ID
13754
Beschreibung
Decitabine Maintenance in Elderly Acute Myeloid Leukemia Patients; ODM derived from: https://clinicaltrials.gov/show/NCT01149408
Link
https://clinicaltrials.gov/show/NCT01149408
Stichworte
Versionen (1)
- 03.03.16 03.03.16 -
Rechteinhaber
CC BY-NC 3.0
Hochgeladen am
3. März 2016
DOI
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Lizenz
Creative Commons BY-NC 3.0
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Eligibility Acute Myeloid Leukemia NCT01149408
Eligibility Acute Myeloid Leukemia NCT01149408
- StudyEvent: Eligibility
Beschreibung
Exclusion Criteria
Alias
- UMLS CUI
- C0680251
Beschreibung
1. diagnosis of acute promyelocytic leukemia (apl, who classification of apl with t(15;17)(q22;q12)
Datentyp
boolean
Alias
- UMLS CUI [1]
- C0023487
Beschreibung
2. prior diagnosis and treatment for aml, including hematopoietic stem cell transplant (hsct)
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0023467
- UMLS CUI [1,2]
- C1514463
- UMLS CUI [2,1]
- C0472699
- UMLS CUI [2,2]
- C1514463
Beschreibung
3. previous therapy with a hypomethylating agent including decitabine or azacitidine (i.e. for an antecedent myelodysplastic syndrome)
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C2613367
- UMLS CUI [1,2]
- C0013227
Beschreibung
4. any prior therapy for aml except for hydroxyurea for the control of blood counts
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C0023467
- UMLS CUI [1,2]
- C1514463
- UMLS CUI [2]
- C0020402
Beschreibung
5. psychiatric disorders that would interfere with consent, study participation, or follow-up
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C1321605
- UMLS CUI [1,2]
- C0439801
- UMLS CUI [1,3]
- C0009488
Beschreibung
6. cardiac disease: heart failure nyha class 3 or 4; unstable coronary artery disease (mi more than 6 months prior to study entry is permitted); serious cardiac ventricular arrhythmias requiring anti-arrhythmic therapy (beta blockers or digoxin are permitted)
Datentyp
boolean
Alias
- UMLS CUI [1]
- C1275491
- UMLS CUI [2,1]
- C0010068
- UMLS CUI [2,2]
- C0443343
- UMLS CUI [3]
- C0085612
- UMLS CUI [4]
- C1979623
- UMLS CUI [5,1]
- C0027051
- UMLS CUI [5,2]
- C0011008
- UMLS CUI [6]
- C0001645
- UMLS CUI [7]
- C0012265
Beschreibung
7. chronically impaired renal function (creatinine clearance < 30 ml / min)
Datentyp
boolean
Alias
- UMLS CUI [1]
- C0373595
Beschreibung
8. inadequate liver function (alt and ast ≥ 2.5 x uln) if not caused by leukemic infiltration
Datentyp
boolean
Alias
- UMLS CUI [1]
- C0201836
- UMLS CUI [2]
- C0201899
Beschreibung
9. total bilirubin ≥ 1.5 x uln if not caused by leukemic infiltration
Datentyp
boolean
Alias
- UMLS CUI [1]
- C1278039
Beschreibung
10. known hiv and/or hepatitis c infection
Datentyp
boolean
Alias
- UMLS CUI [1]
- C0019682
- UMLS CUI [2]
- C0019196
Beschreibung
11. evidence or history of severe non-leukemia associated bleeding diathesis or coagulopathy
Datentyp
boolean
Alias
- UMLS CUI [1]
- C0005779
Beschreibung
12. evidence or recent history of cns disease, including primary or metastatic brain tumors, seizure disorders
Datentyp
boolean
Alias
- UMLS CUI [1]
- C0007682
Beschreibung
13. clinical evidence suggestive of central nervous system (cns) involvement with leukemia unless a lumbar puncture confirms the absence of leukemic blasts in the cerebrospinal fluid (csf)
Datentyp
boolean
Alias
- UMLS CUI [1]
- C1332884
- UMLS CUI [2,1]
- C0368761
- UMLS CUI [2,2]
- C0007806
Beschreibung
14. any other severe concurrent disease, or have a history of serious organ dysfunction or disease involving the heart, kidney, liver, or other organ system that may place the patient at undue risk to undergo therapy on this protocol
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C1321605
- UMLS CUI [1,2]
- C0439801
- UMLS CUI [1,3]
- C0009488
Beschreibung
15. systemic fungal, bacterial, viral, or other infection not controlled (defined as exhibiting ongoing signs/symptoms related to the infection and without improvement, despite appropriate antibiotics or other treatment)
Datentyp
boolean
Alias
- UMLS CUI [1]
- C0009450
Beschreibung
16. diagnosis of another malignancy, unless the patient has been disease-free for at least 5 years following the completion of curative intent therapy with the following exceptions: patients with treated non-melanoma skin cancer, in situ carcinoma, or cervical intraepithelial neoplasia, regardless of the disease-free duration, are eligible for this study if definitive treatment for the condition has been completed. patients with organ-confined prostate cancer with no evidence of recurrent or progressive disease based on prostate-specific antigen (psa) values are also eligible for this study if hormonal therapy has been initiated or a radical prostatectomy has been performed
Datentyp
boolean
Alias
- UMLS CUI [1]
- C0006826
- UMLS CUI [2]
- C0007099
- UMLS CUI [3]
- C0699893
- UMLS CUI [4]
- C0206708
- UMLS CUI [5]
- C0600139
Beschreibung
17. history of organ allograft
Datentyp
boolean
Alias
- UMLS CUI [1]
- C0178784
Beschreibung
18. any severe concomitant condition, which makes it undesirable for the patient to participate in the study or which could jeopardize compliance with the protocol
Datentyp
boolean
Alias
- UMLS CUI [1,1]
- C1321605
- UMLS CUI [1,2]
- C0439801
- UMLS CUI [1,3]
- C0009488
Beschreibung
19. patients who have an indication for and can undergo a non-myeloablative transplant procedure
Datentyp
boolean
Alias
- UMLS CUI [1]
- C1831742
Ähnliche Modelle
Eligibility Acute Myeloid Leukemia NCT01149408
- StudyEvent: Eligibility
C1515568 (UMLS CUI [1,2])
C0677874 (UMLS CUI [1,3])
C0280449 (UMLS CUI [2,1])
C0677874 (UMLS CUI [2,2])
C0023487 (UMLS CUI [3])
C0010711 (UMLS CUI [4])
C0020789 (UMLS CUI [5])
C0677874 (UMLS CUI [2])
C0700589 (UMLS CUI [2])
C1278039 (UMLS CUI [2])
C0201899 (UMLS CUI [3])
C0201836 (UMLS CUI [4])
C1514463 (UMLS CUI [1,2])
C0472699 (UMLS CUI [2,1])
C1514463 (UMLS CUI [2,2])
C0013227 (UMLS CUI [1,2])
C1514463 (UMLS CUI [1,2])
C0020402 (UMLS CUI [2])
C0439801 (UMLS CUI [1,2])
C0009488 (UMLS CUI [1,3])
C0010068 (UMLS CUI [2,1])
C0443343 (UMLS CUI [2,2])
C0085612 (UMLS CUI [3])
C1979623 (UMLS CUI [4])
C0027051 (UMLS CUI [5,1])
C0011008 (UMLS CUI [5,2])
C0001645 (UMLS CUI [6])
C0012265 (UMLS CUI [7])
C0201899 (UMLS CUI [2])
C0019196 (UMLS CUI [2])
C0368761 (UMLS CUI [2,1])
C0007806 (UMLS CUI [2,2])
C0439801 (UMLS CUI [1,2])
C0009488 (UMLS CUI [1,3])
C0007099 (UMLS CUI [2])
C0699893 (UMLS CUI [3])
C0206708 (UMLS CUI [4])
C0600139 (UMLS CUI [5])
C0439801 (UMLS CUI [1,2])
C0009488 (UMLS CUI [1,3])