Description:

Study Comparing Imatinib With Chemotherapy as Induction in Elderly Patients With Philadelphia Positive Acute Lymphoblastic Leukemia (ALL); ODM derived from: https://clinicaltrials.gov/show/NCT00199186

Link:

https://clinicaltrials.gov/show/NCT00199186

Keywords:
Versions (1) ▾
  1. 7/31/17
Uploaded on:

July 31, 2017

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License:
Creative Commons BY-NC 3.0
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Eligibility Philadelphia Positive Acute Lymphoblastic Leukemia NCT00199186

Eligibility Philadelphia Positive Acute Lymphoblastic Leukemia NCT00199186

Inclusion Criteria
male or female patients
age > 55 years (biological age)
diagnosis of ph1 chromosome-positive all (pre-b, common- or pre-pre-b all)
newly diagnosed, lymphoid blast crisis of chronic myeloid leukemia
only pre-phase chemotherapy prior to study start
world health organization (who) status 0, 1 or 2
voluntary written informed consent
Exclusion Criteria
creatinine levels more than 2 x the upper limit of normal (uln)
total serum bilirubin more than 1.5 x the uln
ast (sgot) or alt (sgpt) more than 5 x the uln
any other prior antineoplastic treatment except for pre-phase chemotherapy
active central nervous system (cns) leukemia
new york heart association (nyha) grade 3/4 cardiac disease
active severe infection
serious concomitant medical condition
patients with a history of non-compliance to medical regimens