Informações:
Falhas:
ID
42247
Descrição
Ticagrelor is a new, reversible binding, anti-platelet medication. Anti-platelet medications work to prevent the formation of blood clots. Ticagrelor is being developed as a treatment for patients with acute coronary syndrome (ACS). ACS is a term that is used to describe both heart attacks in progress or the imminent threat of a heart attack. ACS is usually caused by the formation of a blood clot in an artery that partially or totally blocks the blood supply to a portion of the heart muscle. Ticagrelor will be compared with clopidogrel to determine which drug, when either is used in conjunction with aspirin, is better at reducing deaths from vascular causes, future heart attacks and/or strokes in patients with ACS. https://clinicaltrials.gov/ct2/show/NCT00391872
Link
https://clinicaltrials.gov/ct2/show/NCT00391872
Palavras-chave
Versões (3)
- 28/11/2015 28/11/2015 -
- 14/04/2021 14/04/2021 - Ahmed Rafee, MD
- 15/04/2021 15/04/2021 - Ahmed Rafee, MD
Titular dos direitos
AstraZeneca
Transferido a
15 de abril de 2021
DOI
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Licença
Creative Commons BY 4.0
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Excerpt PLATO Acute coronary Syndrome NCT00391872
Section Procedures and Operations
Similar models
Section Procedures and Operations
Name
Tipo
Description | Question | Decode (Coded Value)
Tipo de dados
Alias
CL Item
Cardiac ischaemic event (1)
I (UMLS CUI-1)
CL Item
Serious adverse event (2)
I (UMLS CUI-1)
CL Item
Elective hospitalization (3)
I (UMLS CUI-1)
CL Item
Other (4)
I (UMLS CUI-1)
Date of admission
Item
Date of admission
date
C1302393 (UMLS CUI [1])
Date of discharge
Item
Date of discharge
date
C2361123 (UMLS CUI [1])
Days in ICU
Item
Number of days in intensive care
integer
C0023303 (UMLS CUI [1,1])
C0021708 (UMLS CUI [1,2])
C0021708 (UMLS CUI [1,2])
Discharge diagnosis
Item
Final discharge diagnosis
text
C0332144 (UMLS CUI [1])
Additional hospitalizations
Item
Any additional hospitalizations since previous visit
boolean
C0019993 (UMLS CUI [1])
Date of procedure
Item
Procedure date and time
datetime
C2584899 (UMLS CUI [1])
Procedure number
Item
Procedure number
text
C0087111 (UMLS CUI [1,1])
C0237753 (UMLS CUI [1,2])
C0237753 (UMLS CUI [1,2])
Urgent procedure
Item
Urgent procedure
boolean
C3272275 (UMLS CUI [1])
Most recent AZD6140/placebo dose prior to surgery
Item
Most recent AZD6140/placebo dose prior to surgery
datetime
C3173975 (UMLS CUI [1,1])
C1608718 (UMLS CUI [1,2])
C1608718 (UMLS CUI [1,2])
Most recent clopidogrel/placebo dose prior to surgery
Item
Most recent clopidogrel/placebo dose prior to surgery
datetime
C0070166 (UMLS CUI [1,1])
C3173975 (UMLS CUI [1,2])
C3173975 (UMLS CUI [1,2])
CL Item
CABG without valve replacement (1)
C0010055 (UMLS CUI-1)
CL Item
CABG with valve replacement (2)
N (UMLS CUI-1)
CL Item
Valve replacement(s), no CABG (3)
C0190173 (UMLS CUI-1)
CL Item
Other cardiac surgery (4)
I (UMLS CUI-1)
CL Item
Re-operation due to bleeding (5)
C0035110 (UMLS CUI-1)
CL Item
Other re-operation (6)
I (UMLS CUI-1)
Number of grafts placed
Item
Number of grafts placed
integer
C1391985 (UMLS CUI [1])
Were any grafts placed to the target vessel of the index event
Item
Were any grafts placed to the target vessel of the index event
boolean
C3543860 (UMLS CUI [1])
Were any grafts placed to a previously treated vessel
Item
Were any grafts placed to a previously treated vessel
boolean
C0740038 (UMLS CUI [1,1])
C0205156 (UMLS CUI [1,2])
C0205156 (UMLS CUI [1,2])
Were any grafts placed due to stent thrombosis
Item
Were any grafts placed due to stent thrombosis
boolean
C0740038 (UMLS CUI [1,1])
C0678226 (UMLS CUI [1,2])
C0040053 (UMLS CUI [1,3])
C0678226 (UMLS CUI [1,2])
C0040053 (UMLS CUI [1,3])
Chest tube drainage volume within first 24 hours
Item
Chest tube drainage volume within first 24 hours
integer
C0008034 (UMLS CUI [1])
Cardiopulmonary bypass
Item
Cardiopulmonary bypass
boolean
C0007202 (UMLS CUI [1])
CL Item
Aprotinin (Aprotinin)
C0003641 (UMLS CUI-1)
CL Item
Desmopressin (Desmopressin)
C0011701 (UMLS CUI-1)
CL Item
Tranexamic acid (Tranexamic acid)
C0040613 (UMLS CUI-1)
CL Item
Aminocaproic acid (Aminocaproic acid)
C0000608 (UMLS CUI-1)
CL Item
Other (Other)
I (UMLS CUI-1)
Local cardiac biomarker measurements
Item
Local cardiac biomarker measurements
text
C1271630 (UMLS CUI [1])
Central lab blood samples for analysis of CK-MB and Troponin I have been collected
Item
Central lab blood samples for analysis of CK-MB and Troponin I have been collected
boolean
C0010290 (UMLS CUI [1,1])
C0041199 (UMLS CUI [1,2])
C0041199 (UMLS CUI [1,2])
Accession number (Pre-CABG)
Item
Accession number (Pre-CABG)
text
C1510755 (UMLS CUI [1,1])
C0332152 (UMLS CUI [1,2])
C0010055 (UMLS CUI [1,3])
C0332152 (UMLS CUI [1,2])
C0010055 (UMLS CUI [1,3])
Accession number (8-12 hrs post CABG)
Item
Accession number (8-12 hrs post CABG)
text
C1510755 (UMLS CUI [1,1])
C0332152 (UMLS CUI [1,2])
C0010055 (UMLS CUI [1,3])
C0332152 (UMLS CUI [1,2])
C0010055 (UMLS CUI [1,3])
Accession number (12-24 hrs post CABG)
Item
Accession number (12-24 hrs post CABG)
text
C1510755 (UMLS CUI [1,1])
C0332152 (UMLS CUI [1,2])
C0010055 (UMLS CUI [1,3])
C0332152 (UMLS CUI [1,2])
C0010055 (UMLS CUI [1,3])
Additional cardiac surgeries
Item
Were there any additional cardiac surgeries performed since last visit
boolean
C0018821 (UMLS CUI [1])
Procedure date and time
Item
Procedure date and time
datetime
C2584899 (UMLS CUI [1])
Urgent procedure
Item
Urgent procedure
boolean
C3272275 (UMLS CUI [1])
CL Item
None (None)
I (UMLS CUI-1)
CL Item
Left main (Left main)
C2062905 (UMLS CUI-1)
CL Item
Left anterior descending (Left anterior descending)
N (UMLS CUI-1)
CL Item
Left circumflex (Left circumflex)
N (UMLS CUI-1)
CL Item
Right coronary (Right coronary)
C3267166 (UMLS CUI-1)
CL Item
Bypass graft (Bypass graft)
C0010055 (UMLS CUI-1)
CL Item
>50% (>50%)
CL Item
40-50% (40-50%)
CL Item
30-39% (30-39%)
CL Item
<30% (<30%)
Additional coronary angiographies
Item
Were there any additional coronary angiographies performed since last visit
boolean
C0085532 (UMLS CUI [1])
Procedure date
Item
Procedure date
datetime
C2584899 (UMLS CUI [1])
CL Item
CT scan (CT scan)
C0040405 (UMLS CUI-1)
CL Item
MRI (MRI)
C0024485 (UMLS CUI-1)
CL Item
Head/brain (Head/brain)
I (UMLS CUI-1)
CL Item
Spinal (Spinal)
I (UMLS CUI-1)
CL Item
Chest (Chest)
I (UMLS CUI-1)
CL Item
Helical CT scan (Helical CT scan)
I (UMLS CUI-1)
CL Item
Abdomen (Abdomen)
I (UMLS CUI-1)
CL Item
Extremity (Extremity)
I (UMLS CUI-1)
CL Item
Other (Other)
I (UMLS CUI-1)
CL Item
Head/brain (Head/brain)
I (UMLS CUI-1)
CL Item
Spinal (Spinal)
I (UMLS CUI-1)
CL Item
Chest (Chest)
I (UMLS CUI-1)
CL Item
Abdomen (Abdomen)
I (UMLS CUI-1)
CL Item
Extremity (Extremity)
I (UMLS CUI-1)
CL Item
Other (Other)
I (UMLS CUI-1)
Additional CT or MRI imaging performed since last visit
Item
Was there any additional CT or MRI imaging performed since last visit
boolean
C0024485|C0040405 (UMLS CUI [1])
Procedure date
Item
Procedure date
datetime
C2584899 (UMLS CUI [1])
CL Item
ECG (ECG)
C1623258 (UMLS CUI-1)
CL Item
Echocardiography (Echocardiography)
C0013516 (UMLS CUI-1)
CL Item
Myocardial (Myocardial)
C1455714 (UMLS CUI-1)
CL Item
perfusion imaging (perfusion imaging)
N (UMLS CUI-1)
Item
Result of stress test
text
C1274040 (UMLS CUI [1,1])
C1384495 (UMLS CUI [1,2])
C1384495 (UMLS CUI [1,2])
CL Item
Negative (Negative)
C1096370 (UMLS CUI-1)
CL Item
Positive (Positive)
C1096350 (UMLS CUI-1)
CL Item
Indeterminate (Indeterminate)
I (UMLS CUI-1)
Additional stress tests
Item
Were there any additional stress tests performed since last visit
boolean
C1384495 (UMLS CUI [1])
Item Group
Echocardiography/Radionuclide Angiography
C0013516 (UMLS CUI-1)
Procedure date
Item
Procedure date
datetime
C2584899 (UMLS CUI [1])
CL Item
>50% (>50%)
CL Item
40-50% (40-50%)
CL Item
30-39% (30-39%)
CL Item
<30% (<30%)
Additional echocardiographies/radionuclide angiographies
Item
Were there any additional echocardiographies/radionuclide angiographies performed since last visit
boolean
C0013516 (UMLS CUI [1])
Item Group
Percutaneous Coronary Revascularization
C1532338 (UMLS CUI-1)
Procedure date
Item
Procedure date and time
datetime
C2584899 (UMLS CUI [1])
Urgent procedure
Item
Urgent procedure
boolean
C3272275 (UMLS CUI [1])
CL Item
PCI without stent (PCI without stent)
N (UMLS CUI-1)
CL Item
PCI with stent (PCI with stent)
N (UMLS CUI-1)
CL Item
Balloon PTCA (Balloon PTCA)
C0002997 (UMLS CUI-1)
CL Item
Other (Other)
I (UMLS CUI-1)
Number of vessels treated
Item
Number of vessels treated
integer
C0005847 (UMLS CUI [1,1])
C0750480 (UMLS CUI [1,2])
C0750480 (UMLS CUI [1,2])
Was PCI performed to the target vessel of the index event
Item
Was PCI performed to the target vessel of the index event
boolean
C1532338 (UMLS CUI [1,1])
C0205156 (UMLS CUI [1,2])
C0205156 (UMLS CUI [1,2])
Was PCI performed to a previously treated vessel
Item
Was PCI performed to a previously treated vessel
boolean
C1532338 (UMLS CUI [1,1])
C0205156 (UMLS CUI [1,2])
C0205156 (UMLS CUI [1,2])
Coronary stent thrombosis
Item
Was PCI performed due to stent thrombosis
boolean
C1536080 (UMLS CUI [1])
Number of drug eluting stents placed
Item
Number of drug eluting stents placed
integer
C2024081 (UMLS CUI [1,1])
C1262327 (UMLS CUI [1,2])
C1262327 (UMLS CUI [1,2])
Number of bare metal stents placed
Item
Number of bare metal stents placed
integer
C2024081 (UMLS CUI [1,1])
C2825200 (UMLS CUI [1,2])
C2825200 (UMLS CUI [1,2])
Were any stents placed to the target vessel of the index event
Item
Were any stents placed to the target vessel of the index event
boolean
C0687568 (UMLS CUI [1,1])
C0205156 (UMLS CUI [1,2])
C0150312 (UMLS CUI [1,3])
C0205156 (UMLS CUI [1,2])
C0150312 (UMLS CUI [1,3])
Were any stents placed to a previously treated vessel
Item
Were any stents placed to a previously treated vessel
float
C0687568 (UMLS CUI [1,1])
C0205156 (UMLS CUI [1,2])
C0150312 (UMLS CUI [1,3])
C0205156 (UMLS CUI [1,2])
C0150312 (UMLS CUI [1,3])
Were any stents placed for a stent thrombosis
Item
Were any stents placed for a stent thrombosis
boolean
C3272316 (UMLS CUI [1,1])
C0678226 (UMLS CUI [1,2])
C0040053 (UMLS CUI [1,3])
C0678226 (UMLS CUI [1,2])
C0040053 (UMLS CUI [1,3])
Item
Main reason for revascularization
text
C0027056 (UMLS CUI [1,1])
C0392360 (UMLS CUI [1,2])
C0392360 (UMLS CUI [1,2])
CL Item
Unstable angina (Unstable angina)
I (UMLS CUI-1)
CL Item
Stable angina (Stable angina)
I (UMLS CUI-1)
CL Item
Acute myocardial infarction (Acute myocardial infarction)
I (UMLS CUI-1)
CL Item
Positive exercise test (Positive exercise test)
I (UMLS CUI-1)
CL Item
Cardiogenic shock (Cardiogenic shock)
I (UMLS CUI-1)
CL Item
Physician decision (Physician decision)
I (UMLS CUI-1)
CL Item
Other (Other)
I (UMLS CUI-1)
Cardiac biomarker measurements
Item
Local cardiac biomarker measurements
text
C1271630 (UMLS CUI [1])
CK-MB and Troponin I
Item
Central lab blood samples for analysis of CK-MB and Troponin I have been collected
boolean
C0523584|C0920210 (UMLS CUI [1])
Accession number (Pre-PCI)
Item
Accession number (Pre-PCI)
text
C1510755 (UMLS CUI [1,1])
C0332152 (UMLS CUI [1,2])
C1532338 (UMLS CUI [1,3])
C0332152 (UMLS CUI [1,2])
C1532338 (UMLS CUI [1,3])
Accession number (8-12 hrs post pCI)
Item
Accession number (8-12 hrs post pCI)
text
C1510755 (UMLS CUI [1,1])
C0332152 (UMLS CUI [1,2])
C1532338 (UMLS CUI [1,3])
C0332152 (UMLS CUI [1,2])
C1532338 (UMLS CUI [1,3])
Accession number (12-24 hrs post PCI)
Item
Accession number (12-24 hrs post PCI)
text
C1510755 (UMLS CUI [1,1])
C0332152 (UMLS CUI [1,2])
C1532338 (UMLS CUI [1,3])
C0332152 (UMLS CUI [1,2])
C1532338 (UMLS CUI [1,3])
Additional percutaneous coronary revascularizations
Item
Were there any additional percutaneous coronary revascularizations performed since last visit
boolean
C1532338 (UMLS CUI [1])
Blood transfusion
Item
Any transfusion during the study
boolean
C0005841 (UMLS CUI [1])