ID

13335

Descrição

Haploid Allogeneic Transplant Using the CliniMACS System; ODM derived from: https://clinicaltrials.gov/show/NCT00185679

Link

https://clinicaltrials.gov/show/NCT00185679

Palavras-chave

Versões (1)
  1. 05/02/2016 05/02/2016 -
Transferido a

5 de fevereiro de 2016

DOI

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Licença

Creative Commons BY 4.0
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Eligibility Acute Myelogenous Leukemia (AML) - Relapsed, Primary Refractory Disease or Poor Risk Factors NCT00185679

Inglês

Eligibility Acute Myelogenous Leukemia (AML) - Relapsed, Primary Refractory Disease or Poor Risk Factors NCT00185679

1 Formulários  
Inclusion Criteria Recipient
Descrição

Inclusion Criteria Recipient

Alias
UMLS CUI-1
C1512693
UMLS CUI-2
C1709854
Histopathologically-confirmed diagnosis of hematological or lymphatic malignancy, defined as one of the following:
Descrição

hematological or lymphatic malignancy

Tipo de dados

boolean

Alias
UMLS CUI [1]
C0376545
UMLS CUI [2,1]
C0006826
UMLS CUI [2,2]
C1522604
Acute myeloid leukemia (aml) as primary refractory disease, or in relapse
Descrição

AML as primary ref disease or in relapse

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0023467
UMLS CUI [1,2]
C1514815
UMLS CUI [2,1]
C0023467
UMLS CUI [2,2]
C0277556
acute leukemia in first remission with poor risk factors and molecular prognosis
Descrição

AML first remission

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0153886
UMLS CUI [1,2]
C0205435
aml with -5,-7, t(6;9), tri8, -11
Descrição

chromosome abnormalities

Tipo de dados

boolean

Alias
UMLS CUI [1]
C4015468
acute lymphocytic / lymphoblastic leukemia (all) with phil+ t(9;22),(q34;q11.2), and t(4:11)(q21;23)
Descrição

ALL type

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0023449
UMLS CUI [1,2]
C1709527
UMLS CUI [2,1]
C0023449
UMLS CUI [2,2]
C3688703
Chronic myelogenous leukemia (cml in accelerated, second chronic phase)
Descrição

CML

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0023474
UMLS CUI [1,2]
C0521110
Myelodysplastic syndrome with high intermediate to high risk categories
Descrição

myelodysplastic syndrome

Tipo de dados

boolean

Alias
UMLS CUI [1]
C3463824
Non-hodgkin's lymphoma (nhl)
Descrição

NHL

Tipo de dados

boolean

Alias
UMLS CUI [1]
C0024305
Chronic lymphocytic leukemia (cll), refractory
Descrição

CLL

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0023434
UMLS CUI [1,2]
C0205269
Creatinine clearance > 50 ml/min for those above serum creatinine of 1.5 mg/dl, serum bilirubin < 2.0 mg/dl, alt < 2x uln (unless secondary to disease)
Descrição

creatinine clearance bilirubin and alt measurement

Tipo de dados

boolean

Alias
UMLS CUI [1]
C0373595
UMLS CUI [2]
C1278039
UMLS CUI [3]
C0201836
< 50 years old at time of registration
Descrição

< 50 years old at time of registration

Tipo de dados

boolean

Alias
UMLS CUI [1]
C1828181
Donor is related, Donor is genotypically-matched and haploidentical for HLA-A, B,C and DRB1, DQ loci Donor differs for 2 or 3 HLA alleles on the unshared haplotype in the GvHD direction
Descrição

donor criteria

Tipo de dados

boolean

Alias
UMLS CUI [1]
C3494891
UMLS CUI [2]
C1285573
UMLS CUI [3,1]
C3829897
UMLS CUI [3,2]
C0019721
UMLS CUI [4,1]
C3829897
UMLS CUI [4,2]
C0122040
UMLS CUI [5]
C0972850
No HLA-matched sibling or matched unrelated donor is identified
Descrição

no HLA match identified

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0019721
UMLS CUI [1,2]
C3242262
ECOG performance status not more than 2
Descrição

ECOG performance status not more than 2

Tipo de dados

boolean

Alias
UMLS CUI [1]
C1520224
LVEF
Descrição

LVEF

Tipo de dados

boolean

Alias
UMLS CUI [1]
C0428772
DLCO > 50%
Descrição

DLCO > 50%

Tipo de dados

boolean

Alias
UMLS CUI [1]
C1516251
Corrected for hemoglobin Serum creatinine < 1.5 mg/dL
Descrição

serum creatinine

Tipo de dados

boolean

Alias
UMLS CUI [1]
C0201976
Females of childbearing potential must have a negative serum or urine beta-HCG test within 3 weeks of registration
Descrição

pregnancy test beta-HCG

Tipo de dados

boolean

Alias
UMLS CUI [1]
C0032961
UMLS CUI [2]
C0106132
No prior cancer within 5 years with the exception of surgically-cured, non-melanoma skin cancer or in situ cancer of the cervix
Descrição

no prior cancer

Tipo de dados

text

Alias
UMLS CUI [1]
C0006826
No prior myeloablative therapy or transplant
Descrição

myeloablative therapy or transplant

Tipo de dados

boolean

Alias
UMLS CUI [1]
C1513784
UMLS CUI [2]
C0005961
Duly-executed informed consent
Descrição

informed consent

Tipo de dados

boolean

Alias
UMLS CUI [1]
C0021430
Exclusion Criteria Recipient
Descrição

Exclusion Criteria Recipient

Alias
UMLS CUI-1
C0680251
UMLS CUI-2
C1709854
Suitable candidate for autologous transplantation
Descrição

autologous transplantation

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0040736
UMLS CUI [1,2]
C1548635
Participation in other investigational drugs or devices trials that might influence the study endpoints
Descrição

participation in another study

Tipo de dados

boolean

Alias
UMLS CUI [1]
C2348568
Evidence of active hepatitis
Descrição

active hepatitis

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0019158
UMLS CUI [1,2]
C0205177
Evidence of active cirrhosis
Descrição

active cirrhosis

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C1623038
UMLS CUI [1,2]
C0205177
HIV-positive
Descrição

HIV positive

Tipo de dados

boolean

Alias
UMLS CUI [1]
C0019699
History of invasive aspergillosis
Descrição

invasive aspergillosis

Tipo de dados

boolean

Alias
UMLS CUI [1]
C0238013
Presence of any other uncontrolled, active infection, ie, bacterial, viral or fungal
Descrição

uncontrolled active infection

Tipo de dados

boolean

Alias
UMLS CUI [1]
C0009450
Uncontrolled CNS involvement
Descrição

uncontrolled CNS involvement

Tipo de dados

boolean

Alias
UMLS CUI [1]
C0449389
Documented allergy to murine proteins
Descrição

allergy to murine proteins

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0020517
UMLS CUI [1,2]
C1699668
Documented allergy to iron dextran
Descrição

allergy to iron dextran

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0020517
UMLS CUI [1,2]
C0022092
Female of child-bearing potential unwilling to implement adequate birth control
Descrição

contraceptive use

Tipo de dados

boolean

Alias
UMLS CUI [1]
C1999124
Medical problem / neurologic/psychiatric dysfunction which would impair his/her ability to be compliant with the medical regimen and/or to tolerate transplantation, in the opinion of the principal investigator
Descrição

comorbidities affecting compliance and transplantation

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C1321605
UMLS CUI [1,2]
C0439801
UMLS CUI [1,3]
C0009488
UMLS CUI [2,1]
C0009488
UMLS CUI [2,2]
C0392760
UMLS CUI [2,3]
C0005961
Medical problem / neurologic/psychiatric dysfunction which would prolong hematologic recovery and place the recipient at unacceptable risk, in the opinion of the principal investigator would
Descrição

comorbidities prolonging hematologic recovery

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0009488
UMLS CUI [1,2]
C0392760
UMLS CUI [1,3]
C0237820
Inclusion Criteria Donor
Descrição

Inclusion Criteria Donor

Alias
UMLS CUI-1
C1512693
UMLS CUI-2
C0013018
Age < 60 years
Descrição

age

Tipo de dados

boolean

Alias
UMLS CUI [1]
C0001779
Weight > 25 kg
Descrição

weight

Tipo de dados

boolean

Alias
UMLS CUI [1]
C0005910
Medical history and physical examination confirm good health status as defined by institutional standards
Descrição

good health status

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0018759
UMLS CUI [1,2]
C0205170
Within 30 days of apheresis collection, seronegative for HIV assessed as HIV Ag; HIV 1+2 Ab; or HTLV I/II Ab
Descrição

HIV negative

Tipo de dados

boolean

Alias
UMLS CUI [1]
C0481430
Within 30 days of apheresis collection, seronegative for hepatitis assessed as HBsAg; HBcAb (IgM and IgG); or HCV Ab
Descrição

seronegative for hepatitis

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0019158
UMLS CUI [1,2]
C0521144
Within 30 days of apheresis collection, seronegative for syphilis assessed as RPR
Descrição

seronegative for syphilis

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0039128
UMLS CUI [1,2]
C0521144
Genotypically haploidentical as determined by HLA typing
Descrição

HLA haploidentical

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0242318
UMLS CUI [1,2]
C3829897
Female donors of child-bearing potential must have a negative serum or urine beta-HCG test within 3 weeks of mobilization
Descrição

pregnancy test donor

Tipo de dados

boolean

Alias
UMLS CUI [1]
C0032961
UMLS CUI [2]
C0106132
Capable of undergoing leukapheresis, Has adequate venous access
Descrição

capable leukapheresis

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0023416
UMLS CUI [1,2]
C1548635
UMLS CUI [2,1]
C0750164
UMLS CUI [2,2]
C1548635
Willing to undergo insertion of a central catheter should leukapheresis via peripheral vein be inadequate
Descrição

consent to central catheter

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C2322576
UMLS CUI [1,2]
C1511481
Agreeable to second donation of PBPC (or a bone marrow harvest) should the recipient fail to demonstrate sustained engraftment following the transplant
Descrição

consent to second donation

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0242602
UMLS CUI [1,2]
C1517331
UMLS CUI [1,3]
C1511481
Duly-executed informed consent
Descrição

informed consent donor

Tipo de dados

boolean

Alias
UMLS CUI [1]
C0021430
Screened for CMV seroreactivity
Descrição

CMV seroreactivity

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0010823
UMLS CUI [1,2]
C0521143
Exclusion Criteria Donor
Descrição

Exclusion Criteria Donor

Alias
UMLS CUI-1
C0680251
UMLS CUI-2
C0013018
Evidence of active infection (including urinary tract infection, or upper respiratory tract infection)
Descrição

active infection

Tipo de dados

boolean

Alias
UMLS CUI [1]
C0009450
UMLS CUI [2]
C0042029
UMLS CUI [3]
C0041912
Evidence of hepatitis (on screening)
Descrição

hepatitis donor

Tipo de dados

boolean

Alias
UMLS CUI [1]
C0019158
Medical, physical or psychological reason which makes the donor unlikely to tolerate or cooperate with growth factor therapy and leukapheresis
Descrição

contraindications to growth factor therapy and leukapheresis

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0009488
UMLS CUI [1,2]
C0392760
UMLS CUI [1,3]
C0280112
UMLS CUI [2,1]
C0009488
UMLS CUI [2,2]
C0392760
UMLS CUI [2,3]
C0023416
Factors placing donor at increased risk for leukapheresis or G-CSF-related complications
Descrição

increased risk for leukapheresis or G-CSF-related complications

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0035648
UMLS CUI [1,2]
C0023416
UMLS CUI [2,1]
C0035648
UMLS CUI [2,2]
C0079459
Lactating female, Female of child-bearing potential unwilling to implement adequate birth control
Descrição

lactation and contraceptive use

Tipo de dados

boolean

Alias
UMLS CUI [1]
C2828358
UMLS CUI [2]
C1999124
HIV-positive
Descrição

HIV positive donor

Tipo de dados

boolean

Alias
UMLS CUI [1]
C0019699
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Similar models

Eligibility Acute Myelogenous Leukemia (AML) - Relapsed, Primary Refractory Disease or Poor Risk Factors NCT00185679

1 Formulários
Name
Tipo
Description | Question | Decode (Coded Value)
Tipo de dados
Alias
Item Group
Inclusion Criteria Recipient
C1512693 (UMLS CUI-1)
C1709854 (UMLS CUI-2)
hematological or lymphatic malignancy
Item
Histopathologically-confirmed diagnosis of hematological or lymphatic malignancy, defined as one of the following:
boolean
C0376545 (UMLS CUI [1])
C0006826 (UMLS CUI [2,1])
C1522604 (UMLS CUI [2,2])
AML as primary ref disease or in relapse
Item
Acute myeloid leukemia (aml) as primary refractory disease, or in relapse
boolean
C0023467 (UMLS CUI [1,1])
C1514815 (UMLS CUI [1,2])
C0023467 (UMLS CUI [2,1])
C0277556 (UMLS CUI [2,2])
AML first remission
Item
acute leukemia in first remission with poor risk factors and molecular prognosis
boolean
C0153886 (UMLS CUI [1,1])
C0205435 (UMLS CUI [1,2])
chromosome abnormalities
Item
aml with -5,-7, t(6;9), tri8, -11
boolean
C4015468 (UMLS CUI [1])
ALL type
Item
acute lymphocytic / lymphoblastic leukemia (all) with phil+ t(9;22),(q34;q11.2), and t(4:11)(q21;23)
boolean
C0023449 (UMLS CUI [1,1])
C1709527 (UMLS CUI [1,2])
C0023449 (UMLS CUI [2,1])
C3688703 (UMLS CUI [2,2])
CML
Item
Chronic myelogenous leukemia (cml in accelerated, second chronic phase)
boolean
C0023474 (UMLS CUI [1,1])
C0521110 (UMLS CUI [1,2])
myelodysplastic syndrome
Item
Myelodysplastic syndrome with high intermediate to high risk categories
boolean
C3463824 (UMLS CUI [1])
NHL
Item
Non-hodgkin's lymphoma (nhl)
boolean
C0024305 (UMLS CUI [1])
CLL
Item
Chronic lymphocytic leukemia (cll), refractory
boolean
C0023434 (UMLS CUI [1,1])
C0205269 (UMLS CUI [1,2])
creatinine clearance bilirubin and alt measurement
Item
Creatinine clearance > 50 ml/min for those above serum creatinine of 1.5 mg/dl, serum bilirubin < 2.0 mg/dl, alt < 2x uln (unless secondary to disease)
boolean
C0373595 (UMLS CUI [1])
C1278039 (UMLS CUI [2])
C0201836 (UMLS CUI [3])
age diagnosis CLL
Item
< 50 years old at time of registration
boolean
C1828181 (UMLS CUI [1])
donor criteria
Item
Donor is related, Donor is genotypically-matched and haploidentical for HLA-A, B,C and DRB1, DQ loci Donor differs for 2 or 3 HLA alleles on the unshared haplotype in the GvHD direction
boolean
C3494891 (UMLS CUI [1])
C1285573 (UMLS CUI [2])
C3829897 (UMLS CUI [3,1])
C0019721 (UMLS CUI [3,2])
C3829897 (UMLS CUI [4,1])
C0122040 (UMLS CUI [4,2])
C0972850 (UMLS CUI [5])
no HLA match identified
Item
No HLA-matched sibling or matched unrelated donor is identified
boolean
C0019721 (UMLS CUI [1,1])
C3242262 (UMLS CUI [1,2])
ECOG performance status
Item
ECOG performance status not more than 2
boolean
C1520224 (UMLS CUI [1])
LVEF
Item
LVEF
boolean
C0428772 (UMLS CUI [1])
DLCO
Item
DLCO > 50%
boolean
C1516251 (UMLS CUI [1])
serum creatinine
Item
Corrected for hemoglobin Serum creatinine < 1.5 mg/dL
boolean
C0201976 (UMLS CUI [1])
pregnancy test beta-HCG
Item
Females of childbearing potential must have a negative serum or urine beta-HCG test within 3 weeks of registration
boolean
C0032961 (UMLS CUI [1])
C0106132 (UMLS CUI [2])
no prior cancer
Item
No prior cancer within 5 years with the exception of surgically-cured, non-melanoma skin cancer or in situ cancer of the cervix
text
C0006826 (UMLS CUI [1])
myeloablative therapy or transplant
Item
No prior myeloablative therapy or transplant
boolean
C1513784 (UMLS CUI [1])
C0005961 (UMLS CUI [2])
informed consent
Item
Duly-executed informed consent
boolean
C0021430 (UMLS CUI [1])
Item Group
Exclusion Criteria Recipient
C0680251 (UMLS CUI-1)
C1709854 (UMLS CUI-2)
autologous transplantation
Item
Suitable candidate for autologous transplantation
boolean
C0040736 (UMLS CUI [1,1])
C1548635 (UMLS CUI [1,2])
participation in another study
Item
Participation in other investigational drugs or devices trials that might influence the study endpoints
boolean
C2348568 (UMLS CUI [1])
active hepatitis
Item
Evidence of active hepatitis
boolean
C0019158 (UMLS CUI [1,1])
C0205177 (UMLS CUI [1,2])
active cirrhosis
Item
Evidence of active cirrhosis
boolean
C1623038 (UMLS CUI [1,1])
C0205177 (UMLS CUI [1,2])
HIV positive
Item
HIV-positive
boolean
C0019699 (UMLS CUI [1])
invasive aspergillosis
Item
History of invasive aspergillosis
boolean
C0238013 (UMLS CUI [1])
uncontrolled active infection
Item
Presence of any other uncontrolled, active infection, ie, bacterial, viral or fungal
boolean
C0009450 (UMLS CUI [1])
uncontrolled CNS involvement
Item
Uncontrolled CNS involvement
boolean
C0449389 (UMLS CUI [1])
allergy to murine proteins
Item
Documented allergy to murine proteins
boolean
C0020517 (UMLS CUI [1,1])
C1699668 (UMLS CUI [1,2])
allergy to iron dextran
Item
Documented allergy to iron dextran
boolean
C0020517 (UMLS CUI [1,1])
C0022092 (UMLS CUI [1,2])
contraceptive use
Item
Female of child-bearing potential unwilling to implement adequate birth control
boolean
C1999124 (UMLS CUI [1])
comorbidities affecting compliance and transplantation
Item
Medical problem / neurologic/psychiatric dysfunction which would impair his/her ability to be compliant with the medical regimen and/or to tolerate transplantation, in the opinion of the principal investigator
boolean
C1321605 (UMLS CUI [1,1])
C0439801 (UMLS CUI [1,2])
C0009488 (UMLS CUI [1,3])
C0009488 (UMLS CUI [2,1])
C0392760 (UMLS CUI [2,2])
C0005961 (UMLS CUI [2,3])
comorbidities prolonging hematologic recovery
Item
Medical problem / neurologic/psychiatric dysfunction which would prolong hematologic recovery and place the recipient at unacceptable risk, in the opinion of the principal investigator would
boolean
C0009488 (UMLS CUI [1,1])
C0392760 (UMLS CUI [1,2])
C0237820 (UMLS CUI [1,3])
Item Group
Inclusion Criteria Donor
C1512693 (UMLS CUI-1)
C0013018 (UMLS CUI-2)
age
Item
Age < 60 years
boolean
C0001779 (UMLS CUI [1])
weight
Item
Weight > 25 kg
boolean
C0005910 (UMLS CUI [1])
good health status
Item
Medical history and physical examination confirm good health status as defined by institutional standards
boolean
C0018759 (UMLS CUI [1,1])
C0205170 (UMLS CUI [1,2])
HIV negative
Item
Within 30 days of apheresis collection, seronegative for HIV assessed as HIV Ag; HIV 1+2 Ab; or HTLV I/II Ab
boolean
C0481430 (UMLS CUI [1])
seronegative for hepatitis
Item
Within 30 days of apheresis collection, seronegative for hepatitis assessed as HBsAg; HBcAb (IgM and IgG); or HCV Ab
boolean
C0019158 (UMLS CUI [1,1])
C0521144 (UMLS CUI [1,2])
seronegative for syphilis
Item
Within 30 days of apheresis collection, seronegative for syphilis assessed as RPR
boolean
C0039128 (UMLS CUI [1,1])
C0521144 (UMLS CUI [1,2])
HLA haploidentical
Item
Genotypically haploidentical as determined by HLA typing
boolean
C0242318 (UMLS CUI [1,1])
C3829897 (UMLS CUI [1,2])
pregnancy test donor
Item
Female donors of child-bearing potential must have a negative serum or urine beta-HCG test within 3 weeks of mobilization
boolean
C0032961 (UMLS CUI [1])
C0106132 (UMLS CUI [2])
capable leukapheresis
Item
Capable of undergoing leukapheresis, Has adequate venous access
boolean
C0023416 (UMLS CUI [1,1])
C1548635 (UMLS CUI [1,2])
C0750164 (UMLS CUI [2,1])
C1548635 (UMLS CUI [2,2])
consent to central catheter
Item
Willing to undergo insertion of a central catheter should leukapheresis via peripheral vein be inadequate
boolean
C2322576 (UMLS CUI [1,1])
C1511481 (UMLS CUI [1,2])
consent to second donation
Item
Agreeable to second donation of PBPC (or a bone marrow harvest) should the recipient fail to demonstrate sustained engraftment following the transplant
boolean
C0242602 (UMLS CUI [1,1])
C1517331 (UMLS CUI [1,2])
C1511481 (UMLS CUI [1,3])
informed consent donor
Item
Duly-executed informed consent
boolean
C0021430 (UMLS CUI [1])
CMV seroreactivity
Item
Screened for CMV seroreactivity
boolean
C0010823 (UMLS CUI [1,1])
C0521143 (UMLS CUI [1,2])
Item Group
Exclusion Criteria Donor
C0680251 (UMLS CUI-1)
C0013018 (UMLS CUI-2)
active infection
Item
Evidence of active infection (including urinary tract infection, or upper respiratory tract infection)
boolean
C0009450 (UMLS CUI [1])
C0042029 (UMLS CUI [2])
C0041912 (UMLS CUI [3])
hepatitis donor
Item
Evidence of hepatitis (on screening)
boolean
C0019158 (UMLS CUI [1])
contraindications to growth factor therapy and leukapheresis
Item
Medical, physical or psychological reason which makes the donor unlikely to tolerate or cooperate with growth factor therapy and leukapheresis
boolean
C0009488 (UMLS CUI [1,1])
C0392760 (UMLS CUI [1,2])
C0280112 (UMLS CUI [1,3])
C0009488 (UMLS CUI [2,1])
C0392760 (UMLS CUI [2,2])
C0023416 (UMLS CUI [2,3])
increased risk for leukapheresis or G-CSF-related complications
Item
Factors placing donor at increased risk for leukapheresis or G-CSF-related complications
boolean
C0035648 (UMLS CUI [1,1])
C0023416 (UMLS CUI [1,2])
C0035648 (UMLS CUI [2,1])
C0079459 (UMLS CUI [2,2])
lactation and contraceptive use
Item
Lactating female, Female of child-bearing potential unwilling to implement adequate birth control
boolean
C2828358 (UMLS CUI [1])
C1999124 (UMLS CUI [2])
HIV positive donor
Item
HIV-positive
boolean
C0019699 (UMLS CUI [1])
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