ID

38580

Description

Study ID: 108062 Clinical Study ID: 108062 Study Title: A three part, staggered cohort, open-label and double blind, randomized, placebo controlled study to investigate the efficacy, safety, tolerability and pharmacokinetics of eltrombopag, a thrombopoietin receptor agonist, in previously treated pediatric patients with chronic idiopathic thrombocytopenic purpura (ITP). Eltrombopag PETIT: Eltrombopag in PEdiatric patients with Thrombocytopenia from ITP Patient Level Data: Study Listed on ClinicalStudyDataRequest.com Clinicaltrials.gov Identifier: NCT00908037 https://clinicaltrials.gov/ct2/show/NCT00908037 Sponsor: GlaxoSmithKline Collaborators: N/A Phase: Phase 2 Study Recruitment Status: Completed Generic Name: eltrombopag, Placebo Trade Name: N/A Study Indication: Purpura, Thrombocytopaenic, Idiopathic The study consists of a screening, Day 1 and three parts. All subjects were supposed to receive 24 weeks (6 months) of eltrombopag treatment during Part 2/3. Screening period: Up to 28 days prior to Day 1 of treatment. Day 1 Part 1 (Dose Finding Phase): A 24-week (6 months) open label treatment period for 5 subjects in each age cohort. (short: P1W1-P1W7, P1W8-23, P1W24/EW). A safety, PK and platelet count review took place after 12 weeks (3 months) of treatment. Subjects in the Dose Finding Phase did not participate in the Randomized Period. Part 2 (Randomized Period): A 7-week randomized, double-blind, placebo-controlled period involving 18 subjects per cohort (short: P2W1-P2W7). Part 3: An open-label treatment period where subjects randomized to eltrombopag in Part 2 received an additional 17 weeks of eltrombopag in Part 3 and subjects randomized to placebo in Part 2 received 24 weeks of eltrombopag in Part 3 (short: P3W8-P3W23, P3W24/EW, P3W8-30, P3W31/EW). Follow-up: 4 weeks following the last dose of eltrombopag (short: FUW1- FUW4). Additional ocular examinations were performed at 12 and 24 weeks (3 and 6 months) after the last dose of eltrombopag (short: FUM3, FUM6). The subjects were enrolled in 3 cohorts: Cohort 1: Subjects between 12 and 17 years old (<18 years of age at Day 1). Cohort 2: Subjects between 6 and 11 years old (<12 years of age at Day 1). Cohort 3: Subjects between 1 and 5 years old (<6 years of age at Day 1). The enrollment was started with the oldest cohort (Cohort 1). The younger cohorts were not enrolled until safety, PK and platelet counts had been reviewed in the older cohort(s). This document contains the liver biopsy form. It has to be filled in if a liver biopsy is taken during study.

Link

https://clinicaltrials.gov/ct2/show/NCT00908037

Keywords

Versions (1)
  1. 10/24/19 10/24/19 -
Copyright Holder

GlaxoSmithKline

Uploaded on

October 24, 2019

DOI

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License

Creative Commons BY-NC 3.0
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    Effects of eltrombopag in children with chronic idiopathic thrombocytopenic purpura, NCT00908037

    English

    Liver biopsy

    1 forms  
    1. StudyEvent: ODM
      1. Liver biopsy
    Administrative data
    Description

    Administrative data

    Alias
    UMLS CUI-1
    C1320722
    Subject number
    Description

    Subject number

    Data type

    text

    Alias
    UMLS CUI [1]
    C2348585
    Liver biopsy
    Description

    Liver biopsy

    Alias
    UMLS CUI-1
    C0193388
    Date of liver biopsy
    Description

    day month year

    Data type

    date

    Alias
    UMLS CUI [1,1]
    C0193388
    UMLS CUI [1,2]
    C0011008
    Approximate size of liver biopsy
    Description

    Size of liver biopsy

    Data type

    integer

    Measurement units
    • mm
    Alias
    UMLS CUI [1,1]
    C1299482
    UMLS CUI [1,2]
    C0193388
    mm
    Biopsy size unit
    Description

    In the original form this item is hidden.

    Data type

    integer

    Alias
    UMLS CUI [1,1]
    C1299482
    UMLS CUI [1,2]
    C0193388
    UMLS CUI [1,3]
    C1519795
    Final diagnosis
    Description

    Final diagnosis

    Alias
    UMLS CUI-1
    C1546485
    Normal
    Description

    Normal

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0205307
    Acute hepatitis
    Description

    Acute hepatitis

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0267797
    Chronic hepatitis
    Description

    Chronic hepatitis

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0019189
    Cholestatic hepatitis
    Description

    Cholestatic hepatitis

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0149904
    Drug-induced cholestasis
    Description

    Drug-induced cholestasis

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C2062350
    Acute viral hepatitis
    Description

    Acute viral hepatitis

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0276622
    Chronic viral hepatitis
    Description

    Chronic viral hepatitis

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0276623
    Drug-induced hepatitis
    Description

    Drug-induced hepatitis

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C1262760
    Autoimmune hepatitis
    Description

    Autoimmune hepatitis

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0241910
    Bridging necrosis
    Description

    Bridging necrosis

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0333511
    Submassive hepatic necrosis
    Description

    Submassive hepatic necrosis

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0151798
    Massive hepatic necrosis
    Description

    Massive hepatic necrosis

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0001364
    Steatosis - microvesicular
    Description

    Steatosis - microvesicular

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C1850415
    Steatosis - macrovesicular
    Description

    Steatosis - macrovesicular

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C1837256
    Steatosis - mixed
    Description

    Steatosis - mixed

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0015695
    UMLS CUI [1,2]
    C0205430
    Non-alcoholic steatohepatitis
    Description

    Non-alcoholic steatohepatitis

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C3241937
    Alcoholic hepatitis
    Description

    Alcoholic hepatitis

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0019187
    Hepatic granulomas
    Description

    Hepatic granulomas

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0745754
    Sarcoidosis
    Description

    Sarcoidosis

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0036202
    Fibrosis
    Description

    Fibrosis

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0239946
    Cirrhosis
    Description

    Cirrhosis

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0023890
    Primary biliary cirrhosis
    Description

    Primary biliary cirrhosis

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0008312
    Primary sclerosing cholangitis
    Description

    Primary sclerosing cholangitis

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0566602
    Autoimmune overlap syndrome
    Description

    Autoimmune overlap syndrome

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C2702837
    Hemochromatosis
    Description

    Hemochromatosis

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0018995
    Alpha-1-antitrypsin deficiency
    Description

    Alpha-1-antitrypsin deficiency

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0221757
    Wilson's disease
    Description

    Wilson's disease

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0019202
    Veno-occlusive disease
    Description

    Veno-occlusive disease

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0948441
    Budd-Chiari syndrome
    Description

    Budd-Chiari syndrome

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0856761
    Neoplasia
    Description

    Neoplasia

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C1882062
    UMLS CUI [1,2]
    C0023884
    Other final diagnosis
    Description

    Other final diagnosis

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0205394
    UMLS CUI [1,2]
    C0011900
    If other final diagnosis, please specify
    Description

    Other final diagnosis specification

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C0205394
    UMLS CUI [1,2]
    C0011900
    Liver Architecture
    Description

    Liver Architecture

    Alias
    UMLS CUI-1
    C0023884
    UMLS CUI-2
    C0935919
    UMLS CUI-3
    C0193388
    Normal
    Description

    Normal

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0205307
    Bridging fibrosis
    Description

    Bridging fibrosis

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0334160
    Diffuse fibrosis
    Description

    Diffuse fibrosis

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0016059
    UMLS CUI [1,2]
    C0205219
    Nodular regenerative hyperplasia
    Description

    Nodular regenerative hyperplasia

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0020510
    Congenital hepatic fibrosis
    Description

    Congenital hepatic fibrosis

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0009714
    Cirrhosis
    Description

    Cirrhosis

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0023890
    Centrilobular congestion
    Description

    Centrilobular congestion

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0267821
    UMLS CUI [1,2]
    C0442080
    Endophlebitis
    Description

    Endophlebitis

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0014234
    Veno-occlusive disease
    Description

    Veno-occlusive disease

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0948441
    Canalicular cholestasis
    Description

    Canalicular cholestasis

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C3150342
    Apoptosis
    Description

    Apoptosis

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0162638
    Focal (or spotty or mild ) hepatocellular necrosis
    Description

    Focal hepatocellular necrosis

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0267800
    lnterface hepatitis (periportal hepatitis or piecemealnecrosis)
    Description

    lnterface hepatitis

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0019158
    UMLS CUI [1,2]
    C0333515
    lschaemic necrosis
    Description

    lschaemic necrosis

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C3887513
    Centrolobular (Zone 3) necrosis
    Description

    Centrolobular (Zone 3) necrosis

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C3672032
    Focal coagulative necrosis
    Description

    Focal coagulative necrosis

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0205234
    UMLS CUI [1,2]
    C1522058
    Centrolobular (Zone 3) coagulative necrosis
    Description

    Centrolobular (Zone 3) coagulative necrosis

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0682619
    UMLS CUI [1,2]
    C1522058
    Bridging hepatocellular necrosis
    Description

    Bridging hepatocellular necrosis

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C1855038
    UMLS CUI [1,2]
    C0333511
    Massive or panlobular hepatocellular necrosis
    Description

    Massive or panlobular hepatocellular necrosis

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0522501
    UMLS CUI [1,2]
    C1855038
    UMLS CUI [2,1]
    C0442131
    UMLS CUI [2,2]
    C1855038
    Dysplasia liver
    Description

    Dysplasia liver

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0334044
    UMLS CUI [1,2]
    C0023884
    Neoplasia liver
    Description

    Neoplasia liver

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C1882062
    UMLS CUI [1,2]
    C0023884
    Other liver architecture
    Description

    Other liver architecture

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0205394
    UMLS CUI [1,2]
    C0023884
    UMLS CUI [1,3]
    C0935919
    If other liver architecture, please specify
    Description

    Other liver architecture specification

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C0205394
    UMLS CUI [1,2]
    C0023884
    UMLS CUI [1,3]
    C0935919
    Description of Liver Cells or Hepatocytes
    Description

    Description of Liver Cells or Hepatocytes

    Alias
    UMLS CUI-1
    C0227525
    UMLS CUI-2
    C0678257
    UMLS CUI-3
    C0193388
    Normal
    Description

    Normal

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0205307
    Ballooning
    Description

    Ballooning

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0333445
    UMLS CUI [1,2]
    C0227525
    Acidophilic
    Description

    Acidophilic

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0333931
    UMLS CUI [1,2]
    C0227525
    Pseudoxanthomatous
    Description

    Pseudoxanthomatous

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0227525
    UMLS CUI [1,2]
    C3277905
    Multinucleated giant hepatocytes
    Description

    Multinucleated giant hepatocytes

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C3550474
    UMLS CUI [1,2]
    C4054455
    Other Description of Liver Cells or Hepatocytes
    Description

    Other Description of Liver Cells or Hepatocytes

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0205394
    UMLS CUI [1,2]
    C0227525
    UMLS CUI [1,3]
    C0678257
    If other Description of Liver Cells or Hepatocytes, please specify
    Description

    Other Description of Liver Cells or Hepatocytes specification

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C0205394
    UMLS CUI [1,2]
    C0227525
    UMLS CUI [1,3]
    C0678257
    Liver Cell or Hepatocyte Inclusions or Vacuoles
    Description

    Liver Cell or Hepatocyte Inclusions or Vacuoles

    Alias
    UMLS CUI-1
    C0227525
    UMLS CUI-2
    C0042219
    UMLS CUI-3
    C1512693
    UMLS CUI-4
    C0193388
    No inclusions
    Description

    No inclusions

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C1512693
    UMLS CUI [1,2]
    C1298908
    Macrovesicular steatosis
    Description

    Macrovesicular steatosis

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C1837256
    Microvesicular steatosis
    Description

    Microvesicular steatosis

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C1850415
    Bile accumulation
    Description

    Bile accumulation

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C3686784
    Diastase-resistant, PAS-positive cytoplasmic inclusions
    Description

    Diastase-resistant, PAS-positive cytoplasmic inclusions

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C1856311
    UMLS CUI [1,2]
    C0205708
    Alpha-1-antitrypsin inclusions
    Description

    Alpha-1-antitrypsin inclusions

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0002191
    UMLS CUI [1,2]
    C1512693
    UMLS CUI [1,3]
    C0227525
    Megamitochondria
    Description

    Megamitochondria

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0544931
    Mallory bodies
    Description

    Mallory bodies

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0333744
    Ground Glass inclusions
    Description

    Ground Glass inclusions

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0598786
    Lipofuscin pigment
    Description

    Lipofuscin pigment

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0023789
    Hemosiderin granules
    Description

    Hemosiderin granules

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0019113
    Orcein positive cytoplasmin granules
    Description

    Orcein positive cytoplasmin granules

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0069596
    Protoporphyrin crystals (birefringent under polarised light)
    Description

    Protoporphyrin crystals

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0033733
    Uroporphyrin crystals (red fluorescence under ultraviolet light)
    Description

    Uroporphyrin crystals

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0042093
    Other Liver Cell or Hepatocyte Inclusions or Vacuoles
    Description

    Other Liver Cell or Hepatocyte Inclusions or Vacuoles

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0205394
    UMLS CUI [1,2]
    C0227525
    UMLS CUI [1,3]
    C0042219
    UMLS CUI [2,1]
    C0205394
    UMLS CUI [2,2]
    C1512693
    If other Liver Cell or Hepatocyte Inclusions or Vacuoles, please specify
    Description

    Other Liver Cell or Hepatocyte Inclusions or Vacuoles specification

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C0205394
    UMLS CUI [1,2]
    C0227525
    UMLS CUI [1,3]
    C0042219
    UMLS CUI [2,1]
    C0205394
    UMLS CUI [2,2]
    C1512693
    Hepatocyte or Liver Cell Nuclear Abnormalities
    Description

    Hepatocyte or Liver Cell Nuclear Abnormalities

    Alias
    UMLS CUI-1
    C0227525
    UMLS CUI-2
    C1849376
    UMLS CUI-3
    C0193388
    None abnormality
    Description

    None abnormality

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0549184
    UMLS CUI [1,2]
    C1704258
    Hepatocellular mitosis
    Description

    Hepatocellular mitosis

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0026255
    UMLS CUI [1,2]
    C2697585
    Binucleated or multinucleated hepatocytes
    Description

    Binucleated or multinucleated hepatocytes

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0333909
    UMLS CUI [2]
    C4054455
    CMV inclusion bodies
    Description

    CMV inclusion bodies

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0010825
    UMLS CUI [1,2]
    C0227525
    UMLS CUI [1,3]
    C1512693
    HSV inclusions
    Description

    HSV inclusions

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0319232
    UMLS CUI [1,2]
    C0227525
    UMLS CUI [1,3]
    C1512693
    Varicella inclusions
    Description

    Varicella inclusions

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0740380
    UMLS CUI [1,2]
    C0227525
    UMLS CUI [1,3]
    C1512693
    Other Hepatocyte or Liver Cell Nuclear Abnormalities
    Description

    Other Hepatocyte or Liver Cell Nuclear Abnormalities

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0205394
    UMLS CUI [1,2]
    C0227525
    UMLS CUI [1,3]
    C1849376
    If other Hepatocyte or Liver Cell Nuclear Abnormalities, please sepcify
    Description

    Other Hepatocyte or Liver Cell Nuclear Abnormalities specification

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C0205394
    UMLS CUI [1,2]
    C0227525
    UMLS CUI [1,3]
    C1849376
    Liver or Lobular Infiltrates
    Description

    Liver or Lobular Infiltrates

    Alias
    UMLS CUI-1
    C1400896
    UMLS CUI-2
    C0193388
    None Liver or Lobular Infiltrates
    Description

    None Liver or Lobular Infiltrates

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0549184
    UMLS CUI [1,2]
    C1400896
    Eosinophils
    Description

    Eosinophils

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0014467
    UMLS CUI [1,2]
    C1400896
    Lymphocytes
    Description

    Lymphocytes

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0024264
    UMLS CUI [1,2]
    C1400896
    Plasma cells
    Description

    Plasma cells

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0032112
    UMLS CUI [1,2]
    C1400896
    Neutrophils
    Description

    Neutrophils

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0027950
    UMLS CUI [1,2]
    C1400896
    Macrophages and proliferating Kupffer cells
    Description

    Macrophages and proliferating Kupffer cells

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0022801
    UMLS CUI [1,2]
    C1400896
    Granulomas
    Description

    Granulomas

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0745754
    Other Liver or Lobular Infiltrates
    Description

    Other Liver or Lobular Infiltrates

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0205394
    UMLS CUI [1,2]
    C1400896
    If Other Liver or Lobular Infiltrates, please specify
    Description

    Other Liver or Lobular Infiltrates specification

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C0205394
    UMLS CUI [1,2]
    C1400896
    Portal Tract Inflammation
    Description

    Portal Tract Inflammation

    Alias
    UMLS CUI-1
    C3854488
    UMLS CUI-2
    C0193388
    None Portal Tract Inflammation
    Description

    None Portal Tract Inflammation

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C1298908
    UMLS CUI [1,2]
    C3854488
    Eosinophils
    Description

    Eosinophils

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0014467
    UMLS CUI [1,2]
    C3854488
    Lymphoid aggregates and/or follicles
    Description

    Lymphoid aggregates and/or follicles

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0229653
    UMLS CUI [1,2]
    C3854488
    Plasma cells
    Description

    Plasma cells

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0032112
    UMLS CUI [1,2]
    C3854488
    Neutrophils
    Description

    Neutrophils

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0027950
    UMLS CUI [1,2]
    C3854488
    Histocytes and macrophages
    Description

    Histocytes and macrophages

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0019612
    UMLS CUI [2]
    C0024432
    UMLS CUI [3]
    C3854488
    Other Portal Tract Inflammation
    Description

    Other Portal Tract Inflammation

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0205394
    UMLS CUI [1,2]
    C3854488
    If Other Portal Tract Inflammation, please specify
    Description

    Other Portal Tract Inflammation specification

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C0205394
    UMLS CUI [1,2]
    C3854488
    Bile Ducts
    Description

    Bile Ducts

    Alias
    UMLS CUI-1
    C0005400
    UMLS CUI-2
    C0193388
    Normal bile ducts
    Description

    Normal bile ducts

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0205307
    UMLS CUI [1,2]
    C0005400
    Proliferation of bile ducts (bile ductular reaction)
    Description

    Proliferation of bile ducts

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0005400
    UMLS CUI [1,2]
    C0334094
    Dilation, degeneration or disruption of portal bile ducts
    Description

    Dilation, degeneration or disruption of portal bile ducts

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0005400
    UMLS CUI [2,1]
    C0011164
    UMLS CUI [2,2]
    C0005400
    UMLS CUI [3,1]
    C0700124
    UMLS CUI [3,2]
    C0005400
    UMLS CUI [4,1]
    C0332453
    UMLS CUI [4,2]
    C0005400
    Paucity of bile ducts
    Description

    Paucity of bile ducts

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C4273160
    Periductal fibrosis
    Description

    Periductal fibrosis

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0016059
    UMLS CUI [1,2]
    C0005400
    Other Bile Ducts
    Description

    Other Bile Ducts

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0205394
    UMLS CUI [1,2]
    C0005400
    If other Bile Ducts, please specify
    Description

    Other Bile Ducts specification

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C0205394
    UMLS CUI [1,2]
    C0005400
    Portal veins
    Description

    Portal veins

    Alias
    UMLS CUI-1
    C0032718
    UMLS CUI-2
    C0193388
    Normal
    Description

    Normal

    Data type

    integer

    Alias
    UMLS CUI [1]
    C0205307
    Pyelophlebitis
    Description

    Pyelophlebitis

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C1405883
    Thrombosis, sclerosis or occlusion of portal vein
    Description

    Thrombosis, sclerosis or occlusion of portal vein

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0155773
    UMLS CUI [2]
    C0400960
    UMLS CUI [3,1]
    C0028778
    UMLS CUI [3,2]
    C0032718
    Neoplastic Invasion of portal vein
    Description

    Neoplastic Invasion of portal vein

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0585133
    Granulomatous compression of portal vein
    Description

    Granulomatous compression of portal vein

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0032718
    UMLS CUI [1,2]
    C0439667
    UMLS CUI [1,3]
    C0728907
    Other Portal Veins abnormality
    Description

    Other Portal Veins abnormality

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0205394
    UMLS CUI [1,2]
    C0032718
    UMLS CUI [1,3]
    C0205161
    If other Portal Veins abnormality, please specify
    Description

    Other Portal Veins abnormality specification

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C0205394
    UMLS CUI [1,2]
    C0032718
    UMLS CUI [1,3]
    C0205161
    Liver Infections
    Description

    Liver Infections

    Alias
    UMLS CUI-1
    C1112211
    UMLS CUI-2
    C0193388
    Normal
    Description

    Normal

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0205307
    Leishmaniasis donovani
    Description

    Leishmaniasis donovani

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0023273
    Plasmodium falciparum
    Description

    Plasmodium falciparum

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0032150
    Toxoplasmosis
    Description

    Toxoplasmosis

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0040558
    Cryptococcus neoformans
    Description

    Cryptococcus neoformans

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0010416
    Histoplasma capsulatum
    Description

    Histoplasma capsulatum

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0319941
    Mycobacterium tuberculois
    Description

    Mycobacterium tuberculois

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0026926
    Other mycobacterial species
    Description

    Other mycobacterial species

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0205394
    UMLS CUI [1,2]
    C0026912
    Other Liver Infections
    Description

    Other Liver Infections

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0205394
    UMLS CUI [1,2]
    C1112211
    If Other Liver Infections, please specify
    Description

    Other Liver Infections specification

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C0205394
    UMLS CUI [1,2]
    C1112211
    Parasites or Ova
    Description

    Parasites or Ova

    Alias
    UMLS CUI-1
    C0030498
    UMLS CUI-2
    C1267673
    UMLS CUI-3
    C0023884
    UMLS CUI-4
    C0193388
    None Parasites or ova
    Description

    None Parasites or ova

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0549184
    UMLS CUI [1,2]
    C0030498
    UMLS CUI [1,3]
    C0023884
    UMLS CUI [2,1]
    C0549184
    UMLS CUI [2,2]
    C1267673
    Schistosome and/or ova
    Description

    Schistosome and/or ova

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0036315
    UMLS CUI [2,1]
    C1267673
    UMLS CUI [2,2]
    C0036315
    Ascaris and/or ova
    Description

    Ascaris and/or ova

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0003954
    UMLS CUI [2]
    C3698183
    Toxocara and/or ova
    Description

    Toxocara and/or ova

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0040550
    UMLS CUI [2,1]
    C1267673
    UMLS CUI [2,2]
    C0040550
    Echinococcus cysts
    Description

    Echinococcus cysts

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0013502
    Hepatic capillariasis worms and/or ova
    Description

    Hepatic capillariasis worms and/or ova

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0277202
    UMLS CUI [2,1]
    C1267673
    UMLS CUI [2,2]
    C0277202
    Other Parasites or ova
    Description

    Other Parasites or ova

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0205394
    UMLS CUI [1,2]
    C0030498
    UMLS CUI [1,3]
    C0023884
    UMLS CUI [2,1]
    C0205394
    UMLS CUI [2,2]
    C1267673
    If Other Parasites or ova, please specify
    Description

    Other Parasites or ova specification

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C0205394
    UMLS CUI [1,2]
    C0030498
    UMLS CUI [1,3]
    C0023884
    UMLS CUI [2,1]
    C0205394
    UMLS CUI [2,2]
    C1267673
    Histologic Staining or Additional Studies Obtained
    Description

    Histologic Staining or Additional Studies Obtained

    Alias
    UMLS CUI-1
    C0487602
    UMLS CUI-2
    C0430022
    UMLS CUI-3
    C0023884
    UMLS CUI-4
    C0193388
    Haematoxylin and eosin (or H&E)
    Description

    Haematoxylin and eosin (or H&E)

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0523207
    Masson
    Description

    Masson

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C1294297
    Toluidine blue or Giemsa
    Description

    Toluidine blue or Giemsa

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0523203
    UMLS CUI [2]
    C0017542
    Prussian blue
    Description

    Prussian blue

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C1294004
    Periodic Acidic Schiff (PAS) with or without diastase
    Description

    Periodic Acidic Schiff (PAS) with or without diastase

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0440048
    UMLS CUI [2]
    C0002712
    Oil red O
    Description

    Oil red O

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C1294000
    Congo red
    Description

    Congo red

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0009742
    Hall's stain
    Description

    Hall's stain

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C1720394
    Gridley's stain
    Description

    Gridley's stain

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C1293978
    Rhodanine (copper)
    Description

    Rhodanine (copper)

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0035486
    UMLS CUI [1,2]
    C0487602
    UMLS CUI [1,3]
    C0009968
    Rubeanic acid (copper)
    Description

    Rubeanic acid (copper)

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0073680
    UMLS CUI [1,2]
    C0487602
    UMLS CUI [1,3]
    C0009968
    Orcein, aldehyde fuchsin or Victoria blue
    Description

    Orcein, aldehyde fuchsin or Victoria blue

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C1294001
    UMLS CUI [2]
    C0491984
    UMLS CUI [3,1]
    C0078232
    UMLS CUI [3,2]
    C0487602
    Electron microscopy
    Description

    Electron microscopy

    Data type

    boolean

    Alias
    UMLS CUI [1]
    C0026019
    Hepatitis A lmmunostains positive
    Description

    Hepatitis A lmmunostains positive

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0560226
    UMLS CUI [1,2]
    C3687908
    Hepatitis B core antigen or hepatitis B surface antibody immunostains positive
    Description

    Hepatitis B core antigen or hepatitis B surface antibody immunostains positive

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0149709
    UMLS CUI [1,2]
    C3687908
    Hepatitis D immunostains
    Description

    Hepatitis D immunostains

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0850990
    UMLS CUI [1,2]
    C0021044
    UMLS CUI [1,3]
    C3687908
    Other immunostains
    Description

    Other immunostains

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0021044
    UMLS CUI [1,2]
    C3687908
    Other Histologic Staining or Additional Studies Obtained
    Description

    Other Histologic Staining or Additional Studies Obtained

    Data type

    boolean

    Alias
    UMLS CUI [1,1]
    C0205394
    UMLS CUI [1,2]
    C0487602
    UMLS CUI [1,3]
    C0023884
    If Other Histologic Staining or Additional Studies Obtained, please specify
    Description

    Other Histologic Staining or Additional Studies Obtained specification

    Data type

    text

    Alias
    UMLS CUI [1,1]
    C0205394
    UMLS CUI [1,2]
    C0487602
    UMLS CUI [1,3]
    C0023884
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    Similar models

    Liver biopsy

    1 forms
    1. StudyEvent: ODM
      1. Liver biopsy
    Name
    Type
    Description | Question | Decode (Coded Value)
    Data type
    Alias
    Item Group
    Administrative data
    C1320722 (UMLS CUI-1)
    Subject number
    Item
    Subject number
    text
    C2348585 (UMLS CUI [1])
    Item Group
    Liver biopsy
    C0193388 (UMLS CUI-1)
    Date of liver biopsy
    Item
    Date of liver biopsy
    date
    C0193388 (UMLS CUI [1,1])
    C0011008 (UMLS CUI [1,2])
    Size of liver biopsy
    Item
    Approximate size of liver biopsy
    integer
    C1299482 (UMLS CUI [1,1])
    C0193388 (UMLS CUI [1,2])
    Item
    Biopsy size unit
    integer
    C1299482 (UMLS CUI [1,1])
    C0193388 (UMLS CUI [1,2])
    C1519795 (UMLS CUI [1,3])
    Biopsy size unit
    Code List
    Biopsy size unit
    CL Item
    MM (1)
    Item Group
    Final diagnosis
    C1546485 (UMLS CUI-1)
    Normal
    Item
    Normal
    boolean
    C0205307 (UMLS CUI [1])
    Acute hepatitis
    Item
    Acute hepatitis
    boolean
    C0267797 (UMLS CUI [1])
    Chronic hepatitis
    Item
    Chronic hepatitis
    boolean
    C0019189 (UMLS CUI [1])
    Cholestatic hepatitis
    Item
    Cholestatic hepatitis
    boolean
    C0149904 (UMLS CUI [1])
    Drug-induced cholestasis
    Item
    Drug-induced cholestasis
    boolean
    C2062350 (UMLS CUI [1])
    Acute viral hepatitis
    Item
    Acute viral hepatitis
    boolean
    C0276622 (UMLS CUI [1])
    Chronic viral hepatitis
    Item
    Chronic viral hepatitis
    boolean
    C0276623 (UMLS CUI [1])
    Drug-induced hepatitis
    Item
    Drug-induced hepatitis
    boolean
    C1262760 (UMLS CUI [1])
    Autoimmune hepatitis
    Item
    Autoimmune hepatitis
    boolean
    C0241910 (UMLS CUI [1])
    Bridging necrosis
    Item
    Bridging necrosis
    boolean
    C0333511 (UMLS CUI [1])
    Submassive hepatic necrosis
    Item
    Submassive hepatic necrosis
    boolean
    C0151798 (UMLS CUI [1])
    Massive hepatic necrosis
    Item
    Massive hepatic necrosis
    boolean
    C0001364 (UMLS CUI [1])
    Steatosis - microvesicular
    Item
    Steatosis - microvesicular
    boolean
    C1850415 (UMLS CUI [1])
    Steatosis - macrovesicular
    Item
    Steatosis - macrovesicular
    boolean
    C1837256 (UMLS CUI [1])
    Steatosis - mixed
    Item
    Steatosis - mixed
    boolean
    C0015695 (UMLS CUI [1,1])
    C0205430 (UMLS CUI [1,2])
    Non-alcoholic steatohepatitis
    Item
    Non-alcoholic steatohepatitis
    boolean
    C3241937 (UMLS CUI [1])
    Alcoholic hepatitis
    Item
    Alcoholic hepatitis
    boolean
    C0019187 (UMLS CUI [1])
    Hepatic granulomas
    Item
    Hepatic granulomas
    boolean
    C0745754 (UMLS CUI [1])
    Sarcoidosis
    Item
    Sarcoidosis
    boolean
    C0036202 (UMLS CUI [1])
    Fibrosis
    Item
    Fibrosis
    boolean
    C0239946 (UMLS CUI [1])
    Cirrhosis
    Item
    Cirrhosis
    boolean
    C0023890 (UMLS CUI [1])
    Primary biliary cirrhosis
    Item
    Primary biliary cirrhosis
    boolean
    C0008312 (UMLS CUI [1])
    Primary sclerosing cholangitis
    Item
    Primary sclerosing cholangitis
    boolean
    C0566602 (UMLS CUI [1])
    Autoimmune overlap syndrome
    Item
    Autoimmune overlap syndrome
    boolean
    C2702837 (UMLS CUI [1])
    Hemochromatosis
    Item
    Hemochromatosis
    boolean
    C0018995 (UMLS CUI [1])
    Alpha-1-antitrypsin deficiency
    Item
    Alpha-1-antitrypsin deficiency
    boolean
    C0221757 (UMLS CUI [1])
    Wilson's disease
    Item
    Wilson's disease
    boolean
    C0019202 (UMLS CUI [1])
    Veno-occlusive disease
    Item
    Veno-occlusive disease
    boolean
    C0948441 (UMLS CUI [1])
    Budd-Chiari syndrome
    Item
    Budd-Chiari syndrome
    boolean
    C0856761 (UMLS CUI [1])
    Neoplasia
    Item
    Neoplasia
    boolean
    C1882062 (UMLS CUI [1,1])
    C0023884 (UMLS CUI [1,2])
    Other final diagnosis
    Item
    Other final diagnosis
    boolean
    C0205394 (UMLS CUI [1,1])
    C0011900 (UMLS CUI [1,2])
    Other final diagnosis specification
    Item
    If other final diagnosis, please specify
    text
    C0205394 (UMLS CUI [1,1])
    C0011900 (UMLS CUI [1,2])
    Item Group
    Liver Architecture
    C0023884 (UMLS CUI-1)
    C0935919 (UMLS CUI-2)
    C0193388 (UMLS CUI-3)
    Normal
    Item
    Normal
    boolean
    C0205307 (UMLS CUI [1])
    Bridging fibrosis
    Item
    Bridging fibrosis
    boolean
    C0334160 (UMLS CUI [1])
    Diffuse fibrosis
    Item
    Diffuse fibrosis
    boolean
    C0016059 (UMLS CUI [1,1])
    C0205219 (UMLS CUI [1,2])
    Nodular regenerative hyperplasia
    Item
    Nodular regenerative hyperplasia
    boolean
    C0020510 (UMLS CUI [1])
    Congenital hepatic fibrosis
    Item
    Congenital hepatic fibrosis
    boolean
    C0009714 (UMLS CUI [1])
    Cirrhosis
    Item
    Cirrhosis
    boolean
    C0023890 (UMLS CUI [1])
    Centrilobular congestion
    Item
    Centrilobular congestion
    boolean
    C0267821 (UMLS CUI [1,1])
    C0442080 (UMLS CUI [1,2])
    Endophlebitis
    Item
    Endophlebitis
    boolean
    C0014234 (UMLS CUI [1])
    Veno-occlusive disease
    Item
    Veno-occlusive disease
    boolean
    C0948441 (UMLS CUI [1])
    Canalicular cholestasis
    Item
    Canalicular cholestasis
    boolean
    C3150342 (UMLS CUI [1])
    Apoptosis
    Item
    Apoptosis
    boolean
    C0162638 (UMLS CUI [1])
    Focal hepatocellular necrosis
    Item
    Focal (or spotty or mild ) hepatocellular necrosis
    boolean
    C0267800 (UMLS CUI [1])
    lnterface hepatitis
    Item
    lnterface hepatitis (periportal hepatitis or piecemealnecrosis)
    boolean
    C0019158 (UMLS CUI [1,1])
    C0333515 (UMLS CUI [1,2])
    lschaemic necrosis
    Item
    lschaemic necrosis
    boolean
    C3887513 (UMLS CUI [1])
    Centrolobular (Zone 3) necrosis
    Item
    Centrolobular (Zone 3) necrosis
    boolean
    C3672032 (UMLS CUI [1])
    Focal coagulative necrosis
    Item
    Focal coagulative necrosis
    boolean
    C0205234 (UMLS CUI [1,1])
    C1522058 (UMLS CUI [1,2])
    Centrolobular (Zone 3) coagulative necrosis
    Item
    Centrolobular (Zone 3) coagulative necrosis
    boolean
    C0682619 (UMLS CUI [1,1])
    C1522058 (UMLS CUI [1,2])
    Bridging hepatocellular necrosis
    Item
    Bridging hepatocellular necrosis
    boolean
    C1855038 (UMLS CUI [1,1])
    C0333511 (UMLS CUI [1,2])
    Massive or panlobular hepatocellular necrosis
    Item
    Massive or panlobular hepatocellular necrosis
    boolean
    C0522501 (UMLS CUI [1,1])
    C1855038 (UMLS CUI [1,2])
    C0442131 (UMLS CUI [2,1])
    C1855038 (UMLS CUI [2,2])
    Dysplasia liver
    Item
    Dysplasia liver
    boolean
    C0334044 (UMLS CUI [1,1])
    C0023884 (UMLS CUI [1,2])
    Neoplasia liver
    Item
    Neoplasia liver
    boolean
    C1882062 (UMLS CUI [1,1])
    C0023884 (UMLS CUI [1,2])
    Other liver architecture
    Item
    Other liver architecture
    boolean
    C0205394 (UMLS CUI [1,1])
    C0023884 (UMLS CUI [1,2])
    C0935919 (UMLS CUI [1,3])
    Other liver architecture specification
    Item
    If other liver architecture, please specify
    text
    C0205394 (UMLS CUI [1,1])
    C0023884 (UMLS CUI [1,2])
    C0935919 (UMLS CUI [1,3])
    Item Group
    Description of Liver Cells or Hepatocytes
    C0227525 (UMLS CUI-1)
    C0678257 (UMLS CUI-2)
    C0193388 (UMLS CUI-3)
    Normal
    Item
    Normal
    boolean
    C0205307 (UMLS CUI [1])
    Ballooning
    Item
    Ballooning
    boolean
    C0333445 (UMLS CUI [1,1])
    C0227525 (UMLS CUI [1,2])
    Acidophilic
    Item
    Acidophilic
    boolean
    C0333931 (UMLS CUI [1,1])
    C0227525 (UMLS CUI [1,2])
    Pseudoxanthomatous
    Item
    Pseudoxanthomatous
    boolean
    C0227525 (UMLS CUI [1,1])
    C3277905 (UMLS CUI [1,2])
    Multinucleated giant hepatocytes
    Item
    Multinucleated giant hepatocytes
    boolean
    C3550474 (UMLS CUI [1,1])
    C4054455 (UMLS CUI [1,2])
    Other Description of Liver Cells or Hepatocytes
    Item
    Other Description of Liver Cells or Hepatocytes
    boolean
    C0205394 (UMLS CUI [1,1])
    C0227525 (UMLS CUI [1,2])
    C0678257 (UMLS CUI [1,3])
    Other Description of Liver Cells or Hepatocytes specification
    Item
    If other Description of Liver Cells or Hepatocytes, please specify
    text
    C0205394 (UMLS CUI [1,1])
    C0227525 (UMLS CUI [1,2])
    C0678257 (UMLS CUI [1,3])
    Item Group
    Liver Cell or Hepatocyte Inclusions or Vacuoles
    C0227525 (UMLS CUI-1)
    C0042219 (UMLS CUI-2)
    C1512693 (UMLS CUI-3)
    C0193388 (UMLS CUI-4)
    No inclusions
    Item
    No inclusions
    boolean
    C1512693 (UMLS CUI [1,1])
    C1298908 (UMLS CUI [1,2])
    Macrovesicular steatosis
    Item
    Macrovesicular steatosis
    boolean
    C1837256 (UMLS CUI [1])
    Microvesicular steatosis
    Item
    Microvesicular steatosis
    boolean
    C1850415 (UMLS CUI [1])
    Bile accumulation
    Item
    Bile accumulation
    boolean
    C3686784 (UMLS CUI [1])
    Diastase-resistant, PAS-positive cytoplasmic inclusions
    Item
    Diastase-resistant, PAS-positive cytoplasmic inclusions
    boolean
    C1856311 (UMLS CUI [1,1])
    C0205708 (UMLS CUI [1,2])
    Alpha-1-antitrypsin inclusions
    Item
    Alpha-1-antitrypsin inclusions
    boolean
    C0002191 (UMLS CUI [1,1])
    C1512693 (UMLS CUI [1,2])
    C0227525 (UMLS CUI [1,3])
    Megamitochondria
    Item
    Megamitochondria
    boolean
    C0544931 (UMLS CUI [1])
    Mallory bodies
    Item
    Mallory bodies
    boolean
    C0333744 (UMLS CUI [1])
    Ground Glass inclusions
    Item
    Ground Glass inclusions
    boolean
    C0598786 (UMLS CUI [1])
    Lipofuscin pigment
    Item
    Lipofuscin pigment
    boolean
    C0023789 (UMLS CUI [1])
    Hemosiderin granules
    Item
    Hemosiderin granules
    boolean
    C0019113 (UMLS CUI [1])
    Orcein positive cytoplasmin granules
    Item
    Orcein positive cytoplasmin granules
    boolean
    C0069596 (UMLS CUI [1])
    Protoporphyrin crystals
    Item
    Protoporphyrin crystals (birefringent under polarised light)
    boolean
    C0033733 (UMLS CUI [1])
    Uroporphyrin crystals
    Item
    Uroporphyrin crystals (red fluorescence under ultraviolet light)
    boolean
    C0042093 (UMLS CUI [1])
    Other Liver Cell or Hepatocyte Inclusions or Vacuoles
    Item
    Other Liver Cell or Hepatocyte Inclusions or Vacuoles
    boolean
    C0205394 (UMLS CUI [1,1])
    C0227525 (UMLS CUI [1,2])
    C0042219 (UMLS CUI [1,3])
    C0205394 (UMLS CUI [2,1])
    C1512693 (UMLS CUI [2,2])
    Other Liver Cell or Hepatocyte Inclusions or Vacuoles specification
    Item
    If other Liver Cell or Hepatocyte Inclusions or Vacuoles, please specify
    text
    C0205394 (UMLS CUI [1,1])
    C0227525 (UMLS CUI [1,2])
    C0042219 (UMLS CUI [1,3])
    C0205394 (UMLS CUI [2,1])
    C1512693 (UMLS CUI [2,2])
    Item Group
    Hepatocyte or Liver Cell Nuclear Abnormalities
    C0227525 (UMLS CUI-1)
    C1849376 (UMLS CUI-2)
    C0193388 (UMLS CUI-3)
    None abnormality
    Item
    None abnormality
    boolean
    C0549184 (UMLS CUI [1,1])
    C1704258 (UMLS CUI [1,2])
    Hepatocellular mitosis
    Item
    Hepatocellular mitosis
    boolean
    C0026255 (UMLS CUI [1,1])
    C2697585 (UMLS CUI [1,2])
    Binucleated or multinucleated hepatocytes
    Item
    Binucleated or multinucleated hepatocytes
    boolean
    C0333909 (UMLS CUI [1])
    C4054455 (UMLS CUI [2])
    CMV inclusion bodies
    Item
    CMV inclusion bodies
    boolean
    C0010825 (UMLS CUI [1,1])
    C0227525 (UMLS CUI [1,2])
    C1512693 (UMLS CUI [1,3])
    HSV inclusions
    Item
    HSV inclusions
    boolean
    C0319232 (UMLS CUI [1,1])
    C0227525 (UMLS CUI [1,2])
    C1512693 (UMLS CUI [1,3])
    Varicella inclusions
    Item
    Varicella inclusions
    boolean
    C0740380 (UMLS CUI [1,1])
    C0227525 (UMLS CUI [1,2])
    C1512693 (UMLS CUI [1,3])
    Other Hepatocyte or Liver Cell Nuclear Abnormalities
    Item
    Other Hepatocyte or Liver Cell Nuclear Abnormalities
    boolean
    C0205394 (UMLS CUI [1,1])
    C0227525 (UMLS CUI [1,2])
    C1849376 (UMLS CUI [1,3])
    Other Hepatocyte or Liver Cell Nuclear Abnormalities specification
    Item
    If other Hepatocyte or Liver Cell Nuclear Abnormalities, please sepcify
    text
    C0205394 (UMLS CUI [1,1])
    C0227525 (UMLS CUI [1,2])
    C1849376 (UMLS CUI [1,3])
    Item Group
    Liver or Lobular Infiltrates
    C1400896 (UMLS CUI-1)
    C0193388 (UMLS CUI-2)
    None Liver or Lobular Infiltrates
    Item
    None Liver or Lobular Infiltrates
    boolean
    C0549184 (UMLS CUI [1,1])
    C1400896 (UMLS CUI [1,2])
    Eosinophils
    Item
    Eosinophils
    boolean
    C0014467 (UMLS CUI [1,1])
    C1400896 (UMLS CUI [1,2])
    Lymphocytes
    Item
    Lymphocytes
    boolean
    C0024264 (UMLS CUI [1,1])
    C1400896 (UMLS CUI [1,2])
    Plasma cells
    Item
    Plasma cells
    boolean
    C0032112 (UMLS CUI [1,1])
    C1400896 (UMLS CUI [1,2])
    Neutrophils
    Item
    Neutrophils
    boolean
    C0027950 (UMLS CUI [1,1])
    C1400896 (UMLS CUI [1,2])
    Macrophages and proliferating Kupffer cells
    Item
    Macrophages and proliferating Kupffer cells
    boolean
    C0022801 (UMLS CUI [1,1])
    C1400896 (UMLS CUI [1,2])
    Granulomas
    Item
    Granulomas
    boolean
    C0745754 (UMLS CUI [1])
    Other Liver or Lobular Infiltrates
    Item
    Other Liver or Lobular Infiltrates
    boolean
    C0205394 (UMLS CUI [1,1])
    C1400896 (UMLS CUI [1,2])
    Other Liver or Lobular Infiltrates specification
    Item
    If Other Liver or Lobular Infiltrates, please specify
    text
    C0205394 (UMLS CUI [1,1])
    C1400896 (UMLS CUI [1,2])
    Item Group
    Portal Tract Inflammation
    C3854488 (UMLS CUI-1)
    C0193388 (UMLS CUI-2)
    None Portal Tract Inflammation
    Item
    None Portal Tract Inflammation
    boolean
    C1298908 (UMLS CUI [1,1])
    C3854488 (UMLS CUI [1,2])
    Eosinophils
    Item
    Eosinophils
    boolean
    C0014467 (UMLS CUI [1,1])
    C3854488 (UMLS CUI [1,2])
    Lymphoid aggregates and/or follicles
    Item
    Lymphoid aggregates and/or follicles
    boolean
    C0229653 (UMLS CUI [1,1])
    C3854488 (UMLS CUI [1,2])
    Plasma cells
    Item
    Plasma cells
    boolean
    C0032112 (UMLS CUI [1,1])
    C3854488 (UMLS CUI [1,2])
    Neutrophils
    Item
    Neutrophils
    boolean
    C0027950 (UMLS CUI [1,1])
    C3854488 (UMLS CUI [1,2])
    Histocytes and macrophages
    Item
    Histocytes and macrophages
    boolean
    C0019612 (UMLS CUI [1])
    C0024432 (UMLS CUI [2])
    C3854488 (UMLS CUI [3])
    Other Portal Tract Inflammation
    Item
    Other Portal Tract Inflammation
    boolean
    C0205394 (UMLS CUI [1,1])
    C3854488 (UMLS CUI [1,2])
    Other Portal Tract Inflammation specification
    Item
    If Other Portal Tract Inflammation, please specify
    text
    C0205394 (UMLS CUI [1,1])
    C3854488 (UMLS CUI [1,2])
    Item Group
    Bile Ducts
    C0005400 (UMLS CUI-1)
    C0193388 (UMLS CUI-2)
    Normal bile ducts
    Item
    Normal bile ducts
    boolean
    C0205307 (UMLS CUI [1,1])
    C0005400 (UMLS CUI [1,2])
    Proliferation of bile ducts
    Item
    Proliferation of bile ducts (bile ductular reaction)
    boolean
    C0005400 (UMLS CUI [1,1])
    C0334094 (UMLS CUI [1,2])
    Dilation, degeneration or disruption of portal bile ducts
    Item
    Dilation, degeneration or disruption of portal bile ducts
    boolean
    C0005400 (UMLS CUI [1])
    C0011164 (UMLS CUI [2,1])
    C0005400 (UMLS CUI [2,2])
    C0700124 (UMLS CUI [3,1])
    C0005400 (UMLS CUI [3,2])
    C0332453 (UMLS CUI [4,1])
    C0005400 (UMLS CUI [4,2])
    Paucity of bile ducts
    Item
    Paucity of bile ducts
    boolean
    C4273160 (UMLS CUI [1])
    Periductal fibrosis
    Item
    Periductal fibrosis
    boolean
    C0016059 (UMLS CUI [1,1])
    C0005400 (UMLS CUI [1,2])
    Other Bile Ducts
    Item
    Other Bile Ducts
    boolean
    C0205394 (UMLS CUI [1,1])
    C0005400 (UMLS CUI [1,2])
    Other Bile Ducts specification
    Item
    If other Bile Ducts, please specify
    text
    C0205394 (UMLS CUI [1,1])
    C0005400 (UMLS CUI [1,2])
    Item Group
    Portal veins
    C0032718 (UMLS CUI-1)
    C0193388 (UMLS CUI-2)
    Normal
    Item
    Normal
    integer
    C0205307 (UMLS CUI [1])
    Pyelophlebitis
    Item
    Pyelophlebitis
    boolean
    C1405883 (UMLS CUI [1])
    Thrombosis, sclerosis or occlusion of portal vein
    Item
    Thrombosis, sclerosis or occlusion of portal vein
    boolean
    C0155773 (UMLS CUI [1])
    C0400960 (UMLS CUI [2])
    C0028778 (UMLS CUI [3,1])
    C0032718 (UMLS CUI [3,2])
    Neoplastic Invasion of portal vein
    Item
    Neoplastic Invasion of portal vein
    boolean
    C0585133 (UMLS CUI [1])
    Granulomatous compression of portal vein
    Item
    Granulomatous compression of portal vein
    boolean
    C0032718 (UMLS CUI [1,1])
    C0439667 (UMLS CUI [1,2])
    C0728907 (UMLS CUI [1,3])
    Other Portal Veins abnormality
    Item
    Other Portal Veins abnormality
    boolean
    C0205394 (UMLS CUI [1,1])
    C0032718 (UMLS CUI [1,2])
    C0205161 (UMLS CUI [1,3])
    Other Portal Veins abnormality specification
    Item
    If other Portal Veins abnormality, please specify
    text
    C0205394 (UMLS CUI [1,1])
    C0032718 (UMLS CUI [1,2])
    C0205161 (UMLS CUI [1,3])
    Item Group
    Liver Infections
    C1112211 (UMLS CUI-1)
    C0193388 (UMLS CUI-2)
    Normal
    Item
    Normal
    boolean
    C0205307 (UMLS CUI [1])
    Leishmaniasis donovani
    Item
    Leishmaniasis donovani
    boolean
    C0023273 (UMLS CUI [1])
    Plasmodium falciparum
    Item
    Plasmodium falciparum
    boolean
    C0032150 (UMLS CUI [1])
    Toxoplasmosis
    Item
    Toxoplasmosis
    boolean
    C0040558 (UMLS CUI [1])
    Cryptococcus neoformans
    Item
    Cryptococcus neoformans
    boolean
    C0010416 (UMLS CUI [1])
    Histoplasma capsulatum
    Item
    Histoplasma capsulatum
    boolean
    C0319941 (UMLS CUI [1])
    Mycobacterium tuberculois
    Item
    Mycobacterium tuberculois
    boolean
    C0026926 (UMLS CUI [1])
    Other mycobacterial species
    Item
    Other mycobacterial species
    boolean
    C0205394 (UMLS CUI [1,1])
    C0026912 (UMLS CUI [1,2])
    Other Liver Infections
    Item
    Other Liver Infections
    boolean
    C0205394 (UMLS CUI [1,1])
    C1112211 (UMLS CUI [1,2])
    Other Liver Infections specification
    Item
    If Other Liver Infections, please specify
    text
    C0205394 (UMLS CUI [1,1])
    C1112211 (UMLS CUI [1,2])
    Item Group
    Parasites or Ova
    C0030498 (UMLS CUI-1)
    C1267673 (UMLS CUI-2)
    C0023884 (UMLS CUI-3)
    C0193388 (UMLS CUI-4)
    None Parasites or ova
    Item
    None Parasites or ova
    boolean
    C0549184 (UMLS CUI [1,1])
    C0030498 (UMLS CUI [1,2])
    C0023884 (UMLS CUI [1,3])
    C0549184 (UMLS CUI [2,1])
    C1267673 (UMLS CUI [2,2])
    Schistosome and/or ova
    Item
    Schistosome and/or ova
    boolean
    C0036315 (UMLS CUI [1])
    C1267673 (UMLS CUI [2,1])
    C0036315 (UMLS CUI [2,2])
    Ascaris and/or ova
    Item
    Ascaris and/or ova
    boolean
    C0003954 (UMLS CUI [1])
    C3698183 (UMLS CUI [2])
    Toxocara and/or ova
    Item
    Toxocara and/or ova
    boolean
    C0040550 (UMLS CUI [1])
    C1267673 (UMLS CUI [2,1])
    C0040550 (UMLS CUI [2,2])
    Echinococcus cysts
    Item
    Echinococcus cysts
    boolean
    C0013502 (UMLS CUI [1])
    Hepatic capillariasis worms and/or ova
    Item
    Hepatic capillariasis worms and/or ova
    boolean
    C0277202 (UMLS CUI [1])
    C1267673 (UMLS CUI [2,1])
    C0277202 (UMLS CUI [2,2])
    Other Parasites or ova
    Item
    Other Parasites or ova
    boolean
    C0205394 (UMLS CUI [1,1])
    C0030498 (UMLS CUI [1,2])
    C0023884 (UMLS CUI [1,3])
    C0205394 (UMLS CUI [2,1])
    C1267673 (UMLS CUI [2,2])
    Other Parasites or ova specification
    Item
    If Other Parasites or ova, please specify
    text
    C0205394 (UMLS CUI [1,1])
    C0030498 (UMLS CUI [1,2])
    C0023884 (UMLS CUI [1,3])
    C0205394 (UMLS CUI [2,1])
    C1267673 (UMLS CUI [2,2])
    Item Group
    Histologic Staining or Additional Studies Obtained
    C0487602 (UMLS CUI-1)
    C0430022 (UMLS CUI-2)
    C0023884 (UMLS CUI-3)
    C0193388 (UMLS CUI-4)
    Haematoxylin and eosin (or H&E)
    Item
    Haematoxylin and eosin (or H&E)
    boolean
    C0523207 (UMLS CUI [1])
    Masson
    Item
    Masson
    boolean
    C1294297 (UMLS CUI [1])
    Toluidine blue or Giemsa
    Item
    Toluidine blue or Giemsa
    boolean
    C0523203 (UMLS CUI [1])
    C0017542 (UMLS CUI [2])
    Prussian blue
    Item
    Prussian blue
    boolean
    C1294004 (UMLS CUI [1])
    Periodic Acidic Schiff (PAS) with or without diastase
    Item
    Periodic Acidic Schiff (PAS) with or without diastase
    boolean
    C0440048 (UMLS CUI [1])
    C0002712 (UMLS CUI [2])
    Oil red O
    Item
    Oil red O
    boolean
    C1294000 (UMLS CUI [1])
    Congo red
    Item
    Congo red
    boolean
    C0009742 (UMLS CUI [1])
    Hall's stain
    Item
    Hall's stain
    boolean
    C1720394 (UMLS CUI [1])
    Gridley's stain
    Item
    Gridley's stain
    boolean
    C1293978 (UMLS CUI [1])
    Rhodanine (copper)
    Item
    Rhodanine (copper)
    boolean
    C0035486 (UMLS CUI [1,1])
    C0487602 (UMLS CUI [1,2])
    C0009968 (UMLS CUI [1,3])
    Rubeanic acid (copper)
    Item
    Rubeanic acid (copper)
    boolean
    C0073680 (UMLS CUI [1,1])
    C0487602 (UMLS CUI [1,2])
    C0009968 (UMLS CUI [1,3])
    Orcein, aldehyde fuchsin or Victoria blue
    Item
    Orcein, aldehyde fuchsin or Victoria blue
    boolean
    C1294001 (UMLS CUI [1])
    C0491984 (UMLS CUI [2])
    C0078232 (UMLS CUI [3,1])
    C0487602 (UMLS CUI [3,2])
    Electron microscopy
    Item
    Electron microscopy
    boolean
    C0026019 (UMLS CUI [1])
    Hepatitis A lmmunostains positive
    Item
    Hepatitis A lmmunostains positive
    boolean
    C0560226 (UMLS CUI [1,1])
    C3687908 (UMLS CUI [1,2])
    Hepatitis B core antigen or hepatitis B surface antibody immunostains positive
    Item
    Hepatitis B core antigen or hepatitis B surface antibody immunostains positive
    boolean
    C0149709 (UMLS CUI [1,1])
    C3687908 (UMLS CUI [1,2])
    Hepatitis D immunostains
    Item
    Hepatitis D immunostains
    boolean
    C0850990 (UMLS CUI [1,1])
    C0021044 (UMLS CUI [1,2])
    C3687908 (UMLS CUI [1,3])
    Other immunostains
    Item
    Other immunostains
    boolean
    C0021044 (UMLS CUI [1,1])
    C3687908 (UMLS CUI [1,2])
    Other Histologic Staining or Additional Studies Obtained
    Item
    Other Histologic Staining or Additional Studies Obtained
    boolean
    C0205394 (UMLS CUI [1,1])
    C0487602 (UMLS CUI [1,2])
    C0023884 (UMLS CUI [1,3])
    Other Histologic Staining or Additional Studies Obtained specification
    Item
    If Other Histologic Staining or Additional Studies Obtained, please specify
    text
    C0205394 (UMLS CUI [1,1])
    C0487602 (UMLS CUI [1,2])
    C0023884 (UMLS CUI [1,3])
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