Age | Adult
Item
1. adults older than 21 years.
boolean
C0001779 (UMLS CUI [1])
C0001675 (UMLS CUI [2])
Coronary Artery Disease | angiography
Item
2. coronary artery disease established by angiography.
boolean
C1956346 (UMLS CUI [1])
C0002978 (UMLS CUI [2])
Myocardial Infarction
Item
3. no myocardial infarction within 1 month.
boolean
C0027051 (UMLS CUI [1])
Left ventricular ejection fraction
Item
4. left ventricular ejection fraction greater than 30%.
boolean
C0428772 (UMLS CUI [1])
Congestive heart failure Symptoms
Item
5. no congestive heart failure symptoms within 2 months.
boolean
C0018802 (UMLS CUI [1,1])
C1457887 (UMLS CUI [1,2])
medical condition Excludes Exercise performance Successful | nervous system disorder Excludes Exercise performance Successful | orthopedic problem Excludes Exercise performance Successful
Item
6. no associated medical, neurological or orthopedic condition that might prohibit safe performance of exercise.
boolean
C3843040 (UMLS CUI [1,1])
C0332196 (UMLS CUI [1,2])
C0015259 (UMLS CUI [1,3])
C1882330 (UMLS CUI [1,4])
C1272703 (UMLS CUI [1,5])
C0027765 (UMLS CUI [2,1])
C0332196 (UMLS CUI [2,2])
C0015259 (UMLS CUI [2,3])
C1882330 (UMLS CUI [2,4])
C1272703 (UMLS CUI [2,5])
C0029354 (UMLS CUI [3,1])
C0332196 (UMLS CUI [3,2])
C0015259 (UMLS CUI [3,3])
C1882330 (UMLS CUI [3,4])
C1272703 (UMLS CUI [3,5])
Informed Consent | Protocol Compliance | Follow-up Evaluation
Item
7. subject understands protocol and provides written, informed consent in addition to willingness to comply with specified follow-up evaluations.
boolean
C0021430 (UMLS CUI [1])
C0525058 (UMLS CUI [2])
C3274571 (UMLS CUI [3,1])
C1261322 (UMLS CUI [3,2])
Exclusion Criteria
Item
patient exclusion criteria
boolean
C0680251 (UMLS CUI [1])
Structural disorder of heart Significant | Hypertrophic Cardiomyopathy | Cardiomyopathy, Dilated | Heart valve disease | Echocardiography
Item
1. significant structural heart disease (e.g. hypertrophic or dilated cardiomyopathy, valvular heart disease) as determined by echocardiography.
boolean
C1290384 (UMLS CUI [1,1])
C0750502 (UMLS CUI [1,2])
C0007194 (UMLS CUI [2])
C0007193 (UMLS CUI [3])
C0018824 (UMLS CUI [4])
C0013516 (UMLS CUI [5])
Angina, Unstable | Nocturnal angina
Item
2. history of recent (within 2 months) rest or nocturnal angina
boolean
C0002965 (UMLS CUI [1])
C0264679 (UMLS CUI [2])
Nitrate organic | Nitroglycerin | Investigational New Drugs | Exercise testing
Item
3. organic nitrate (e.g., nitroglycerin) use other than study medication within 24 hours of exercise testing
boolean
C0028125 (UMLS CUI [1,1])
C0747055 (UMLS CUI [1,2])
C0017887 (UMLS CUI [2])
C0013230 (UMLS CUI [3])
C0015260 (UMLS CUI [4])
Hypersensitivity Nitrates organic
Item
4. hypersensitivity to organic nitrates.
boolean
C0020517 (UMLS CUI [1,1])
C0028125 (UMLS CUI [1,2])
C0747055 (UMLS CUI [1,3])
Childbearing Potential Pregnancy test negative
Item
5. women of childbearing age unless recent pregnancy test is negative.
boolean
C3831118 (UMLS CUI [1,1])
C0427780 (UMLS CUI [1,2])
Breast Feeding
Item
6. lactating women.
boolean
C0006147 (UMLS CUI [1])
Eligibility Criteria | Healthy Subjects
Item
eligibility criteria - healthy subjects
boolean
C1516637 (UMLS CUI [1])
C1708335 (UMLS CUI [2])
Healthy Subjects | Age | Coronary Artery Disease | Risk factors Free of | Blood Pressure | Glucose measurement, fasting | Smoking | Serum total cholesterol measurement | Drug Prescriptions chronic
Item
healthy subjects must be older than 50 years of age (to approximate the anticipated age of cad patients), without known cad, and be free of the following risk factors: blood pressure greater than 140/90 mmhg, fasting glucose greater than 110 mg/dl, smoking, total cholesterol greater than 250 mg/dl. healthy subjects taking chronic prescription medications will be excluded.
boolean
C1708335 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
C1956346 (UMLS CUI [3])
C0035648 (UMLS CUI [4,1])
C0332296 (UMLS CUI [4,2])
C0005823 (UMLS CUI [5])
C0202045 (UMLS CUI [6])
C0037369 (UMLS CUI [7])
C1445957 (UMLS CUI [8])
C0033081 (UMLS CUI [9,1])
C0205191 (UMLS CUI [9,2])