ID

12417

Description

DIAMOND - Dual Antiplatelet Therapy to Reduce Myocardial Injury; ODM derived from: https://clinicaltrials.gov/show/NCT02110303

Link

https://clinicaltrials.gov/show/NCT02110303

Keywords

Versions (1)
  1. 11/17/15 11/17/15 -
Uploaded on

November 17, 2015

DOI

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License

Creative Commons BY 4.0
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Eligibility Coronary Artery Disease NCT02110303

English

Eligibility Coronary Artery Disease NCT02110303

1 forms  
Inclusion Criteria
Description

Inclusion Criteria

Alias
UMLS CUI
C1512693
patients aged 40 years with angiographically proven multivessel coronary artery disease defined as at least two major epicardial vessels with any combination of either (a) >50% luminal stenosis, or (b) previous revascularization (percutaneous coronary intervention or coronary artery bypass graft surgery).
Description

Multi vessel coronary artery disease

Data type

boolean

Alias
UMLS CUI [1]
C1299432
provision of informed consent prior to any study specific procedures
Description

Informed Consent

Data type

boolean

Alias
UMLS CUI [1]
C0021430
Exclusion Criteria
Description

Exclusion Criteria

Alias
UMLS CUI
C0680251
an acute coronary syndrome within the last 12 months
Description

Acute Coronary Syndrome

Data type

boolean

Alias
UMLS CUI [1]
C0948089
an indication for dual anti-platelet therapy, such as drug eluting stent
Description

Anti-platelet drug therapy

Data type

boolean

Alias
UMLS CUI [1]
C2963157
inability to take aspirin
Description

Inability to take aspirin

Data type

boolean

Alias
UMLS CUI [1]
C0004057
receiving thienopyridine therapy such as clopidogrel or prasugrel
Description

Thienopyridine therapy

Data type

boolean

Alias
UMLS CUI [1]
C1120149
percutaneous coronary intervention or coronary artery bypass graft surgery within the last 3 months
Description

Percutaneous coronary intervention

Data type

boolean

Alias
UMLS CUI [1]
C1532338
UMLS CUI [2]
C0010055
inability or unwilling to give informed consent
Description

Informed Consent

Data type

boolean

Alias
UMLS CUI [1]
C0021430
woman with child-bearing potential and who are breastfeeding will not be enrolled into the trial (woman who have experienced menarche, are pre-menopausal, have not been sterilised or who are currently pregnant)
Description

Child-bearing potential

Data type

boolean

Alias
UMLS CUI [1]
C1960468
known hypersensitivity to ticagrelor or one of its excipients
Description

Hypersensitivity

Data type

boolean

Alias
UMLS CUI [1,1]
C0020517
UMLS CUI [1,2]
C1999375
active pathological bleeding or bleeding diathesis
Description

Pathological bleeding

Data type

boolean

Alias
UMLS CUI [1]
C0005779
significant thrombocytopenia: <100 x 10^9 /l
Description

Thrombocytopenia

Data type

boolean

Alias
UMLS CUI [1]
C0040034
history of intracranial haemorrhage
Description

Intracranial Hemorrhages

Data type

boolean

Alias
UMLS CUI [1]
C0151699
moderate to severe liver impairment (child's grade b or c)
Description

Liver impairment

Data type

boolean

Alias
UMLS CUI [1]
C0023895
maintenance therapy with strong cytochrome p450 3a4 (cyp3a4) inhibitors, such as ketoconazole, nefazodone, ritonavir, indinavir, atazanavir, or clarithromycin
Description

Therapy with strong cytochrome p450 3a4 (cyp3a4) inhibitors

Data type

boolean

Alias
UMLS CUI [1]
C3830624
major intercurrent illness or life expectancy <1 year
Description

Intercurrent illness

Data type

boolean

Alias
UMLS CUI [1]
C3640977
UMLS CUI [2]
C0023671
renal dysfunction (egfr ≤30 ml/min/1.73 m2)
Description

Renal dysfunction

Data type

boolean

Alias
UMLS CUI [1]
C3279454
contraindication to iodinated contrast agents
Description

Contrast agents

Data type

boolean

Alias
UMLS CUI [1]
C0009924
planned coronary revascularization or major non-cardiac surgery in the next 12 months
Description

Coronary revascularisation or major non-cardiac surgery

Data type

boolean

Alias
UMLS CUI [1]
C0877341
UMLS CUI [2]
C0543467
maintenance therapy with simvastatin at doses greater than 40mg daily
Description

Simvastatin therapy

Data type

boolean

Alias
UMLS CUI [1]
C0074554
receiving oral anticoagulants including warfarin, rivaroxaban, dabigatran or apixaban.
Description

Receiving oral anticoagulants

Data type

boolean

Alias
UMLS CUI [1]
C0354604
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Similar models

Eligibility Coronary Artery Disease NCT02110303

1 forms
Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
Item Group
C1512693 (UMLS CUI)
Multi vessel coronary artery disease
Item
patients aged 40 years with angiographically proven multivessel coronary artery disease defined as at least two major epicardial vessels with any combination of either (a) >50% luminal stenosis, or (b) previous revascularization (percutaneous coronary intervention or coronary artery bypass graft surgery).
boolean
C1299432 (UMLS CUI [1])
Informed Consent
Item
provision of informed consent prior to any study specific procedures
boolean
C0021430 (UMLS CUI [1])
Item Group
C0680251 (UMLS CUI)
Acute Coronary Syndrome
Item
an acute coronary syndrome within the last 12 months
boolean
C0948089 (UMLS CUI [1])
Anti-platelet drug therapy
Item
an indication for dual anti-platelet therapy, such as drug eluting stent
boolean
C2963157 (UMLS CUI [1])
Inability to take aspirin
Item
inability to take aspirin
boolean
C0004057 (UMLS CUI [1])
Thienopyridine therapy
Item
receiving thienopyridine therapy such as clopidogrel or prasugrel
boolean
C1120149 (UMLS CUI [1])
Percutaneous coronary intervention
Item
percutaneous coronary intervention or coronary artery bypass graft surgery within the last 3 months
boolean
C1532338 (UMLS CUI [1])
C0010055 (UMLS CUI [2])
Informed Consent
Item
inability or unwilling to give informed consent
boolean
C0021430 (UMLS CUI [1])
Child-bearing potential
Item
woman with child-bearing potential and who are breastfeeding will not be enrolled into the trial (woman who have experienced menarche, are pre-menopausal, have not been sterilised or who are currently pregnant)
boolean
C1960468 (UMLS CUI [1])
Hypersensitivity
Item
known hypersensitivity to ticagrelor or one of its excipients
boolean
C0020517 (UMLS CUI [1,1])
C1999375 (UMLS CUI [1,2])
Pathological bleeding
Item
active pathological bleeding or bleeding diathesis
boolean
C0005779 (UMLS CUI [1])
Thrombocytopenia
Item
significant thrombocytopenia: <100 x 10^9 /l
boolean
C0040034 (UMLS CUI [1])
Intracranial Hemorrhages
Item
history of intracranial haemorrhage
boolean
C0151699 (UMLS CUI [1])
Liver impairment
Item
moderate to severe liver impairment (child's grade b or c)
boolean
C0023895 (UMLS CUI [1])
Therapy with strong cytochrome p450 3a4 (cyp3a4) inhibitors
Item
maintenance therapy with strong cytochrome p450 3a4 (cyp3a4) inhibitors, such as ketoconazole, nefazodone, ritonavir, indinavir, atazanavir, or clarithromycin
boolean
C3830624 (UMLS CUI [1])
Intercurrent illness
Item
major intercurrent illness or life expectancy <1 year
boolean
C3640977 (UMLS CUI [1])
C0023671 (UMLS CUI [2])
Renal dysfunction
Item
renal dysfunction (egfr ≤30 ml/min/1.73 m2)
boolean
C3279454 (UMLS CUI [1])
Contrast agents
Item
contraindication to iodinated contrast agents
boolean
C0009924 (UMLS CUI [1])
Coronary revascularisation or major non-cardiac surgery
Item
planned coronary revascularization or major non-cardiac surgery in the next 12 months
boolean
C0877341 (UMLS CUI [1])
C0543467 (UMLS CUI [2])
Simvastatin therapy
Item
maintenance therapy with simvastatin at doses greater than 40mg daily
boolean
C0074554 (UMLS CUI [1])
Receiving oral anticoagulants
Item
receiving oral anticoagulants including warfarin, rivaroxaban, dabigatran or apixaban.
boolean
C0354604 (UMLS CUI [1])
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