ID

13935

Description

A randomised comparison of daily 25 mg versus 5 mg lenalidomide as maintenance therapy after high-dose therapy and autologous stem cell transplantation in patients with multiple myeloma. Protocol-Code: RV-MM-PI-280 EudraCT-Number: 2007-003945-33 Author: Claus Schreiber Review: Gerd Felder Approval of CRF: Prof. Dr. med. G. Kobbe (LKP) Release for MDM: Prof. Gattermann, Düsseldorf (26.1.2016) Principal Investigator „LenaMain“-Studie: Prof. Roland Fenk, Düsseldorf Coordinating center for clinical trial Medical faculty of University Hospital Heinrich-Heine-University Scientific Director: Herr Dr. J. Grebe Moorenstrasse 5 40225 Düsseldorf Tel.: +49 (0) 211-81-19701 Fax: +49 (0) 211-81-19702

Keywords

  1. 3/17/16 3/17/16 -
Uploaded on

March 17, 2016

DOI

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License

Creative Commons BY-NC 3.0

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Fourth Maintenance Cycle LenaMain-Study

Fourth Maintenance Cycle

Monthly control visit with response evaluation
Description

Monthly control visit with response evaluation

Date of visit
Description

Date

Data type

date

Alias
UMLS CUI [1]
C0011008
Medication dosage of last cycle
Description

Cumulative dosage of trial substance during last cycle in mg

Data type

float

Measurement units
  • mg
Alias
UMLS CUI [1]
C3174092
mg
Prior trial substance dosage
Description

Trial substance dosage

Data type

integer

Measurement units
  • mg
Alias
UMLS CUI [1,1]
C0013230
UMLS CUI [1,2]
C0178602
New trial substance dosage
Description

Trial substance dosage

Data type

integer

Alias
UMLS CUI [1,1]
C0013230
UMLS CUI [1,2]
C0178602
Please specify reason for dose reduction
Description

Dosage reduction

Data type

text

Alias
UMLS CUI [1,1]
C0178602
UMLS CUI [1,2]
C0547047
Response after first consolidation cycle
Description

Response

Data type

integer

Alias
UMLS CUI [1]
C0521982
External assessment of response
Description

External assessment of response

Data type

boolean

Alias
UMLS CUI [1,1]
C0521982
UMLS CUI [1,2]
C0220825
UMLS CUI [1,3]
C0036524
Did any Adverse Events occur?
Description

Adverse Events

Data type

boolean

Alias
UMLS CUI [1]
C0877248
Vital signs
Description

Vital signs

Heart rate
Description

Heart rate

Data type

integer

Measurement units
  • bpm
Alias
UMLS CUI [1]
C0018810
bpm
Blood pressure, systolic
Description

Blood pressure

Data type

integer

Measurement units
  • mmHg
Alias
UMLS CUI [1]
C0005823
mmHg
Blood pressure, diastolic
Description

Blood pressure

Data type

integer

Measurement units
  • mmHg
Alias
UMLS CUI [1]
C0005823
mmHg
Body weight
Description

Body weight

Data type

float

Measurement units
  • kg
Alias
UMLS CUI [1]
C0005910
kg
Body Height
Description

Body Height

Data type

integer

Measurement units
  • cm
Alias
UMLS CUI [1]
C0005890
cm
Ecog performance status
Description

Ecog performance status

Data type

integer

Alias
UMLS CUI [1]
C1520224
Laboratory:Protein electrophoresis
Description

Laboratory:Protein electrophoresis

Albumin
Description

Albumin

Data type

float

Measurement units
  • g/dL
Alias
UMLS CUI [1]
C0201838
g/dL
Total Protein in 24h urine
Description

Total Protein

Data type

float

Measurement units
  • mg/24h
Alias
UMLS CUI [1]
C0428541
mg/24h
Total Serum Protein
Description

Total Serum Protein

Data type

float

Measurement units
  • g/dl
Alias
UMLS CUI [1]
C0036836
g/dl
Beta-globulin measurement
Description

Beta-globulin

Data type

float

Measurement units
  • g/dL
Alias
UMLS CUI [1]
C0005157
g/dL
Gamma-Globulin measurement
Description

Gamma-Globulin

Data type

float

Measurement units
  • g/dL
Alias
UMLS CUI [1]
C0860681
g/dL
Beta and gamma globulin total
Description

Please give the sum only, if stated in the lab sheet

Data type

float

Measurement units
  • g/dL
Alias
UMLS CUI [1]
C1717622
g/dL
Serum immunofixation
Description

Serum immunofixation

Data type

integer

Alias
UMLS CUI [1]
C1271678
Comment on serum immunofixation
Description

Comment

Data type

text

Alias
UMLS CUI [1]
C0947611
Urine immunofixation
Description

Urine immunofixation

Data type

integer

Alias
UMLS CUI [1]
C1271641
Comment on urine immunofixation
Description

Comment

Data type

text

Alias
UMLS CUI [1]
C0947611
IgA measurement
Description

IgA

Data type

float

Measurement units
  • mg/dl
Alias
UMLS CUI [1]
C0202083
mg/dl
IgD measurement
Description

IgD

Data type

float

Measurement units
  • mg/dl
Alias
UMLS CUI [1]
C0577612
mg/dl
IgG measurement
Description

IgG

Data type

float

Measurement units
  • mg/dl
Alias
UMLS CUI [1]
C0202087
mg/dl
Immunoglobulin M measurement
Description

IgM

Data type

float

Measurement units
  • mg/dl
Alias
UMLS CUI [1]
C0202084
mg/dl
FLC kappa measurement
Description

FLC kappa

Data type

float

Measurement units
  • mg/l
Alias
UMLS CUI [1]
C3274397
mg/l
Kappa
Description

Kappa

Data type

integer

Alias
UMLS CUI [1]
C0439099
FLC lambda measurement
Description

FLC lambda

Data type

float

Measurement units
  • mg/l
Alias
UMLS CUI [1]
C3274399
mg/l
Lambda
Description

Lambda

Data type

integer

Alias
UMLS CUI [1]
C1706314
Kappa/lambda quotient
Description

Kappa/lambda quotient

Data type

integer

Alias
UMLS CUI [1]
C1168398
Laboratory:Hematology
Description

Laboratory:Hematology

Erythrocytes
Description

Erythrocytes

Data type

float

Measurement units
  • Mio/μl
Alias
UMLS CUI [1]
C0014772
Mio/μl
Hemoglobin
Description

Hemoglobin

Data type

float

Measurement units
  • g/dL
Alias
UMLS CUI [1]
C0019046
g/dL
Hematocrit
Description

Hematocrit

Data type

float

Measurement units
  • %
Alias
UMLS CUI [1]
C0518014
%
Mean Corpuscular Volume
Description

MCV

Data type

float

Measurement units
  • fl
Alias
UMLS CUI [1]
C1948043
fl
MCH
Description

MCH

Data type

float

Measurement units
  • pg
Alias
UMLS CUI [1]
C0369183
pg
Mean corpuscular hemoglobin concentration
Description

MCHC

Data type

float

Measurement units
  • g Hb/dL Ery
Alias
UMLS CUI [1]
C0474535
g Hb/dL Ery
Leukocytes
Description

Leukocytes

Data type

float

Measurement units
  • 1000/μl
Alias
UMLS CUI [1]
C0023508
1000/μl
Leukocytes (total)
Description

Leukocytes

Data type

integer

Alias
UMLS CUI [1]
C1271681
Platelet count
Description

Platelets

Data type

float

Measurement units
  • 1000/uL
Alias
UMLS CUI [1]
C0005821
1000/uL
Neutrophils percentage
Description

Neutrophils percentage

Data type

float

Measurement units
  • %
Alias
UMLS CUI [1]
C2238207
%
Neutrophils
Description

Neutrophils

Data type

float

Measurement units
  • abs.
Alias
UMLS CUI [1]
C0948762
abs.
Eosinophils percentage
Description

Eosinophils percentage

Data type

float

Measurement units
  • %
Alias
UMLS CUI [1]
C2228144
%
Basophils percentage
Description

Basophils percentage

Data type

float

Measurement units
  • %
Alias
UMLS CUI [1]
C2237945
%
Monocytes percentage
Description

Monocytes percentage

Data type

float

Measurement units
  • %
Alias
UMLS CUI [1]
C2237144
%
Lymphocytes percentage
Description

Lymphocytes percentage

Data type

float

Measurement units
  • %
Alias
UMLS CUI [1]
C2200256
%
Neutrophils
Description

Neutrophils

Data type

float

Measurement units
  • 1000/μl
Alias
UMLS CUI [1]
C0200633
1000/μl
Laboratory:serum chemistry
Description

Laboratory:serum chemistry

Sodium
Description

Sodium

Data type

float

Measurement units
  • mmol/L
Alias
UMLS CUI [1]
C0337443
mmol/L
Potassium
Description

Potassium

Data type

float

Measurement units
  • mmol/l
Alias
UMLS CUI [1]
C0202194
mmol/l
Calcium
Description

Calcium

Data type

float

Measurement units
  • mmol/l
Alias
UMLS CUI [1]
C0201925
mmol/l
Glucose
Description

Glucose

Data type

float

Measurement units
  • mg/dl
Alias
UMLS CUI [1]
C0202042
mg/dl
Alkaline Phosphatase
Description

Alkaline Phosphatase

Data type

float

Measurement units
  • U/L
Alias
UMLS CUI [1]
C0201850
U/L
Bilirubin
Description

Bilirubin

Data type

float

Measurement units
  • mg/dL
Alias
UMLS CUI [1]
C0005437
mg/dL
AST (SGOT)
Description

AST

Data type

float

Measurement units
  • U/L
Alias
UMLS CUI [1]
C0201899
U/L
ALT
Description

ALT

Data type

float

Measurement units
  • U/L
Alias
UMLS CUI [1]
C0201836
U/L
Gamma GT
Description

Gamma GT

Data type

float

Measurement units
  • U/l
Alias
UMLS CUI [1]
C0202035
U/l
Lactate Dehydrogenase (LDH)
Description

LDH

Data type

float

Measurement units
  • U/L
Alias
UMLS CUI [1]
C0202113
U/L
Urea
Description

Urea

Data type

float

Measurement units
  • mg/dl
Alias
UMLS CUI [1]
C0523961
mg/dl
CRP
Description

CRP

Data type

float

Measurement units
  • md/dl
Alias
UMLS CUI [1]
C0201657
md/dl
Serum creatinine
Description

Creatinine, Serum

Data type

float

Measurement units
  • mg/dL
Alias
UMLS CUI [1]
C0201976
mg/dL
Creatinine Clearance
Description

Creatinine Clearance

Data type

float

Measurement units
  • mL/min
Alias
UMLS CUI [1]
C0373595
mL/min
Laboratory:pregnancy test
Description

Laboratory:pregnancy test

Is the subject of childbearing potential?
Description

Childbearing potential

Data type

boolean

Alias
UMLS CUI [1]
C3831118
Pregnancy test result
Description

Pregnancy test

Data type

integer

Alias
UMLS CUI [1]
C0032976
Has the patient experienced irregularities with her menstrual period since her last pregnancy test?
Description

Menstruation

Data type

integer

Alias
UMLS CUI [1]
C0025344
Quality of life
Description

Quality of life

Total Score QoL
Description

Please answer questions 1-30 of the EORTC QIQ-C30 Quality of Life

Data type

float

Alias
UMLS CUI [1]
C3476431
Hematotoxicity CTC
Description

Hematotoxicity CTC

Hemoglobin CTC
Description

Hematotoxicity evaluation according to CTC during the last cycle (please document CTC grade of the lowest hemoglobin value)

Data type

integer

Alias
UMLS CUI [1,1]
C0019046
UMLS CUI [1,2]
C1516728
Date of lowest hemoglobin value
Description

Date of lowest hemoglobin value

Data type

date

Alias
UMLS CUI [1,1]
C0011008
UMLS CUI [1,2]
C0518015
Hemoglobin: actions taken with study medication
Description

Actions taken with study medication

Data type

integer

Alias
UMLS CUI [1]
C1704758
Leukocytes CTC
Description

Hematotoxicity evaluation according to CTC during the last cycle (please document CTC grade of the lowest leukocytes value)

Data type

integer

Alias
UMLS CUI [1,1]
C1516728
UMLS CUI [1,2]
C0023516
Date of lowest leukocytes value
Description

Date of lowest leukocytes value

Data type

date

Alias
UMLS CUI [1,1]
C0011008
UMLS CUI [1,2]
C0023508
Actions taken with study medication:leukocytes
Description

Actions taken with study medication

Data type

integer

Alias
UMLS CUI [1]
C1704758
Platelets CTC
Description

Hematotoxicity evaluation according to CTC during the last cycle (please document CTC grade of the lowest platelets value)

Data type

integer

Alias
UMLS CUI [1,1]
C1516728
UMLS CUI [1,2]
C0032181
Date of lowest platelets value
Description

Date of lowest platelets value

Data type

date

Alias
UMLS CUI [1,1]
C0011008
UMLS CUI [1,2]
C0032181
Actions taken with study medication:platelets
Description

Actions taken with study medication

Data type

integer

Alias
UMLS CUI [1]
C1704758
Neutrophils CTC
Description

Hematotoxicity evaluation according to CTC during the last cycle (please document CTC grade of the lowest neutrophils value)

Data type

integer

Alias
UMLS CUI [1,1]
C1516728
UMLS CUI [1,2]
C0948762
Date of lowest neutrophils value
Description

Date of lowest neutrophils value

Data type

date

Alias
UMLS CUI [1,1]
C0011008
UMLS CUI [1,2]
C0948762
Actions taken with study medication:neutrophils
Description

Actions taken with study medication

Data type

integer

Alias
UMLS CUI [1]
C1704758

Similar models

Fourth Maintenance Cycle

Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
Item Group
Monthly control visit with response evaluation
Date
Item
Date of visit
date
C0011008 (UMLS CUI [1])
Medication dosage
Item
Medication dosage of last cycle
float
C3174092 (UMLS CUI [1])
Item
Prior trial substance dosage
integer
C0013230 (UMLS CUI [1,1])
C0178602 (UMLS CUI [1,2])
Code List
Prior trial substance dosage
CL Item
25 mg (1)
CL Item
15 mg (2)
CL Item
10 mg (3)
CL Item
5 mg (4)
CL Item
20 mg (5)
Item
New trial substance dosage
integer
C0013230 (UMLS CUI [1,1])
C0178602 (UMLS CUI [1,2])
Code List
New trial substance dosage
CL Item
25 mg (1)
CL Item
15 mg (2)
CL Item
10 mg (3)
CL Item
5 mg (4)
CL Item
20 mg (5)
Dosage reduction
Item
Please specify reason for dose reduction
text
C0178602 (UMLS CUI [1,1])
C0547047 (UMLS CUI [1,2])
Item
Response after first consolidation cycle
integer
C0521982 (UMLS CUI [1])
Code List
Response after first consolidation cycle
CL Item
sCR (0)
CL Item
CR (1)
CL Item
vgPR (2)
CL Item
PR (3)
CL Item
SD (5)
CL Item
PD (6)
External assessment of response
Item
External assessment of response
boolean
C0521982 (UMLS CUI [1,1])
C0220825 (UMLS CUI [1,2])
C0036524 (UMLS CUI [1,3])
Adverse Events
Item
Did any Adverse Events occur?
boolean
C0877248 (UMLS CUI [1])
Item Group
Vital signs
Heart rate
Item
Heart rate
integer
C0018810 (UMLS CUI [1])
Blood pressure
Item
Blood pressure, systolic
integer
C0005823 (UMLS CUI [1])
Blood pressure
Item
Blood pressure, diastolic
integer
C0005823 (UMLS CUI [1])
Body weight
Item
Body weight
float
C0005910 (UMLS CUI [1])
Body Height
Item
Body Height
integer
C0005890 (UMLS CUI [1])
Item
Ecog performance status
integer
C1520224 (UMLS CUI [1])
Code List
Ecog performance status
CL Item
Score 0 (0)
CL Item
Score 1 (1)
CL Item
Score 2 (2)
CL Item
Score 3 (3)
CL Item
Score 4 (4)
CL Item
Score 5 (5)
Item Group
Laboratory:Protein electrophoresis
Albumin
Item
Albumin
float
C0201838 (UMLS CUI [1])
Total Protein
Item
Total Protein in 24h urine
float
C0428541 (UMLS CUI [1])
Total Serum Protein
Item
Total Serum Protein
float
C0036836 (UMLS CUI [1])
Beta-globulin
Item
Beta-globulin measurement
float
C0005157 (UMLS CUI [1])
Gamma-Globulin
Item
Gamma-Globulin measurement
float
C0860681 (UMLS CUI [1])
Beta and gamma globulin total
Item
Beta and gamma globulin total
float
C1717622 (UMLS CUI [1])
Item
Serum immunofixation
integer
C1271678 (UMLS CUI [1])
Code List
Serum immunofixation
CL Item
positive (1)
CL Item
negative (2)
Comment
Item
Comment on serum immunofixation
text
C0947611 (UMLS CUI [1])
Item
Urine immunofixation
integer
C1271641 (UMLS CUI [1])
Code List
Urine immunofixation
CL Item
positive (1)
CL Item
negative (2)
Comment
Item
Comment on urine immunofixation
text
C0947611 (UMLS CUI [1])
IgA
Item
IgA measurement
float
C0202083 (UMLS CUI [1])
IgD
Item
IgD measurement
float
C0577612 (UMLS CUI [1])
IgG
Item
IgG measurement
float
C0202087 (UMLS CUI [1])
IgM
Item
Immunoglobulin M measurement
float
C0202084 (UMLS CUI [1])
FLC kappa
Item
FLC kappa measurement
float
C3274397 (UMLS CUI [1])
Kappa
Item
Kappa
integer
C0439099 (UMLS CUI [1])
FLC lambda
Item
FLC lambda measurement
float
C3274399 (UMLS CUI [1])
Lambda
Item
Lambda
integer
C1706314 (UMLS CUI [1])
Kappa/lambda quotient
Item
Kappa/lambda quotient
integer
C1168398 (UMLS CUI [1])
Item Group
Laboratory:Hematology
Erythrocytes
Item
Erythrocytes
float
C0014772 (UMLS CUI [1])
Hemoglobin
Item
Hemoglobin
float
C0019046 (UMLS CUI [1])
Hematocrit
Item
Hematocrit
float
C0518014 (UMLS CUI [1])
MCV
Item
Mean Corpuscular Volume
float
C1948043 (UMLS CUI [1])
MCH
Item
MCH
float
C0369183 (UMLS CUI [1])
MCHC
Item
Mean corpuscular hemoglobin concentration
float
C0474535 (UMLS CUI [1])
Leukocytes
Item
Leukocytes
float
C0023508 (UMLS CUI [1])
Leukocytes
Item
Leukocytes (total)
integer
C1271681 (UMLS CUI [1])
Platelets
Item
Platelet count
float
C0005821 (UMLS CUI [1])
Neutrophils percentage
Item
Neutrophils percentage
float
C2238207 (UMLS CUI [1])
Neutrophils
Item
Neutrophils
float
C0948762 (UMLS CUI [1])
Eosinophils percentage
Item
Eosinophils percentage
float
C2228144 (UMLS CUI [1])
Basophils percentage
Item
Basophils percentage
float
C2237945 (UMLS CUI [1])
Monocytes percentage
Item
Monocytes percentage
float
C2237144 (UMLS CUI [1])
Lymphocytes percentage
Item
Lymphocytes percentage
float
C2200256 (UMLS CUI [1])
Neutrophils
Item
Neutrophils
float
C0200633 (UMLS CUI [1])
Item Group
Laboratory:serum chemistry
Sodium
Item
Sodium
float
C0337443 (UMLS CUI [1])
Potassium
Item
Potassium
float
C0202194 (UMLS CUI [1])
Calcium
Item
Calcium
float
C0201925 (UMLS CUI [1])
Glucose
Item
Glucose
float
C0202042 (UMLS CUI [1])
Alkaline Phosphatase
Item
Alkaline Phosphatase
float
C0201850 (UMLS CUI [1])
Bilirubin
Item
Bilirubin
float
C0005437 (UMLS CUI [1])
AST
Item
AST (SGOT)
float
C0201899 (UMLS CUI [1])
ALT
Item
ALT
float
C0201836 (UMLS CUI [1])
Gamma GT
Item
Gamma GT
float
C0202035 (UMLS CUI [1])
LDH
Item
Lactate Dehydrogenase (LDH)
float
C0202113 (UMLS CUI [1])
Urea
Item
Urea
float
C0523961 (UMLS CUI [1])
CRP
Item
CRP
float
C0201657 (UMLS CUI [1])
Creatinine, Serum
Item
Serum creatinine
float
C0201976 (UMLS CUI [1])
Creatinine Clearance
Item
Creatinine Clearance
float
C0373595 (UMLS CUI [1])
Item Group
Laboratory:pregnancy test
Childbearing potential
Item
Is the subject of childbearing potential?
boolean
C3831118 (UMLS CUI [1])
Item
Pregnancy test result
integer
C0032976 (UMLS CUI [1])
Code List
Pregnancy test result
CL Item
positive (1)
CL Item
negative (2)
Item
Has the patient experienced irregularities with her menstrual period since her last pregnancy test?
integer
C0025344 (UMLS CUI [1])
Code List
Has the patient experienced irregularities with her menstrual period since her last pregnancy test?
CL Item
No menstruation (0)
CL Item
Yes (1)
CL Item
No (2)
Item Group
Quality of life
Quality of life score
Item
Total Score QoL
float
C3476431 (UMLS CUI [1])
Item Group
Hematotoxicity CTC
Item
Hemoglobin CTC
integer
C0019046 (UMLS CUI [1,1])
C1516728 (UMLS CUI [1,2])
Code List
Hemoglobin CTC
CL Item
1 (1)
CL Item
2 (2)
CL Item
3 (3)
CL Item
4 (4)
CL Item
5 (5)
Date of lowest hemoglobin value
Item
Date of lowest hemoglobin value
date
C0011008 (UMLS CUI [1,1])
C0518015 (UMLS CUI [1,2])
Item
Hemoglobin: actions taken with study medication
integer
C1704758 (UMLS CUI [1])
Code List
Hemoglobin: actions taken with study medication
CL Item
No change required (0)
CL Item
Interruption/ prolongation without dose reduction (1)
CL Item
Interruption/ prolongation with dose reduction (2)
Item
Leukocytes CTC
integer
C1516728 (UMLS CUI [1,1])
C0023516 (UMLS CUI [1,2])
Code List
Leukocytes CTC
CL Item
1 (1)
CL Item
2 (2)
CL Item
3 (3)
CL Item
4 (4)
CL Item
5 (5)
Date of lowest leukocytes value
Item
Date of lowest leukocytes value
date
C0011008 (UMLS CUI [1,1])
C0023508 (UMLS CUI [1,2])
Item
Actions taken with study medication:leukocytes
integer
C1704758 (UMLS CUI [1])
Code List
Actions taken with study medication:leukocytes
CL Item
No change required (0)
CL Item
Interruption/ prolongation without dose reduction (1)
CL Item
Interruption/ prolongation with dose reduction (2)
Item
Platelets CTC
integer
C1516728 (UMLS CUI [1,1])
C0032181 (UMLS CUI [1,2])
Code List
Platelets CTC
CL Item
1 (1)
CL Item
2 (2)
CL Item
3 (3)
CL Item
4 (4)
CL Item
5 (5)
Date of lowest platelets value
Item
Date of lowest platelets value
date
C0011008 (UMLS CUI [1,1])
C0032181 (UMLS CUI [1,2])
Item
Actions taken with study medication:platelets
integer
C1704758 (UMLS CUI [1])
Code List
Actions taken with study medication:platelets
CL Item
No change required (0)
CL Item
Interruption/ prolongation without dose reduction (1)
CL Item
Interruption/ prolongation with dose reduction (2)
Item
Neutrophils CTC
integer
C1516728 (UMLS CUI [1,1])
C0948762 (UMLS CUI [1,2])
Code List
Neutrophils CTC
CL Item
1 (1)
CL Item
2 (2)
CL Item
3 (3)
CL Item
4 (4)
CL Item
5 (5)
Date of lowest neutrophils value
Item
Date of lowest neutrophils value
date
C0011008 (UMLS CUI [1,1])
C0948762 (UMLS CUI [1,2])
Item
Actions taken with study medication:neutrophils
integer
C1704758 (UMLS CUI [1])
Code List
Actions taken with study medication:neutrophils
CL Item
No change required (0)
CL Item
Interruption/ prolongation without dose reduction (1)
CL Item
Interruption/ prolongation with dose reduction (2)

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