ID

22109

Description

The present pharmacokinetic study is designed to assess the pharmacokinetics of RSG XR as monotherapy in patients with mild Alzheimer's disease (AD) as such information will not be obtained from the current phase III trials . The study aims to enroll fourteen patients (seven of each APOE genotype). Each patient will receive a single oral dose of 4mg of RSG XR in the morning under fasted conditions and PK samples will be taken up to 36h. Same Timeslicing as Screening Clinical Chemistry. To be sourced from Lab normal range. GSK Source & Descriptions: https://clinicaltrials.gov/ct2/show/NCT00688207?term=NCT00688207&rank=1

Link

https://clinicaltrials.gov/ct2/show/NCT00688207?term=NCT00688207&rank=1

Keywords

Versions (2)
  1. 5/8/17 5/8/17 -
  2. 5/20/17 5/20/17 -
Uploaded on

May 20, 2017

DOI

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License

Creative Commons BY-NC 3.0
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Screening Clinical Chemistry 2 Mild Alzheimer's Disease to Assess the of Extended Release Formulation of Rosiglitazone NCT00688207 / GSK-AVA109941

English

Screening Clinical Chemistry 2 Mild Alzheimer's Disease to Assess the of Extended Release Formulation of Rosiglitazone NCT00688207 / GSK-AVA109941

1 forms  
Laboratory result data (Clinical Chemistry)
Description

Laboratory result data (Clinical Chemistry)

Alias
UMLS CUI-1
C2826772
UMLS CUI-2
C0008000
Date and time of specimen collection
Description

Specimen collection

Data type

datetime

Alias
UMLS CUI [1,1]
C0200345
UMLS CUI [1,2]
C0008000
Has the subject fasted?
Description

Fasting

Data type

boolean

Alias
UMLS CUI [1,1]
C0015663
UMLS CUI [1,2]
C0008000
Clinical Chemistry Test Result
Description

Clinical Chemistry Test Result

Alias
UMLS CUI-1
C0008000
UMLS CUI-2
C2826772
BUN
Description

BUN

Data type

float

Alias
UMLS CUI [1]
C0005845
Creatinine
Description

Creatinine

Data type

float

Alias
UMLS CUI [1]
C0201976
Glucose, fasting
Description

Glucose

Data type

float

Alias
UMLS CUI [1,1]
C0017725
UMLS CUI [1,2]
C0008000
Sodium
Description

Sodium

Data type

float

Alias
UMLS CUI [1]
C0337443
Potassium
Description

Potassium

Data type

float

Alias
UMLS CUI [1]
C0202194
Chloride
Description

Chloride

Data type

float

Alias
UMLS CUI [1]
C0201952
Calcium
Description

Calcium

Data type

float

Alias
UMLS CUI [1]
C0201925
AST (SGOT)
Description

AST

Data type

float

Alias
UMLS CUI [1]
C0201899
ALT (SGPT)
Description

ALT

Data type

float

Alias
UMLS CUI [1]
C0201836
GGT
Description

GGT

Data type

float

Alias
UMLS CUI [1]
C0202035
Alkaline Phosphatase
Description

Alkaline Phosphatase

Data type

float

Alias
UMLS CUI [1]
C0201850
Total Bilirubin
Description

Total Bilirubin

Data type

float

Alias
UMLS CUI [1]
C0201913
Direct Bilirubin
Description

Direct Bilirubin

Data type

float

Alias
UMLS CUI [1]
C0201916
Uric acid
Description

Uric acid

Data type

float

Alias
UMLS CUI [1,1]
C0041980
UMLS CUI [1,2]
C0008000
Albumin
Description

Albumin

Data type

float

Alias
UMLS CUI [1]
C0201838
Total Protein
Description

Total Protein

Data type

float

Alias
UMLS CUI [1]
C0555903
FSH
Description

FSH

Data type

float

Alias
UMLS CUI [1]
C0202022
Estradiol
Description

Estradiol

Data type

float

Alias
UMLS CUI [1,1]
C0014912
UMLS CUI [1,2]
C0008000
Vitamin B 12
Description

Vitamin B 12 measurement

Data type

float

Alias
UMLS CUI [1]
C0202252
Thyroid-Stimulating Hormone (TSH)
Description

Thyroid Stimulating Hormone

Data type

float

Alias
UMLS CUI [1]
C0202230
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Similar models

Screening Clinical Chemistry 2 Mild Alzheimer's Disease to Assess the of Extended Release Formulation of Rosiglitazone NCT00688207 / GSK-AVA109941

1 forms
Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
Item Group
Laboratory result data (Clinical Chemistry)
C2826772 (UMLS CUI-1)
C0008000 (UMLS CUI-2)
Specimen collection
Item
Date and time of specimen collection
datetime
C0200345 (UMLS CUI [1,1])
C0008000 (UMLS CUI [1,2])
Fasting
Item
Has the subject fasted?
boolean
C0015663 (UMLS CUI [1,1])
C0008000 (UMLS CUI [1,2])
Item Group
Clinical Chemistry Test Result
C0008000 (UMLS CUI-1)
C2826772 (UMLS CUI-2)
BUN
Item
BUN
float
C0005845 (UMLS CUI [1])
Creatinine
Item
Creatinine
float
C0201976 (UMLS CUI [1])
Glucose
Item
Glucose, fasting
float
C0017725 (UMLS CUI [1,1])
C0008000 (UMLS CUI [1,2])
Sodium
Item
Sodium
float
C0337443 (UMLS CUI [1])
Potassium
Item
Potassium
float
C0202194 (UMLS CUI [1])
Chloride
Item
Chloride
float
C0201952 (UMLS CUI [1])
Calcium
Item
Calcium
float
C0201925 (UMLS CUI [1])
AST
Item
AST (SGOT)
float
C0201899 (UMLS CUI [1])
ALT
Item
ALT (SGPT)
float
C0201836 (UMLS CUI [1])
GGT
Item
GGT
float
C0202035 (UMLS CUI [1])
Alkaline Phosphatase
Item
Alkaline Phosphatase
float
C0201850 (UMLS CUI [1])
Total Bilirubin
Item
Total Bilirubin
float
C0201913 (UMLS CUI [1])
Direct Bilirubin
Item
Direct Bilirubin
float
C0201916 (UMLS CUI [1])
Uric acid
Item
Uric acid
float
C0041980 (UMLS CUI [1,1])
C0008000 (UMLS CUI [1,2])
Albumin
Item
Albumin
float
C0201838 (UMLS CUI [1])
Total Protein
Item
Total Protein
float
C0555903 (UMLS CUI [1])
FSH
Item
FSH
float
C0202022 (UMLS CUI [1])
Estradiol
Item
Estradiol
float
C0014912 (UMLS CUI [1,1])
C0008000 (UMLS CUI [1,2])
Vitamin B 12 measurement
Item
Vitamin B 12
float
C0202252 (UMLS CUI [1])
Thyroid Stimulating Hormone
Item
Thyroid-Stimulating Hormone (TSH)
float
C0202230 (UMLS CUI [1])
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