ID

14035

Description

Comparison of Combination Therapy of Corticosteroids and Bovine Colostrum Versus Corticosteroids and Placebo: Randomized Double Blind Placebo Controlled Trial in Treatment of Severe Alcoholic Hepatitis; ODM derived from: https://clinicaltrials.gov/show/NCT02473341

Link

https://clinicaltrials.gov/show/NCT02473341

Keywords

  1. 3/22/16 3/22/16 -
Uploaded on

March 22, 2016

DOI

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License

Creative Commons BY 4.0

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Eligibility Alcoholic Hepatitis NCT02473341

Eligibility Alcoholic Hepatitis NCT02473341

Inclusion Criteria
Description

Inclusion Criteria

Alias
UMLS CUI
C1512693
alcoholic hepatitis
Description

alcoholic hepatitis

Data type

boolean

Alias
UMLS CUI [1]
C0019187
jaundice < 3 months
Description

Icterus

Data type

boolean

Alias
UMLS CUI [1]
C0022346
first liver decompensating event
Description

Liver Failure

Data type

boolean

Alias
UMLS CUI [1]
C0085605
bilirubin > 5 mg/dl
Description

Bilirubin

Data type

boolean

Alias
UMLS CUI [1]
C0005437
pti (inr) increased
Description

INR

Data type

boolean

Alias
UMLS CUI [1]
C0853225
neutrophilia
Description

Neutrophilia

Data type

boolean

Alias
UMLS CUI [1]
C0151683
ast< 300 iu/l ; ast/alt >2
Description

ast

Data type

boolean

Alias
UMLS CUI [1]
C0004002
hepatic encephalopathy
Description

hepatic encephalopathy

Data type

boolean

Alias
UMLS CUI [1]
C0019151
men and women age > 18 years and above
Description

Age

Data type

boolean

Alias
UMLS CUI [1]
C0001779
df≥32 or meld≥20
Description

Meld

Data type

boolean

Alias
UMLS CUI [1]
C1718072
actively consuming alcohol within 6 weeks of entry into the study
Description

Alcohol consumption

Data type

boolean

Alias
UMLS CUI [1]
C0001948
patient with controlled upper gi bleed, resolved sepsis and acute kidney injury can be enrolled
Description

upper gi bleed

Data type

boolean

Alias
UMLS CUI [1]
C0041909
liver biopsy (as many as possible)
Description

liver biopsy

Data type

boolean

Alias
UMLS CUI [1]
C0193388
Exclusion Criteria
Description

Exclusion Criteria

Alias
UMLS CUI
C0680251
failure to obtain informed consent
Description

Informed Consent

Data type

boolean

Alias
UMLS CUI [1]
C0021430
jaundice more then 3 months
Description

jaundice more then 3 months

Data type

boolean

Alias
UMLS CUI [1]
C0745473
ast>300 iu/l
Description

Aspartate Transaminase

Data type

boolean

Alias
UMLS CUI [1]
C0004002
active infection or sepsis
Description

Sepsis

Data type

boolean

Alias
UMLS CUI [1]
C0243026
other concomitant causes of liver disease: viral hepatitis, autoimmune liver disease, metabolic liver disease, vascular liver disease
Description

concomitant causes of liver disease

Data type

boolean

Alias
UMLS CUI [1]
C0243087
hiv positive
Description

hiv positive

Data type

boolean

Alias
UMLS CUI [1]
C0019699
cow milk allergy or severe lactose intolerance
Description

FOOD ALLERGY TO LACTOSE

Data type

boolean

Alias
UMLS CUI [1]
C0744078
active gastrointestinal bleeding.
Description

Acute gastrointestinal hemorrhage

Data type

boolean

Alias
UMLS CUI [1]
C0266807
acute kidney injury at time of randomization with creatinine > 1.5 mg/dl
Description

Kidney Failure, Acute

Data type

boolean

Alias
UMLS CUI [1]
C0022660
evidence of acute pancreatitis or biliary obstruction
Description

acute pancreatitis

Data type

boolean

Alias
UMLS CUI [1]
C0001339
subjects who are pregnant or lactating
Description

Patient pregnant

Data type

boolean

Alias
UMLS CUI [1]
C0549206
UMLS CUI [2]
C2828358
Significant systemic cardio-pulmonary illness
Description

Cardiopulmonary disease

Data type

boolean

Alias
UMLS CUI [1]
C0553534
patients requiring the use of vasopressors or inotropic support in 12 hours prior to randomization
Description

Vasoconstrictor Agents

Data type

boolean

Alias
UMLS CUI [1]
C0042397
treatment for alcoholic hepatitis within 1 month of study entry with corticosteroids use>1 week.
Description

Treatment for alcoholic hepatitis

Data type

boolean

Alias
UMLS CUI [1]
C0019187
any patient who has received any investigational drug or device within 30 days entering into the study.
Description

Investigational Drugs

Data type

boolean

Alias
UMLS CUI [1]
C0013230

Similar models

Eligibility Alcoholic Hepatitis NCT02473341

Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
Item Group
C1512693 (UMLS CUI)
alcoholic hepatitis
Item
alcoholic hepatitis
boolean
C0019187 (UMLS CUI [1])
Icterus
Item
jaundice < 3 months
boolean
C0022346 (UMLS CUI [1])
Liver Failure
Item
first liver decompensating event
boolean
C0085605 (UMLS CUI [1])
Bilirubin
Item
bilirubin > 5 mg/dl
boolean
C0005437 (UMLS CUI [1])
INR
Item
pti (inr) increased
boolean
C0853225 (UMLS CUI [1])
Neutrophilia
Item
neutrophilia
boolean
C0151683 (UMLS CUI [1])
ast
Item
ast< 300 iu/l ; ast/alt >2
boolean
C0004002 (UMLS CUI [1])
hepatic encephalopathy
Item
hepatic encephalopathy
boolean
C0019151 (UMLS CUI [1])
Age
Item
men and women age > 18 years and above
boolean
C0001779 (UMLS CUI [1])
Meld
Item
df≥32 or meld≥20
boolean
C1718072 (UMLS CUI [1])
Alcohol consumption
Item
actively consuming alcohol within 6 weeks of entry into the study
boolean
C0001948 (UMLS CUI [1])
upper gi bleed
Item
patient with controlled upper gi bleed, resolved sepsis and acute kidney injury can be enrolled
boolean
C0041909 (UMLS CUI [1])
liver biopsy
Item
liver biopsy (as many as possible)
boolean
C0193388 (UMLS CUI [1])
Item Group
C0680251 (UMLS CUI)
Informed Consent
Item
failure to obtain informed consent
boolean
C0021430 (UMLS CUI [1])
jaundice more then 3 months
Item
jaundice more then 3 months
boolean
C0745473 (UMLS CUI [1])
Aspartate Transaminase
Item
ast>300 iu/l
boolean
C0004002 (UMLS CUI [1])
Sepsis
Item
active infection or sepsis
boolean
C0243026 (UMLS CUI [1])
concomitant causes of liver disease
Item
other concomitant causes of liver disease: viral hepatitis, autoimmune liver disease, metabolic liver disease, vascular liver disease
boolean
C0243087 (UMLS CUI [1])
hiv positive
Item
hiv positive
boolean
C0019699 (UMLS CUI [1])
FOOD ALLERGY TO LACTOSE
Item
cow milk allergy or severe lactose intolerance
boolean
C0744078 (UMLS CUI [1])
Acute gastrointestinal hemorrhage
Item
active gastrointestinal bleeding.
boolean
C0266807 (UMLS CUI [1])
Kidney Failure, Acute
Item
acute kidney injury at time of randomization with creatinine > 1.5 mg/dl
boolean
C0022660 (UMLS CUI [1])
acute pancreatitis
Item
evidence of acute pancreatitis or biliary obstruction
boolean
C0001339 (UMLS CUI [1])
Patient pregnant
Item
subjects who are pregnant or lactating
boolean
C0549206 (UMLS CUI [1])
C2828358 (UMLS CUI [2])
Cardiopulmonary disease
Item
Significant systemic cardio-pulmonary illness
boolean
C0553534 (UMLS CUI [1])
Vasoconstrictor Agents
Item
patients requiring the use of vasopressors or inotropic support in 12 hours prior to randomization
boolean
C0042397 (UMLS CUI [1])
Treatment for alcoholic hepatitis
Item
treatment for alcoholic hepatitis within 1 month of study entry with corticosteroids use>1 week.
boolean
C0019187 (UMLS CUI [1])
Investigational Drugs
Item
any patient who has received any investigational drug or device within 30 days entering into the study.
boolean
C0013230 (UMLS CUI [1])

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