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ID
14078
Beschrijving
Integrated Approaches for Identifying Molecular Targets in Alcoholic Hepatitis; ODM derived from: https://clinicaltrials.gov/show/NCT02075918
Link
https://clinicaltrials.gov/show/NCT02075918
Trefwoorden
Versies (1)
- 27-03-16 27-03-16 -
Geüploaded op
27 maart 2016
DOI
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Licentie
Creative Commons BY 4.0
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Eligibility Alcoholic Hepatitis NCT02075918
Eligibility Alcoholic Hepatitis NCT02075918
- StudyEvent: Eligibility
Similar models
Eligibility Alcoholic Hepatitis NCT02075918
- StudyEvent: Eligibility
Name
Type
Description | Question | Decode (Coded Value)
Datatype
Alias
Age
Item
patients ≥18 and <70 years of age.
boolean
C0001779 (UMLS CUI [1])
Alcohol abuse
Item
active alcohol abuse defined according to the diagnostic and statistical manual of mental disorders iv (dsm iv) and excessive alcohol consumption prior to admission (> 60 g per day for men and> 40 g per day for women).
boolean
C0085762 (UMLS CUI [1])
Transaminases
Item
moderate elevation of aminotransferases (usually less than 300 u / l) with a characteristic pattern of ast/ alt ratio of 2:1.
boolean
C0002594 (UMLS CUI [1])
GGT
Item
elevated serum ggt and bilirubin levels.
boolean
C0017040 (UMLS CUI [1])
C0005437 (UMLS CUI [2])
C0005437 (UMLS CUI [2])
autoimmune liver disease
Item
absence of prior autoimmune liver disease (ana<1/80, sma<1/80, lkm1 neg, ama neg).
boolean
C0400936 (UMLS CUI [1])
Hepatitis B and hepatitis C
Item
absence of hepatitis b and c and hiv infection (anti-hcv, surface hbv antigen and anti-hiv neg).
boolean
C2711110 (UMLS CUI [1])
C0019693 (UMLS CUI [2])
C0019693 (UMLS CUI [2])
Decompensated cirrhosis
Item
patients with decompensated alcoholic cirrhosis will be suitable for inclusion (eg, acute gastrointestinal bleeding, acute renal failure, hepatic encephalopathy and bacterial infections).
boolean
C1619727 (UMLS CUI [1])
Item
because there are no non-diagnostic tools to diagnose alcoholic hepatitis, histological confirmation is required in all patients (preferably through a transjugular biopsy): alcoholic hepatitis will be diagnosed on the presence of the following histologic features:
integer
C0449575 (UMLS CUI [1])
Code List
because there are no non-diagnostic tools to diagnose alcoholic hepatitis, histological confirmation is required in all patients (preferably through a transjugular biopsy): alcoholic hepatitis will be diagnosed on the presence of the following histologic features:
CL Item
steatosis (either macro or microvesicular). (1)
C2711227 (UMLS CUI-1)
CL Item
hepatocellular damage (eg, hepatocyte ballooning and presence of mallory-denk bodies). (2)
C0151763 (UMLS CUI-1)
CL Item
inflammatory infiltrate (predominantly polymorphonuclear cells). (3)
C3887644 (UMLS CUI-1)
CL Item
pericellular or sinusoidal fibrosis. (4)
C0016059 (UMLS CUI-1)
hepatocellular carcinoma
Item
hepatocellular carcinoma.
boolean
C2239176 (UMLS CUI [1])
undefined item
Item
complete portal vein thrombosis.
boolean
extrahepatic diseases
Item
advanced or terminal extrahepatic diseases (eg heart failure, advanced lung diseases, advanced oncologic diseases).
boolean
C1517058 (UMLS CUI [1])
consent
Item
lack of consent to participate in the study.
boolean
C1511481 (UMLS CUI [1])
pregnancy
Item
pregnancy
boolean
C0032961 (UMLS CUI [1])