ID

24255

Beschreibung

Traumatic brain injury (TBI) is a leading cause of death and disability. A reliable prediction of outcome on admission is of great clinical relevance. Using several large patient series for model development as available in the International Mission for Prognosis and Analysis of Clinical Trials in TBI (IMPACT) project, three prognostic models of increasing complexity (Core, Core + CT, Core + CT + Lab) were developed. They provide adequate discrimination between patients with good and poor 6 month outcomes after TBI, especially if CT and laboratory findings are considered in addition to traditional predictors. The model predictions may support clinical practice and research, including the design and analysis of randomized controlled trials. Reference: Steyerberg, E. W., Mushkudiani, N., Perel, P., Butcher, I., Lu, J., McHugh, G. S., ... & Maas, A. I. (2008). Predicting outcome after traumatic brain injury: development and international validation of prognostic scores based on admission characteristics. PLoS medicine, 5(8), e165. http://www.tbi-impact.org/?p=impact/calc

Link

http://www.tbi-impact.org/?p=impact/calc

Stichworte

Versionen (2)
  1. 28.07.17 28.07.17 -
  2. 25.01.18 25.01.18 -
Rechteinhaber

Ewout Steyerberg

Hochgeladen am

28. Juli 2017

DOI

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Lizenz

Creative Commons BY-NC 3.0
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IMPACT model for 6 month outcome after TBI

Englisch

IMPACT model for 6 month outcome after TBI

1 Formulare  
Core data
Beschreibung

Core data

Age
Beschreibung

Age

Datentyp

integer

Maßeinheiten
  • years
Alias
UMLS CUI [1]
C0001779
Motor score
Beschreibung

Motor score

Datentyp

integer

Pupillary reactivity
Beschreibung

Pupillary reactivity

Datentyp

integer

CT data
Beschreibung

CT data

Hypoxia
Beschreibung

Hypoxia

Datentyp

integer

Hypotension
Beschreibung

Hypotension

Datentyp

integer

CT classification
Beschreibung

CT classification

Datentyp

integer

Traumatic subarachnoid hemorrhage (CT)
Beschreibung

Traumatic subarachnoid hemorrhage

Datentyp

integer

Epidural hematoma (CT)
Beschreibung

Epidural hematoma

Datentyp

integer

Sub score CT
Beschreibung

Sub score CT = hypoxia + hypotension + CT characteristics

Datentyp

integer

Lab data
Beschreibung

Lab data

Glucose
Beschreibung

Glucose

Datentyp

integer

Maßeinheiten
  • mmol/L
Hb
Beschreibung

Hemoglobin

Datentyp

integer

Maßeinheiten
  • g/dL
Sub score lab
Beschreibung

glucose + Hb

Datentyp

integer

Sum scores
Beschreibung

Sum scores

Sum score: core model
Beschreibung

Sum score core model = age + motor score + pupillary reactivity. The probability of 6 mo outcome is defined as 1 / (1+e^-LP), where LP refers to the linear predictor in a logistic regression model. LP core, mortality = -2.55 + 0.275 x sum score core. LP core, unfavorable outcome = -1.62 + 0.299 x sum score core.

Datentyp

integer

Sum score: extended model
Beschreibung

Sum score extended model = core + hypoxia + hypotension + CT characteristics. The probability of 6 mo outcome is defined as 1 / (1+e^-LP), where LP refers to the linear predictor in a logistic regression model. LP extended, mortality = -2.98 + 0.256 x (sum score core + subscore CT). LP extended, unfavorable outcome = -2.10 + 0.276 x (sum score core + subscore CT).

Datentyp

integer

Sum score: lab model
Beschreibung

Sum score lab model = core + hypoxia + hypotension + CT + glucose + Hb. The probability of 6 mo outcome is defined as 1 / (1+e^-LP), where LP refers to the linear predictor in a logistic regression model. LP lab, mortality = -3.42 + 0.216 x (sum score core + subscore CT + subscore lab). LP lab, unfavorable outcome = -2.82 + 0.257 x (sum score core + subscore CT + subscore lab).

Datentyp

integer

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Ähnliche Modelle

IMPACT model for 6 month outcome after TBI

1 Formulare
Name
Typ
Description | Question | Decode (Coded Value)
Datentyp
Alias
Item Group
Core data
Item
Age
integer
C0001779 (UMLS CUI [1])
Age
Code List
Age
CL Item
≤30 (0)
CL Item
30-39 (1)
CL Item
40-49 (2)
CL Item
50-59 (3)
CL Item
60-69 (4)
CL Item
70+ (5)
Item
Motor score
integer
Motor score
Code List
Motor score
CL Item
None/extension (6)
CL Item
Abnormal flexion (4)
CL Item
Normal flexion (2)
CL Item
Localizes/obeys (0)
CL Item
Untestable/missing (3)
Item
Pupillary reactivity
integer
Pupillary reactivity
Code List
Pupillary reactivity
CL Item
Both pupils reacted (0)
CL Item
One pupil reacted (2)
CL Item
No pupil reacted (4)
Item Group
CT data
Item
Hypoxia
integer
Hypoxia
Code List
Hypoxia
CL Item
Yes or suspected (1)
CL Item
No (0)
Item
Hypotension
integer
Hypotension
Code List
Hypotension
CL Item
Yes or suspected (2)
CL Item
No (0)
Item
CT classification
integer
CT classification
Code List
CT classification
CL Item
I (-2)
CL Item
II (0)
CL Item
III/IV/V/VI (2)
Item
Traumatic subarachnoid hemorrhage (CT)
integer
Traumatic subarachnoid hemorrhage
Code List
Traumatic subarachnoid hemorrhage (CT)
CL Item
Yes (2)
CL Item
No (0)
Item
Epidural hematoma (CT)
integer
Epidural hematoma
Code List
Epidural hematoma (CT)
CL Item
Yes (-2)
CL Item
No (0)
Sub score CT
Item
Sub score CT
integer
Item Group
Lab data
Item
Glucose
integer
Glucose
Code List
Glucose
CL Item
<6 (0)
CL Item
6-8.9 (1)
CL Item
9-11.9 (2)
CL Item
12-14.9 (3)
CL Item
15+ (4)
Item
Hb
integer
Hemoglobin
Code List
Hb
CL Item
<9 (3)
CL Item
9-11.9 (2)
CL Item
12-14.9 (1)
CL Item
15+ (0)
Sub score lab
Item
Sub score lab
integer
Item Group
Sum scores
Sum score core model
Item
Sum score: core model
integer
Sum score extended model
Item
Sum score: extended model
integer
Sum score lab model
Item
Sum score: lab model
integer
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