ID

44951

Description

https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000088.v1.p1 Genetics of Kidneys in Diabetes (GoKinD) study is an initiative aimed at identifying susceptibility genes for diabetic nephropathy in type 1 diabetes. A large number of individuals with type 1 diabetes were screened to identify two subsets, one with clear-cut kidney disease and another with normal renal status despite long-term diabetes. Those who met additional entry criteria and consented to participate were enrolled. When possible, both parents were also enrolled to form family trios. Altogether, GoKinD includes 3043 participants comprising 931 cases, 944 singletons, 268 pairs of parents of cases, and 316 pairs of parents of control. Accessible as a GAIN database are 905 of the cases, 890 of the controls, 10 pairs of parents of cases and 10 pairs of parents of controls (dbGaP phs000018 *Search for Susceptibility Genes for Diabetic Nephropathy in Type 1 Diabetes (GoKinD study participants), GAIN*). The other parents and the remaining cases and controls are available by a separate application process through NIDDK. Interested investigators may request the DNA collection and corresponding clinical data for GoKinD participants using the instructions and application form available at http://www.niddkrepository.org or by contacting the Juvenile Diabetes Research Foundation.

Link

https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000088.v1.p1

Keywords

Versions (5)
  1. 5/13/22 5/13/22 - Martin Dugas
  2. 5/13/22 5/13/22 - Martin Dugas
  3. 5/20/22 5/20/22 - Dr. Christian Niklas
  4. 8/15/22 8/15/22 - Dr. Christian Niklas
  5. 10/12/22 10/12/22 - Adrian Schulz
Copyright Holder

J.H. Warram, Joslin Diabetes Center, Boston, MA, USA

Uploaded on

May 13, 2022

DOI

To request one please log in.

License

Creative Commons BY 4.0
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dbGaP phs000088 Search for Susceptibility Genes for Diabetic Nephropathy in Type 1 Diabetes (GoKinD study participants and parents), NIDDK

English

This table contains diagnostic phenotype information about renal function status and medical history related to diabetes (e.g. status, treatment and duration) and diabetes related complications, plus general socio-demographic information (see also Search for Susceptibility Genes for Diabetic Nephropathy in Type 1 Diabetes (GoKinD study participants), GAIN ).

4 forms  
pht000072.v1.p1
Description

pht000072.v1.p1

External patient ID (masked family ID) - See also GAIN - GoKinD phs000018: EXTIDPAT
Description

EXTIDPAT

Data type

text

Accession number barcode - See also GAIN - GoKinD phs000018: X_BARCOD
Description

X_BARCOD

Data type

text

Current eligibility family - See also GAIN - GoKinD phs000018: CURRELIG
Description

CURRELIG

Data type

text

Current trio family - See also GAIN - GoKinD phs000018: CURRTRIO
Description

CURRTRIO

Data type

text

T_FAMID2 masked, external family ID - See also GAIN - GoKinD phs000018: T_FAMID2
Description

T_FAMID2

Data type

text

SITEJORG Joslin or GW or qc (j, g, q) - See also GAIN - GoKinD phs000018: SITEJORG
Description

SITEJORG

Data type

text

T_N_KID # proband/sib records/family - See also GAIN - GoKinD phs000018: T_N_KID
Description

T_N_KID

Data type

text

X_ID_REL ID relative - See also GAIN - GoKinD phs000018: X_ID_REL
Description

X_ID_REL

Data type

text

Proband or sibling (Y/N) - See also GAIN - GoKinD phs000018: PROBAND
Description

PROBAND

Data type

text

RASS proband (Y/N) - See also GAIN - GoKinD phs000018: X_RASSPR
Description

X_RASSPR

Data type

text

Participant's gender - See also GAIN - GoKinD phs000018: SEX
Description

SEX

Data type

text

Age at entry (years) - See also GAIN - GoKinD phs000018: AGE
Description

AGE

Data type

text

Predominant race/ethnicity - See also GAIN - GoKinD phs000018: RACE
Description

RACE

Data type

text

Eligibility/trio status - See also GAIN - GoKinD phs000018: ELIGTRIO
Description

ELIGTRIO

Data type

text

Renal function status - See also GAIN - GoKinD phs000018: RENALST
Description

RENALST

Data type

text

End-stage renal disease (Y/N/U) - See also GAIN - GoKinD phs000018: ESRD
Description

ESRD

Data type

text

Did proband have a pancreas transplant? (Y/N/U) - See also GAIN - GoKinD phs000018: PANCR
Description

PANCR

Data type

text

Albumin-creatinine ratio (ACR)/Albumin-excretion rate (AER), 1st urine sample - See also GAIN - GoKinD phs000018: ACR1
Description

ACR1

Data type

text

Albumin-creatinine ratio (ACR)/Albumin-excretion rate (AER), 2nd urine sample - See also GAIN - GoKinD phs000018: ACR2
Description

ACR2

Data type

text

Albumin-creatinine ratio (ACR)/Albumin-excretion rate (AER), 3rd urine sample - See also GAIN - GoKinD phs000018: ACR3
Description

ACR3

Data type

text

Abnormal creatinine (Y/N/U) - See also GAIN - GoKinD phs000018: ABCREATN
Description

ABCREATN

Data type

text

Serum creatinine (mg/dL) - See also GAIN - GoKinD phs000018: CREATN
Description

CREATN

Data type

text

Serum cystatin (mg/L) - See also GAIN - GoKinD phs000018: CYSTATIN
Description

CYSTATIN

Data type

text

Serum lipid cholesterol (mg/dL) - See also GAIN - GoKinD phs000018: CHOLSTR
Description

CHOLSTR

Data type

text

Serum lipid HDL (mg/dL) - See also GAIN - GoKinD phs000018: HDL
Description

HDL

Data type

text

Hemoglobin A1c (HbA1c; %) - See also GAIN - GoKinD phs000018: HBA1C
Description

HBA1C

Data type

text

Glomerular filtration rate 1 (GFR1; MDRD [Modification of Diet in Renal Disease, see Levey et al., 1999, PMID: 10075613] ) - See also GAIN - GoKinD phs000018: GFR1
Description

GFR1

Data type

text

Glomerular filtration rate 2 (GFR2; Cockcroft-Gault; ml/min) - See also GAIN - GoKinD phs000018: GFR2
Description

GFR2

Data type

text

Glomerular filtration rate 3 (GFR3; 1/Serum Creatinine; dL/mg) - See also GAIN - GoKinD phs000018: GFR3
Description

GFR3

Data type

text

Body Mass Index (kg/m²) - See also GAIN - GoKinD phs000018: BMI
Description

BMI

Data type

text

Natural waist circumference (cm) - See also GAIN - GoKinD phs000018: WAIST
Description

WAIST

Data type

text

Is proband a current smoker? (Y/N/U) - See also GAIN - GoKinD phs000018: CURRSMK
Description

CURRSMK

Data type

text

Has proband ever smoked? (Y/N/U) - See also GAIN - GoKinD phs000018: EVERSMK
Description

EVERSMK

Data type

text

Is proband diabetic? (Y/N/U) - See also GAIN - GoKinD phs000018: DIABETES
Description

DIABETES

Data type

text

Is proband diabetic? If yes, has he/she been diagnosed with type 1 or type 2 diabetes? - See also GAIN - GoKinD phs000018: T1T2DIA
Description

T1T2DIA

Data type

text

Is proband taking insulin? (Y/N/U) - See also GAIN - GoKinD phs000018: INSULIN
Description

INSULIN

Data type

text

Is proband taking insulin? If yes, what is the insulin regimen? - See also GAIN - GoKinD phs000018: INSREGMN
Description

INSREGMN

Data type

text

Is proband taking insulin? If yes, what is the insulin dosage per kg body weight? - See also GAIN - GoKinD phs000018: INSDOSG
Description

INSDOSG

Data type

text

Is proband diabetic? If yes, since how long? (years) - See also GAIN - GoKinD phs000018: DIABDUR
Description

DIABDUR

Data type

text

Is proband taking angiotensin converting enzyme (ACE) inhibitors? (Y/N/U) - See also GAIN - GoKinD phs000018: ACE
Description

ACE

Data type

text

Is proband taking anti-hypertensive drugs? (Y/N/U) - See also GAIN - GoKinD phs000018: ANTH
Description

ANTH

Data type

text

Is proband taking lipid lowering medication? (Y/N/U) - See also GAIN - GoKinD phs000018: LIP
Description

LIP

Data type

text

Systolic blood pressure (mmHg) - See also GAIN - GoKinD phs000018: SYSBP
Description

SYSBP

Data type

text

Diastolic blood pressure (mmHg) - See also GAIN - GoKinD phs000018: DIABP
Description

DIABP

Data type

text

Does proband have a history of hypertension? (Y/N/U) - See also GAIN - GoKinD phs000018: HYPERTEN
Description

HYPERTEN

Data type

text

Does proband have a history of cardiovascular complication(s)? (Y/N/U) - See also GAIN - GoKinD phs000018: CARDIOV
Description

CARDIOV

Data type

text

Does proband have a history of peripheral vascular complication(s)? (Y/N/U) - See also GAIN - GoKinD phs000018: PERIPHV
Description

PERIPHV

Data type

text

Does proband have a history of gangrene? (Y/N/U) - See also GAIN - GoKinD phs000018: GANGREN
Description

GANGREN

Data type

text

Does proband have a history of non-traumatic amputation? (Y/N/U) - See also GAIN - GoKinD phs000018: AMPUTATN
Description

AMPUTATN

Data type

text

Does proband have a history of neuropathy due to diabetes? (Y/N/U) - See also GAIN - GoKinD phs000018: NEURP
Description

NEURP

Data type

text

Does proband have a history of focal laser treatment? (Y/N/U) - See also GAIN - GoKinD phs000018: FLASER
Description

FLASER

Data type

text

Does proband have a history of pan-retinal laser treatment? (Y/N/U) - See also GAIN - GoKinD phs000018: PLASER
Description

PLASER

Data type

text

Does proband have a history of auto-immune disease? - See also GAIN - GoKinD phs000018: AUTOIMMU
Description

AUTOIMMU

Data type

text

Time between diagnosis of type 1 diabetes (T1D) and kidney complications (years) - See also GAIN - GoKinD phs000018: TIMEEVNT
Description

TIMEEVNT

Data type

text

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Similar models

This table contains diagnostic phenotype information about renal function status and medical history related to diabetes (e.g. status, treatment and duration) and diabetes related complications, plus general socio-demographic information (see also Search for Susceptibility Genes for Diabetic Nephropathy in Type 1 Diabetes (GoKinD study participants), GAIN ).

4 forms
Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
Item Group
pht000072.v1.p1
EXTIDPAT
Item
External patient ID (masked family ID) - See also GAIN - GoKinD phs000018: EXTIDPAT
text
X_BARCOD
Item
Accession number barcode - See also GAIN - GoKinD phs000018: X_BARCOD
text
Item
Current eligibility family - See also GAIN - GoKinD phs000018: CURRELIG
text
CURRELIG
Code List
Current eligibility family - See also GAIN - GoKinD phs000018: CURRELIG
CL Item
Control (0)
CL Item
Case (1)
Item
Current trio family - See also GAIN - GoKinD phs000018: CURRTRIO
text
CURRTRIO
Code List
Current trio family - See also GAIN - GoKinD phs000018: CURRTRIO
CL Item
Singleton (1)
CL Item
Trio (2)
T_FAMID2
Item
T_FAMID2 masked, external family ID - See also GAIN - GoKinD phs000018: T_FAMID2
text
Item
SITEJORG Joslin or GW or qc (j, g, q) - See also GAIN - GoKinD phs000018: SITEJORG
text
SITEJORG
Code List
SITEJORG Joslin or GW or qc (j, g, q) - See also GAIN - GoKinD phs000018: SITEJORG
CL Item
George-Washington University (g)
CL Item
Joslin Diabetes Center (j)
CL Item
Quality Control (q)
Item
T_N_KID # proband/sib records/family - See also GAIN - GoKinD phs000018: T_N_KID
text
T_N_KID
Code List
T_N_KID # proband/sib records/family - See also GAIN - GoKinD phs000018: T_N_KID
CL Item
1 child in study (1)
CL Item
2 children in study (2)
Item
X_ID_REL ID relative - See also GAIN - GoKinD phs000018: X_ID_REL
text
X_ID_REL
Code List
X_ID_REL ID relative - See also GAIN - GoKinD phs000018: X_ID_REL
CL Item
Father (1)
CL Item
Mother (2)
CL Item
Proband (3)
CL Item
Sibling (4)
Item
Proband or sibling (Y/N) - See also GAIN - GoKinD phs000018: PROBAND
text
PROBAND
Code List
Proband or sibling (Y/N) - See also GAIN - GoKinD phs000018: PROBAND
CL Item
No (0)
CL Item
Yes (1)
Item
RASS proband (Y/N) - See also GAIN - GoKinD phs000018: X_RASSPR
text
X_RASSPR
Code List
RASS proband (Y/N) - See also GAIN - GoKinD phs000018: X_RASSPR
CL Item
No (0)
CL Item
Yes (1)
Item
Participant's gender - See also GAIN - GoKinD phs000018: SEX
text
SEX
Code List
Participant's gender - See also GAIN - GoKinD phs000018: SEX
CL Item
Male (1)
CL Item
Female (2)
AGE
Item
Age at entry (years) - See also GAIN - GoKinD phs000018: AGE
text
Item
Predominant race/ethnicity - See also GAIN - GoKinD phs000018: RACE
text
RACE
Code List
Predominant race/ethnicity - See also GAIN - GoKinD phs000018: RACE
CL Item
White, not of Hispanic origin (1)
CL Item
Black, not of Hispanic origin (2)
CL Item
Hispanic (3)
CL Item
Asian or Pacific Islander (4)
CL Item
American Indian or Alaskan Native American (5)
CL Item
Other or unknown (6)
ELIGTRIO
Item
Eligibility/trio status - See also GAIN - GoKinD phs000018: ELIGTRIO
text
Item
Renal function status - See also GAIN - GoKinD phs000018: RENALST
text
RENALST
Code List
Renal function status - See also GAIN - GoKinD phs000018: RENALST
CL Item
Microalbuminuric (0)
CL Item
Control (1)
CL Item
Proteinuric (2)
CL Item
Dialysis (3)
CL Item
Transplant (4)
Item
End-stage renal disease (Y/N/U) - See also GAIN - GoKinD phs000018: ESRD
text
ESRD
Code List
End-stage renal disease (Y/N/U) - See also GAIN - GoKinD phs000018: ESRD
CL Item
No (1)
CL Item
Yes (2)
CL Item
Unknown (3)
Item
Did proband have a pancreas transplant? (Y/N/U) - See also GAIN - GoKinD phs000018: PANCR
text
PANCR
Code List
Did proband have a pancreas transplant? (Y/N/U) - See also GAIN - GoKinD phs000018: PANCR
CL Item
No (1)
CL Item
Yes (2)
CL Item
Unknown (3)
ACR1
Item
Albumin-creatinine ratio (ACR)/Albumin-excretion rate (AER), 1st urine sample - See also GAIN - GoKinD phs000018: ACR1
text
ACR2
Item
Albumin-creatinine ratio (ACR)/Albumin-excretion rate (AER), 2nd urine sample - See also GAIN - GoKinD phs000018: ACR2
text
ACR3
Item
Albumin-creatinine ratio (ACR)/Albumin-excretion rate (AER), 3rd urine sample - See also GAIN - GoKinD phs000018: ACR3
text
Item
Abnormal creatinine (Y/N/U) - See also GAIN - GoKinD phs000018: ABCREATN
text
ABCREATN
Code List
Abnormal creatinine (Y/N/U) - See also GAIN - GoKinD phs000018: ABCREATN
CL Item
No (1)
CL Item
Yes (2)
CL Item
Unknown (3)
CREATN
Item
Serum creatinine (mg/dL) - See also GAIN - GoKinD phs000018: CREATN
text
CYSTATIN
Item
Serum cystatin (mg/L) - See also GAIN - GoKinD phs000018: CYSTATIN
text
CHOLSTR
Item
Serum lipid cholesterol (mg/dL) - See also GAIN - GoKinD phs000018: CHOLSTR
text
HDL
Item
Serum lipid HDL (mg/dL) - See also GAIN - GoKinD phs000018: HDL
text
HBA1C
Item
Hemoglobin A1c (HbA1c; %) - See also GAIN - GoKinD phs000018: HBA1C
text
GFR1
Item
Glomerular filtration rate 1 (GFR1; MDRD [Modification of Diet in Renal Disease, see Levey et al., 1999, PMID: 10075613] ) - See also GAIN - GoKinD phs000018: GFR1
text
GFR2
Item
Glomerular filtration rate 2 (GFR2; Cockcroft-Gault; ml/min) - See also GAIN - GoKinD phs000018: GFR2
text
GFR3
Item
Glomerular filtration rate 3 (GFR3; 1/Serum Creatinine; dL/mg) - See also GAIN - GoKinD phs000018: GFR3
text
BMI
Item
Body Mass Index (kg/m²) - See also GAIN - GoKinD phs000018: BMI
text
WAIST
Item
Natural waist circumference (cm) - See also GAIN - GoKinD phs000018: WAIST
text
Item
Is proband a current smoker? (Y/N/U) - See also GAIN - GoKinD phs000018: CURRSMK
text
CURRSMK
Code List
Is proband a current smoker? (Y/N/U) - See also GAIN - GoKinD phs000018: CURRSMK
CL Item
No (1)
CL Item
Yes (2)
CL Item
Unknown (3)
Item
Has proband ever smoked? (Y/N/U) - See also GAIN - GoKinD phs000018: EVERSMK
text
EVERSMK
Code List
Has proband ever smoked? (Y/N/U) - See also GAIN - GoKinD phs000018: EVERSMK
CL Item
No (1)
CL Item
Yes (2)
CL Item
Unknown (3)
Item
Is proband diabetic? (Y/N/U) - See also GAIN - GoKinD phs000018: DIABETES
text
DIABETES
Code List
Is proband diabetic? (Y/N/U) - See also GAIN - GoKinD phs000018: DIABETES
CL Item
No (1)
CL Item
Yes (2)
CL Item
Unknown (3)
Item
Is proband diabetic? If yes, has he/she been diagnosed with type 1 or type 2 diabetes? - See also GAIN - GoKinD phs000018: T1T2DIA
text
T1T2DIA
Code List
Is proband diabetic? If yes, has he/she been diagnosed with type 1 or type 2 diabetes? - See also GAIN - GoKinD phs000018: T1T2DIA
CL Item
Unknown (0)
CL Item
Type 1 Diabetes (1)
CL Item
Type 2 Diabetes (2)
Item
Is proband taking insulin? (Y/N/U) - See also GAIN - GoKinD phs000018: INSULIN
text
INSULIN
Code List
Is proband taking insulin? (Y/N/U) - See also GAIN - GoKinD phs000018: INSULIN
CL Item
No (1)
CL Item
Yes (2)
CL Item
Unknown (3)
Item
Is proband taking insulin? If yes, what is the insulin regimen? - See also GAIN - GoKinD phs000018: INSREGMN
text
INSREGMN
Code List
Is proband taking insulin? If yes, what is the insulin regimen? - See also GAIN - GoKinD phs000018: INSREGMN
CL Item
< 2 shots (1)
CL Item
MDI (Multiple Daily Injections) (2)
CL Item
Pump (3)
CL Item
Other (4)
INSDOSG
Item
Is proband taking insulin? If yes, what is the insulin dosage per kg body weight? - See also GAIN - GoKinD phs000018: INSDOSG
text
DIABDUR
Item
Is proband diabetic? If yes, since how long? (years) - See also GAIN - GoKinD phs000018: DIABDUR
text
Item
Is proband taking angiotensin converting enzyme (ACE) inhibitors? (Y/N/U) - See also GAIN - GoKinD phs000018: ACE
text
ACE
Code List
Is proband taking angiotensin converting enzyme (ACE) inhibitors? (Y/N/U) - See also GAIN - GoKinD phs000018: ACE
CL Item
No (1)
CL Item
Yes (2)
CL Item
Unknown (3)
Item
Is proband taking anti-hypertensive drugs? (Y/N/U) - See also GAIN - GoKinD phs000018: ANTH
text
ANTH
Code List
Is proband taking anti-hypertensive drugs? (Y/N/U) - See also GAIN - GoKinD phs000018: ANTH
CL Item
No (1)
CL Item
Yes (2)
CL Item
Unknown (3)
Item
Is proband taking lipid lowering medication? (Y/N/U) - See also GAIN - GoKinD phs000018: LIP
text
LIP
Code List
Is proband taking lipid lowering medication? (Y/N/U) - See also GAIN - GoKinD phs000018: LIP
CL Item
No (1)
CL Item
Yes (2)
CL Item
Unknown (3)
SYSBP
Item
Systolic blood pressure (mmHg) - See also GAIN - GoKinD phs000018: SYSBP
text
DIABP
Item
Diastolic blood pressure (mmHg) - See also GAIN - GoKinD phs000018: DIABP
text
Item
Does proband have a history of hypertension? (Y/N/U) - See also GAIN - GoKinD phs000018: HYPERTEN
text
HYPERTEN
Code List
Does proband have a history of hypertension? (Y/N/U) - See also GAIN - GoKinD phs000018: HYPERTEN
CL Item
No (1)
CL Item
Yes (2)
CL Item
Unknown (3)
Item
Does proband have a history of cardiovascular complication(s)? (Y/N/U) - See also GAIN - GoKinD phs000018: CARDIOV
text
CARDIOV
Code List
Does proband have a history of cardiovascular complication(s)? (Y/N/U) - See also GAIN - GoKinD phs000018: CARDIOV
CL Item
No (1)
CL Item
Yes (2)
CL Item
Unknown (3)
Item
Does proband have a history of peripheral vascular complication(s)? (Y/N/U) - See also GAIN - GoKinD phs000018: PERIPHV
text
PERIPHV
Code List
Does proband have a history of peripheral vascular complication(s)? (Y/N/U) - See also GAIN - GoKinD phs000018: PERIPHV
CL Item
No (1)
CL Item
Yes (2)
CL Item
Unknown (3)
Item
Does proband have a history of gangrene? (Y/N/U) - See also GAIN - GoKinD phs000018: GANGREN
text
GANGREN
Code List
Does proband have a history of gangrene? (Y/N/U) - See also GAIN - GoKinD phs000018: GANGREN
CL Item
No (1)
CL Item
Yes (2)
CL Item
Unknown (3)
Item
Does proband have a history of non-traumatic amputation? (Y/N/U) - See also GAIN - GoKinD phs000018: AMPUTATN
text
AMPUTATN
Code List
Does proband have a history of non-traumatic amputation? (Y/N/U) - See also GAIN - GoKinD phs000018: AMPUTATN
CL Item
No (1)
CL Item
Yes (2)
CL Item
Unknown (3)
Item
Does proband have a history of neuropathy due to diabetes? (Y/N/U) - See also GAIN - GoKinD phs000018: NEURP
text
NEURP
Code List
Does proband have a history of neuropathy due to diabetes? (Y/N/U) - See also GAIN - GoKinD phs000018: NEURP
CL Item
No (1)
CL Item
Yes (2)
CL Item
Unknown (3)
Item
Does proband have a history of focal laser treatment? (Y/N/U) - See also GAIN - GoKinD phs000018: FLASER
text
FLASER
Code List
Does proband have a history of focal laser treatment? (Y/N/U) - See also GAIN - GoKinD phs000018: FLASER
CL Item
No (1)
CL Item
Yes (2)
CL Item
Unknown (3)
Item
Does proband have a history of pan-retinal laser treatment? (Y/N/U) - See also GAIN - GoKinD phs000018: PLASER
text
PLASER
Code List
Does proband have a history of pan-retinal laser treatment? (Y/N/U) - See also GAIN - GoKinD phs000018: PLASER
CL Item
No (1)
CL Item
Yes (2)
CL Item
Unknown (3)
Item
Does proband have a history of auto-immune disease? - See also GAIN - GoKinD phs000018: AUTOIMMU
text
AUTOIMMU
Code List
Does proband have a history of auto-immune disease? - See also GAIN - GoKinD phs000018: AUTOIMMU
CL Item
None (0)
CL Item
Yes (1)
CL Item
Yes >1 disease (2)
TIMEEVNT
Item
Time between diagnosis of type 1 diabetes (T1D) and kidney complications (years) - See also GAIN - GoKinD phs000018: TIMEEVNT
text
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