ID

38386

Description

Ethaselen for the Treatment of Thioredoxin Reductase High Expression Advanced Non-small Cell Lung Cancers; ODM derived from: https://clinicaltrials.gov/show/NCT02166242

Link

https://clinicaltrials.gov/show/NCT02166242

Keywords

Versions (1)
  1. 10/15/19 10/15/19 -
Copyright Holder

See clinicaltrials.gov

Uploaded on

October 15, 2019

DOI

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License

Creative Commons BY 4.0
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Eligibility Carcinoma, Non-small Cell Lung NCT02166242

English

Eligibility Carcinoma, Non-small Cell Lung NCT02166242

1 forms  
Inclusion Criteria
Description

Inclusion Criteria

Alias
UMLS CUI
C1512693
advanced non-small cell lung cancer, stage iiib/iv who had received more than 2 standard treatment scheme
Description

Non-Small Cell Lung Carcinoma Advanced TNM clinical staging | Standard of Care Quantity

Data type

boolean

Alias
UMLS CUI [1,1]
C0007131
UMLS CUI [1,2]
C0205179
UMLS CUI [1,3]
C3258246
UMLS CUI [2,1]
C2936643
UMLS CUI [2,2]
C1265611
18-75 years old, anticipate overall survival more than 3 months, ecog 0-2
Description

Age | Overall Survival | ECOG performance status

Data type

boolean

Alias
UMLS CUI [1]
C0001779
UMLS CUI [2]
C4086681
UMLS CUI [3]
C1520224
within 4 weeks, not receive chemotherapy, radiotherapy or surgery
Description

Chemotherapy Absent | Therapeutic radiology procedure Absent | Operative Surgical Procedures Absent

Data type

boolean

Alias
UMLS CUI [1,1]
C0392920
UMLS CUI [1,2]
C0332197
UMLS CUI [2,1]
C1522449
UMLS CUI [2,2]
C0332197
UMLS CUI [3,1]
C0543467
UMLS CUI [3,2]
C0332197
hb≥90g/l； anc ≥1.5×109/l；plt ≥80×109/l
Description

Hemoglobin measurement | Absolute neutrophil count | Platelet Count measurement

Data type

boolean

Alias
UMLS CUI [1]
C0518015
UMLS CUI [2]
C0948762
UMLS CUI [3]
C0032181
egfr/alk mutation negative
Description

EGFR gene mutation Negative | ALK gene mutation Negative

Data type

boolean

Alias
UMLS CUI [1,1]
C3266992
UMLS CUI [1,2]
C1513916
UMLS CUI [2,1]
C2825843
UMLS CUI [2,2]
C1513916
immunohistochemistry test of cancer tissue showed ++ or +++ of thioredoxin reductase
Description

Tumor tissue sample Immunohistochemistry | Thioredoxin Reductase Positive

Data type

boolean

Alias
UMLS CUI [1,1]
C0475358
UMLS CUI [1,2]
C0021044
UMLS CUI [2,1]
C0039941
UMLS CUI [2,2]
C1514241
brain metastasis without symptoms
Description

Metastatic malignant neoplasm to brain Without Symptoms

Data type

boolean

Alias
UMLS CUI [1,1]
C0220650
UMLS CUI [1,2]
C0332288
UMLS CUI [1,3]
C1457887
Exclusion Criteria
Description

Exclusion Criteria

Alias
UMLS CUI
C0680251
according to nccn non-small cell lung cancer guidelines (2014 v3), there were standard treatment scheme for the patients
Description

Standard of Care

Data type

boolean

Alias
UMLS CUI [1]
C2936643
pregnancy or breast-feeding women
Description

Pregnancy | Breast Feeding

Data type

boolean

Alias
UMLS CUI [1]
C0032961
UMLS CUI [2]
C0006147
any serious disease which could not be controled
Description

Disease Serious Uncontrolled

Data type

boolean

Alias
UMLS CUI [1,1]
C0012634
UMLS CUI [1,2]
C0205404
UMLS CUI [1,3]
C0205318
urine protein≥++, or 24h urine protein＞1g
Description

Urine protein test | 24 Hour Urine Protein Test

Data type

boolean

Alias
UMLS CUI [1]
C0262923
UMLS CUI [2]
C1254855
received any anti-cancer treatment within 4 weeks
Description

Cancer treatment

Data type

boolean

Alias
UMLS CUI [1]
C0920425
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Similar models

Eligibility Carcinoma, Non-small Cell Lung NCT02166242

1 forms
Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
Item Group
C1512693 (UMLS CUI)
Non-Small Cell Lung Carcinoma Advanced TNM clinical staging | Standard of Care Quantity
Item
advanced non-small cell lung cancer, stage iiib/iv who had received more than 2 standard treatment scheme
boolean
C0007131 (UMLS CUI [1,1])
C0205179 (UMLS CUI [1,2])
C3258246 (UMLS CUI [1,3])
C2936643 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
Age | Overall Survival | ECOG performance status
Item
18-75 years old, anticipate overall survival more than 3 months, ecog 0-2
boolean
C0001779 (UMLS CUI [1])
C4086681 (UMLS CUI [2])
C1520224 (UMLS CUI [3])
Chemotherapy Absent | Therapeutic radiology procedure Absent | Operative Surgical Procedures Absent
Item
within 4 weeks, not receive chemotherapy, radiotherapy or surgery
boolean
C0392920 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C1522449 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C0543467 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
Hemoglobin measurement | Absolute neutrophil count | Platelet Count measurement
Item
hb≥90g/l； anc ≥1.5×109/l；plt ≥80×109/l
boolean
C0518015 (UMLS CUI [1])
C0948762 (UMLS CUI [2])
C0032181 (UMLS CUI [3])
EGFR gene mutation Negative | ALK gene mutation Negative
Item
egfr/alk mutation negative
boolean
C3266992 (UMLS CUI [1,1])
C1513916 (UMLS CUI [1,2])
C2825843 (UMLS CUI [2,1])
C1513916 (UMLS CUI [2,2])
Tumor tissue sample Immunohistochemistry | Thioredoxin Reductase Positive
Item
immunohistochemistry test of cancer tissue showed ++ or +++ of thioredoxin reductase
boolean
C0475358 (UMLS CUI [1,1])
C0021044 (UMLS CUI [1,2])
C0039941 (UMLS CUI [2,1])
C1514241 (UMLS CUI [2,2])
Metastatic malignant neoplasm to brain Without Symptoms
Item
brain metastasis without symptoms
boolean
C0220650 (UMLS CUI [1,1])
C0332288 (UMLS CUI [1,2])
C1457887 (UMLS CUI [1,3])
Item Group
C0680251 (UMLS CUI)
Standard of Care
Item
according to nccn non-small cell lung cancer guidelines (2014 v3), there were standard treatment scheme for the patients
boolean
C2936643 (UMLS CUI [1])
Pregnancy | Breast Feeding
Item
pregnancy or breast-feeding women
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Disease Serious Uncontrolled
Item
any serious disease which could not be controled
boolean
C0012634 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C0205318 (UMLS CUI [1,3])
Urine protein test | 24 Hour Urine Protein Test
Item
urine protein≥++, or 24h urine protein＞1g
boolean
C0262923 (UMLS CUI [1])
C1254855 (UMLS CUI [2])
Cancer treatment
Item
received any anti-cancer treatment within 4 weeks
boolean
C0920425 (UMLS CUI [1])
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