ID

24255

Beskrivning

Traumatic brain injury (TBI) is a leading cause of death and disability. A reliable prediction of outcome on admission is of great clinical relevance. Using several large patient series for model development as available in the International Mission for Prognosis and Analysis of Clinical Trials in TBI (IMPACT) project, three prognostic models of increasing complexity (Core, Core + CT, Core + CT + Lab) were developed. They provide adequate discrimination between patients with good and poor 6 month outcomes after TBI, especially if CT and laboratory findings are considered in addition to traditional predictors. The model predictions may support clinical practice and research, including the design and analysis of randomized controlled trials. Reference: Steyerberg, E. W., Mushkudiani, N., Perel, P., Butcher, I., Lu, J., McHugh, G. S., ... & Maas, A. I. (2008). Predicting outcome after traumatic brain injury: development and international validation of prognostic scores based on admission characteristics. PLoS medicine, 5(8), e165. http://www.tbi-impact.org/?p=impact/calc

Länk

http://www.tbi-impact.org/?p=impact/calc

Nyckelord

Versioner (2)
  1. 2017-07-28 2017-07-28 -
  2. 2018-01-25 2018-01-25 -
Rättsinnehavare

Ewout Steyerberg

Uppladdad den

28 juli 2017

DOI

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Licens

Creative Commons BY-NC 3.0
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IMPACT model for 6 month outcome after TBI

Engelsk

IMPACT model for 6 month outcome after TBI

1 Formulär  
Core data
Beskrivning

Core data

Age
Beskrivning

Age

Datatyp

integer

Måttenheter
  • years
Alias
UMLS CUI [1]
C0001779
Motor score
Beskrivning

Motor score

Datatyp

integer

Pupillary reactivity
Beskrivning

Pupillary reactivity

Datatyp

integer

CT data
Beskrivning

CT data

Hypoxia
Beskrivning

Hypoxia

Datatyp

integer

Hypotension
Beskrivning

Hypotension

Datatyp

integer

CT classification
Beskrivning

CT classification

Datatyp

integer

Traumatic subarachnoid hemorrhage (CT)
Beskrivning

Traumatic subarachnoid hemorrhage

Datatyp

integer

Epidural hematoma (CT)
Beskrivning

Epidural hematoma

Datatyp

integer

Sub score CT
Beskrivning

Sub score CT = hypoxia + hypotension + CT characteristics

Datatyp

integer

Lab data
Beskrivning

Lab data

Glucose
Beskrivning

Glucose

Datatyp

integer

Måttenheter
  • mmol/L
Hb
Beskrivning

Hemoglobin

Datatyp

integer

Måttenheter
  • g/dL
Sub score lab
Beskrivning

glucose + Hb

Datatyp

integer

Sum scores
Beskrivning

Sum scores

Sum score: core model
Beskrivning

Sum score core model = age + motor score + pupillary reactivity. The probability of 6 mo outcome is defined as 1 / (1+e^-LP), where LP refers to the linear predictor in a logistic regression model. LP core, mortality = -2.55 + 0.275 x sum score core. LP core, unfavorable outcome = -1.62 + 0.299 x sum score core.

Datatyp

integer

Sum score: extended model
Beskrivning

Sum score extended model = core + hypoxia + hypotension + CT characteristics. The probability of 6 mo outcome is defined as 1 / (1+e^-LP), where LP refers to the linear predictor in a logistic regression model. LP extended, mortality = -2.98 + 0.256 x (sum score core + subscore CT). LP extended, unfavorable outcome = -2.10 + 0.276 x (sum score core + subscore CT).

Datatyp

integer

Sum score: lab model
Beskrivning

Sum score lab model = core + hypoxia + hypotension + CT + glucose + Hb. The probability of 6 mo outcome is defined as 1 / (1+e^-LP), where LP refers to the linear predictor in a logistic regression model. LP lab, mortality = -3.42 + 0.216 x (sum score core + subscore CT + subscore lab). LP lab, unfavorable outcome = -2.82 + 0.257 x (sum score core + subscore CT + subscore lab).

Datatyp

integer

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Similar models

IMPACT model for 6 month outcome after TBI

1 Formulär
Name
Typ
Description | Question | Decode (Coded Value)
Datatyp
Alias
Item Group
Core data
Item
Age
integer
C0001779 (UMLS CUI [1])
Age
Code List
Age
CL Item
≤30 (0)
CL Item
30-39 (1)
CL Item
40-49 (2)
CL Item
50-59 (3)
CL Item
60-69 (4)
CL Item
70+ (5)
Item
Motor score
integer
Motor score
Code List
Motor score
CL Item
None/extension (6)
CL Item
Abnormal flexion (4)
CL Item
Normal flexion (2)
CL Item
Localizes/obeys (0)
CL Item
Untestable/missing (3)
Item
Pupillary reactivity
integer
Pupillary reactivity
Code List
Pupillary reactivity
CL Item
Both pupils reacted (0)
CL Item
One pupil reacted (2)
CL Item
No pupil reacted (4)
Item Group
CT data
Item
Hypoxia
integer
Hypoxia
Code List
Hypoxia
CL Item
Yes or suspected (1)
CL Item
No (0)
Item
Hypotension
integer
Hypotension
Code List
Hypotension
CL Item
Yes or suspected (2)
CL Item
No (0)
Item
CT classification
integer
CT classification
Code List
CT classification
CL Item
I (-2)
CL Item
II (0)
CL Item
III/IV/V/VI (2)
Item
Traumatic subarachnoid hemorrhage (CT)
integer
Traumatic subarachnoid hemorrhage
Code List
Traumatic subarachnoid hemorrhage (CT)
CL Item
Yes (2)
CL Item
No (0)
Item
Epidural hematoma (CT)
integer
Epidural hematoma
Code List
Epidural hematoma (CT)
CL Item
Yes (-2)
CL Item
No (0)
Sub score CT
Item
Sub score CT
integer
Item Group
Lab data
Item
Glucose
integer
Glucose
Code List
Glucose
CL Item
<6 (0)
CL Item
6-8.9 (1)
CL Item
9-11.9 (2)
CL Item
12-14.9 (3)
CL Item
15+ (4)
Item
Hb
integer
Hemoglobin
Code List
Hb
CL Item
<9 (3)
CL Item
9-11.9 (2)
CL Item
12-14.9 (1)
CL Item
15+ (0)
Sub score lab
Item
Sub score lab
integer
Item Group
Sum scores
Sum score core model
Item
Sum score: core model
integer
Sum score extended model
Item
Sum score: extended model
integer
Sum score lab model
Item
Sum score: lab model
integer
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