0 Evaluaciones

ID

30925

Descripción

This ODM file contains Information about Liver Biopsy. Use separate forms for each liver biopsy performed. Study ID: 109710 Clinical Study ID: DAN109710 Study Title: A single-blind, randomized, placebo controlled, two-period crossover fMRI study to investigate the effects of the D3 antagonist GSK598809 on neural and behavioural responses to food reward and reinforcement after a single oral dose of GSK598809 in overweight and obese subjects. Patient Level Data: Study Listed on ClinicalStudyDataRequest.com Clinicaltrials.gov Identifier: NCT01039454 https://clinicaltrials.gov/ct2/show/NCT01039454 Sponsor: GlaxoSmithKline Collaborators: N/A Phase: Phase 1 Study Recruitment Status: Completed Generic Name: GSK598809 Trade Name: Study Indication: Substance Dependence Brief Summary: This novel compound is a new experimental treatment that may help people to stop compulsive overeating. Compulsive overeating or binge eating is one of the main reasons why people are overweight or obese. Recent research has shown that some kinds of overeating may be linked to a brain chemical called dopamine. There is some evidence that blocking the action of this chemical in animals can reduce food intake, particularly of foods that are high in fat and sugar. The purpose of this study is to find out if this compound (which blocks the effects of dopamine) has the same effect in overweight or obese people, as it does in animals.

Link

https://clinicaltrials.gov/ct2/show/NCT01039454

Palabras clave

Appetite Depressants

D016430

Biopsy

Leber

E66

3/7/18 3/7/18 - Sarah Riepenhausen

Titular de derechos de autor

GlaxoSmithKline

Subido en

3 de julio de 2018

DOI

Para solicitar uno, por favor iniciar sesión.

Licencia

Creative Commons BY-NC 3.0

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Effects of D3 antagonist GSK598809 on neural and behavioural responses to food reward/reinforcement after a single dose in overweight/obese subjects NCT01039454

model
Detalles

Liver Biopsy

1 formularios

StudyEvent: ODM
1. Liver Biopsy

Name

Tipo

Description | Question | Decode (Coded Value)

Tipo de datos

Alias

Administrative Data

Item Group

Administrative Data

C1320722 (UMLS CUI-1)

Subject Identifier

Item

Subject Identifier

text

C2348585 (UMLS CUI [1])

Centre Number

Item

Centre Number

text

C0600091 (UMLS CUI [1,1])
C0019994 (UMLS CUI [1,2])

Liver Biopsy

Item Group

Liver Biopsy

C0193388 (UMLS CUI-1)

Date of Liver Biopsy

Item

Date of Liver Biopsy

date

C0193388 (UMLS CUI [1,1])
C0011008 (UMLS CUI [1,2])

Size of Liver Biopsy

Item

Size of Liver Biopsy

integer

C1299482 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Final Diagnosis

Item Group

A. Final Diagnosis

C1546485 (UMLS CUI-1)
C0193388 (UMLS CUI-2)

Normal Liver Tissue

Item

[A0] Normal

boolean

C0332441 (UMLS CUI [1,1])
C0023884 (UMLS CUI [1,2])

Acute hepatitis

Item

[A1] Acute hepatitis

boolean

C0267797 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Chronic hepatitis

Item

[A2] Chronic hepatitis

boolean

C0019189 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Cholestatic hepatitis

Item

[A3] Cholestatic hepatitis

boolean

C0149904 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Drug-induced cholestasis

Item

[A4] Drug-induced cholestasis

boolean

C2062350 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Acute viral hepatitis

Item

[A5] Acute viral hepatitis

boolean

C0276622 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Chronic viral hepatitis

Item

[A6] Chronic viral hepatitis

boolean

C0276623 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Drug-induced hepatitis

Item

[A7] Drug-induced hepatitis

boolean

C1262760 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Autoimmune hepatitis

Item

[A8] Autoimmune hepatitis

boolean

C0241910 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Bridging necrosis

Item

[A9] Bridging necrosis

boolean

C0333511 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Submassive hepatic necrosis

Item

[A10] Submassive hepatic necrosis

boolean

C0151798 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Massive hepatic necrosis

Item

[A11] Massive hepatic necrosis

boolean

C0001364 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Steatosis - microvesicular

Item

[A12] Steatosis - microvesicular

boolean

C1850415 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Steatosis - macrovesicular

Item

[A13] Steatosis - macrovesicular

boolean

C1837256 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Steatosis - mixed

Item

[A14] Steatosis - mixed

boolean

C0015695 (UMLS CUI [1,1])
C0205430 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])

Non-alcoholic steatohepatitis

Item

[A15] Non-alcoholic steatohepatitis

boolean

C3241937 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Alcoholic hepatitis

Item

[A16] Alcoholic hepatitis

boolean

C0019187 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Hepatic granulomas

Item

[A17] Hepatic granulomas

boolean

C0745754 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Sarcoidosis

Item

[A18] Sarcoidosis

boolean

C0744822 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Fibrosis

Item

[A19] Fibrosis

boolean

C0239946 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Cirrhosis

Item

[A20] Cirrhosis

boolean

C0023890 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Primary biliary cirrhosis

Item

[A21] Primary biliary cirrhosis

boolean

C0008312 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Primary sclerosing cholangitis

Item

[A22] Primary sclerosing cholangitis

boolean

C0566602 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Autoimmune overlap syndrome

Item

[A23] Autoimmune overlap syndrome

boolean

C2702837 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Hemochromatosis

Item

[A24] Hemochromatosis

boolean

C0018995 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Alpha-1-antitrypsin deficiency

Item

[A25] Alpha-1-antitrypsin deficiency

boolean

C0221757 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Wilson's disease

Item

[A26] Wilson's disease

boolean

C0019202 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Veno-occlusive disease

Item

[A27] Veno-occlusive disease

boolean

C0948441 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Budd-Chiari syndrome

Item

[A28] Budd-Chiari syndrome

boolean

C0856761 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Neoplasia

Item

[A29] Neoplasia

boolean

C1882062 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Other Final Diagnosis

Item

[A99] Other

boolean

C1546485 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Other Final Diagnosis specification

Item

Other, specify:

text

C0011900 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])
C2348235 (UMLS CUI [1,3])

Liver Architecture

Item Group

B. Liver Architecture

C0023884 (UMLS CUI-1)
C0935919 (UMLS CUI-2)
C0193388 (UMLS CUI-3)

Normal Liver Architecture

Item

[B1] normal Liver architecture

boolean

C0023884 (UMLS CUI [1,1])
C0935919 (UMLS CUI [1,2])
C0205307 (UMLS CUI [1,3])
C0193388 (UMLS CUI [1,4])

Bridging fibrosis

Item

[B2] Bridging fibrosis

boolean

C0334160 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Diffuse fibrosis

Item

[B3] Diffuse fibrosis

boolean

C1265984 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Nodular regenerative hyperplasia

Item

[B4] Nodular regenerative hyperplasia

boolean

C0020510 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Congenital hepatic fibrosis

Item

[B5] Congenital hepatic fibrosis

boolean

C0009714 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Cirrhosis

Item

[B6] Cirrhosis

boolean

C0023890 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Centrilobular congestion

Item

[B7] Centrilobular congestion

boolean

C0267821 (UMLS CUI [1,1])
C0442080 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])

Endophlebitis

Item

[B8] Endophlebitis

boolean

C0014234 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Veno-occlusive disease

Item

[B9] Veno-occlusive disease

boolean

C0948441 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Canalicular cholestasis

Item

[B10] Canalicular cholestasis

boolean

C3150342 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Apoptosis

Item

[B11] Apoptosis

boolean

C0162638 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Focal (or spotty or mild) hepatocellular necrosis

Item

[B12] Focal (or spotty or mild) hepatocellular necrosis

boolean

C0267800 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Interface hepatitis

Item

[B13] Interface hepatitis (periportal hepatitis or piecemeal necrosis)

boolean

C0333515 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Ischaemic necrosis

Item

[B14] Ischaemic necrosis

boolean

C3887513 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Centrolobular necrosis

Item

[B15] Centrolobular (Zone 3) necrosis

boolean

C3672032 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Focal coagulative necrosis

Item

[B16] Focal coagulative necrosis

boolean

C1522058 (UMLS CUI [1,1])
C0205234 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])

Centrolobular coagulative necrosis

Item

[B17] Centrolobular (Zone 3) coagulative necrosis

boolean

C1522058 (UMLS CUI [1,1])
C0682619 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])

Bridging hepatocellular necrosis

Item

[B18] Bridging hepatocellular necrosis

boolean

C1855038 (UMLS CUI [1,1])
C0333511 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])

Massive or panlobular hepatocellular necrosis

Item

[B19] Massive or panlobular hepatocellular necrosis

boolean

C1855038 (UMLS CUI [1,1])
C0442131 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])
C0001364 (UMLS CUI [2,1])
C0193388 (UMLS CUI [2,2])

Dysplasia

Item

[B20] Dysplasia

boolean

C0334044 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Neoplasia

Item

[B21] Neoplasia

boolean

C1882062 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Other Liver Architecture

Item

[B99] Other

boolean

C0935919 (UMLS CUI [1,1])
C0426686 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])

Other Liver Architecture specification

Item

Other, specify:

text

C0935919 (UMLS CUI [1,1])
C0426686 (UMLS CUI [1,2])
C2348235 (UMLS CUI [1,3])
C0205394 (UMLS CUI [1,4])
C0193388 (UMLS CUI [1,5])

Description of Liver Cells or Hepatocytes

Item Group

C. Description of Liver Cells or Hepatocytes

C0227525 (UMLS CUI-1)
C0678257 (UMLS CUI-2)

Normal Hepatocytes

Item

[C0] Normal Liver Cells or Hepatocytes

boolean

C0227525 (UMLS CUI [1,1])
C0205307 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])

Ballooning Liver Cells or Hepatocytes

Item

[C1] Ballooning

boolean

C0333445 (UMLS CUI [1,1])
C0227525 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])

Acidophilic Liver Cells or Hepatocytes

Item

[C2] Acidophilic

boolean

C0227525 (UMLS CUI [1,1])
C0333931 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])

Pseudoxanthomatous Liver Cells or Hepatocytes

Item

[C3] Pseudoxanthomatous

boolean

C0227525 (UMLS CUI [1,1])
C3277905 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])

Multinucleated giant hepatocytes

Item

[C4] Multinucleated giant hepatocytes

boolean

C1850414 (UMLS CUI [1,1])
C0227525 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])

Other Liver Cells or Hepatocytes

Item

[C99] Other

boolean

C0227525 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])

Other Liver Cells or Hepatocytes specification

Item

Other, specify:

text

C0227525 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])
C1521902 (UMLS CUI [1,4])

Liver Cell or Hepatocyte Inclusions or Vacuoles

Item Group

D. Liver Cell or Hepatocyte Inclusions or Vacuoles

C0227525 (UMLS CUI-1)
C0042219 (UMLS CUI-2)
C1512693 (UMLS CUI-3)
C0193388 (UMLS CUI-4)

Liver Cell or Hepatocyte No Inclusions

Item

[D0] No Inclusions

boolean

C0227525 (UMLS CUI [1,1])
C1512693 (UMLS CUI [1,2])
C1298908 (UMLS CUI [1,3])
C0193388 (UMLS CUI [1,4])

Macrovesicular steatosis

Item

[D1] Macrovesicular steatosis

boolean

C1837256 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Microvesicular steatosis

Item

[D2] Microvesicular steatosis

boolean

C1850415 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Bile accumulation

Item

[D3] Bile accumulation

boolean

C3686784 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Diastase-resistant, PAS-positive cytoplasmic inclusions

Item

[D4] Diastase-resistant, PAS-positive cytoplasmic inclusions

boolean

C1856311 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Alpha-1-antitrypsin inclusions

Item

[D5] Alpha-1-antitrypsin inclusions

boolean

C0002191 (UMLS CUI [1,1])
C1512693 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])

Megamitochondria

Item

[D6] Megamitochondria

boolean

C0544931 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Mallory bodies

Item

[D7] Mallory bodies

boolean

C0333744 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Ground Glass inclusions

Item

[D8] "Ground Glass" inclusions

boolean

C0598786 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Lipofuscin pigment

Item

[D9] Lipofuscin pigment

boolean

C0023789 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Hemosiderin granules

Item

[D10] Hemosiderin granules

boolean

C0019113 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Orcein-positive cytoplasmin granules

Item

[D11] Orcein-positive cytoplasmin granules

boolean

C0069596 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Protoporphyrin crystals

Item

[D12] Protoporphyrin crystals (birefringent under polarised light)

boolean

C0033733 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Uroporphyrin crystals

Item

[D13] Uroporphyrin crystals (red fluorescence under ultraviolet light)

boolean

C0042093 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Other Liver Cell or Hepatocyte Inclusions or Vacuoles

Item

[D99] Other

boolean

C0227525 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])
C1512693 (UMLS CUI [1,3])
C0193388 (UMLS CUI [1,4])
C0227525 (UMLS CUI [2,1])
C0205394 (UMLS CUI [2,2])
C0042219 (UMLS CUI [2,3])
C0193388 (UMLS CUI [2,4])

Other Liver Cell or Hepatocyte Inclusions or Vacuoles specification

Item

Other, specify:

text

C0227525 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])
C1512693 (UMLS CUI [1,3])
C0193388 (UMLS CUI [1,4])
C1521902 (UMLS CUI [1,5])
C0227525 (UMLS CUI [2,1])
C0205394 (UMLS CUI [2,2])
C0042219 (UMLS CUI [2,3])
C0193388 (UMLS CUI [2,4])
C1521902 (UMLS CUI [2,5])

Hepatocyte or Liver Cell Nuclear Abnormalities

Item Group

E. Hepatocyte or Liver Cell Nuclear Abnormalities

C0227525 (UMLS CUI-1)
C1849376 (UMLS CUI-2)
C0193388 (UMLS CUI-3)

Hepatocyte or Liver Cell No Nuclear Abnormalities

Item

[E0] None

text

C0227525 (UMLS CUI [1,1])
C1749565 (UMLS CUI [1,2])
C0205307 (UMLS CUI [1,3])
C0193388 (UMLS CUI [1,4])

Hepatocyte or Liver Cell Nuclear Abnormalities

Code List

[E0] None

Hepatocellular mitosis

Item

[E1] Hepatocellular mitosis

boolean

C2697585 (UMLS CUI [1,1])
C0026255 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])

Binucleated or multinucleated hepatocytes

Item

[E2] Binucleated or multinucleated hepatocytes

boolean

C0227525 (UMLS CUI [1,1])
C0333909 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])
C4054455 (UMLS CUI [2,1])
C0193388 (UMLS CUI [2,2])

CMV inclusion bodies

Item

[E3] CMV inclusion bodies

boolean

C0582172 (UMLS CUI [1,1])
C1366904 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])

HSV inclusions

Item

[E4] HSV inclusions

boolean

C0319232 (UMLS CUI [1])

Varicella inclusions

Item

[E5] Varicella inclusions

boolean

C0740380 (UMLS CUI [1,1])
C1366904 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])

Other Hepatocyte or Liver Cell Nuclear Abnormalities

Item

[E99] Other

boolean

C0227525 (UMLS CUI [1,1])
C1849376 (UMLS CUI [1,2])
C0205394 (UMLS CUI [1,3])
C0193388 (UMLS CUI [1,4])

Other Hepatocyte or Liver Cell Nuclear Abnormalities specification

Item

Other, specify:

text

C0227525 (UMLS CUI [1,1])
C1849376 (UMLS CUI [1,2])
C0205394 (UMLS CUI [1,3])
C0193388 (UMLS CUI [1,4])
C1521902 (UMLS CUI [1,5])

Liver or Lobular Infiltrates

Item Group

F. Liver or Lobular Infiltrates

C1400896 (UMLS CUI-1)
C0193388 (UMLS CUI-2)

No Liver Infiltrates

Item

[F0] None

boolean

C1400896 (UMLS CUI [1,1])
C1298908 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])

Liver or Lobular Infiltrates Eosinophils

Item

[F1] Eosinophils

boolean

C0014467 (UMLS CUI [1,1])
C1400896 (UMLS CUI [1,2])
C0205417 (UMLS CUI [1,3])
C0193388 (UMLS CUI [1,4])

Liver or Lobular Infiltrates Lymphocytes

Item

[F2] Lymphocytes

boolean

C0024264 (UMLS CUI [1,1])
C1400896 (UMLS CUI [1,2])
C0205417 (UMLS CUI [1,3])
C0193388 (UMLS CUI [1,4])

Liver or Lobular Infiltrates Plasma cells

Item

[F3] Plasma cells

boolean

C0032112 (UMLS CUI [1,1])
C1400896 (UMLS CUI [1,2])
C0205417 (UMLS CUI [1,3])
C0193388 (UMLS CUI [1,4])

Liver or Lobular Infiltrates Neutrophils

Item

[F4] Neutrophils

boolean

C0027950 (UMLS CUI [1,1])
C1400896 (UMLS CUI [1,2])
C0205417 (UMLS CUI [1,3])
C0193388 (UMLS CUI [1,4])

Liver or Lobular Infiltrates Macrophages and proliferating Kupffer cells

Item

[F5] Macrophages and proliferating Kupffer cells

boolean

C0022801 (UMLS CUI [1,1])
C1400896 (UMLS CUI [1,2])
C0205417 (UMLS CUI [1,3])
C0193388 (UMLS CUI [1,4])

Liver or Lobular Infiltrates Granulomas

Item

[F6] Granulomas

boolean

C0745754 (UMLS CUI [1,1])
C1400896 (UMLS CUI [1,2])
C0205417 (UMLS CUI [1,3])
C0193388 (UMLS CUI [1,4])

Other Liver or Lobular Infiltrates

Item

[F99] Other

boolean

C0205394 (UMLS CUI [1,1])
C1400896 (UMLS CUI [1,2])
C0205417 (UMLS CUI [1,3])
C0193388 (UMLS CUI [1,4])

Other Liver or Lobular Infiltrates specification

Item

Other, specify:

text

C0205394 (UMLS CUI [1,1])
C1400896 (UMLS CUI [1,2])
C0205417 (UMLS CUI [1,3])
C0193388 (UMLS CUI [1,4])
C1521902 (UMLS CUI [1,5])

Portal Tract Inflammation

Item Group

G. Portal Tract Inflammation

C3854488 (UMLS CUI-1)
C0193388 (UMLS CUI-2)

No Portal Tract Inflammation

Item

[G0] None

boolean

C3854488 (UMLS CUI [1,1])
C1298908 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])

Portal Tract Inflammation Eosinophils

Item

[G1] Eosinophils

boolean

C0014467 (UMLS CUI [1,1])
C3854488 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])

Portal Tract Inflammation Lymphoid aggregates and/or follicles

Item

[G2] Lymphoid aggregates and/or follicles

boolean

C3854488 (UMLS CUI [1,1])
C0229653 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])

Portal Tract Inflammation Plasma cells

Item

[G3] Plasma cells

boolean

C3854488 (UMLS CUI [1,1])
C0032112 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])

Portal Tract Inflammation Neutrophils

Item

[G4] Neutrophils

boolean

C3854488 (UMLS CUI [1,1])
C0027950 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])

Portal Tract Inflammation Histocytes and macrophages

Item

[G5] Histocytes and macrophages

boolean

C3854488 (UMLS CUI [1,1])
C0024432 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])
C3854488 (UMLS CUI [2,1])
C0019612 (UMLS CUI [2,2])
C0193388 (UMLS CUI [2,3])

Other Portal Tract Inflammation

Item

[G99] Other

boolean

C3854488 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])

Other Portal Tract Inflammation specification

Item

Other, specify:

text

C3854488 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])
C3845569 (UMLS CUI [1,4])

Bile Ducts

Item Group

H. Bile Ducts

C0005400 (UMLS CUI-1)
C0193388 (UMLS CUI-2)

Normal Bile Ducts

Item

[H0] Normal

boolean

C0005400 (UMLS CUI [1,1])
C0205307 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])

Proliferation of bile ducts

Item

[H1] Proliferation of bile ducts (bile ductular reaction)

boolean

C0005400 (UMLS CUI [1,1])
C0334094 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])

Dilation, degeneration or disruption of portal bile ducts

Item

[H2] Dilation, degeneration or disruption of portal bile ducts

boolean

C0005400 (UMLS CUI [1,1])
C0011164 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])
C1849767 (UMLS CUI [2,1])
C0193388 (UMLS CUI [2,2])
C0005400 (UMLS CUI [3,1])
C0332453 (UMLS CUI [3,2])
C0193388 (UMLS CUI [3,3])

Paucity of bile ducts

Item

[H3] Paucity of bile ducts

boolean

C4273160 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Periductal fibrosis

Item

[H4] Periductal fibrosis

boolean

C0016059 (UMLS CUI [1,1])
C0005400 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])

Bile ducts Other

Item

[H99] Other

boolean

C0205394 (UMLS CUI [1,1])
C0005400 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])

Bile ducts Other specification

Item

Other, specify

text

C0205394 (UMLS CUI [1,1])
C0005400 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])
C1521902 (UMLS CUI [1,4])

Portal Veins

Item Group

I. Portal Veins

C0032718 (UMLS CUI-1)
C0193388 (UMLS CUI-2)

Normal Portal Veins

Item

[I0] Normal

boolean

C0032718 (UMLS CUI [1,1])
C0205307 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])

Pyelophlebitis

Item

[I1] Pyelophlebitis

boolean

C1405883 (UMLS CUI [1,1])
C0032718 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])

Thrombosis, sclerosis or occlusion of portal vein

Item

[I2] Thrombosis, sclerosis or occlusion of portal vein

boolean

C0155773 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])
C0400960 (UMLS CUI [2,1])
C0193388 (UMLS CUI [2,2])
C0265029 (UMLS CUI [3,1])
C0193388 (UMLS CUI [3,2])

Neoplastic invasion of portal vein

Item

[I3] Neoplastic invasion of portal vein

boolean

C1709160 (UMLS CUI [1,1])
C1510886 (UMLS CUI [1,2])
C0032718 (UMLS CUI [1,3])
C0193388 (UMLS CUI [1,4])

Granulomatous compression of portal vein

Item

[I4] Granulomatous compression of portal vein

boolean

C0032718 (UMLS CUI [1,1])
C0439667 (UMLS CUI [1,2])
C0728907 (UMLS CUI [1,3])
C0193388 (UMLS CUI [1,4])

Portal veins Other

Item

[I99] Other

boolean

C0032718 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])

Portal veins Other specification

Item

Other, specify:

text

C0032718 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])
C1521902 (UMLS CUI [1,3])

Liver Infections

Item Group

J. Liver Infections

C1112211 (UMLS CUI-1)
C0193388 (UMLS CUI-2)

No Liver Infections

Item

[J0] Normal

boolean

C1112211 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Leishmaniasis donovani

Item

[J1] Leishmaniasis donovani

boolean

C0023273 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Plasmodium falciparum

Item

[J2] Plasmodium falciparum

boolean

C0032150 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Toxoplasmosis

Item

[J3] Toxoplasmosis

boolean

C0040558 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Cryptococcus neoformans

Item

[J4] Cryptococcus neoformans

boolean

C0010416 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Histoplasma capsulatum

Item

[J5] Histoplasma capsulatum

boolean

C0319941 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Mycobacterium tuberculois

Item

[J6] Mycobacterium tuberculois

boolean

C0026926 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Other mycobacterial species

Item

[J7] Other mycobacterial species

boolean

C0026918 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])

Other Liver Infections

Item

[J99] Other

boolean

C1112211 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])

Other Liver Infections specification

Item

Other, specify:

text

C1112211 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])
C2348235 (UMLS CUI [1,4])

Parasites or Ova

Item Group

K. Parasites or Ova

C0030498 (UMLS CUI-1)
C1267673 (UMLS CUI-2)
C0193388 (UMLS CUI-3)

No Parasites or Ova

Item

[K0] None

boolean

C0030498 (UMLS CUI [1,1])
C1298908 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])
C1267673 (UMLS CUI [2,1])
C1298908 (UMLS CUI [2,2])
C0193388 (UMLS CUI [2,3])

Schistosome and/or ova

Item

[K1] Schistosome and/or ova

boolean

C0036315 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])
C4303012 (UMLS CUI [2,1])
C0193388 (UMLS CUI [2,2])

Ascaris and/or ova

Item

[K2] Ascaris and/or ova

boolean

C3698183 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])
C0003954 (UMLS CUI [2,1])
C0193388 (UMLS CUI [2,2])

Toxocara and/or ova

Item

[K3] Toxocara and/or ova

boolean

C0040550 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])
C0040550 (UMLS CUI [2,1])
C1267673 (UMLS CUI [2,2])
C0193388 (UMLS CUI [2,3])

Echinococcus cysts

Item

[K4] Echinococcus cysts

boolean

C0013502 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Hepatic capillariasis worms and/or ova

Item

[K5] Hepatic capillariasis worms and/or ova

boolean

C0277202 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])
C0006896 (UMLS CUI [2,1])
C1267673 (UMLS CUI [2,2])
C0193388 (UMLS CUI [2,3])

Other Parasites or Ova

Item

[K99] Other

boolean

C1267673 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])
C0030498 (UMLS CUI [2,1])
C0205394 (UMLS CUI [2,2])
C0193388 (UMLS CUI [2,3])

Other Parasites or Ova specification

Item

Other, specify:

text

C1267673 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])
C2348235 (UMLS CUI [1,4])
C0030498 (UMLS CUI [2,1])
C0205394 (UMLS CUI [2,2])
C0193388 (UMLS CUI [2,3])
C2348235 (UMLS CUI [2,4])

Histologic Staining or Additional Studies Obtained

Item Group

L. Histologic Staining or Additional Studies Obtained

C0487602 (UMLS CUI-1)
C0430022 (UMLS CUI-2)
C0023884 (UMLS CUI-3)
C0193388 (UMLS CUI-4)

Haematoxylin and eosin

Item

[L1] Haematoxylin and eosin (or H & E)

boolean

C0523207 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Masson

Item

[L2] Masson

boolean

C1294297 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Toluidine blue or Giemsa

Item

[L3] Toluidine blue or Giemsa

boolean

C0523203 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])
C0017542 (UMLS CUI [2,1])
C0193388 (UMLS CUI [2,2])

Prussian blue

Item

[L4] Prussian blue

boolean

C1294004 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Periodic Acidic Schiff with or without diastase

Item

[L5] Periodic Acidic Schiff (PAS), with or without diastase

boolean

C0440048 (UMLS CUI [1,1])
C0596624 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])

Oil red O

Item

[L6] Oil red O

boolean

C1294000 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Congo red

Item

[L7] Congo red

boolean

C0009742 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Hall's stain

Item

[L8] Hall's stain

boolean

C1720394 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Gridley's stain

Item

[L9] Gridley's stain

boolean

C1293978 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Rhodanine

Item

[L10] Rhodanine (copper)

boolean

C0035486 (UMLS CUI [1,1])
C0009968 (UMLS CUI [1,2])
C0487602 (UMLS CUI [1,3])
C0193388 (UMLS CUI [1,4])

Rubeanic acid

Item

[L11] Rubeanic acid (copper)

boolean

C0073680 (UMLS CUI [1,1])
C0009968 (UMLS CUI [1,2])
C0487602 (UMLS CUI [1,3])
C0193388 (UMLS CUI [1,4])

Orcein, aldehyde fuchsin or Victoria blue

Item

[L12] Orcein, aldehyde fuchsin or Victoria blue

boolean

C1294001 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])
C0491984 (UMLS CUI [2,1])
C0193388 (UMLS CUI [2,2])
C0078232 (UMLS CUI [3,1])
C0487602 (UMLS CUI [3,2])
C0193388 (UMLS CUI [3,3])

Electron microscopy

Item

[L13] Electron microscopy

boolean

C0026019 (UMLS CUI [1,1])
C0193388 (UMLS CUI [1,2])

Hepatitis A immunostains positive

Item

[L14] Hepatitis A immunostains positive

boolean

C0560226 (UMLS CUI [1,1])
C3687908 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])

Hepatitis B core antigen or hepatitis B surface antibody immunostains positive

Item

[L15] Hepatitis B core antigen or hepatitis B surface antibody immunostains positive

boolean

C0019166 (UMLS CUI [1,1])
C3687908 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])
C0369334 (UMLS CUI [2,1])
C3687908 (UMLS CUI [2,2])
C0193388 (UMLS CUI [2,3])

Hepatitis D immunostains

Item

[L16] Hepatitis D immunostains

boolean

C0011226 (UMLS CUI [1,1])
C3687908 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])

Other immunostains

Item

[L17] Other immunostains

boolean

C3687908 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])

Other Histologic Staining or Additional Studies Obtained

Item

[L99] Other

boolean

C0487602 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])

Other Histologic Staining or Additional Studies Obtained specification

Item

Other, specify:

text

C0487602 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])
C2348235 (UMLS CUI [1,4])

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Effects of D3 antagonist GSK598809 on neural and behavioural responses to food reward/reinforcement after a single dose in overweight/obese subjects NCT01039454

Liver Biopsy

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