Eligibility Depression, Involutional NCT00033787

1 moduli

StudyEvent: Eligibility
1. Eligibility Depression, Involutional NCT00033787

Name

genere

Description | Question | Decode (Coded Value)

Tipo di dati

Alias

Criteria

Item Group

study description

Item

36 subjects with rmdd (ages 18-60) will be selected. remission is defined as a period of at least three months during which the subject has not taken an antidepressant agent, with hamilton depression rating scales (hdrs; 21-item) scores in the non-depressed range (less than 8), and with no more than one clinically significant depressive symptom. additional 17 subjects with current mdd will be selected for the gaba mrs study.

boolean

inclusion criteria

Item

inclusion criteria - healthy control samples:

boolean

C1512693 (UMLS CUI [1])

ID.3

Item

twenty-four healthy subjects (ages 18-60) without a known personal or family history of psychiatric disorders in first-degree relatives will be selected.

boolean

Exclusion Criteria

Item Group

C0680251 (UMLS CUI)

antidepressant medication

Item

subjects must not have taken antidepressant or other medications likely to alter monoamine neurochemistry or cerebrovascular and cardiovascular function for at least 3 months prior to the studies. however, effective medications will not be discontinued for the purposes of this study.

boolean

C0003289 (UMLS CUI [1])

exclusion criteria

Item

subjects will also be excluded if they have:

boolean

C0680251 (UMLS CUI [1])

medical history of psychotic disorders

Item

1. any form of past or current psychosis;

boolean

C3887134 (UMLS CUI [1])

medical or neurological illnesses

Item

2. medical or neurological illnesses likely to affect physiology or anatomy, i.e. hypertension, cardiovascular disorders;

boolean

C0009488 (UMLS CUI [1])

History of substance abuse

Item

3. a history of drug (including benzodiazepines [bzd]) or alcohol abuse within 1 year or a lifetime history of alcohol or drug dependence (dsm iv criteria) longer than 2 years;

boolean

C1299544 (UMLS CUI [1])

current pregnancy

Item

4. current pregnancy (as documented by pregnancy testing at screening or at days of the challenge studies);

boolean

C0747843 (UMLS CUI [1])

breast feeding

Item

f) current breast feeding (tryptophan depletion);

boolean

C0006147 (UMLS CUI [1])

smoker

Item

g) are smokers;

boolean

C0037369 (UMLS CUI [1])

suicidal intent

Item

h) current suicidal ideation or behavior;

boolean

C0582496 (UMLS CUI [1])

mri exclusion criteria

Item

i) general mri exclusion criteria.

boolean

C0024485 (UMLS CUI [1,1])
C0522473 (UMLS CUI [1,2])

alcohol consumption

Item

subjects must exhibit no or only moderate alcohol use.

boolean

C0001948 (UMLS CUI [1])

ID.15

Item

subjects with current excessive use of alcohol (greater than 8 ounces/day for men and greater than 6 ounces/day for women) are ineligible for participation.

boolean

other current axis i diagnoses

Item

j) other current axis i diagnoses beside unipolar major depressive disorder;

boolean

C0270287 (UMLS CUI [1])

lactose intolerance

Item

k) lactose intolerance (tryptophan depletion).

boolean

C0022951 (UMLS CUI [1])

age

Item

subjects beyond the age of 60 are excluded.

boolean

C0001779 (UMLS CUI [1])

secondary depressive episodes

Item

subjects whose first major depressive episodes arose temporally after other medical or psychiatric conditions will also be excluded.

boolean

C0011581 (UMLS CUI [1,1])
C0277555 (UMLS CUI [1,2])

Ritorna all'inizio della pagina

ID

Descrizione

collegamento

Keywords

versioni (1)

Caricato su

DOI

Licenza

Commenti del modello :

Commenti del gruppo di articoli per :

Commenti dell'articolo per :

Eligibility Depression, Involutional NCT00033787