ID

14420

Description

How Different Beta-2 Receptor Genotypes Affect an Asthmatic's Response to Regular Salmeterol Treatment; ODM derived from: https://clinicaltrials.gov/show/NCT00595361

Link

https://clinicaltrials.gov/show/NCT00595361

Keywords

Versions (1)
  1. 4/14/16 4/14/16 -
Copyright Holder

CC BY-NC 3.0

Uploaded on

April 14, 2016

DOI

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License

Creative Commons BY-NC 3.0
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Eligibility Asthma NCT00595361

English

Eligibility Asthma NCT00595361

1 forms  
  1. StudyEvent: Eligibility
    1. Eligibility Asthma NCT00595361
Inclusion Criteria
Description

Inclusion Criteria

Alias
UMLS CUI
C1512693
both male and female
Description

both male and female

Data type

boolean

Alias
UMLS CUI [1]
C0079399
18 to 50 years of age
Description

age

Data type

boolean

Alias
UMLS CUI [1]
C0001779
resting fev1 ≥ 65% of predicted normal
Description

fev1

Data type

boolean

Alias
UMLS CUI [1]
C0748133
exercise-induced bronchoconstriction defined as a decrease in fev1 of ≥ 20% following a standardized exercise challenge when compared to pre-exercise baseline fev1 value measured 5 minutes before exercise
Description

exercise-induced bronchoconstriction

Data type

boolean

Alias
UMLS CUI [1,1]
C0079043
UMLS CUI [1,2]
C0239313
UMLS CUI [2]
C0748133
must be arg/arg or gly/gly genotype
Description

genotype

Data type

boolean

Alias
UMLS CUI [1]
C0017431
Exclusion Criteria
Description

Exclusion Criteria

Alias
UMLS CUI
C0680251
long-acting beta agonist use within 12 weeks of the first exercise challenge
Description

long-acting beta agonist

Data type

boolean

Alias
UMLS CUI [1,1]
C0001644
UMLS CUI [1,2]
C0040223
smoking within past 12 months
Description

smoking history

Data type

boolean

Alias
UMLS CUI [1]
C1519384
greater than 10-pack years smoking history
Description

smoking history

Data type

boolean

Alias
UMLS CUI [1]
C1519384
UMLS CUI [2]
C1277691
unresolved signs and/or symptoms of an upper respiratory tract infection within 4 weeks of first exercise challenge
Description

upper respiratory tract infection

Data type

boolean

Alias
UMLS CUI [1,1]
C0041912
UMLS CUI [1,2]
C0040223
asthma exacerbation within 4 weeks of first exercise challenge requiring change in type, dose or frequency of medications and/or an unscheduled visit to an health care provider, including emergency room or hospital
Description

asthma exacerbation

Data type

boolean

Alias
UMLS CUI [1]
C0349790
UMLS CUI [2]
C0019993
UMLS CUI [3]
C0583237
UMLS CUI [4]
C0580105
subject has exercised or performed strenuous activity within 72 hours of the first exercise challenge
Description

strenuous activity

Data type

boolean

Alias
UMLS CUI [1]
C1514989
UMLS CUI [2]
C0040223
subject has been exposed to cold air sufficient to provoke symptoms of bronchospasm within 2 hours of exercise challenge
Description

cold air bronchospasm

Data type

boolean

Alias
UMLS CUI [1]
C0006266
UMLS CUI [2]
C0450029
UMLS CUI [3]
C0040223
in addition to asthma, the subject has an active, acute or chronic pulmonary disorder documented by history, physical examination, or chest x-ray
Description

pulmonary disorder

Data type

boolean

Alias
UMLS CUI [1]
C1096000
subject has evidence of ischemic, valvular, hypertrophic, familial or other forms of heart disease that would put the subject at risk during exercise testing or that would interfere with the ability to achieve protocol-specified heart rates during exercise testing
Description

heart disease limiting study protocol

Data type

boolean

Alias
UMLS CUI [1,1]
C1321605
UMLS CUI [1,2]
C0439801
UMLS CUI [1,3]
C0018799
subject has used systemic corticosteroids within 1 month of first exercise challenge
Description

systemic corticosteroids

Data type

boolean

Alias
UMLS CUI [1]
C4039704
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Similar models

Eligibility Asthma NCT00595361

1 forms
  1. StudyEvent: Eligibility
    1. Eligibility Asthma NCT00595361
Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
Item Group
C1512693 (UMLS CUI)
both male and female
Item
both male and female
boolean
C0079399 (UMLS CUI [1])
age
Item
18 to 50 years of age
boolean
C0001779 (UMLS CUI [1])
fev1
Item
resting fev1 ≥ 65% of predicted normal
boolean
C0748133 (UMLS CUI [1])
exercise-induced bronchoconstriction
Item
exercise-induced bronchoconstriction defined as a decrease in fev1 of ≥ 20% following a standardized exercise challenge when compared to pre-exercise baseline fev1 value measured 5 minutes before exercise
boolean
C0079043 (UMLS CUI [1,1])
C0239313 (UMLS CUI [1,2])
C0748133 (UMLS CUI [2])
genotype
Item
must be arg/arg or gly/gly genotype
boolean
C0017431 (UMLS CUI [1])
Item Group
C0680251 (UMLS CUI)
long-acting beta agonist
Item
long-acting beta agonist use within 12 weeks of the first exercise challenge
boolean
C0001644 (UMLS CUI [1,1])
C0040223 (UMLS CUI [1,2])
smoking history
Item
smoking within past 12 months
boolean
C1519384 (UMLS CUI [1])
smoking history
Item
greater than 10-pack years smoking history
boolean
C1519384 (UMLS CUI [1])
C1277691 (UMLS CUI [2])
upper respiratory tract infection
Item
unresolved signs and/or symptoms of an upper respiratory tract infection within 4 weeks of first exercise challenge
boolean
C0041912 (UMLS CUI [1,1])
C0040223 (UMLS CUI [1,2])
asthma exacerbation
Item
asthma exacerbation within 4 weeks of first exercise challenge requiring change in type, dose or frequency of medications and/or an unscheduled visit to an health care provider, including emergency room or hospital
boolean
C0349790 (UMLS CUI [1])
C0019993 (UMLS CUI [2])
C0583237 (UMLS CUI [3])
C0580105 (UMLS CUI [4])
strenuous activity
Item
subject has exercised or performed strenuous activity within 72 hours of the first exercise challenge
boolean
C1514989 (UMLS CUI [1])
C0040223 (UMLS CUI [2])
cold air bronchospasm
Item
subject has been exposed to cold air sufficient to provoke symptoms of bronchospasm within 2 hours of exercise challenge
boolean
C0006266 (UMLS CUI [1])
C0450029 (UMLS CUI [2])
C0040223 (UMLS CUI [3])
pulmonary disorder
Item
in addition to asthma, the subject has an active, acute or chronic pulmonary disorder documented by history, physical examination, or chest x-ray
boolean
C1096000 (UMLS CUI [1])
heart disease limiting study protocol
Item
subject has evidence of ischemic, valvular, hypertrophic, familial or other forms of heart disease that would put the subject at risk during exercise testing or that would interfere with the ability to achieve protocol-specified heart rates during exercise testing
boolean
C1321605 (UMLS CUI [1,1])
C0439801 (UMLS CUI [1,2])
C0018799 (UMLS CUI [1,3])
systemic corticosteroids
Item
subject has used systemic corticosteroids within 1 month of first exercise challenge
boolean
C4039704 (UMLS CUI [1])
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