pilot: the pilot study will enroll two groups of individuals: 1) patients who have either ipah or a secondary form known to have similar histopathology (pah), and 2) age, gender, and race matched control subjects for each patient.

boolean

C0031928 (UMLS CUI [1])
C0152171 (UMLS CUI [2])
C2973725 (UMLS CUI [3])
C0001779 (UMLS CUI [4])
C0079399 (UMLS CUI [5])
C0034510 (UMLS CUI [6])

Item

main: the main study will enroll three groups of individuals: 1) patients who have either ipah or a secondary form known to have similar histopathology (pah), 2) patients with ph ascribed to a nonvascular injury process, and 3) age, gender, and race matched control subjects for each pah patient. subjects must be at least 18 years of age and must be able to provide informed, written consent for participation in this study. there is no exclusion based on race or gender.

boolean

C0008976 (UMLS CUI [1,1])
C1542147 (UMLS CUI [1,2])
C0152171 (UMLS CUI [2])
C2973725 (UMLS CUI [3])
C0020542 (UMLS CUI [4,1])
C0332281 (UMLS CUI [4,2])
C0178324 (UMLS CUI [4,3])
C0001779 (UMLS CUI [5])
C0079399 (UMLS CUI [6])
C0034510 (UMLS CUI [7])
C0021430 (UMLS CUI [8])

Inclusion criteria Pulmonary arterial hypertension

Item

inclusion criteria for pulmonary arterial hypertension patients:

boolean

C1512693 (UMLS CUI [1,1])
C2973725 (UMLS CUI [1,2])

Inclusion criteria

Item

the inclusion criteria for this study are as follows:

boolean

C1512693 (UMLS CUI [1])

Idiopathic pulmonary hypertension

Item

1. patients diagnosed with ipah

boolean

C0152171 (UMLS CUI [1])

Secondary pulmonary hypertension | Histopathology Similar Pulmonary Hypertension | Histopathology Similar Pulmonary arterial hypertension

Item

2. patients diagnosed with secondary pulmonary hypertension known to have histopathology similar to the primary form or pah. clinical conditions causing pulmonary hypertension with histopathology similar to the primary form are listed below.

boolean

C0264936 (UMLS CUI [1])
C0428093 (UMLS CUI [2,1])
C2348205 (UMLS CUI [2,2])
C0020542 (UMLS CUI [2,3])
C0428093 (UMLS CUI [3,1])
C2348205 (UMLS CUI [3,2])
C2973725 (UMLS CUI [3,3])

Eisenmenger Complex

Item

i. eisenmenger syndrome

boolean

C0013743 (UMLS CUI [1])

Collagen-vascular disease

Item

ii. collagen vascular disease

boolean

C0262428 (UMLS CUI [1])

Liver disease | Portal Hypertension

Item

iii liver disease with portal hypertension

boolean

C0023895 (UMLS CUI [1])
C0020541 (UMLS CUI [2])

Injury caused by Toxin | Appetite Depressants | Brassica Napus Oil

Item

iv. toxin induced injury (anorexic agents, rapeseed oil)

boolean

C3263723 (UMLS CUI [1,1])
C0015127 (UMLS CUI [1,2])
C0040549 (UMLS CUI [1,3])
C0003620 (UMLS CUI [2])
C0072982 (UMLS CUI [3])

HIV Infection

Item

v. hiv disease

boolean

C0019693 (UMLS CUI [1])

Anemia, Sickle Cell

Item

vi. sickle cell disease

boolean

C0002895 (UMLS CUI [1])

Exclusion Criteria Pulmonary arterial hypertension

Item

exclusion criteria for patients with pulmonary arterial hypertension:

boolean

C0680251 (UMLS CUI [1,1])
C2973725 (UMLS CUI [1,2])

Pregnancy | Childbearing Potential Urine pregnancy test | Childbearing Potential pregnancy blood test

Item

1. pregnant women (all women of childbearing age will be required to have a screening urine or blood pregnancy test)

boolean

C0032961 (UMLS CUI [1])
C3831118 (UMLS CUI [2,1])
C0430056 (UMLS CUI [2,2])
C3831118 (UMLS CUI [3,1])
C0850355 (UMLS CUI [3,2])

Age

Item

2. age less than 18 years

boolean

C0001779 (UMLS CUI [1])

Informed Consent Unable

Item

3. inability to provide informed written consent for participation in the study

boolean

C0021430 (UMLS CUI [1,1])
C1299582 (UMLS CUI [1,2])

Mean pulmonary arterial pressure | Pulmonary Vascular Resistance

Item

4. mean pa less than or equal to 25mmhg or pvr less than 3 wood units

boolean

C3854605 (UMLS CUI [1])
C0456261 (UMLS CUI [2])

Pulmonary Capillary Wedge Pressure | Increased pulmonary arterial wedge pressure

Item

5. pcw greater than 16 mmhg unless increase accounted for by increased transpulmonary gradient greater than or equal to 10 mmhg

boolean

C0086879 (UMLS CUI [1])
C0520850 (UMLS CUI [2])

Oral administration of treatment | Intravenous therapy

Item

6. patients receiving more than 1 year of oral therapy or more than 6 months of iv therapy.

boolean

C1273553 (UMLS CUI [1])
C0455142 (UMLS CUI [2])

Inclusion criteria Pulmonary Hypertension caused by Vascular System Injuries

Item

inclusion criteria for patients with nonvascular injury-induced pulmonary hypertension:

boolean

C1512693 (UMLS CUI [1,1])
C0020542 (UMLS CUI [1,2])
C0015127 (UMLS CUI [1,3])
C0178324 (UMLS CUI [1,4])

Inclusion criteria

Item

the inclusion criteria are as follows:

boolean

C1512693 (UMLS CUI [1])

Secondary pulmonary hypertension | Histopathology Similar Pulmonary Hypertension | Etiology aspects

Item

patients diagnosed with pulmonary hypertension not known to have histopathology similar to the primary form. etiologies are listed below.

boolean

C0264936 (UMLS CUI [1])
C0428093 (UMLS CUI [2,1])
C2348205 (UMLS CUI [2,2])
C0020542 (UMLS CUI [2,3])
C0015127 (UMLS CUI [3])

Valvular disease | Cardiomyopathies

Item

1. congenital or acquired valvular or myocardial disease

boolean

C3258293 (UMLS CUI [1])
C0878544 (UMLS CUI [2])

Lung Diseases, Parasitic

Item

2. pulmonary parasitic diseases

boolean

C0024118 (UMLS CUI [1])

Hypoxemia | Hypercapnia

Item

3. arterial hypoxemia with hypercapnea

boolean

C0700292 (UMLS CUI [1])
C0020440 (UMLS CUI [2])

Chronic Obstructive Airway Disease | Hypoxemia | FEV1/FVC ratio abnormal

Item

4. copd with hypoxemia and forced expiratory volume/forced vital capacity (fev1/fvc) greater than 2 standard deviations from normal

boolean

C0024117 (UMLS CUI [1])
C0700292 (UMLS CUI [2])
C0438193 (UMLS CUI [3])

Lung Diseases, Interstitial | Decreased total lung capacity | Plain chest X-ray Infiltration

Item

5. interstitial lung disease with reduced total lung capacity greater than 2 standard deviations from normal and infiltrates on chest x-ray

boolean

C0206062 (UMLS CUI [1])
C0520829 (UMLS CUI [2])
C0039985 (UMLS CUI [3,1])
C0332448 (UMLS CUI [3,2])

Thromboembolism Pulmonary Evidence | Lung Perfusion Scan | Pulmonary angiogram | Intravenous Drug Abuse

Item

6. pulmonary thromboembolic disease as evidenced by lung perfusion scan or pulmonary angiogram, or intravenous drug abuse

boolean

C0040038 (UMLS CUI [1,1])
C2709248 (UMLS CUI [1,2])
C3887511 (UMLS CUI [1,3])
C1518040 (UMLS CUI [2])
C0677490 (UMLS CUI [3])
C0086181 (UMLS CUI [4])

Pulmonary Hypertension Due to Lung Congenital Abnormality | Pulmonary Hypertension Due to Chest Congenital Abnormality | Pulmonary Hypertension Due to Diaphragm Congenital Abnormality

Item

7. pulmonary hypertension due to congenital abnormalities of the lungs, thorax and diaphragm

boolean

C0020542 (UMLS CUI [1,1])
C0678226 (UMLS CUI [1,2])
C0024109 (UMLS CUI [1,3])
C0000768 (UMLS CUI [1,4])
C0020542 (UMLS CUI [2,1])
C0678226 (UMLS CUI [2,2])
C0817096 (UMLS CUI [2,3])
C0000768 (UMLS CUI [2,4])
C0020542 (UMLS CUI [3,1])
C0678226 (UMLS CUI [3,2])
C0011980 (UMLS CUI [3,3])
C0000768 (UMLS CUI [3,4])

Exclusion Criteria Pulmonary Hypertension caused by Vascular System Injuries

Item

exclusion criteria for patients with nonvascular injury induced pulmonary hypertension:

boolean

C0680251 (UMLS CUI [1,1])
C0020542 (UMLS CUI [1,2])
C0015127 (UMLS CUI [1,3])
C0178324 (UMLS CUI [1,4])

Pregnancy | Childbearing Potential Urine pregnancy test | Childbearing Potential pregnancy blood test

Item

1. pregnant women (all women of childbearing age will be required to have a screening urine or blood pregnancy test)

boolean

C0032961 (UMLS CUI [1])
C3831118 (UMLS CUI [2,1])
C0430056 (UMLS CUI [2,2])
C3831118 (UMLS CUI [3,1])
C0850355 (UMLS CUI [3,2])

Age

Item

2. age less than 18 years

boolean

C0001779 (UMLS CUI [1])

Informed Consent Unable

Item

3. inability to provide informed written consent for participation in the study

boolean

C0021430 (UMLS CUI [1,1])
C1299582 (UMLS CUI [1,2])

Mean pulmonary arterial pressure | Pulmonary Vascular Resistance

Item

4. mean pa less than or equal to 25mmhg or pvr less than 3 wood units

boolean

C3854605 (UMLS CUI [1])
C0456261 (UMLS CUI [2])

Exclusion Criteria MRI Pulmonary Hypertension

Item

exclusion criteria for mri in subjects with pulmonary hypertension:

boolean

C0680251 (UMLS CUI [1,1])
C0024485 (UMLS CUI [1,2])
C0020542 (UMLS CUI [1,3])

pacemaker implanted | defibrillator implanted

Item

1) implanted cardiac pacemaker or defibrillator

boolean

C0848753 (UMLS CUI [1])
C0850291 (UMLS CUI [2])

Aneurysm clip Central Nervous System

Item

2) central nervous system aneurysm clips

boolean

C0179977 (UMLS CUI [1,1])
C3714787 (UMLS CUI [1,2])

Cochlear Implants

Item

3) cochlear implants

boolean

C0009199 (UMLS CUI [1])

Neurostimulator

Item

4) neural stimulator

boolean

C0582124 (UMLS CUI [1])

Ocular Foreign Body

Item

5) ocular foreign body (e.g. metal shavings)

boolean

C3898107 (UMLS CUI [1])

Insulin pump

Item

6) insulin pump

boolean

C1140609 (UMLS CUI [1])

Shrapnel | Bullet

Item

7) metal shrapnel or bullets

boolean

C0522670 (UMLS CUI [1])
C0336699 (UMLS CUI [2])

Claustrophobia

Item

8) claustrophobia.

boolean

C0008909 (UMLS CUI [1])

Involvement with Magnetic resonance imaging contrast media

Item

furthermore, the following patient groups will be excluded from studies involving the administration of mri contrast agents:

boolean

C1314939 (UMLS CUI [1,1])
C0180108 (UMLS CUI [1,2])

Breast Feeding

Item

1) lactating women

boolean

C0006147 (UMLS CUI [1])

Kidney Diseases | Creatinine clearance measurement

Item

2) renal disease (crcl less than 20 ml/min)

boolean

C0022658 (UMLS CUI [1])
C0373595 (UMLS CUI [2])

Estimation of creatinine clearance by Cockcroft-Gault formula | Kidney Diseases | Renal Insufficiency | Creatinine measurement | Gadolinium Receive

Item

the creatinine clearance (crcl) will be calculated using the cockroft formula where age is in years, kg is weight in kilograms, and cr is the serum creatinine. if there is no history of kidney disease from the patient or referring physician, additional testing will not be performed. if a patient has a history of renal insufficiency, a recent blood cr will be used unless the physician performing the test believes the cr may have changed since the last test. if the cr may have changed, a blood sample will be obtained for cr or the subject will be excluded from receiving gadolinium.

boolean

C2711451 (UMLS CUI [1])
C0022658 (UMLS CUI [2])
C1565489 (UMLS CUI [3])
C0201975 (UMLS CUI [4])
C0016911 (UMLS CUI [5,1])
C1514756 (UMLS CUI [5,2])

Creatinine clearance | Age | Body Weight | Serum creatinine | Gender

Item

crcl = (140-age) (wt in kg)/72 x serum cr (mg/dl) for men

boolean

C0812399 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
C0005910 (UMLS CUI [3])
C0600061 (UMLS CUI [4])
C0079399 (UMLS CUI [5])

Creatinine clearance | Age | Body Weight | Serum creatinine | Gender

Item

crcl = (0.85) (140-age) (kg)/72 x serum cr (mg/dl) for women

boolean

C0812399 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
C0005910 (UMLS CUI [3])
C0600061 (UMLS CUI [4])
C0079399 (UMLS CUI [5])

Inclusion criteria Control Group

Item

inclusion criteria for control subjects:

boolean

C1512693 (UMLS CUI [1,1])
C0009932 (UMLS CUI [1,2])

Healthy Volunteers | Age | Racial group | Gender | Pulmonary arterial hypertension

Item

1. any healthy man or woman who is the appropriate age, race, and gender for matching to a pah patient

boolean

C1708335 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
C0034510 (UMLS CUI [3])
C0079399 (UMLS CUI [4])
C2973725 (UMLS CUI [5])

HIV Infections

Item

2. no history of hiv infection

boolean

C0019693 (UMLS CUI [1])

Heart Disease Relevant Clinical Evidence | Electrocardiography | Echocardiography

Item

3. ekg and echocardiogram with no evidence of clinically relevant heart disease

boolean

C0018799 (UMLS CUI [1,1])
C2347946 (UMLS CUI [1,2])
C0205210 (UMLS CUI [1,3])
C3887511 (UMLS CUI [1,4])
C1623258 (UMLS CUI [2])
C0013516 (UMLS CUI [3])

Lung disease Relevant Clinical Evidence | Spirometry

Item

4. spirometry with no evidence of clinically relevant lung disease

boolean

C0024115 (UMLS CUI [1,1])
C2347946 (UMLS CUI [1,2])
C0205210 (UMLS CUI [1,3])
C3887511 (UMLS CUI [1,4])
C0037981 (UMLS CUI [2])

Item

5. no history of causes of pulmonary hypertension such as collagen vascular disease, chronic liver disease with alt or ast greater than 2 times the upper limit of normal or cirrhosis of the liver, chronic thromboembolic disease, congenital heart defects, or pulmonary parenchymal disease with hypoxemia

boolean

C0020542 (UMLS CUI [1,1])
C0015127 (UMLS CUI [1,2])
C0262428 (UMLS CUI [2])
C0341439 (UMLS CUI [3])
C0201836 (UMLS CUI [4])
C0201899 (UMLS CUI [5])
C0023890 (UMLS CUI [6])
C0040038 (UMLS CUI [7,1])
C0205191 (UMLS CUI [7,2])
C0018798 (UMLS CUI [8])
C0206062 (UMLS CUI [9])
C0700292 (UMLS CUI [10])

Disease Related Endothelial dysfunction | Hypertensive disease Requirement Pharmacotherapy | Diabetes Mellitus Requirement Pharmacotherapy | Hypercholesterolemia | Obesity

Item

6. no history of diseases thought to be related to development of endothelial dysfunction including systemic hypertension or diabetes requiring drug therapy, hypercholesterolemia and obesity

boolean

C0012634 (UMLS CUI [1,1])
C0439849 (UMLS CUI [1,2])
C0856169 (UMLS CUI [1,3])
C0020538 (UMLS CUI [2,1])
C1514873 (UMLS CUI [2,2])
C0013216 (UMLS CUI [2,3])
C0011849 (UMLS CUI [3,1])
C1514873 (UMLS CUI [3,2])
C0013216 (UMLS CUI [3,3])
C0020443 (UMLS CUI [4])
C0028754 (UMLS CUI [5])

Anemia | Thrombocytopenia | Blood Coagulation Disorders

Item

7. no history of anemia, thrombocytopenia or coagulopathy

boolean

C0002871 (UMLS CUI [1])
C0040034 (UMLS CUI [2])
C0005779 (UMLS CUI [3])

Renal Insufficiency

Item

8. no history of renal insufficiency

boolean

C1565489 (UMLS CUI [1])

medical condition Requirement Pharmaceutical Preparations chronic

Item

9. no medical conditions requiring chronic medication use with the exception of:

boolean

C3843040 (UMLS CUI [1,1])
C1514873 (UMLS CUI [1,2])
C0013227 (UMLS CUI [1,3])
C0205191 (UMLS CUI [1,4])

Heartburn | Gastroesophageal reflux disease

Item

a. heartburn, gerd

boolean

C0018834 (UMLS CUI [1])
C0017168 (UMLS CUI [2])

Environmental Illness | Posterior rhinorrhea | Non-allergic rhinitis

Item

b. environmental allergies, post nasal drip or non-allergic rhinitis

boolean

C0282504 (UMLS CUI [1])
C0032781 (UMLS CUI [2])
C3472698 (UMLS CUI [3])

Asthma | Oral steroid therapy | inhaled steroids | Hospitalization Exacerbation of asthma

Item

c. asthma with no history of oral steroid use, weekly inhaled steroids, or hospitalization for asthma exacerbation

boolean

C0004096 (UMLS CUI [1])
C0574135 (UMLS CUI [2])
C2065041 (UMLS CUI [3])
C0019993 (UMLS CUI [4,1])
C0349790 (UMLS CUI [4,2])

Dermatologic disorders Requirement Oral steroid therapy | Dermatologic disorders Requirement Immunosuppressive Agents

Item

d. dermatologic conditions that do not require the use of oral steroids or other immunosuppressants

boolean

C0037274 (UMLS CUI [1,1])
C1514873 (UMLS CUI [1,2])
C0574135 (UMLS CUI [1,3])
C0037274 (UMLS CUI [2,1])
C1514873 (UMLS CUI [2,2])
C0021081 (UMLS CUI [2,3])

Thyroid Disease Treated Stable | Depressive disorder Treated Stable | Anxiety Treated Stable

Item

e. treated and stable thyroid disease, depression, or anxiety.

boolean

C0040128 (UMLS CUI [1,1])
C1522326 (UMLS CUI [1,2])
C0205360 (UMLS CUI [1,3])
C0011581 (UMLS CUI [2,1])
C1522326 (UMLS CUI [2,2])
C0205360 (UMLS CUI [2,3])
C0003467 (UMLS CUI [3,1])
C1522326 (UMLS CUI [3,2])
C0205360 (UMLS CUI [3,3])

Cigarette Quantity per year | cigarette use

Item

10. no more than 20 cigarettes per years for the previous 2 years and no cigarette use for 30 days prior to the screening evaluation until completion of the study

boolean

C0677453 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0439508 (UMLS CUI [1,3])
C0694535 (UMLS CUI [2])

Exclusion Criteria Control Group

Item

exclusion criteria for control subjects:

boolean

C0680251 (UMLS CUI [1,1])
C0009932 (UMLS CUI [1,2])

Pregnancy | Breast Feeding | Gender Contraceptive methods Inadequate | Childbearing Potential Urine pregnancy test | Childbearing Potential pregnancy blood test

Item

1. current pregnancy, lactation or women not currently using medically acceptable birth control. (all women of childbearing age will be required to have a screening urine or blood pregnancy test)

boolean

C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C0079399 (UMLS CUI [3,1])
C0700589 (UMLS CUI [3,2])
C0205412 (UMLS CUI [3,3])
C3831118 (UMLS CUI [4,1])
C0430056 (UMLS CUI [4,2])
C3831118 (UMLS CUI [5,1])
C0850355 (UMLS CUI [5,2])

Medical contraindication Magnetic Resonance Imaging

Item

2. contraindication to mri scanning including individuals with the following devices:

boolean

C1301624 (UMLS CUI [1,1])
C0024485 (UMLS CUI [1,2])

pacemaker implanted | defibrillator implanted

Item

a) implanted cardiac pacemaker or defibrillator

boolean

C0848753 (UMLS CUI [1])
C0850291 (UMLS CUI [2])

Aneurysm clip Central Nervous System

Item

b) central nervous system aneurysm clips

boolean

C0179977 (UMLS CUI [1,1])
C3714787 (UMLS CUI [1,2])

Cochlear Implants

Item

c) cochlear implants

boolean

C0009199 (UMLS CUI [1])

Implanted Neurostimulators

Item

d) implanted neural stimulator

boolean

C2048402 (UMLS CUI [1])

Ocular Foreign Body

Item

e) ocular foreign body (e.g. metal shavings)

boolean

C3898107 (UMLS CUI [1])

Insulin pump

Item

f) insulin pump

boolean

C1140609 (UMLS CUI [1])

Shrapnel | Bullet

Item

g) metal shrapnel or bullet

boolean

C0522670 (UMLS CUI [1])
C0336699 (UMLS CUI [2])

Claustrophobia

Item

h) claustophobia

boolean

C0008909 (UMLS CUI [1])

Medical contraindication Magnetic resonance imaging contrast media

Item

3. contraindications to mri contrast agent administration

boolean

C1301624 (UMLS CUI [1,1])
C0180108 (UMLS CUI [1,2])

Informed Consent Unable

Item

4. inability to provide informed written consent for participation in the study

boolean

C0021430 (UMLS CUI [1,1])
C1299582 (UMLS CUI [1,2])

Tachyarrhythmia Atrial refractory chronic

Item

5. chronic, medically refractory atrial tacharrhythmias

boolean

C0080203 (UMLS CUI [1,1])
C0018792 (UMLS CUI [1,2])
C0205269 (UMLS CUI [1,3])
C0205191 (UMLS CUI [1,4])

Heart failure Symptoms

Item

6. symptoms of heart failure.

boolean

C0018801 (UMLS CUI [1,1])
C1457887 (UMLS CUI [1,2])

Pulmonary artery mean pressure | Pulmonary Vascular Resistance | Pulmonary Capillary Wedge Pressure

Item

7. mean pa greater than 25mmhg or pvr greater than 1.5 wood units, or pcwp greater than 15 mmhg

boolean

C0428645 (UMLS CUI [1])
C0456261 (UMLS CUI [2])
C0086879 (UMLS CUI [3])

Drug abuse | Marijuana Smoking

Item

8. history of recreational drug use with the exception of marijuana. no marijuana use within 3 months of protocol screening through completion of the study.

boolean

C0013146 (UMLS CUI [1])
C0024810 (UMLS CUI [2])

Intravenous Drug Abuse

Item

9. intravenous drug abuse.

boolean

C0086181 (UMLS CUI [1])

Condition Affecting research results | Condition Affecting patient safety

Item

volunteers may be excluded if in the opinion of the study investigators they have a condition that may adversely affect the outcome of the study or the safety of the volunteer.

boolean

C0348080 (UMLS CUI [1,1])
C0392760 (UMLS CUI [1,2])
C0683954 (UMLS CUI [1,3])
C0348080 (UMLS CUI [2,1])
C0392760 (UMLS CUI [2,2])
C1113679 (UMLS CUI [2,3])

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Eligibility Hypertension, Pulmonary NCT00098072