ID
38181
Beschrijving
Study ID: 110951 Clinical Study ID: 110951 Study Title: A two-part, randomised, placebo-controlled study to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of single doses of intravenously infused GSK1995057 in healthy subjects. Patient Level Data: Study Listed on ClinicalStudyDataRequest.com Clinicaltrials.gov Identifier: NCT01476046 See https://clinicaltrials.gov/ct2/show/NCT01476046 Sponsor: GlaxoSmithKline Collaborators: N/A Phase: Phase 1 Study Recruitment Status: Completed Generic Name: N/A, Placebo Trade Name: N/A Study Indication: Respiratory Disorders This phase I trial primarily studies the safety and tolerability of ascending single intravenous doses of the selective TNFR1 antagonist GSK1995057 in healthy volunteers, and secondly explores the drug's pharmacodynamics, pharmacokinetics, concentration in lung epithelial lining fluid as well as its effect on immune system markers. The drug is hypothesized to be useful for Acute Lung Injury. The single-centre study consists of two parts A and B with seven cohorts/ten subcohorts in total. Part A includes ascending doses of the investigational product given to subjects negative or positive for pre-existing human anti-heavy chain variable domain (HAVH) antibodies (Cohorts 1 to 3 with Subcohorts 1a, 2a and 3a negative for HAVH and 1b, 2b, 3b positive for HAVH). Part B includes only subjects negative for HAVH, with ascending doses given to Cohorts 4 to 6. Cohort 7 receives the same dose as Cohort 6, but whereas the other Cohorts are single-blinded, Cohort 7 is open-label and additionally receives a bronchoalveolar lavage (BAL). The study consists of a Screening Visit (up to 56 days before Day 1, the day of the drug administration), Visits on Day -1, 1, 2, 3, 5, 7, 14, 28 and Follow-Up Visits on Day 57 and 85. This form contains the participants' basic vital signs, which are recorded at Screening, on Days 1, 2, 3, 5, 7, 14, 28, in case of early withdrawal and as an unscheduled (repeat) assessment.
Link
https://clinicaltrials.gov/ct2/show/NCT01476046
Trefwoorden
Versies (1)
- 24-09-19 24-09-19 -
Houder van rechten
GlaxoSmithKline
Geüploaded op
24 september 2019
DOI
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Licentie
Creative Commons BY-NC 3.0
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Phase I Trial of Intravenous TNFR1 Antagonist GSK1995057 in Healthy Subjects - NCT01476046
Vitals Signs
- StudyEvent: ODM
Beschrijving
Dosing Date and Time
Alias
- UMLS CUI-1
- C0178602
- UMLS CUI-2
- C1264639
Beschrijving
Vital Signs
Alias
- UMLS CUI-1
- C0518766
Beschrijving
Only applicable on Day 1 (identical for all Parts/Cohorts/Subcohorts). Fill in the entire repeating itemgroup once per Vital Sign assessment on this day.
Datatype
integer
Alias
- UMLS CUI [1,1]
- C0439564
- UMLS CUI [1,2]
- C3469597
- UMLS CUI [1,3]
- C0304229
Beschrijving
At Screening, record Vital Signs three times (Measurements 1 to 3). Fill in for repeat Vital Signs if necessary. Fill in the entire repeating itemgroup once per Vital Sign assessment. At Screening, Measurement 1 (of 3), fill in all items. At the two other Screening Measurements, record time, blood pressure, heart rate and respiratory rate.
Datatype
integer
Alias
- UMLS CUI [1]
- C0449788
Beschrijving
Date/time
Datatype
datetime
Alias
- UMLS CUI [1]
- C1264639
Beschrijving
Height
Datatype
integer
Maateenheden
- cm
Alias
- UMLS CUI [1]
- C0005890
Beschrijving
Weight
Datatype
float
Maateenheden
- kg
Alias
- UMLS CUI [1]
- C0005910
Beschrijving
calculated from height and weight
Datatype
float
Maateenheden
- kg/m2
Alias
- UMLS CUI [1]
- C1305855
Beschrijving
Blood pressure systolic
Datatype
integer
Maateenheden
- mmHg
Alias
- UMLS CUI [1]
- C0871470
Beschrijving
Blood pressure diastolic
Datatype
integer
Maateenheden
- mmHg
Alias
- UMLS CUI [1]
- C0428883
Beschrijving
Heart Rate
Datatype
integer
Maateenheden
- beats/min
Alias
- UMLS CUI [1]
- C0018810
Beschrijving
Body Temperature
Datatype
float
Maateenheden
- °C
Alias
- UMLS CUI [1]
- C0005903
Beschrijving
Respiration rate
Datatype
integer
Maateenheden
- breaths/min
Alias
- UMLS CUI [1]
- C0231832
Similar models
Vitals Signs
- StudyEvent: ODM
C3469597 (UMLS CUI [1,2])
C0304229 (UMLS CUI [1,3])
C3469597 (UMLS CUI [1,2])
C0304229 (UMLS CUI [1,3])