3]
C0030193
UMLS CUI [3,4]
C0871208
UMLS CUI [3,5]
C1514721
UMLS CUI [3,6]
C0205081
UMLS CUI [3,7]
C0205082
Symptoms current.
Description

Symptoms current.

Data type

boolean

Alias
UMLS CUI [1,1]
C1706256
UMLS CUI [1,2]
C1512693
UMLS CUI [1,3]
C1457887
UMLS CUI [1,4]
C0521116
Less than 95th percentile blood pressure for age.
Description

Less than 95th percentile blood pressure for age.

Data type

boolean

Alias
UMLS CUI [1,1]
C1706256
UMLS CUI [1,2]
C1512693
UMLS CUI [1,3]
C0005823
UMLS CUI [1,4]
C0439092
UMLS CUI [1,5]
C1264641
UMLS CUI [1,6]
C0001779
Controls:
Description

Controls:

Data type

boolean

Alias
UMLS CUI [1,1]
C0009932
Asymptomatic with regards to abdominal pain and without significant chronic health issues.
Description

Asymptomatic with regards to abdominal pain and without significant chronic health issues.

Data type

boolean

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0009932
UMLS CUI [1,3]
C1298908
UMLS CUI [1,4]
C0000737
UMLS CUI [2,1]
C1512693
UMLS CUI [2,2]
C0009932
UMLS CUI [2,3]
C1298908
UMLS CUI [2,4]
C0008679
Less than 95% blood pressure for age
Description

Less than 95% blood pressure for age

Data type

boolean

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0009932
UMLS CUI [1,3]
C0439092
UMLS CUI [1,4]
C1264641
UMLS CUI [1,5]
C0005823
UMLS CUI [1,6]
C0001779
*Exclusion Criteria:*
Description

Exclusion Criteria

Data type

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C1706256
IBS/FAP:
Description

IBS/FAP

Data type

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C1706256
UMLS CUI [1,3]
C0022104
UMLS CUI [1,4]
C0000737
Organic disease that accounts for abdominal pain.
Description

Organic disease that accounts for abdominal pain

Data type

boolean

Alias
UMLS CUI [1,1]
C1706256
UMLS CUI [1,2]
C0680251
UMLS CUI [1,3]
C0683324
UMLS CUI [1,4]
C0681841
UMLS CUI [1,5]
C0000737
UMLS CUI [1,6]
C0022104
Child currently taking an anti-inflammatory medication, or if their abdominal pain responded to an anti-inflammatory medication in the past.
Description

Child currently taking an anti-inflammatory medication, or if their abdominal pain responded to an anti-inflammatory medication in the past.

Data type

boolean

Alias
UMLS CUI [1,1]
C1706256
UMLS CUI [1,2]
C0022104
UMLS CUI [1,3]
C0000737
UMLS CUI [1,4]
C0680251
UMLS CUI [1,5]
C3843777
UMLS CUI [2,1]
C1706256
UMLS CUI [2,2]
C0680251
UMLS CUI [2,3]
C0000737
UMLS CUI [2,4]
C0205342
UMLS CUI [2,5]
C0003209
UMLS CUI [2,6]
C1444637
Child currently taking medication for reflux to which abdominal pain symptoms are responding.
Description

Child currently taking medication for reflux to which abdominal pain symptoms are responding

Data type

boolean

Alias
UMLS CUI [1,1]
C1706256
UMLS CUI [1,2]
C0680251
UMLS CUI [1,3]
C0521116
UMLS CUI [1,4]
C0013227
UMLS CUI [1,5]
C0017168
UMLS CUI [1,6]
C0564405
UMLS CUI [1,7]
C0000737
UMLS CUI [1,8]
C0022104
Other chronic health condition or chronic illness (except mild intermittent or mild persistent asthma).
Description

Other chronic health condition or chronic illness (except mild intermittent or mild persistent asthma).

Data type

boolean

Alias
UMLS CUI [1,1]
C1706256
UMLS CUI [1,2]
C0680251
UMLS CUI [1,3]
C0008679
UMLS CUI [1,4]
C0205191
UMLS CUI [1,5]
C0221423
UMLS CUI [1,6]
C1705847
UMLS CUI [1,7]
C1960046
UMLS CUI [1,8]
C1960045
UMLS CUI [1,9]
C0022104
UMLS CUI [1,10]
C0000737
Cognitive impairment significantly below average age and/or grade level.
Description

Cognitive impairment significantly below average age and/or grade level.

Data type

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0022104
UMLS CUI [1,3]
C0000737
UMLS CUI [1,4]
C1706256
UMLS CUI [1,5]
C0338656
UMLS CUI [1,6]
C0443151
UMLS CUI [1,7]
C0001779
UMLS CUI [2,1]
C0680251
UMLS CUI [2,2]
C0022104
UMLS CUI [2,3]
C0000737
UMLS CUI [2,4]
C1706256
UMLS CUI [2,5]
C0338656
UMLS CUI [2,6]
C0443151
UMLS CUI [2,7]
C0441800
Vomiting ≥ 2 times per month within 3 months prior to enrolling on study.
Description

Vomiting more than 2 times per month within 3 months prior to enrolling on study.

Data type

boolean

Alias
UMLS CUI [1,1]
C1706256
UMLS CUI [1,2]
C0680251
UMLS CUI [1,3]
C0022104
UMLS CUI [1,4]
C0000737
UMLS CUI [1,5]
C0042963
UMLS CUI [1,6]
C0439093
UMLS CUI [1,7]
C0439603
UMLS CUI [1,8]
C0205156
UMLS CUI [1,9]
C1442461
Unintentional weight loss of ≥ 5% body weight within 3-month period.
Description

Unintentional weight loss of more than 5% body weight within 3-month period

Data type

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C1706256
UMLS CUI [1,3]
C0000737
UMLS CUI [1,4]
C0022104
UMLS CUI [1,5]
C2363736
UMLS CUI [1,6]
C0439093
UMLS CUI [1,7]
C0439165
UMLS CUI [1,8]
C0205451
UMLS CUI [1,9]
C4086725
Females who have menses.
Description

Females who have menses.

Data type

boolean

Alias
UMLS CUI [1,1]
C1706256
UMLS CUI [1,2]
C0000737
UMLS CUI [1,3]
C0680251
UMLS CUI [1,4]
C0086287
UMLS CUI [1,5]
C0025344
Use of the following drugs within the last 6 months: systemic antibiotics, oral, intravenous, intramuscular, nasal or inhaled corticosteroids, cytokines, methotrexate or immunosuppressive cytotoxic agents, or large doses of commercial probiotics (10e8 cfu per day or higher).
Description

Use of the following drugs within the last 6 months

Data type

boolean

Alias
UMLS CUI [1,1]
C1706256
UMLS CUI [1,2]
C0680251
UMLS CUI [1,3]
C1524063
UMLS CUI [1,4]
C0239126
UMLS CUI [1,5]
C1527415
UMLS CUI [1,6]
C1522726
UMLS CUI [1,7]
C1556154
UMLS CUI [1,8]
C0586793
UMLS CUI [1,9]
C3539185
UMLS CUI [1,10]
C1517741
UMLS CUI [1,11]
C0205452
UMLS CUI [1,12]
C0439231
UMLS CUI [2,1]
C1706256
UMLS CUI [2,2]
C0680251
UMLS CUI [2,3]
C1524063
UMLS CUI [2,4]
C0025677
UMLS CUI [2,5]
C1517741
UMLS CUI [2,6]
C0205452
UMLS CUI [2,7]
C0439231
UMLS CUI [3,1]
C1706256
UMLS CUI [3,2]
C0680251
UMLS CUI [3,3]
C1524063
UMLS CUI [3,4]
C0079189
UMLS CUI [3,5]
C1517741
UMLS CUI [3,6]
C0205452
UMLS CUI [3,7]
C0439231
UMLS CUI [4,1]
C1706256
UMLS CUI [4,2]
C0680251
UMLS CUI [4,3]
C1524063
UMLS CUI [4,4]
C3540704
UMLS CUI [4,5]
C1517741
UMLS CUI [4,6]
C0205452
UMLS CUI [4,7]
C0439231
UMLS CUI [5,1]
C1706256
UMLS CUI [5,2]
C0680251
UMLS CUI [5,3]
C1524063
UMLS CUI [5,4]
C0021081
UMLS CUI [5,5]
C0677881
UMLS CUI [5,6]
C1517741
UMLS CUI [5,7]
C0205452
UMLS CUI [5,8]
C0439231
UMLS CUI [6,1]
C1706256
UMLS CUI [6,2]
C0680251
UMLS CUI [6,3]
C1524063
UMLS CUI [6,4]
C0549177
UMLS CUI [6,5]
C0178602
UMLS CUI [6,6]
C0680536
UMLS CUI [6,7]
C1517741
UMLS CUI [6,8]
C0525033
UMLS CUI [6,9]
C0205452
UMLS CUI [6,10]
C0439231
Major diet change in the past month prior to enrollment (e.g., change to vegetarianism or vice versa; avoidance or inclusion of major food group [fruit, vegetables]). This does not include diet changes related to lactose intolerance.
Description

Major diet change in the past month prior to enrollmen

Data type

boolean

Alias
UMLS CUI [1,1]
C1706256
UMLS CUI [1,2]
C0680251
UMLS CUI [1,3]
C0205164
UMLS CUI [1,4]
C3671772
UMLS CUI [1,5]
C1444637
UMLS CUI [1,6]
C0439231
Major surgery including surgery involving the gastrointestinal tract.
Description

Major surgery including surgery involving the gastrointestinal tract.

Data type

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C1706256
UMLS CUI [1,3]
C0022104
UMLS CUI [1,4]
C0000737
UMLS CUI [1,5]
C0679637
UMLS CUI [1,6]
C0524722
Controls:
Description

Controls

Data type

boolean

Alias
UMLS CUI [1,1]
C0009932
UMLS CUI [1,2]
C0680251
Other chronic illness or health condition or chronic illness (except mild intermittent or mild persistent asthma)
Description

Other chronic illness or health condition or chronic illness (except mild intermittent or mild persistent asthma)

Data type

boolean

Alias
UMLS CUI [1,1]
C0009932
UMLS CUI [1,2]
C0680251
UMLS CUI [1,3]
C0008679
UMLS CUI [1,4]
C1705847
UMLS CUI [1,5]
C1960046
UMLS CUI [1,6]
C1960045
Cognitive impairment significantly below average age and/or grade level
Description

Cognitive impairment significantly below average age and/or grade level

Data type

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0009932
UMLS CUI [1,3]
C0338656
UMLS CUI [1,4]
C0443151
UMLS CUI [1,5]
C0001779
UMLS CUI [2,1]
C0680251
UMLS CUI [2,2]
C0009932
UMLS CUI [2,3]
C0338656
UMLS CUI [2,4]
C0443151
UMLS CUI [2,5]
C0441800
Child seen a physician more than once in past year for abdominal pain unexplained by common illness (e.g., gastroenteritis)
Description

Child seen a physician more than once in past year for abdominal pain unexplained by common illness (e.g., gastroenteritis)

Data type

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0009932
UMLS CUI [1,3]
C0583527
UMLS CUI [1,4]
C0566251
UMLS CUI [1,5]
C0000737
UMLS CUI [1,6]
C0439093
UMLS CUI [1,7]
C1948045
UMLS CUI [1,8]
C3887293
UMLS CUI [1,9]
C4288071
UMLS CUI [1,10]
C0205214
UMLS CUI [1,11]
C0221423
Females who have menses
Description

Females who have menses

Data type

boolean

Alias
UMLS CUI [1,1]
C0009932
UMLS CUI [1,2]
C0680251
UMLS CUI [1,3]
C0086287
UMLS CUI [1,4]
C0025344
Use of the following drugs within the last 6 months: systemic antibiotics, oral, intravenous, intramuscular, nasal or inhaled corticosteroids, cytokines, methotrexate or immunosuppressive cytotoxic agents, or large doses of commercial probiotics (10e8 cfu per day or higher).
Description

Use of the following drugs within the last 6 months

Data type

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0009932
UMLS CUI [1,3]
C1524063
UMLS CUI [1,4]
C0239126
UMLS CUI [1,5]
C1527415
UMLS CUI [1,6]
C1522726
UMLS CUI [1,7]
C1556154
UMLS CUI [1,8]
C0586793
UMLS CUI [1,9]
C3539185
UMLS CUI [1,10]
C1517741
UMLS CUI [1,11]
C0205452
UMLS CUI [1,12]
C0439231
UMLS CUI [2,1]
C0009932
UMLS CUI [2,2]
C0680251
UMLS CUI [2,3]
C1524063
UMLS CUI [2,4]
C0549177
UMLS CUI [2,5]
C0178602
UMLS CUI [2,6]
C0680536
UMLS CUI [2,7]
C0525033
UMLS CUI [2,8]
C1517741
UMLS CUI [2,9]
C0205452
UMLS CUI [2,10]
C0439231
UMLS CUI [3,1]
C0009932
UMLS CUI [3,2]
C0680251
UMLS CUI [3,3]
C1524063
UMLS CUI [3,4]
C0021081
UMLS CUI [3,5]
C0677881
UMLS CUI [3,6]
C1517741
UMLS CUI [3,7]
C0205452
UMLS CUI [3,8]
C0439231
UMLS CUI [4,1]
C0009932
UMLS CUI [4,2]
C0680251
UMLS CUI [4,3]
C1524063
UMLS CUI [4,4]
C0025677
UMLS CUI [4,5]
C1517741
UMLS CUI [4,6]
C0205452
UMLS CUI [4,7]
C0439231
UMLS CUI [5,1]
C0009932
UMLS CUI [5,2]
C0079189
UMLS CUI [5,3]
C0680251
UMLS CUI [5,4]
C1524063
UMLS CUI [5,5]
C1517741
UMLS CUI [5,6]
C0205452
UMLS CUI [5,7]
C0439231
UMLS CUI [6,1]
C0009932
UMLS CUI [6,2]
C0680251
UMLS CUI [6,3]
C1524063
UMLS CUI [6,4]
C3540704
UMLS CUI [6,5]
C1517741
UMLS CUI [6,6]
C0205452
UMLS CUI [6,7]
C0439231
Major diet change in the past month prior to enrollment (e.g., change to vegetarianism or vice versa; avoidance or inclusion of major food group [fruit, vegetables]). This does not include diet changes related to lactose intolerance.
Description

Major diet change in the past month prior to enrollment

Data type

boolean

Alias
UMLS CUI [1,1]
C0009932
UMLS CUI [1,2]
C0680251
UMLS CUI [1,3]
C0205164
UMLS CUI [1,4]
C1444637
UMLS CUI [1,5]
C0439231
Major surgery including surgery involving the gastrointestinal tract.
Description

Major surgery including surgery involving the gastrointestinal tract.

Data type

boolean

Alias
UMLS CUI [1,1]
C0009932
UMLS CUI [1,2]
C0680251
UMLS CUI [1,3]
C0679637
UMLS CUI [1,4]
C0524722
Non-English speaking parent or child.
Description

Non-English speaking parent or child.

Data type

boolean

Alias
UMLS CUI [1,1]
C0332268
UMLS CUI [1,2]
C0564215
UMLS CUI [1,3]
C0376245
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Similar models

Eligibility Criteria

5 forms
Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
Item Group
Inclusion and exclusion criteria
Inclusion Criteria
Item
*Inclusion Criteria:*
boolean
C1512693 (UMLS CUI [1,1])
Children aged 7-12 years of age who either have IBS or FAP or are healthy without complaints (Controls)
Item
Children aged 7-12 years of age who either have IBS or FAP or are healthy without complaints (Controls).
boolean
C1706256 (UMLS CUI [1,1])
C1512693 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
C0022104 (UMLS CUI [1,4])
C0000737 (UMLS CUI [1,5])
C3898900 (UMLS CUI [1,6])
C1512693 (UMLS CUI [2,1])
C0009932 (UMLS CUI [2,2])
C0332288 (UMLS CUI [2,3])
C0871764 (UMLS CUI [2,4])
IBS
Item
IBS:
boolean
C1706256 (UMLS CUI [1,1])
C1512693 (UMLS CUI [1,2])
C0022104 (UMLS CUI [1,3])
Minimum of 1 healthcare visit for abdominal pain.
Item
Minimum of 1 healthcare visit for abdominal pain.
boolean
C1706256 (UMLS CUI [1,1])
C1512693 (UMLS CUI [1,2])
C1524031 (UMLS CUI [1,3])
C0205447 (UMLS CUI [1,4])
C0086388 (UMLS CUI [1,5])
C0545082 (UMLS CUI [1,6])
C0566251 (UMLS CUI [1,7])
C0000737 (UMLS CUI [1,8])
Minimum number of pain episodes of at least once per month, for three consecutive months within the year prior to enrolling in study.
Item
Minimum number of pain episodes of at least once per month, for three consecutive months within the year prior to enrolling in study.
boolean
C1706256 (UMLS CUI [1,1])
C1512693 (UMLS CUI [1,2])
C1524031 (UMLS CUI [1,3])
C4086638 (UMLS CUI [1,4])
C0030193 (UMLS CUI [1,5])
C3845349 (UMLS CUI [1,6])
C0347984 (UMLS CUI [1,7])
C1442461 (UMLS CUI [1,8])
C1707491 (UMLS CUI [1,9])
C0872291 (UMLS CUI [1,10])
C0205156 (UMLS CUI [1,11])
C4082117 (UMLS CUI [1,12])
Pain episodes have been severe enough to cause functional impairment; or have prompted medication use; or have been rated moderate to severe
Item
Pain episodes have been severe enough to cause functional impairment; or have prompted medication use; or have been rated moderate to severe (≥ 3/10).
boolean
C1706256 (UMLS CUI [1,1])
C1512693 (UMLS CUI [1,2])
C0030193 (UMLS CUI [1,3])
C0678227 (UMLS CUI [1,4])
C4062321 (UMLS CUI [1,5])
C1512693 (UMLS CUI [2,1])
C0030193 (UMLS CUI [2,2])
C0205263 (UMLS CUI [2,3])
C0240320 (UMLS CUI [2,4])
C1706256 (UMLS CUI [3,1])
C1512693 (UMLS CUI [3,2])
C0030193 (UMLS CUI [3,3])
C0871208 (UMLS CUI [3,4])
C1514721 (UMLS CUI [3,5])
C0205081 (UMLS CUI [3,6])
C0205082 (UMLS CUI [3,7])
Symptoms current.
Item
Symptoms current.
boolean
C1706256 (UMLS CUI [1,1])
C1512693 (UMLS CUI [1,2])
C1457887 (UMLS CUI [1,3])
C0521116 (UMLS CUI [1,4])
Less than 95th percentile blood pressure for age.
Item
Less than 95th percentile blood pressure for age.
boolean
C1706256 (UMLS CUI [1,1])
C1512693 (UMLS CUI [1,2])
C0005823 (UMLS CUI [1,3])
C0439092 (UMLS CUI [1,4])
C1264641 (UMLS CUI [1,5])
C0001779 (UMLS CUI [1,6])
Controls:
Item
Controls:
boolean
C0009932 (UMLS CUI [1,1])
Asymptomatic with regards to abdominal pain and without significant chronic health issues.
Item
Asymptomatic with regards to abdominal pain and without significant chronic health issues.
boolean
C1512693 (UMLS CUI [1,1])
C0009932 (UMLS CUI [1,2])
C1298908 (UMLS CUI [1,3])
C0000737 (UMLS CUI [1,4])
C1512693 (UMLS CUI [2,1])
C0009932 (UMLS CUI [2,2])
C1298908 (UMLS CUI [2,3])
C0008679 (UMLS CUI [2,4])
Less than 95% blood pressure for age
Item
Less than 95% blood pressure for age
boolean
C1512693 (UMLS CUI [1,1])
C0009932 (UMLS CUI [1,2])
C0439092 (UMLS CUI [1,3])
C1264641 (UMLS CUI [1,4])
C0005823 (UMLS CUI [1,5])
C0001779 (UMLS CUI [1,6])
Exclusion Criteria
Item
*Exclusion Criteria:*
boolean
C0680251 (UMLS CUI [1,1])
C1706256 (UMLS CUI [1,2])
IBS/FAP
Item
IBS/FAP:
boolean
C0680251 (UMLS CUI [1,1])
C1706256 (UMLS CUI [1,2])
C0022104 (UMLS CUI [1,3])
C0000737 (UMLS CUI [1,4])
Organic disease that accounts for abdominal pain
Item
Organic disease that accounts for abdominal pain.
boolean
C1706256 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
C0683324 (UMLS CUI [1,3])
C0681841 (UMLS CUI [1,4])
C0000737 (UMLS CUI [1,5])
C0022104 (UMLS CUI [1,6])
Child currently taking an anti-inflammatory medication, or if their abdominal pain responded to an anti-inflammatory medication in the past.
Item
Child currently taking an anti-inflammatory medication, or if their abdominal pain responded to an anti-inflammatory medication in the past.
boolean
C1706256 (UMLS CUI [1,1])
C0022104 (UMLS CUI [1,2])
C0000737 (UMLS CUI [1,3])
C0680251 (UMLS CUI [1,4])
C3843777 (UMLS CUI [1,5])
C1706256 (UMLS CUI [2,1])
C0680251 (UMLS CUI [2,2])
C0000737 (UMLS CUI [2,3])
C0205342 (UMLS CUI [2,4])
C0003209 (UMLS CUI [2,5])
C1444637 (UMLS CUI [2,6])
Child currently taking medication for reflux to which abdominal pain symptoms are responding
Item
Child currently taking medication for reflux to which abdominal pain symptoms are responding.
boolean
C1706256 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
C0521116 (UMLS CUI [1,3])
C0013227 (UMLS CUI [1,4])
C0017168 (UMLS CUI [1,5])
C0564405 (UMLS CUI [1,6])
C0000737 (UMLS CUI [1,7])
C0022104 (UMLS CUI [1,8])
Other chronic health condition or chronic illness (except mild intermittent or mild persistent asthma).
Item
Other chronic health condition or chronic illness (except mild intermittent or mild persistent asthma).
boolean
C1706256 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
C0008679 (UMLS CUI [1,3])
C0205191 (UMLS CUI [1,4])
C0221423 (UMLS CUI [1,5])
C1705847 (UMLS CUI [1,6])
C1960046 (UMLS CUI [1,7])
C1960045 (UMLS CUI [1,8])
C0022104 (UMLS CUI [1,9])
C0000737 (UMLS CUI [1,10])
Cognitive impairment significantly below average age and/or grade level.
Item
Cognitive impairment significantly below average age and/or grade level.
boolean
C0680251 (UMLS CUI [1,1])
C0022104 (UMLS CUI [1,2])
C0000737 (UMLS CUI [1,3])
C1706256 (UMLS CUI [1,4])
C0338656 (UMLS CUI [1,5])
C0443151 (UMLS CUI [1,6])
C0001779 (UMLS CUI [1,7])
C0680251 (UMLS CUI [2,1])
C0022104 (UMLS CUI [2,2])
C0000737 (UMLS CUI [2,3])
C1706256 (UMLS CUI [2,4])
C0338656 (UMLS CUI [2,5])
C0443151 (UMLS CUI [2,6])
C0441800 (UMLS CUI [2,7])
Vomiting more than 2 times per month within 3 months prior to enrolling on study.
Item
Vomiting ≥ 2 times per month within 3 months prior to enrolling on study.
boolean
C1706256 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
C0022104 (UMLS CUI [1,3])
C0000737 (UMLS CUI [1,4])
C0042963 (UMLS CUI [1,5])
C0439093 (UMLS CUI [1,6])
C0439603 (UMLS CUI [1,7])
C0205156 (UMLS CUI [1,8])
C1442461 (UMLS CUI [1,9])
Unintentional weight loss of more than 5% body weight within 3-month period
Item
Unintentional weight loss of ≥ 5% body weight within 3-month period.
boolean
C0680251 (UMLS CUI [1,1])
C1706256 (UMLS CUI [1,2])
C0000737 (UMLS CUI [1,3])
C0022104 (UMLS CUI [1,4])
C2363736 (UMLS CUI [1,5])
C0439093 (UMLS CUI [1,6])
C0439165 (UMLS CUI [1,7])
C0205451 (UMLS CUI [1,8])
C4086725 (UMLS CUI [1,9])
Females who have menses.
Item
Females who have menses.
boolean
C1706256 (UMLS CUI [1,1])
C0000737 (UMLS CUI [1,2])
C0680251 (UMLS CUI [1,3])
C0086287 (UMLS CUI [1,4])
C0025344 (UMLS CUI [1,5])
Use of the following drugs within the last 6 months
Item
Use of the following drugs within the last 6 months: systemic antibiotics, oral, intravenous, intramuscular, nasal or inhaled corticosteroids, cytokines, methotrexate or immunosuppressive cytotoxic agents, or large doses of commercial probiotics (10e8 cfu per day or higher).
boolean
C1706256 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
C1524063 (UMLS CUI [1,3])
C0239126 (UMLS CUI [1,4])
C1527415 (UMLS CUI [1,5])
C1522726 (UMLS CUI [1,6])
C1556154 (UMLS CUI [1,7])
C0586793 (UMLS CUI [1,8])
C3539185 (UMLS CUI [1,9])
C1517741 (UMLS CUI [1,10])
C0205452 (UMLS CUI [1,11])
C0439231 (UMLS CUI [1,12])
C1706256 (UMLS CUI [2,1])
C0680251 (UMLS CUI [2,2])
C1524063 (UMLS CUI [2,3])
C0025677 (UMLS CUI [2,4])
C1517741 (UMLS CUI [2,5])
C0205452 (UMLS CUI [2,6])
C0439231 (UMLS CUI [2,7])
C1706256 (UMLS CUI [3,1])
C0680251 (UMLS CUI [3,2])
C1524063 (UMLS CUI [3,3])
C0079189 (UMLS CUI [3,4])
C1517741 (UMLS CUI [3,5])
C0205452 (UMLS CUI [3,6])
C0439231 (UMLS CUI [3,7])
C1706256 (UMLS CUI [4,1])
C0680251 (UMLS CUI [4,2])
C1524063 (UMLS CUI [4,3])
C3540704 (UMLS CUI [4,4])
C1517741 (UMLS CUI [4,5])
C0205452 (UMLS CUI [4,6])
C0439231 (UMLS CUI [4,7])
C1706256 (UMLS CUI [5,1])
C0680251 (UMLS CUI [5,2])
C1524063 (UMLS CUI [5,3])
C0021081 (UMLS CUI [5,4])
C0677881 (UMLS CUI [5,5])
C1517741 (UMLS CUI [5,6])
C0205452 (UMLS CUI [5,7])
C0439231 (UMLS CUI [5,8])
C1706256 (UMLS CUI [6,1])
C0680251 (UMLS CUI [6,2])
C1524063 (UMLS CUI [6,3])
C0549177 (UMLS CUI [6,4])
C0178602 (UMLS CUI [6,5])
C0680536 (UMLS CUI [6,6])
C1517741 (UMLS CUI [6,7])
C0525033 (UMLS CUI [6,8])
C0205452 (UMLS CUI [6,9])
C0439231 (UMLS CUI [6,10])
Major diet change in the past month prior to enrollmen
Item
Major diet change in the past month prior to enrollment (e.g., change to vegetarianism or vice versa; avoidance or inclusion of major food group [fruit, vegetables]). This does not include diet changes related to lactose intolerance.
boolean
C1706256 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
C0205164 (UMLS CUI [1,3])
C3671772 (UMLS CUI [1,4])
C1444637 (UMLS CUI [1,5])
C0439231 (UMLS CUI [1,6])
Major surgery including surgery involving the gastrointestinal tract.
Item
Major surgery including surgery involving the gastrointestinal tract.
boolean
C0680251 (UMLS CUI [1,1])
C1706256 (UMLS CUI [1,2])
C0022104 (UMLS CUI [1,3])
C0000737 (UMLS CUI [1,4])
C0679637 (UMLS CUI [1,5])
C0524722 (UMLS CUI [1,6])
Controls
Item
Controls:
boolean
C0009932 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
Other chronic illness or health condition or chronic illness (except mild intermittent or mild persistent asthma)
Item
Other chronic illness or health condition or chronic illness (except mild intermittent or mild persistent asthma)
boolean
C0009932 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
C0008679 (UMLS CUI [1,3])
C1705847 (UMLS CUI [1,4])
C1960046 (UMLS CUI [1,5])
C1960045 (UMLS CUI [1,6])
Cognitive impairment significantly below average age and/or grade level
Item
Cognitive impairment significantly below average age and/or grade level
boolean
C0680251 (UMLS CUI [1,1])
C0009932 (UMLS CUI [1,2])
C0338656 (UMLS CUI [1,3])
C0443151 (UMLS CUI [1,4])
C0001779 (UMLS CUI [1,5])
C0680251 (UMLS CUI [2,1])
C0009932 (UMLS CUI [2,2])
C0338656 (UMLS CUI [2,3])
C0443151 (UMLS CUI [2,4])
C0441800 (UMLS CUI [2,5])
Child seen a physician more than once in past year for abdominal pain unexplained by common illness (e.g., gastroenteritis)
Item
Child seen a physician more than once in past year for abdominal pain unexplained by common illness (e.g., gastroenteritis)
boolean
C0680251 (UMLS CUI [1,1])
C0009932 (UMLS CUI [1,2])
C0583527 (UMLS CUI [1,3])
C0566251 (UMLS CUI [1,4])
C0000737 (UMLS CUI [1,5])
C0439093 (UMLS CUI [1,6])
C1948045 (UMLS CUI [1,7])
C3887293 (UMLS CUI [1,8])
C4288071 (UMLS CUI [1,9])
C0205214 (UMLS CUI [1,10])
C0221423 (UMLS CUI [1,11])
Females who have menses
Item
Females who have menses
boolean
C0009932 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
C0086287 (UMLS CUI [1,3])
C0025344 (UMLS CUI [1,4])
Use of the following drugs within the last 6 months
Item
Use of the following drugs within the last 6 months: systemic antibiotics, oral, intravenous, intramuscular, nasal or inhaled corticosteroids, cytokines, methotrexate or immunosuppressive cytotoxic agents, or large doses of commercial probiotics (10e8 cfu per day or higher).
boolean
C0680251 (UMLS CUI [1,1])
C0009932 (UMLS CUI [1,2])
C1524063 (UMLS CUI [1,3])
C0239126 (UMLS CUI [1,4])
C1527415 (UMLS CUI [1,5])
C1522726 (UMLS CUI [1,6])
C1556154 (UMLS CUI [1,7])
C0586793 (UMLS CUI [1,8])
C3539185 (UMLS CUI [1,9])
C1517741 (UMLS CUI [1,10])
C0205452 (UMLS CUI [1,11])
C0439231 (UMLS CUI [1,12])
C0009932 (UMLS CUI [2,1])
C0680251 (UMLS CUI [2,2])
C1524063 (UMLS CUI [2,3])
C0549177 (UMLS CUI [2,4])
C0178602 (UMLS CUI [2,5])
C0680536 (UMLS CUI [2,6])
C0525033 (UMLS CUI [2,7])
C1517741 (UMLS CUI [2,8])
C0205452 (UMLS CUI [2,9])
C0439231 (UMLS CUI [2,10])
C0009932 (UMLS CUI [3,1])
C0680251 (UMLS CUI [3,2])
C1524063 (UMLS CUI [3,3])
C0021081 (UMLS CUI [3,4])
C0677881 (UMLS CUI [3,5])
C1517741 (UMLS CUI [3,6])
C0205452 (UMLS CUI [3,7])
C0439231 (UMLS CUI [3,8])
C0009932 (UMLS CUI [4,1])
C0680251 (UMLS CUI [4,2])
C1524063 (UMLS CUI [4,3])
C0025677 (UMLS CUI [4,4])
C1517741 (UMLS CUI [4,5])
C0205452 (UMLS CUI [4,6])
C0439231 (UMLS CUI [4,7])
C0009932 (UMLS CUI [5,1])
C0079189 (UMLS CUI [5,2])
C0680251 (UMLS CUI [5,3])
C1524063 (UMLS CUI [5,4])
C1517741 (UMLS CUI [5,5])
C0205452 (UMLS CUI [5,6])
C0439231 (UMLS CUI [5,7])
C0009932 (UMLS CUI [6,1])
C0680251 (UMLS CUI [6,2])
C1524063 (UMLS CUI [6,3])
C3540704 (UMLS CUI [6,4])
C1517741 (UMLS CUI [6,5])
C0205452 (UMLS CUI [6,6])
C0439231 (UMLS CUI [6,7])
Major diet change in the past month prior to enrollment
Item
Major diet change in the past month prior to enrollment (e.g., change to vegetarianism or vice versa; avoidance or inclusion of major food group [fruit, vegetables]). This does not include diet changes related to lactose intolerance.
boolean
C0009932 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
C0205164 (UMLS CUI [1,3])
C1444637 (UMLS CUI [1,4])
C0439231 (UMLS CUI [1,5])
Major surgery including surgery involving the gastrointestinal tract.
Item
Major surgery including surgery involving the gastrointestinal tract.
boolean
C0009932 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
C0679637 (UMLS CUI [1,3])
C0524722 (UMLS CUI [1,4])
Non-English speaking parent or child.
Item
Non-English speaking parent or child.
boolean
C0332268 (UMLS CUI [1,1])
C0564215 (UMLS CUI [1,2])
C0376245 (UMLS CUI [1,3])
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