ID

44998

Descrição

Principal Investigator: Ulrike Peters, PhD, Fred Hutchinson Cancer Research Center, Seattle, WA, USA MeSH: Colorectal Neoplasms,Sequence Analysis, DNA https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000410 This project was designed to use next generation sequencing technology to screen the protein coding regions of the genome for low frequency variants in a panel of high-risk colorectal adenocarcinoma cases. Blood and cell-line DNA for colorectal cancer patients and a subset of quality control samples that had existing whole exome sequence data were analyzed using Illumina HiSeq sequencers. Samples from this project were from participants in the Women's Health Initiative (WHI) and the Diet, Activity, and Lifestyle Study (DALS).

Link

https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000410

Palavras-chave

  1. 01/07/2022 01/07/2022 - Dr. Christian Niklas
  2. 12/10/2022 12/10/2022 - Adrian Schulz
Titular dos direitos

Ulrike Peters, PhD, Fred Hutchinson Cancer Research Center, Seattle, WA, USA

Transferido a

1 de julho de 2022

DOI

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Licença

Creative Commons BY 4.0

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dbGaP phs000410 Whole Exome Sequencing for Colorectal Cancer

Eligibility Criteria

Inclusion and exclusion criteria
Descrição

Inclusion and exclusion criteria

DALS and WHI have study-specific inclusion and exclusion criteria, which can be found in the selected publications. The composition of this study includes un-related Caucasian participants with colorectal adenocarcinoma and a subset of controls. Cases were selected based on having one or more first-degree relatives with colorectal cancer and/or early onset of colorectal cancer (age at diagnosis <55 years). Cases with the following diagnoses related to the colon or rectum were excluded: any *in situ* adenocarcinoma or carcinoma, (large cell) neuroendocrine carcinoma, squamous cell carcinoma, carcinoid tumor, Goblet cell carcinoid, and any type of lymphoma, including non-Hodgkin, Mantle cell, large B-cell, or follicular lymphoma.
Descrição

Elig.phs000410.v1.p1.1

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0043157
UMLS CUI [1,3]
C0445356
UMLS CUI [1,4]
C1517194
UMLS CUI [1,5]
C0009402
UMLS CUI [1,6]
C3554772
UMLS CUI [2,1]
C0680251
UMLS CUI [2,2]
C0007099
UMLS CUI [2,3]
C1265996
UMLS CUI [2,4]
C0007137
UMLS CUI [2,5]
C0007095
UMLS CUI [2,6]
C0205695
UMLS CUI [2,7]
C0024299

Similar models

Eligibility Criteria

Name
Tipo
Description | Question | Decode (Coded Value)
Tipo de dados
Alias
Item Group
Inclusion and exclusion criteria
Elig.phs000410.v1.p1.1
Item
DALS and WHI have study-specific inclusion and exclusion criteria, which can be found in the selected publications. The composition of this study includes un-related Caucasian participants with colorectal adenocarcinoma and a subset of controls. Cases were selected based on having one or more first-degree relatives with colorectal cancer and/or early onset of colorectal cancer (age at diagnosis <55 years). Cases with the following diagnoses related to the colon or rectum were excluded: any *in situ* adenocarcinoma or carcinoma, (large cell) neuroendocrine carcinoma, squamous cell carcinoma, carcinoid tumor, Goblet cell carcinoid, and any type of lymphoma, including non-Hodgkin, Mantle cell, large B-cell, or follicular lymphoma.
boolean
C1512693 (UMLS CUI [1,1])
C0043157 (UMLS CUI [1,2])
C0445356 (UMLS CUI [1,3])
C1517194 (UMLS CUI [1,4])
C0009402 (UMLS CUI [1,5])
C3554772 (UMLS CUI [1,6])
C0680251 (UMLS CUI [2,1])
C0007099 (UMLS CUI [2,2])
C1265996 (UMLS CUI [2,3])
C0007137 (UMLS CUI [2,4])
C0007095 (UMLS CUI [2,5])
C0205695 (UMLS CUI [2,6])
C0024299 (UMLS CUI [2,7])

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