ID
40322
Beskrivning
DELCODE is conducted by DZNE, the German Center for Neurodegenerative Diseases within the Helmholtz Association. The following information was taken from https://www.dzne.de/en/research/studies/clinical-studies/delcode/. Background and aims: One of the important aims of research into Alzheimer's is to find ways of detecting the disease early – if at all possible, as soon as the first minor symptoms appear, or even before any symptoms at all have appeared. Such detection capabilities are the necessary basis for development of therapies that can be applied at such early stages in the disease. Recent research indicates that such therapies could be more effective than therapies initiated during the disease's later stages. Over a period of several years, the DELCODE study is studying persons in early stages of the disease, along with various risk groups. The research is aimed at the development of procedures for characterizing early stages of the disease, at improving prediction of the course of the disease and at identifying new markers for early diagnosis of Alzheimer's-related dementia. Overview: DELCODE is set up to run for an initial period of three years, and to include a total of 1,000 study participants, who will be examined on a yearly basis. The group of participants will include persons with no complaints (healthy control subjects), patients with slight memory impairment or mild dementia and first-degree relatives of patients with diagnosed Alzheimer's disease. The minimum age for participants is 60. Course of the study: The examinations in the framework of the study will include a comprehensive interview carried out by a study investigator, a detailed neuropsychological examination (testing of memory functions and other areas of cognitive performance), a blood test and a cranial MRI scan. Optionally, subject to the study participant's consent in each case, a lumbar puncture (collection of cerebrospinal fluid) will be carried out." For more information (e.g. principle investigator and study coordination), please visit the above link or https://www.dzne.de. This document contains the Eligibility criteria. It has to be filled in at the baseline of the study.
Länk
https://www.dzne.de/en/research/studies/clinical-studies/delcode/
Nyckelord
Versioner (2)
- 2020-03-23 2020-03-23 -
- 2020-04-08 2020-04-08 - Sarah Riepenhausen
Rättsinnehavare
DZNE
Uppladdad den
8 april 2020
DOI
För en begäran logga in.
Licens
Creative Commons BY-NC 4.0
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DELCODE: DZNE – Longitudinal Cognitive Impairment and Dementia Study
Eligibility criteria (Ein- und Ausschlusskriterien)
- StudyEvent: ODM
Beskrivning
Einschlusskriterien
Alias
- UMLS CUI-1
- C1512693
Beskrivning
Informed consent
Datatyp
boolean
Alias
- UMLS CUI [1]
- C0021430
Beskrivning
Bitte beachten Sie: Der Informant darf gleichzeitig als Kontrollproband in DELCODE teilnehmen, sofern ein weiterer Informant vorhanden ist, der über sie/ihn Auskunft gibt.
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0027361
- UMLS CUI [1,2]
- C1533716
- UMLS CUI [1,3]
- C1997894
- UMLS CUI [1,4]
- C0347984
- UMLS CUI [1,5]
- C2347804
Beskrivning
Sufficient knowledge of German, neuropsychological tests
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0205410
- UMLS CUI [1,2]
- C0376554
- UMLS CUI [1,3]
- C0017477
- UMLS CUI [1,4]
- C0027902
Beskrivning
Age
Datatyp
boolean
Alias
- UMLS CUI [1]
- C0001779
Beskrivning
Informed consent for lumbar puncture
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0037943
- UMLS CUI [1,2]
- C0021430
Beskrivning
Ausschlusskriterien
Alias
- UMLS CUI-1
- C0680251
Beskrivning
Unable to give consent
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0021430
- UMLS CUI [1,2]
- C0332197
Beskrivning
Conditions affecting protocol compliance
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0348080
- UMLS CUI [1,2]
- C0392760
- UMLS CUI [1,3]
- C0525058
Beskrivning
Condition affecting Clinical/ neuropsychological examination
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0348080
- UMLS CUI [1,2]
- C0392760
- UMLS CUI [1,3]
- C1456356
- UMLS CUI [2,1]
- C0348080
- UMLS CUI [2,2]
- C0392760
- UMLS CUI [2,3]
- C0027902
Beskrivning
Sensory disorders (e.g. blindness or deafness) affecting neuropsychological examination
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0152027
- UMLS CUI [1,2]
- C0392760
- UMLS CUI [1,3]
- C0027902
- UMLS CUI [2]
- C0456909
- UMLS CUI [3]
- C0011053
Beskrivning
Clinical instable/ significant disease
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0012634
- UMLS CUI [1,2]
- C2826293
- UMLS CUI [2,1]
- C0012634
- UMLS CUI [2,2]
- C0443343
Beskrivning
Current depressive episode
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0521116
- UMLS CUI [1,2]
- C0349217
Beskrivning
Current/ medical history of Psychotic or bipolar disorder or substance dependency
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0521116
- UMLS CUI [1,2]
- C0005586
- UMLS CUI [2,1]
- C0262926
- UMLS CUI [2,2]
- C0005586
- UMLS CUI [3,1]
- C0521116
- UMLS CUI [3,2]
- C0033975
- UMLS CUI [4,1]
- C0262926
- UMLS CUI [4,2]
- C0033975
- UMLS CUI [5,1]
- C0521116
- UMLS CUI [5,2]
- C0038580
- UMLS CUI [6,1]
- C0262926
- UMLS CUI [6,2]
- C0038580
Beskrivning
Neurodegenerative diseases (except AD)
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0524851
- UMLS CUI [1,2]
- C0332300
- UMLS CUI [1,3]
- C0002395
Beskrivning
Vascular dementia
Datatyp
boolean
Alias
- UMLS CUI [1]
- C0011269
Beskrivning
History of stroke with residual symptoms
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0559159
- UMLS CUI [1,2]
- C1609982
- UMLS CUI [1,3]
- C1457887
Beskrivning
Clinical significant pathological laboratory values (incl. TSH, vitamin B12)
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C2826293
- UMLS CUI [1,2]
- C1521733
- UMLS CUI [1,3]
- C1254595
- UMLS CUI [2,1]
- C0332257
- UMLS CUI [2,2]
- C0202230
- UMLS CUI [3,1]
- C0332257
- UMLS CUI [3,2]
- C0202252
Beskrivning
Current in treatment/ Life expectancy limiting malignant disease
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0521116
- UMLS CUI [1,2]
- C0087111
- UMLS CUI [1,3]
- C0442867
- UMLS CUI [2,1]
- C0023671
- UMLS CUI [2,2]
- C0439801
- UMLS CUI [2,3]
- C0442867
Beskrivning
Chronic use of sedative/ anticholinergic psychotropic drugs
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C0205191
- UMLS CUI [1,2]
- C0036557
- UMLS CUI [1,3]
- C0033978
- UMLS CUI [2,1]
- C0205191
- UMLS CUI [2,2]
- C0242896
- UMLS CUI [2,3]
- C0033978
Beskrivning
Use of anti-dementia medication excluding ginkgo
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C1524063
- UMLS CUI [1,2]
- C3653789
- UMLS CUI [1,3]
- C0332300
- UMLS CUI [1,4]
- C0330205
Beskrivning
Participation in a clinical trial with antidementia / cognitively active substances
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C2348568
- UMLS CUI [1,2]
- C0008976
- UMLS CUI [1,3]
- C3653789
- UMLS CUI [2,1]
- C2348568
- UMLS CUI [2,2]
- C0008976
- UMLS CUI [2,3]
- C0009240
- UMLS CUI [2,4]
- C0205177
- UMLS CUI [2,5]
- C0439861
Beskrivning
Contraindications to lumbar punctures/ MRT examinations
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C1301624
- UMLS CUI [1,2]
- C0024485
- UMLS CUI [2,1]
- C1301624
- UMLS CUI [2,2]
- C0037943
Similar models
Eligibility criteria (Ein- und Ausschlusskriterien)
- StudyEvent: ODM
C1533716 (UMLS CUI [1,2])
C1997894 (UMLS CUI [1,3])
C0347984 (UMLS CUI [1,4])
C2347804 (UMLS CUI [1,5])
C0376554 (UMLS CUI [1,2])
C0017477 (UMLS CUI [1,3])
C0027902 (UMLS CUI [1,4])
C0021430 (UMLS CUI [1,2])
C0332197 (UMLS CUI [1,2])
C0392760 (UMLS CUI [1,2])
C0525058 (UMLS CUI [1,3])
C0392760 (UMLS CUI [1,2])
C1456356 (UMLS CUI [1,3])
C0348080 (UMLS CUI [2,1])
C0392760 (UMLS CUI [2,2])
C0027902 (UMLS CUI [2,3])
C0392760 (UMLS CUI [1,2])
C0027902 (UMLS CUI [1,3])
C0456909 (UMLS CUI [2])
C0011053 (UMLS CUI [3])
C2826293 (UMLS CUI [1,2])
C0012634 (UMLS CUI [2,1])
C0443343 (UMLS CUI [2,2])
C0349217 (UMLS CUI [1,2])
C0005586 (UMLS CUI [1,2])
C0262926 (UMLS CUI [2,1])
C0005586 (UMLS CUI [2,2])
C0521116 (UMLS CUI [3,1])
C0033975 (UMLS CUI [3,2])
C0262926 (UMLS CUI [4,1])
C0033975 (UMLS CUI [4,2])
C0521116 (UMLS CUI [5,1])
C0038580 (UMLS CUI [5,2])
C0262926 (UMLS CUI [6,1])
C0038580 (UMLS CUI [6,2])
C0332300 (UMLS CUI [1,2])
C0002395 (UMLS CUI [1,3])
C1609982 (UMLS CUI [1,2])
C1457887 (UMLS CUI [1,3])
C1521733 (UMLS CUI [1,2])
C1254595 (UMLS CUI [1,3])
C0332257 (UMLS CUI [2,1])
C0202230 (UMLS CUI [2,2])
C0332257 (UMLS CUI [3,1])
C0202252 (UMLS CUI [3,2])
C0087111 (UMLS CUI [1,2])
C0442867 (UMLS CUI [1,3])
C0023671 (UMLS CUI [2,1])
C0439801 (UMLS CUI [2,2])
C0442867 (UMLS CUI [2,3])
C0036557 (UMLS CUI [1,2])
C0033978 (UMLS CUI [1,3])
C0205191 (UMLS CUI [2,1])
C0242896 (UMLS CUI [2,2])
C0033978 (UMLS CUI [2,3])
C3653789 (UMLS CUI [1,2])
C0332300 (UMLS CUI [1,3])
C0330205 (UMLS CUI [1,4])
C0008976 (UMLS CUI [1,2])
C3653789 (UMLS CUI [1,3])
C2348568 (UMLS CUI [2,1])
C0008976 (UMLS CUI [2,2])
C0009240 (UMLS CUI [2,3])
C0205177 (UMLS CUI [2,4])
C0439861 (UMLS CUI [2,5])
C0024485 (UMLS CUI [1,2])
C1301624 (UMLS CUI [2,1])
C0037943 (UMLS CUI [2,2])