ID
44931
Beskrivning
https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000741.v2.p1 The GOLDN study was initiated to assess how genetic factors interact with environmental (diet and drug) interventions to influence blood levels of triglycerides and other atherogenic lipid species and inflammation markers (registered at clinicaltrails.gov, number NCT00083369). The study recruited Caucasian participants primarily from three-generational pedigrees from two NHLBI Family Heart Study (FHS) field centers (Minneapolis, MN and Salt Lake City, UT). Only families with at least two siblings were recruited and only participants who did not take lipid-lowering agents (pharmaceuticals or nutraceuticals) for at least 4 weeks prior to the initial visit were included. A total of 1048 GOLDN participants were included in the diet intervention. The diet intervention followed the protocol of Patsch et al. (1992). The whipping cream (83% fat) meal had 700 Calories/m2 body surface area (2.93 MJ/m2 body surface area): 3% of calories were derived from protein (instant nonfat dry milk) and 14% from carbohydrate (sugar). The ratio of polyunsaturated to saturated fat was 0.06 and the cholesterol content of the average meal was 240 mg. The mixture was blended with ice and flavorings. Blood samples were drawn immediately before (fasting) and at 3.5 and 6 hours after consuming the high-fat meal. For the GOLDN lipidomics study, sterols and fatty acids were measured from stored plasma (-80 degrees Celsius) collected at fasting and 3.5 hours after the diet intervention using TrueMass Panels from Lipomics (West Sacramento, CA). A total of 11 sterols were quantified in nmols/gram of sample including total cholesterol, 7-dehydrocholesterol, desmosterol, lanosterol, lathasterol, cholestanol, coprostanol, beta-sitosterol, campesterol, stigmasterol, and 7alpha-hydroxycholesterol. A total of 35 fatty acids were quantified in nmols/gram of sample inlcuding myristic acid (14:0); pentadecanoic acid (15:0); palmitic acid (16:0); stearic acid (18:0); arachidic acid (20:0); behenic acid (22:0); lignoceric acid (24:0); myristoleic acid (14:1n5); palmitoleic acid (16:1n7); palmitelaidic acid (t16:1n7); oleic acid (18:1n9); elaidic acid (t18:1n9); vaccenic acid (18:1n7); linoleic acid (18:2n6); gamma-linolenic acid (18:3n6); alpha-linolenic acid (18:3n3); stearidonic acid (18:4n3); eicosenoic acid (20:1n9); eicosadienoic acid (20:2n6); mead acid (20:3n9); di-homo-gamma-linolenic acid (20:3n6); arachidonic acid (20:4n6); eicsoatetraenoic acid (20:4n3); eicosapentaenoic acid (20:5n3); erucic acid (22:1n9); docosadienoic acid (22:2n6); adrenic acid (22:4n6); docosapentaenoic acid (22:5n6); docosapentaenoic acid (22:5n3); docosahexaenoic acid (22:6n3); nervonic acid (24:1n9); and plasmalogen derivatives of 16:0, 18:0, 18:1n9, and 18:1n7.
Länk
https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000741.v2.p1
Nyckelord
Versioner (4)
- 30/4/22 30/4/22 - Martin Dugas
- 30/4/22 30/4/22 - Martin Dugas
- 12/5/22 12/5/22 - Martin Dugas
- 13/6/22 13/6/22 - Dr. Christian Niklas
Rättsinnehavare
Donna K Arnett, PhD. University of Alabama at Birmingham, Birmingham, AL, USA
Uppladdad den
30 de abril de 2022
DOI
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Licens
Creative Commons BY-NC 4.0
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Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) Lipidomics Study NCT00083369 dbGaP phs000741.v2.p1
GOLDN_Lipid_Lowering_Subject_Phenotypes Dataset Accession: pht003918.v2.p1 The dataset provides steroid, sterol, stanol, and plasmalogen data (fasting/postprandial/following diet intervention) of participants, in addition to basic sociodemographic data. An extensive pedigree file is also available indicating the position of participating subjects within their family. In study version 2, data of n=932 additional study participants have been added, plus blood pressure, blood lipid values and BMI/metabolic syndrome ( presence/absence) data have been added.
Similar models
GOLDN_Lipid_Lowering_Subject_Phenotypes Dataset Accession: pht003918.v2.p1 The dataset provides steroid, sterol, stanol, and plasmalogen data (fasting/postprandial/following diet intervention) of participants, in addition to basic sociodemographic data. An extensive pedigree file is also available indicating the position of participating subjects within their family. In study version 2, data of n=932 additional study participants have been added, plus blood pressure, blood lipid values and BMI/metabolic syndrome ( presence/absence) data have been added.
C4684638 (UMLS CUI [1,2])
C0027138 (UMLS CUI [1,2])
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