Eligibility NCT00408473 Atrial Fibrillation

Alter 18 bis 65 Jahre

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History of first symptomatic & documented episode of AF

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LVEF > 40% and not on AAD and in sinus rhythm at time of recruitment

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History of more than 1 symptomatic documented AF episode, persistent or permanent AF.

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History of ablation for previous AF

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Reversible cause for AF (e.g.thyroid, alcohol, pulmonary embolism, surgery

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Severe symptoms during AF episode (e.g.syncope, chest pain)

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All types of treated arrhythmias other than AF

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History of myocardial infarction (MI), coronary artery disease (CAD), heart failure (I, II, III and IV of New York Heart Association -NYHA- classification) or valvular diseases

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LVEF - Left ventricular ejection fraction

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Bradycardia < 40 beats/min and all ECG abnormalities: PR> 240ms or QRS> 120 ms or QTc> 440 ms

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Brugada Syndrome (disorder)

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Conduction disturbances: complete bundle branch block (LBBB) or (RBBB), bifascicular block

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2nd or 3rd degree atrioventricular (AV) block

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Coronary sinus rhythm disorder

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Severe hypertension with:Systolic blood pressure >= 180 mmHg, and / or Diastolic blood pressure >= 100 mmHg

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Left ventricular hypertrophy (LVH) with septal thickness > 14 mm on Echocardiogram

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Herzschrittmacher

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Heart surgery within the last 6 months, or non-stable postoperative condition

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Renal failure: serum creatinine >= 150 µmol/l or creatinine clearance <= 50 ml/min (Cockroft and Gault formula

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Uncorrected electrolytic abnormalities

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Have used recently in the last 3 months prior to the inclusion any of the following treatments: Oral amiodarone, Treatments that lengthen QT interval (e.g.Sultopride, Drugs causing torsades de pointe (e.g.mizolastine, pentamidine, sparfloxacin, moxifloxacin, Bupropion

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Anti-hypertensive drugs other than permitted in the study: ACE-I, ARB (sartans) and DHP from Calcium channel blockers (CCB

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