ID
24255
Beschrijving
Traumatic brain injury (TBI) is a leading cause of death and disability. A reliable prediction of outcome on admission is of great clinical relevance. Using several large patient series for model development as available in the International Mission for Prognosis and Analysis of Clinical Trials in TBI (IMPACT) project, three prognostic models of increasing complexity (Core, Core + CT, Core + CT + Lab) were developed. They provide adequate discrimination between patients with good and poor 6 month outcomes after TBI, especially if CT and laboratory findings are considered in addition to traditional predictors. The model predictions may support clinical practice and research, including the design and analysis of randomized controlled trials. Reference: Steyerberg, E. W., Mushkudiani, N., Perel, P., Butcher, I., Lu, J., McHugh, G. S., ... & Maas, A. I. (2008). Predicting outcome after traumatic brain injury: development and international validation of prognostic scores based on admission characteristics. PLoS medicine, 5(8), e165. http://www.tbi-impact.org/?p=impact/calc
Link
http://www.tbi-impact.org/?p=impact/calc
Trefwoorden
Versies (2)
- 28-07-17 28-07-17 -
- 25-01-18 25-01-18 -
Houder van rechten
Ewout Steyerberg
Geüploaded op
28 juli 2017
DOI
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Licentie
Creative Commons BY-NC 3.0
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IMPACT model for 6 month outcome after TBI
IMPACT model for 6 month outcome after TBI
- StudyEvent: ODM
Beschrijving
CT data
Beschrijving
Hypoxia
Datatype
integer
Beschrijving
Hypotension
Datatype
integer
Beschrijving
CT classification
Datatype
integer
Beschrijving
Traumatic subarachnoid hemorrhage
Datatype
integer
Beschrijving
Epidural hematoma
Datatype
integer
Beschrijving
Sub score CT = hypoxia + hypotension + CT characteristics
Datatype
integer
Beschrijving
Lab data
Beschrijving
Sum scores
Beschrijving
Sum score core model = age + motor score + pupillary reactivity. The probability of 6 mo outcome is defined as 1 / (1+e^-LP), where LP refers to the linear predictor in a logistic regression model. LP core, mortality = -2.55 + 0.275 x sum score core. LP core, unfavorable outcome = -1.62 + 0.299 x sum score core.
Datatype
integer
Beschrijving
Sum score extended model = core + hypoxia + hypotension + CT characteristics. The probability of 6 mo outcome is defined as 1 / (1+e^-LP), where LP refers to the linear predictor in a logistic regression model. LP extended, mortality = -2.98 + 0.256 x (sum score core + subscore CT). LP extended, unfavorable outcome = -2.10 + 0.276 x (sum score core + subscore CT).
Datatype
integer
Beschrijving
Sum score lab model = core + hypoxia + hypotension + CT + glucose + Hb. The probability of 6 mo outcome is defined as 1 / (1+e^-LP), where LP refers to the linear predictor in a logistic regression model. LP lab, mortality = -3.42 + 0.216 x (sum score core + subscore CT + subscore lab). LP lab, unfavorable outcome = -2.82 + 0.257 x (sum score core + subscore CT + subscore lab).
Datatype
integer
Similar models
IMPACT model for 6 month outcome after TBI
- StudyEvent: ODM