pregnancy test
Item
negative pregnancy test within two days of the scan and willingness to adhere to reliable birth control until the completion of the protocol.
boolean
C0032976 (UMLS CUI [1])
C0032961 (UMLS CUI [2])
informed consent
Item
subjects must be able to give informed consent.
boolean
C0021430 (UMLS CUI [1])
asthma or other lung disease
Item
subjects in the negative control group must have no history of asthma or other lung disease.
boolean
C0004096 (UMLS CUI [1])
C0024115 (UMLS CUI [2])
control subjects - allergy testing
Item
control subjects must have negative prick skin tests to the allergens used.
boolean
C0199747 (UMLS CUI [1])
C0430561 (UMLS CUI [2])
Asthma by study definition
Item
asthmatic subjects must have asthma as defined in this study.
boolean
C0004096 (UMLS CUI [1])
asthma subjects - allergy testing
Item
asthmatic subjects must have positive prick skin tests to one or more allergens used.
boolean
C0199747 (UMLS CUI [1])
C0430561 (UMLS CUI [2])
primary medical care provider
Item
subjects must have access to a primary medical care provider outside of the nih.
boolean
body weight
Item
subjects must weigh less than 136 kg.
boolean
C0005910 (UMLS CUI [1])
breast feeding
Item
no breast feeding.
boolean
C0006147 (UMLS CUI [1])
smoking history
Item
no smoking in the last 3 years, or greater than 6 months of smoking in the past ten years.
boolean
C1519384 (UMLS CUI [1])
antihistamines
Item
no antihistamines one week prior to the skin test on the first visit.
boolean
C0019590 (UMLS CUI [1])
coronary artery disease
Item
no history of coronary artery disease.
boolean
C1956346 (UMLS CUI [1])
Lung, autoimmune and inflammatory disease
Item
no evidence of lung disease other than asthma; no evidence of autoimmune or inflammatory disease which could affect lung function such as lupus erythematosus (except for the control subjects with wegener's granulomatosis).
boolean
C0024115 (UMLS CUI [1])
C0004364 (UMLS CUI [2])
C1290884 (UMLS CUI [3])
lung infection
Item
no evidence of either acute (e.g., bacterial or viral pneumonia) or chronic (e.g., bronchiectasis) lung infection.
boolean
C0876973 (UMLS CUI [1])
diabetes, glucose intolerance
Item
no diabetes, or history of glucose intolerance (e.g., gestational diabetes).
boolean
C0011849 (UMLS CUI [1])
C0271650 (UMLS CUI [2])
allergy to methacholine
Item
no allergy to methacholine.
boolean
C0020517 (UMLS CUI [1,1])
C0600370 (UMLS CUI [1,2])
beta-adrenergic antagonists
Item
no beta-adrenergic blocking medication.
boolean
C0001645 (UMLS CUI [1])
control subjects - asthma, atopic rhinitis or atopic dermatitis
Item
control subjects must not have a history of asthma, atopic rhinitis or atopic dermatitis.
boolean
C0004096 (UMLS CUI [1])
C0002103 (UMLS CUI [2])
C0011615 (UMLS CUI [3])
control subjects - metacholine response, fev1
Item
control subjects must not have any response to inhaled methacholine with a fall in fev1 in excess of 20% to less than or equal to 25 mg/ml.
boolean
C0600370 (UMLS CUI [1])
C0748133 (UMLS CUI [2])
asthmatic subjects - chronic bronchitis or copd
Item
asthmatic subjects must not have chronic bronchitis or a diagnosis of chronic obstructive lung disease (copd).
boolean
C0008677 (UMLS CUI [1])
C0024117 (UMLS CUI [2])