ID

31758

Description

Evaluation of a Handheld Event Related Potential (ERP)/Quantitative Electroencephalography (qEEG) System (COGNISION™) as a Useful Cognitive Biomarker for Alzheimer's Disease.; ODM derived from: https://clinicaltrials.gov/show/NCT00938665

Link

https://clinicaltrials.gov/show/NCT00938665

Keywords

Versions (1)
  1. 9/26/18 9/26/18 -
Copyright Holder

Neuronetrix, Inc.

Uploaded on

September 26, 2018

DOI

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License

Creative Commons BY-NC 3.0
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Eligibility Memory Disorders NCT00938665

English

Eligibility Memory Disorders NCT00938665

1 forms  
Inclusion Criteria AD Cohort
Description

Inclusion Criteria AD Cohort

Alias
UMLS CUI-1
C1512693
UMLS CUI-2
C0599755
UMLS CUI-3
C0002395
subjects between 60 and 90 years old
Description

Age

Data type

boolean

Alias
UMLS CUI [1]
C0001779
subjects meeting nincds-adrda criteria for probable ad2 and dsm-iv criteria for dementia of the alzheimer's type3 will be recruited in the ad cohort (mmse ≥21, ≤26).
Description

NINCDS-ADRDA for AD2, DSM-IV criteria for dementia, MMSE

Data type

boolean

Alias
UMLS CUI [1,1]
C2828081
UMLS CUI [1,2]
C0002395
UMLS CUI [2,1]
C0220952
UMLS CUI [2,2]
C0497327
UMLS CUI [2,3]
C0002395
UMLS CUI [3]
C0451306
memory complaint by subject and/or study partner srp-1418 n page: 8 of 26
Description

Memory complaint

Data type

boolean

Alias
UMLS CUI [1,1]
C0439655
UMLS CUI [1,2]
C0233794
UMLS CUI [1,3]
C0277786
UMLS CUI [2,1]
C0233794
UMLS CUI [2,2]
C0277786
UMLS CUI [2,3]
C2079578
abnormal memory function score on logical memory ii subscale (delayed paragraph recall) from the wechsler memory scale - revised (adjusted for education. maximum score is 25): i. < 10 for 16 or more years of education ii. < 6 for 8-15 years of education iii. < 4 for 0-7 years of education
Description

Memory function by wechsler memory scale, education

Data type

boolean

Alias
UMLS CUI [1,1]
C4027320
UMLS CUI [1,2]
C0456081
UMLS CUI [1,3]
C0013658
UMLS CUI [2,1]
C4027320
UMLS CUI [2,2]
C0589057
clinical dementia rating (cdr) = 0.5, 1.0 or 2.0 modified hachinski ischemic scale (his) ≤ 4 geriatric depression scale (gds) < 6
Description

CDR, HIS, GDS

Data type

boolean

Alias
UMLS CUI [1]
C0451074
UMLS CUI [2]
C3826978
UMLS CUI [3]
C1954099
for subjects that decide to provide a csf sample: platelet count ≥ 100,000/μl, prothrombin time (pt) = 11 to 16 seconds, international normalized ratio = 0.8 to 1.2
Description

CSF, Platelet count, PT, INR

Data type

boolean

Alias
UMLS CUI [1,1]
C0007806
UMLS CUI [1,2]
C0680240
UMLS CUI [2]
C0005821
UMLS CUI [3]
C0033707
UMLS CUI [4]
C0525032
study partner or caregiver to accompany subject to all scheduled visits
Description

study partner/caregiver to accompany subject to all scheduled visits

Data type

boolean

Alias
UMLS CUI [1]
C2079578
UMLS CUI [2]
C0085537
fluent in english
Description

Fluently speaking english

Data type

boolean

Alias
UMLS CUI [1,1]
C0564241
UMLS CUI [1,2]
C0376245
adequate visual acuity to allow neuropsychological testing
Description

Visual acuity to allow neuropsychological testing

Data type

boolean

Alias
UMLS CUI [1,1]
C0042812
UMLS CUI [1,2]
C0205410
UMLS CUI [1,3]
C0027902
adequate auditory acuity to allow neuropsychological and erp testing
Description

Auditory acuity to allow neuropsychological testing, erp testing

Data type

boolean

Alias
UMLS CUI [1,1]
C0679027
UMLS CUI [1,2]
C0205410
UMLS CUI [1,3]
C0027902
UMLS CUI [1,4]
C0282171
UMLS CUI [1,5]
C0039593
good general health with no additional diseases expected to interfere with the study
Description

Healthy, no other diseases/conditions

Data type

boolean

Alias
UMLS CUI [1]
C1277245
UMLS CUI [2,1]
C2359476
UMLS CUI [2,2]
C0392760
UMLS CUI [2,3]
C2603343
willing to undergo neuroimaging and provide blood. the subject may optionally provide a csf sample by lumbar puncture.
Description

Willingness to neuroimaging and blood; CSF and diagnostic lumbar puncture

Data type

boolean

Alias
UMLS CUI [1,1]
C0600109
UMLS CUI [1,2]
C0679575
UMLS CUI [2,1]
C0600109
UMLS CUI [2,2]
C0005834
UMLS CUI [3,1]
C0007806
UMLS CUI [3,2]
C0553794
Inclusion criteria normal control
Description

Inclusion criteria normal control

Alias
UMLS CUI-1
C1512693
UMLS CUI-2
C2986479
healthy subjects matched for age, gender, and education level will be recruited as normal controls (mmse ≥ 27).
Description

Matched for age, gender and education level (mmse ≥ 27)

Data type

boolean

Alias
UMLS CUI [1]
C1708335
UMLS CUI [2,1]
C0001779
UMLS CUI [2,2]
C1708943
UMLS CUI [3,1]
C0079399
UMLS CUI [3,2]
C1708943
UMLS CUI [4,1]
C0013658
UMLS CUI [4,2]
C1708943
UMLS CUI [5]
C0451306
normal memory function will be documented by scoring at specific cutoffs on the logical memory ii subscale (delayed paragraph recall) from the wechsler memory scale - revised: i. ≥ 10 for 16 or more years of education ii. ≥ 6 for 8-15 years of education iii. ≥ 4 for 0-7 years of education
Description

Memory function, wechsler memory scale, education

Data type

boolean

Alias
UMLS CUI [1,1]
C4027320
UMLS CUI [1,2]
C0456081
UMLS CUI [1,3]
C0013658
UMLS CUI [2,1]
C4027320
UMLS CUI [2,2]
C0589057
study partner or caregiver
Description

study partner/ caregiver

Data type

boolean

Alias
UMLS CUI [1]
C2079578
UMLS CUI [2]
C0085537
fluent in english
Description

Fluently speaking english

Data type

boolean

Alias
UMLS CUI [1,1]
C0564241
UMLS CUI [1,2]
C0376245
adequate visual acuity to allow neuropsychological testing
Description

Visual acuity to allow neuropsychological testing

Data type

boolean

Alias
UMLS CUI [1,1]
C0042812
UMLS CUI [1,2]
C0205410
UMLS CUI [1,3]
C0027902
adequate auditory acuity to allow neuropsychological and erp testing
Description

Auditory acuity to allow neuropsychological, erp testing

Data type

boolean

Alias
UMLS CUI [1,1]
C0679027
UMLS CUI [1,2]
C0205410
UMLS CUI [1,3]
C0027902
UMLS CUI [1,4]
C0282171
Exclusion Criteria AD Cohort
Description

Exclusion Criteria AD Cohort

Alias
UMLS CUI-1
C0680251
UMLS CUI-2
C0002395
UMLS CUI-3
C0599755
severe or unstable forms of diabetes, heart disease, hiv, drug or alcohol abuse, etc. including severe ad:mmse ≤20
Description

Diabetes, heart disease, HIV, drug/alcohol abuse, severe AD, MMSE

Data type

boolean

Alias
UMLS CUI [1,1]
C0011849
UMLS CUI [1,2]
C0205082
UMLS CUI [2,1]
C0011849
UMLS CUI [2,2]
C0443343
UMLS CUI [3]
C0018799
UMLS CUI [4]
C0019682
UMLS CUI [5,1]
C0013146
UMLS CUI [5,2]
C0085762
UMLS CUI [6,1]
C0205082
UMLS CUI [6,2]
C0002395
UMLS CUI [6,3]
C0451306
platelet count < 100,000/μl, prothrombin time (pt) > 16 seconds, international normalized ratio > 1.2 (for subjects that choose to provide a csf sample by lumbar puncture).
Description

Platelet count, PT, INR

Data type

boolean

Alias
UMLS CUI [1,1]
C0553794
UMLS CUI [1,2]
C0007806
UMLS CUI [1,3]
C0680240
UMLS CUI [2]
C0032181
UMLS CUI [3]
C0033707
UMLS CUI [4]
C0525032
medical or psychiatric disorders that might complicate the assessment of dementia (i.e., mental retardation, alcohol abuse, drug abuse, hiv)
Description

Medical or psychiatric disorders complicating assessment of dementia

Data type

boolean

Alias
UMLS CUI [1,1]
C0205476
UMLS CUI [1,2]
C0012634
UMLS CUI [1,3]
C0009566
UMLS CUI [1,4]
C1516048
UMLS CUI [1,5]
C0497327
UMLS CUI [2,1]
C0004936
UMLS CUI [2,2]
C0009566
UMLS CUI [2,3]
C1516048
UMLS CUI [2,4]
C0497327
UMLS CUI [3]
C0025362
UMLS CUI [4]
C0085762
UMLS CUI [5]
C0013146
UMLS CUI [6]
C0019682
a disability that may prevent the subject from completing all study requirements (e.g., blindness, deafness, language difficulty)
Description

Disability of completing study requirements

Data type

boolean

Alias
UMLS CUI [1,1]
C0231170
UMLS CUI [1,2]
C1292733
UMLS CUI [1,3]
C0525058
UMLS CUI [2]
C0456909
UMLS CUI [3]
C0011053
UMLS CUI [4]
C0566027
recent intake of drugs known to cause major organ system toxicity or cns alteration (e.g. sedation)
Description

Recent intake of drugs causing major organ system toxicity or cns alteration

Data type

boolean

Alias
UMLS CUI [1,1]
C0332185
UMLS CUI [1,2]
C0013227
UMLS CUI [1,3]
C0013221
UMLS CUI [1,4]
C0678852
UMLS CUI [2,1]
C0332185
UMLS CUI [2,2]
C0013227
UMLS CUI [2,3]
C3160947
UMLS CUI [3]
C0344106
diseases of the dementia type other than ad (i.e., vascular dementia, frontotemporal dementia, lewy body disease, huntington's disease)
Description

Diseases of the dementia type except than AD

Data type

boolean

Alias
UMLS CUI [1,1]
C0497327
UMLS CUI [1,2]
C0332300
UMLS CUI [1,3]
C0002395
UMLS CUI [2]
C0011269
UMLS CUI [3]
C0338451
UMLS CUI [4]
C0752347
UMLS CUI [5]
C0020179
presence of non-mri compatible implants/devices
Description

Non-mri compatible implants/ devices

Data type

boolean

Alias
UMLS CUI [1,1]
C0021102
UMLS CUI [1,2]
C0522473
UMLS CUI [1,3]
C0024485
prohibited medications: warfarin or other anticoagulants (for subjects that choose to provide a csf sample by lumbar puncture), investigational agents.
Description

Prohibited medication (Warfarin, anticoagulants), csf sample by lumbar puncture, investigational agents

Data type

boolean

Alias
UMLS CUI [1,1]
C0043031
UMLS CUI [1,2]
C0007806
UMLS CUI [1,3]
C0553794
UMLS CUI [2,1]
C0003280
UMLS CUI [2,2]
C0007806
UMLS CUI [2,3]
C0553794
UMLS CUI [3,1]
C0013227
UMLS CUI [3,2]
C0683610
UMLS CUI [4]
C0013230
Exclusion criteria normal control
Description

Exclusion criteria normal control

Alias
UMLS CUI-1
C0680251
UMLS CUI-2
C2986479
severe or unstable forms of diabetes, heart disease, hiv, drug or alcohol abuse, etc.
Description

Diabetes Mellitus, heart diseases, HIV, drug or alcohol abuse

Data type

boolean

Alias
UMLS CUI [1,1]
C0011849
UMLS CUI [1,2]
C0205082
UMLS CUI [2,1]
C0011849
UMLS CUI [2,2]
C0443343
UMLS CUI [3]
C0018799
UMLS CUI [4]
C0019682
UMLS CUI [5,1]
C0013146
UMLS CUI [5,2]
C0085762
a disability that may prevent the subject from completing all study requirements (e.g., blindness, deafness, language difficulty)
Description

Disability of completing study requirements

Data type

boolean

Alias
UMLS CUI [1,1]
C0231170
UMLS CUI [1,2]
C1292733
UMLS CUI [1,3]
C0525058
UMLS CUI [2]
C0456909
UMLS CUI [3]
C0011053
UMLS CUI [4]
C0566027
use of psychoactive drugs (only ssri's are allowed)
Description

Psychoactive drugs, SSRI's accepted

Data type

boolean

Alias
UMLS CUI [1]
C0033978
UMLS CUI [2,1]
C0033978
UMLS CUI [2,2]
C1705847
UMLS CUI [2,3]
C0360105
psychiatric disorders (schizophrenia, bipolar, etc.)
Description

Psychiatric disorders

Data type

boolean

Alias
UMLS CUI [1]
C0004936
UMLS CUI [2]
C0036341
UMLS CUI [3]
C0005586
depression (gds > 6)
Description

GDS

Data type

boolean

Alias
UMLS CUI [1]
C0011581
UMLS CUI [2]
C1954099
vascular dementia (his > 4) other dementia (cdr > 0)
Description

Other forms of dementia, HIS, CDR

Data type

boolean

Alias
UMLS CUI [1,1]
C0011269
UMLS CUI [1,2]
C0475492
UMLS CUI [2,1]
C0205394
UMLS CUI [2,2]
C0497327
UMLS CUI [2,3]
C0451074
abnormal memory function score on wechsler memory scale -logical memory ii subscale (delayed paragraph recall) from the wechsler memory scale - revised (the maximum score is 25): i. < 10 for 16 or more years of education ii. < 6 for 8-15 years of education iii. < 4 for 0-7 years of education
Description

Memory function, wechsler memory scale, education

Data type

boolean

Alias
UMLS CUI [1,1]
C4027320
UMLS CUI [1,2]
C0456081
UMLS CUI [1,3]
C0013658
UMLS CUI [2,1]
C4027320
UMLS CUI [2,2]
C0589057
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Similar models

Eligibility Memory Disorders NCT00938665

1 forms
Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
Item Group
Inclusion Criteria AD Cohort
C1512693 (UMLS CUI-1)
C0599755 (UMLS CUI-2)
C0002395 (UMLS CUI-3)
Age
Item
subjects between 60 and 90 years old
boolean
C0001779 (UMLS CUI [1])
NINCDS-ADRDA for AD2, DSM-IV criteria for dementia, MMSE
Item
subjects meeting nincds-adrda criteria for probable ad2 and dsm-iv criteria for dementia of the alzheimer's type3 will be recruited in the ad cohort (mmse ≥21, ≤26).
boolean
C2828081 (UMLS CUI [1,1])
C0002395 (UMLS CUI [1,2])
C0220952 (UMLS CUI [2,1])
C0497327 (UMLS CUI [2,2])
C0002395 (UMLS CUI [2,3])
C0451306 (UMLS CUI [3])
Memory complaint
Item
memory complaint by subject and/or study partner srp-1418 n page: 8 of 26
boolean
C0439655 (UMLS CUI [1,1])
C0233794 (UMLS CUI [1,2])
C0277786 (UMLS CUI [1,3])
C0233794 (UMLS CUI [2,1])
C0277786 (UMLS CUI [2,2])
C2079578 (UMLS CUI [2,3])
Memory function by wechsler memory scale, education
Item
abnormal memory function score on logical memory ii subscale (delayed paragraph recall) from the wechsler memory scale - revised (adjusted for education. maximum score is 25): i. < 10 for 16 or more years of education ii. < 6 for 8-15 years of education iii. < 4 for 0-7 years of education
boolean
C4027320 (UMLS CUI [1,1])
C0456081 (UMLS CUI [1,2])
C0013658 (UMLS CUI [1,3])
C4027320 (UMLS CUI [2,1])
C0589057 (UMLS CUI [2,2])
CDR, HIS, GDS
Item
clinical dementia rating (cdr) = 0.5, 1.0 or 2.0 modified hachinski ischemic scale (his) ≤ 4 geriatric depression scale (gds) < 6
boolean
C0451074 (UMLS CUI [1])
C3826978 (UMLS CUI [2])
C1954099 (UMLS CUI [3])
CSF, Platelet count, PT, INR
Item
for subjects that decide to provide a csf sample: platelet count ≥ 100,000/μl, prothrombin time (pt) = 11 to 16 seconds, international normalized ratio = 0.8 to 1.2
boolean
C0007806 (UMLS CUI [1,1])
C0680240 (UMLS CUI [1,2])
C0005821 (UMLS CUI [2])
C0033707 (UMLS CUI [3])
C0525032 (UMLS CUI [4])
study partner/caregiver to accompany subject to all scheduled visits
Item
study partner or caregiver to accompany subject to all scheduled visits
boolean
C2079578 (UMLS CUI [1])
C0085537 (UMLS CUI [2])
Fluently speaking english
Item
fluent in english
boolean
C0564241 (UMLS CUI [1,1])
C0376245 (UMLS CUI [1,2])
Visual acuity to allow neuropsychological testing
Item
adequate visual acuity to allow neuropsychological testing
boolean
C0042812 (UMLS CUI [1,1])
C0205410 (UMLS CUI [1,2])
C0027902 (UMLS CUI [1,3])
Auditory acuity to allow neuropsychological testing, erp testing
Item
adequate auditory acuity to allow neuropsychological and erp testing
boolean
C0679027 (UMLS CUI [1,1])
C0205410 (UMLS CUI [1,2])
C0027902 (UMLS CUI [1,3])
C0282171 (UMLS CUI [1,4])
C0039593 (UMLS CUI [1,5])
Healthy, no other diseases/conditions
Item
good general health with no additional diseases expected to interfere with the study
boolean
C1277245 (UMLS CUI [1])
C2359476 (UMLS CUI [2,1])
C0392760 (UMLS CUI [2,2])
C2603343 (UMLS CUI [2,3])
Willingness to neuroimaging and blood; CSF and diagnostic lumbar puncture
Item
willing to undergo neuroimaging and provide blood. the subject may optionally provide a csf sample by lumbar puncture.
boolean
C0600109 (UMLS CUI [1,1])
C0679575 (UMLS CUI [1,2])
C0600109 (UMLS CUI [2,1])
C0005834 (UMLS CUI [2,2])
C0007806 (UMLS CUI [3,1])
C0553794 (UMLS CUI [3,2])
Item Group
Inclusion criteria normal control
C1512693 (UMLS CUI-1)
C2986479 (UMLS CUI-2)
Matched for age, gender and education level (mmse ≥ 27)
Item
healthy subjects matched for age, gender, and education level will be recruited as normal controls (mmse ≥ 27).
boolean
C1708335 (UMLS CUI [1])
C0001779 (UMLS CUI [2,1])
C1708943 (UMLS CUI [2,2])
C0079399 (UMLS CUI [3,1])
C1708943 (UMLS CUI [3,2])
C0013658 (UMLS CUI [4,1])
C1708943 (UMLS CUI [4,2])
C0451306 (UMLS CUI [5])
Memory function, wechsler memory scale, education
Item
normal memory function will be documented by scoring at specific cutoffs on the logical memory ii subscale (delayed paragraph recall) from the wechsler memory scale - revised: i. ≥ 10 for 16 or more years of education ii. ≥ 6 for 8-15 years of education iii. ≥ 4 for 0-7 years of education
boolean
C4027320 (UMLS CUI [1,1])
C0456081 (UMLS CUI [1,2])
C0013658 (UMLS CUI [1,3])
C4027320 (UMLS CUI [2,1])
C0589057 (UMLS CUI [2,2])
study partner/ caregiver
Item
study partner or caregiver
boolean
C2079578 (UMLS CUI [1])
C0085537 (UMLS CUI [2])
Fluently speaking english
Item
fluent in english
boolean
C0564241 (UMLS CUI [1,1])
C0376245 (UMLS CUI [1,2])
Visual acuity to allow neuropsychological testing
Item
adequate visual acuity to allow neuropsychological testing
boolean
C0042812 (UMLS CUI [1,1])
C0205410 (UMLS CUI [1,2])
C0027902 (UMLS CUI [1,3])
Auditory acuity to allow neuropsychological, erp testing
Item
adequate auditory acuity to allow neuropsychological and erp testing
boolean
C0679027 (UMLS CUI [1,1])
C0205410 (UMLS CUI [1,2])
C0027902 (UMLS CUI [1,3])
C0282171 (UMLS CUI [1,4])
Item Group
Exclusion Criteria AD Cohort
C0680251 (UMLS CUI-1)
C0002395 (UMLS CUI-2)
C0599755 (UMLS CUI-3)
Diabetes, heart disease, HIV, drug/alcohol abuse, severe AD, MMSE
Item
severe or unstable forms of diabetes, heart disease, hiv, drug or alcohol abuse, etc. including severe ad:mmse ≤20
boolean
C0011849 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0011849 (UMLS CUI [2,1])
C0443343 (UMLS CUI [2,2])
C0018799 (UMLS CUI [3])
C0019682 (UMLS CUI [4])
C0013146 (UMLS CUI [5,1])
C0085762 (UMLS CUI [5,2])
C0205082 (UMLS CUI [6,1])
C0002395 (UMLS CUI [6,2])
C0451306 (UMLS CUI [6,3])
Platelet count, PT, INR
Item
platelet count < 100,000/μl, prothrombin time (pt) > 16 seconds, international normalized ratio > 1.2 (for subjects that choose to provide a csf sample by lumbar puncture).
boolean
C0553794 (UMLS CUI [1,1])
C0007806 (UMLS CUI [1,2])
C0680240 (UMLS CUI [1,3])
C0032181 (UMLS CUI [2])
C0033707 (UMLS CUI [3])
C0525032 (UMLS CUI [4])
Medical or psychiatric disorders complicating assessment of dementia
Item
medical or psychiatric disorders that might complicate the assessment of dementia (i.e., mental retardation, alcohol abuse, drug abuse, hiv)
boolean
C0205476 (UMLS CUI [1,1])
C0012634 (UMLS CUI [1,2])
C0009566 (UMLS CUI [1,3])
C1516048 (UMLS CUI [1,4])
C0497327 (UMLS CUI [1,5])
C0004936 (UMLS CUI [2,1])
C0009566 (UMLS CUI [2,2])
C1516048 (UMLS CUI [2,3])
C0497327 (UMLS CUI [2,4])
C0025362 (UMLS CUI [3])
C0085762 (UMLS CUI [4])
C0013146 (UMLS CUI [5])
C0019682 (UMLS CUI [6])
Disability of completing study requirements
Item
a disability that may prevent the subject from completing all study requirements (e.g., blindness, deafness, language difficulty)
boolean
C0231170 (UMLS CUI [1,1])
C1292733 (UMLS CUI [1,2])
C0525058 (UMLS CUI [1,3])
C0456909 (UMLS CUI [2])
C0011053 (UMLS CUI [3])
C0566027 (UMLS CUI [4])
Recent intake of drugs causing major organ system toxicity or cns alteration
Item
recent intake of drugs known to cause major organ system toxicity or cns alteration (e.g. sedation)
boolean
C0332185 (UMLS CUI [1,1])
C0013227 (UMLS CUI [1,2])
C0013221 (UMLS CUI [1,3])
C0678852 (UMLS CUI [1,4])
C0332185 (UMLS CUI [2,1])
C0013227 (UMLS CUI [2,2])
C3160947 (UMLS CUI [2,3])
C0344106 (UMLS CUI [3])
Diseases of the dementia type except than AD
Item
diseases of the dementia type other than ad (i.e., vascular dementia, frontotemporal dementia, lewy body disease, huntington's disease)
boolean
C0497327 (UMLS CUI [1,1])
C0332300 (UMLS CUI [1,2])
C0002395 (UMLS CUI [1,3])
C0011269 (UMLS CUI [2])
C0338451 (UMLS CUI [3])
C0752347 (UMLS CUI [4])
C0020179 (UMLS CUI [5])
Non-mri compatible implants/ devices
Item
presence of non-mri compatible implants/devices
boolean
C0021102 (UMLS CUI [1,1])
C0522473 (UMLS CUI [1,2])
C0024485 (UMLS CUI [1,3])
Prohibited medication (Warfarin, anticoagulants), csf sample by lumbar puncture, investigational agents
Item
prohibited medications: warfarin or other anticoagulants (for subjects that choose to provide a csf sample by lumbar puncture), investigational agents.
boolean
C0043031 (UMLS CUI [1,1])
C0007806 (UMLS CUI [1,2])
C0553794 (UMLS CUI [1,3])
C0003280 (UMLS CUI [2,1])
C0007806 (UMLS CUI [2,2])
C0553794 (UMLS CUI [2,3])
C0013227 (UMLS CUI [3,1])
C0683610 (UMLS CUI [3,2])
C0013230 (UMLS CUI [4])
Item Group
Exclusion criteria normal control
C0680251 (UMLS CUI-1)
C2986479 (UMLS CUI-2)
Diabetes Mellitus, heart diseases, HIV, drug or alcohol abuse
Item
severe or unstable forms of diabetes, heart disease, hiv, drug or alcohol abuse, etc.
boolean
C0011849 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0011849 (UMLS CUI [2,1])
C0443343 (UMLS CUI [2,2])
C0018799 (UMLS CUI [3])
C0019682 (UMLS CUI [4])
C0013146 (UMLS CUI [5,1])
C0085762 (UMLS CUI [5,2])
Disability of completing study requirements
Item
a disability that may prevent the subject from completing all study requirements (e.g., blindness, deafness, language difficulty)
boolean
C0231170 (UMLS CUI [1,1])
C1292733 (UMLS CUI [1,2])
C0525058 (UMLS CUI [1,3])
C0456909 (UMLS CUI [2])
C0011053 (UMLS CUI [3])
C0566027 (UMLS CUI [4])
Psychoactive drugs, SSRI's accepted
Item
use of psychoactive drugs (only ssri's are allowed)
boolean
C0033978 (UMLS CUI [1])
C0033978 (UMLS CUI [2,1])
C1705847 (UMLS CUI [2,2])
C0360105 (UMLS CUI [2,3])
Psychiatric disorders
Item
psychiatric disorders (schizophrenia, bipolar, etc.)
boolean
C0004936 (UMLS CUI [1])
C0036341 (UMLS CUI [2])
C0005586 (UMLS CUI [3])
GDS
Item
depression (gds > 6)
boolean
C0011581 (UMLS CUI [1])
C1954099 (UMLS CUI [2])
Other forms of dementia, HIS, CDR
Item
vascular dementia (his > 4) other dementia (cdr > 0)
boolean
C0011269 (UMLS CUI [1,1])
C0475492 (UMLS CUI [1,2])
C0205394 (UMLS CUI [2,1])
C0497327 (UMLS CUI [2,2])
C0451074 (UMLS CUI [2,3])
Memory function, wechsler memory scale, education
Item
abnormal memory function score on wechsler memory scale -logical memory ii subscale (delayed paragraph recall) from the wechsler memory scale - revised (the maximum score is 25): i. < 10 for 16 or more years of education ii. < 6 for 8-15 years of education iii. < 4 for 0-7 years of education
boolean
C4027320 (UMLS CUI [1,1])
C0456081 (UMLS CUI [1,2])
C0013658 (UMLS CUI [1,3])
C4027320 (UMLS CUI [2,1])
C0589057 (UMLS CUI [2,2])
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