ID
15423
Descripción
Principal Investigator: Luisa Klotz Collaborator: Novartis Information provided by (Responsible Party):University Hospital Muenster -Study to Assess Immune Function and MRI Disease Activity in RRMS Patients When Switching From Natalizumab to Gilenya (ToFingo2) Purpose A trial in patients with relapsing remitting multiple sclerosis (RRMS) Main objectives: •To evaluate changes in the reconstitution of immune surveillance over time upon switching from natalizumab to fingolimod assessed by a change in the expression of CD49d. •To evaluate changes in the migratory capacity of immune cells/peripheral blood mononuclear cells (PBMCs) upon switching from natalizumab to fingolimod in an in-vitro model of the blood-brain-barrier (BBB). •To evaluate changes in paraclinical disease activity over time upon switching from natalizumab to fingolimod assessed by MRI (changes in Gd+, T2w lesions and DTI). •To evaluate changes in T1w / FLAIR lesions upon switching from natalizumab to fingolimod. For further Information please visit https://clinicaltrials.gov/ct2/show/NCT02325440
Link
https://clinicaltrials.gov/ct2/show/NCT02325440
Palabras clave
Versiones (1)
- 31/5/16 31/5/16 -
Subido en
31 de mayo de 2016
DOI
Para solicitar uno, por favor iniciar sesión.
Licencia
Creative Commons BY 4.0
Comentarios del modelo :
Puede comentar sobre el modelo de datos aquí. A través de las burbujas de diálogo en los grupos de elementos y elementos, puede agregar comentarios específicos.
Comentarios de grupo de elementos para :
Comentarios del elemento para :
Para descargar modelos de datos, debe haber iniciado sesión. Por favor iniciar sesión o Registrate gratis.
ToFingo V5 Study relevant assessments NCT02325440
ToFingo Screening V5 Study relevant assessments NCT02325440
- StudyEvent: ODM
Descripción
MRI
Alias
- UMLS CUI-1
- C0024485
Descripción
MRT performed
Tipo de datos
boolean
Alias
- UMLS CUI [1]
- C0024485
Descripción
Gadolinium enhancement marker for bloodbarrier breakdown
Tipo de datos
boolean
Alias
- UMLS CUI [1]
- C0855566
Descripción
T2w
Tipo de datos
text
Descripción
Number of GD+ lesions
Tipo de datos
integer
Alias
- UMLS CUI [1,1]
- C1333400
- UMLS CUI [1,2]
- C0449788
Descripción
Number of enlarging GD+ lesions
Tipo de datos
integer
Alias
- UMLS CUI [1,1]
- C1333400
- UMLS CUI [1,2]
- C0442800
- UMLS CUI [1,3]
- C0449788
Descripción
Number of new T2w lesions
Tipo de datos
integer
Descripción
Number of enlarging T2w lesions
Tipo de datos
integer
Descripción
Blood
Alias
- UMLS CUI-1
- C0005767
Descripción
Peripheral blood taken
Tipo de datos
boolean
Alias
- UMLS CUI [1]
- C0005834
Descripción
Date of collection
Tipo de datos
date
Alias
- UMLS CUI [1]
- C2584899
Descripción
PBMCs isolated
Tipo de datos
boolean
Alias
- UMLS CUI [1,1]
- C1321301
- UMLS CUI [1,2]
- C0185115
Descripción
Date of isolation
Tipo de datos
date
Alias
- UMLS CUI [1]
- C2584899
Similar models
ToFingo Screening V5 Study relevant assessments NCT02325440
- StudyEvent: ODM
C0449788 (UMLS CUI [1,2])
C0442800 (UMLS CUI [1,2])
C0449788 (UMLS CUI [1,3])
C0185115 (UMLS CUI [1,2])