ID
15422
Beskrivning
Principal Investigator: Luisa Klotz Collaborator: Novartis Information provided by (Responsible Party):University Hospital Muenster -Study to Assess Immune Function and MRI Disease Activity in RRMS Patients When Switching From Natalizumab to Gilenya (ToFingo2) Purpose A trial in patients with relapsing remitting multiple sclerosis (RRMS) Main objectives: •To evaluate changes in the reconstitution of immune surveillance over time upon switching from natalizumab to fingolimod assessed by a change in the expression of CD49d. •To evaluate changes in the migratory capacity of immune cells/peripheral blood mononuclear cells (PBMCs) upon switching from natalizumab to fingolimod in an in-vitro model of the blood-brain-barrier (BBB). •To evaluate changes in paraclinical disease activity over time upon switching from natalizumab to fingolimod assessed by MRI (changes in Gd+, T2w lesions and DTI). •To evaluate changes in T1w / FLAIR lesions upon switching from natalizumab to fingolimod. For further Information please visit https://clinicaltrials.gov/ct2/show/NCT02325440
Länk
https://clinicaltrials.gov/ct2/show/NCT02325440
Nyckelord
Versioner (3)
- 2016-05-27 2016-05-27 -
- 2016-05-31 2016-05-31 -
- 2016-05-31 2016-05-31 -
Uppladdad den
31 maj 2016
DOI
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Licens
Creative Commons BY-NC 3.0
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ToFingo Screening V1 Pre-examination NCT02325440
ToFingo Screening V1 Pre-examination NCT02325440
- StudyEvent: ODM
Beskrivning
MSFC (Multiple Sclerosis Functional Composite Measure)
Alias
- UMLS CUI-1
- C0026769
- UMLS CUI-2
- C0449820
Beskrivning
Last natalizumab dose
Alias
- UMLS CUI-1
- C1762893
- UMLS CUI-2
- C1172734
Beskrivning
Ophthalmologic examination
Alias
- UMLS CUI-1
- C0200149
Beskrivning
Opthalmologic examination: Result
Datatyp
text
Alias
- UMLS CUI [1]
- C0200149
Beskrivning
Opthalmologic examination: Comment
Datatyp
text
Alias
- UMLS CUI [1,1]
- C0200149
- UMLS CUI [1,2]
- C0947611
Beskrivning
History of uveitis or diabetes melitus: Result
Datatyp
text
Alias
- UMLS CUI [1]
- C0042164
- UMLS CUI [2]
- C0011849
Beskrivning
History of uveitis or diabetes mellitus: Comment
Datatyp
text
Alias
- UMLS CUI [1,1]
- C0042164
- UMLS CUI [1,2]
- C0947611
- UMLS CUI [2,1]
- C0011849
- UMLS CUI [2,2]
- C0947611
Beskrivning
Abnormalities: Result
Datatyp
text
Alias
- UMLS CUI [1]
- C1704258
Beskrivning
Abnormalities: Comment
Datatyp
text
Alias
- UMLS CUI [1,1]
- C1704258
- UMLS CUI [1,2]
- C0947611
Beskrivning
Virus antibody status
Alias
- UMLS CUI-1
- C0201278
Beskrivning
Anti-JCV-IgG: Result
Datatyp
float
Alias
- UMLS CUI [1]
- C3511565
Beskrivning
Anti-JCV-IgG: Comment
Datatyp
text
Alias
- UMLS CUI [1,1]
- C3511565
- UMLS CUI [1,2]
- C0047611
Beskrivning
Anti-VZV-IgG: Result
Datatyp
float
Måttenheter
- mU/ml
Alias
- UMLS CUI [1]
- C0443710
Beskrivning
Anti-VZV-IgG: Comment
Datatyp
text
Alias
- UMLS CUI [1,1]
- C0443710
- UMLS CUI [1,2]
- C0947611
Beskrivning
Anti-HIV 1+2: Result
Datatyp
float
Alias
- UMLS CUI [1]
- C0019683
Beskrivning
Anti-HIV 1+2: Comment
Datatyp
text
Alias
- UMLS CUI [1,1]
- C0019683
- UMLS CUI [1,2]
- C0947611
Beskrivning
HBsAg (Hepatitis B Surface Antigen): Result
Datatyp
float
Alias
- UMLS CUI [1]
- C0201477
Beskrivning
HBsAg (Hepatitis B Surface Antigen): Comment
Datatyp
text
Alias
- UMLS CUI [1,1]
- C0201477
- UMLS CUI [1,2]
- C0947611
Beskrivning
Anti-HCV: Result
Datatyp
float
Alias
- UMLS CUI [1,1]
- C0166049
- UMLS CUI [1,2]
- C0242485
Beskrivning
Anti-HCV: Comment
Datatyp
text
Alias
- UMLS CUI [1,1]
- C0201485
- UMLS CUI [1,2]
- C0947611
Beskrivning
Anti-HSV 1/2-IgG (Herpes Simplex virus): Result
Datatyp
float
Alias
- UMLS CUI [1]
- C0919754
Beskrivning
Anti-HSV 1/2-IgG (Herpes Simplex virus): Comment
Datatyp
text
Alias
- UMLS CUI [1,1]
- C0919754
- UMLS CUI [1,2]
- C0947611
Beskrivning
Anti-Rubeola-IgG (Measles virus): Result
Datatyp
float
Alias
- UMLS CUI [1]
- C0523315
Beskrivning
Anti-Rubeola-IgG (Measles virus): Comment
Datatyp
text
Alias
- UMLS CUI [1,1]
- C0523315
- UMLS CUI [1,2]
- C0947611
Beskrivning
ECG
Alias
- UMLS CUI-1
- C1623258
Beskrivning
AV-Block 2nd degree, Type II: Result
Datatyp
boolean
Alias
- UMLS CUI [1]
- C0155700
Beskrivning
AV-Block 2nd degree, Type II: Comment
Datatyp
text
Alias
- UMLS CUI [1,1]
- C0155700
- UMLS CUI [1,2]
- C0947611
Beskrivning
AV-Block 3rd degree: Result
Datatyp
boolean
Alias
- UMLS CUI [1]
- C0151517
Beskrivning
AV-Block 3rd degree: Comment
Datatyp
text
Alias
- UMLS CUI [1,1]
- C0151517
- UMLS CUI [1,2]
- C0947611
Beskrivning
QTc intervall: Result
Datatyp
float
Måttenheter
- msec
Alias
- UMLS CUI [1]
- C0489625
Beskrivning
QTc intervall: Comment
Datatyp
text
Alias
- UMLS CUI [1,1]
- C0489625
- UMLS CUI [1,2]
- C0947611
Beskrivning
Abnormalities: Result
Datatyp
boolean
Alias
- UMLS CUI [1,1]
- C1704258
- UMLS CUI [1,2]
- C1623258
Beskrivning
Abnormalities: Comment
Datatyp
text
Alias
- UMLS CUI [1,1]
- C1704258
- UMLS CUI [1,2]
- C1623258
- UMLS CUI [1,3]
- C0947611
Similar models
ToFingo Screening V1 Pre-examination NCT02325440
- StudyEvent: ODM
C0449820 (UMLS CUI-2)
C0449820 (UMLS CUI [1,2])
C1172734 (UMLS CUI [1,2])
C0947611 (UMLS CUI [1,2])
C0011849 (UMLS CUI [2])
C0947611 (UMLS CUI [1,2])
C0011849 (UMLS CUI [2,1])
C0947611 (UMLS CUI [2,2])
C0947611 (UMLS CUI [1,2])
C0047611 (UMLS CUI [1,2])
C0947611 (UMLS CUI [1,2])
C0947611 (UMLS CUI [1,2])
C0947611 (UMLS CUI [1,2])
C0242485 (UMLS CUI [1,2])
C0947611 (UMLS CUI [1,2])
C0947611 (UMLS CUI [1,2])
C0947611 (UMLS CUI [1,2])
C0947611 (UMLS CUI [1,2])
C0947611 (UMLS CUI [1,2])
C0947611 (UMLS CUI [1,2])
C1623258 (UMLS CUI [1,2])
C1623258 (UMLS CUI [1,2])
C0947611 (UMLS CUI [1,3])