ID

14193

Beskrivning

PET Changes in Alzheimer's Disease (AD); ODM derived from: https://clinicaltrials.gov/show/NCT00094913

Länk

https://clinicaltrials.gov/show/NCT00094913

Nyckelord

Versioner (1)
  1. 2016-04-04 2016-04-04 -
Uppladdad den

4 april 2016

DOI

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Licens

Creative Commons BY 4.0
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Eligibility Alzheimer Disease NCT00094913

Engelsk

Eligibility Alzheimer Disease NCT00094913

1 Formulär  
Inclusion Criteria
Beskrivning

Inclusion Criteria

Alias
UMLS CUI
C1512693
males and females with a minimum high school education and between the ages of 50 and 90 will be selected for groups 1 and 2. for group 3, normal subjects between the ages of 20 and 49 years of age will be selected. the groups 1 and 2 will be balanced for age, and all three groups balanced for gender and apoe genotype.
Beskrivning

gender; age

Datatyp

boolean

Alias
UMLS CUI [1]
C0079399
UMLS CUI [2]
C0001779
discontinuance of all psychotropic and/or cognitively active medication at least four weeks prior to evaluation.
Beskrivning

Psychotropic Drugs

Datatyp

boolean

Alias
UMLS CUI [1]
C0033978
Exclusion Criteria
Beskrivning

Exclusion Criteria

Alias
UMLS CUI
C0680251
past history or mri evidence of brain damage including significant trauma, stroke, hydrocephalus, lacunar infarcts, seizures, mental retardation or serious neurological disorder.
Beskrivning

brain trauma; hydrocephalus; lacunar infarcts; seizures; mental retardation; neurological disorder

Datatyp

boolean

Alias
UMLS CUI [1]
C0876926
UMLS CUI [2]
C0020255
UMLS CUI [3]
C0333559
UMLS CUI [4]
C0036572
UMLS CUI [5]
C0025362
UMLS CUI [6]
C0027765
significant history of alcoholism or drug abuse.
Beskrivning

Substance Use Disorder

Datatyp

boolean

Alias
UMLS CUI [1]
C0038586
any history of psychiatric illness (e.g., schizophrenia, mania or depression).
Beskrivning

psychiatric illness schizophrenia

Datatyp

boolean

Alias
UMLS CUI [1,1]
C0004936
UMLS CUI [1,2]
C0036341
any focal signs or significant neuropathology.
Beskrivning

neuropathology

Datatyp

boolean

Alias
UMLS CUI [1]
C0876934
a score of 4 or greater on the modified hachinski ischemia scale, indicative of cerebrovascular disease.
Beskrivning

cerebrovascular disease; hachinski ischemia scale

Datatyp

boolean

Alias
UMLS CUI [1]
C0007820
UMLS CUI [2]
C0475492
a total score of 16 or more on the hamilton depression scale to exclude possible cases of primary depression.
Beskrivning

hamilton depression scale

Datatyp

boolean

Alias
UMLS CUI [1]
C0451203
evidence of clinically relevant hypertensive, cardiac, pulmonary, vascular, metabolic or hematologic conditions. specific exclusion will be made for individuals with fasting glucose levels >110 mg/dl.
Beskrivning

hypertension; cardiac disease; pulmonary disease; vascular disease; metabolic disease; hematologic disease; fasting glucose levels

Datatyp

boolean

Alias
UMLS CUI [1]
C0020538
UMLS CUI [2]
C0018799
UMLS CUI [3]
C0024115
UMLS CUI [4]
C0042373
UMLS CUI [5]
C0025517
UMLS CUI [6]
C0018939
UMLS CUI [7]
C0428568
physical impairment of such severity as to adversely affect the validity of psychological testing.
Beskrivning

physical impairment

Datatyp

boolean

Alias
UMLS CUI [1]
C0231171
hostility or refusal to cooperate.
Beskrivning

compliance behaviour

Datatyp

boolean

Alias
UMLS CUI [1]
C1321605
any prosthetic devices (e.g., pacemaker or surgical clips) that could be affected by the magnetic field employed during mri imaging.
Beskrivning

prosthetic devices pacemaker; mri

Datatyp

boolean

Alias
UMLS CUI [1,1]
C0175649
UMLS CUI [1,2]
C0030163
UMLS CUI [2]
C0024485
evidence of cognitive or memory impairment reaching early ad levels at the initial evaluation. at baseline, delayed paragraph recall z-scores > 2 below the reference group.
Beskrivning

cognitive impairment

Datatyp

boolean

Alias
UMLS CUI [1]
C1839000
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Similar models

Eligibility Alzheimer Disease NCT00094913

1 Formulär
Name
Typ
Description | Question | Decode (Coded Value)
Datatyp
Alias
Item Group
C1512693 (UMLS CUI)
gender; age
Item
males and females with a minimum high school education and between the ages of 50 and 90 will be selected for groups 1 and 2. for group 3, normal subjects between the ages of 20 and 49 years of age will be selected. the groups 1 and 2 will be balanced for age, and all three groups balanced for gender and apoe genotype.
boolean
C0079399 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
Psychotropic Drugs
Item
discontinuance of all psychotropic and/or cognitively active medication at least four weeks prior to evaluation.
boolean
C0033978 (UMLS CUI [1])
Item Group
C0680251 (UMLS CUI)
brain trauma; hydrocephalus; lacunar infarcts; seizures; mental retardation; neurological disorder
Item
past history or mri evidence of brain damage including significant trauma, stroke, hydrocephalus, lacunar infarcts, seizures, mental retardation or serious neurological disorder.
boolean
C0876926 (UMLS CUI [1])
C0020255 (UMLS CUI [2])
C0333559 (UMLS CUI [3])
C0036572 (UMLS CUI [4])
C0025362 (UMLS CUI [5])
C0027765 (UMLS CUI [6])
Substance Use Disorder
Item
significant history of alcoholism or drug abuse.
boolean
C0038586 (UMLS CUI [1])
psychiatric illness schizophrenia
Item
any history of psychiatric illness (e.g., schizophrenia, mania or depression).
boolean
C0004936 (UMLS CUI [1,1])
C0036341 (UMLS CUI [1,2])
neuropathology
Item
any focal signs or significant neuropathology.
boolean
C0876934 (UMLS CUI [1])
cerebrovascular disease; hachinski ischemia scale
Item
a score of 4 or greater on the modified hachinski ischemia scale, indicative of cerebrovascular disease.
boolean
C0007820 (UMLS CUI [1])
C0475492 (UMLS CUI [2])
hamilton depression scale
Item
a total score of 16 or more on the hamilton depression scale to exclude possible cases of primary depression.
boolean
C0451203 (UMLS CUI [1])
hypertension; cardiac disease; pulmonary disease; vascular disease; metabolic disease; hematologic disease; fasting glucose levels
Item
evidence of clinically relevant hypertensive, cardiac, pulmonary, vascular, metabolic or hematologic conditions. specific exclusion will be made for individuals with fasting glucose levels >110 mg/dl.
boolean
C0020538 (UMLS CUI [1])
C0018799 (UMLS CUI [2])
C0024115 (UMLS CUI [3])
C0042373 (UMLS CUI [4])
C0025517 (UMLS CUI [5])
C0018939 (UMLS CUI [6])
C0428568 (UMLS CUI [7])
physical impairment
Item
physical impairment of such severity as to adversely affect the validity of psychological testing.
boolean
C0231171 (UMLS CUI [1])
compliance behaviour
Item
hostility or refusal to cooperate.
boolean
C1321605 (UMLS CUI [1])
prosthetic devices pacemaker; mri
Item
any prosthetic devices (e.g., pacemaker or surgical clips) that could be affected by the magnetic field employed during mri imaging.
boolean
C0175649 (UMLS CUI [1,1])
C0030163 (UMLS CUI [1,2])
C0024485 (UMLS CUI [2])
cognitive impairment
Item
evidence of cognitive or memory impairment reaching early ad levels at the initial evaluation. at baseline, delayed paragraph recall z-scores > 2 below the reference group.
boolean
C1839000 (UMLS CUI [1])
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