ID

28648

Description

Traumatic brain injury (TBI) is a leading cause of death and disability. A reliable prediction of outcome on admission is of great clinical relevance. Using several large patient series for model development as available in the International Mission for Prognosis and Analysis of Clinical Trials in TBI (IMPACT) project, three prognostic models of increasing complexity (Core, Core + CT, Core + CT + Lab) were developed. They provide adequate discrimination between patients with good and poor 6 month outcomes after TBI, especially if CT and laboratory findings are considered in addition to traditional predictors. The model predictions may support clinical practice and research, including the design and analysis of randomized controlled trials. Reference: Steyerberg, E. W., Mushkudiani, N., Perel, P., Butcher, I., Lu, J., McHugh, G. S., ... & Maas, A. I. (2008). Predicting outcome after traumatic brain injury: development and international validation of prognostic scores based on admission characteristics. PLoS medicine, 5(8), e165. http://www.tbi-impact.org/?p=impact/calc

Link

http://www.tbi-impact.org/?p=impact/calc

Keywords

Versions (2)
  1. 7/28/17 7/28/17 -
  2. 1/25/18 1/25/18 -
Copyright Holder

Ewout Steyerberg

Uploaded on

January 25, 2018

DOI

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License

Creative Commons BY-NC 3.0
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IMPACT model for 6 month outcome after TBI

English

IMPACT model for 6 month outcome after TBI

1 forms  
Core data
Description

Core data

Age
Description

Age

Data type

integer

Measurement units
  • years
Alias
UMLS CUI [1]
C0001779
Motor score
Description

Motor score

Data type

integer

Alias
UMLS CUI [1]
C2960436
Pupillary reactivity
Description

Pupillary reactivity

Data type

integer

Alias
UMLS CUI [1]
C0234671
CT data
Description

CT data

Hypoxia
Description

Hypoxia

Data type

integer

Alias
UMLS CUI [1]
C0242184
Hypotension
Description

Hypotension

Data type

integer

Alias
UMLS CUI [1]
C0020649
CT classification
Description

CT classification

Data type

integer

Alias
UMLS CUI [1]
C0040405
Traumatic subarachnoid hemorrhage (CT)
Description

Traumatic subarachnoid hemorrhage

Data type

integer

Alias
UMLS CUI [1]
C0038525
Epidural hematoma (CT)
Description

Epidural hematoma

Data type

integer

Alias
UMLS CUI [1,1]
C0014537
UMLS CUI [1,2]
C0018944
Sub score CT
Description

Sub score CT = hypoxia + hypotension + CT characteristics

Data type

integer

Alias
UMLS CUI [1,1]
C0449820
UMLS CUI [1,2]
C0040405
Lab data
Description

Lab data

Glucose
Description

Glucose

Data type

integer

Measurement units
  • mmol/L
Alias
UMLS CUI [1]
C0202042
Hb
Description

Hemoglobin

Data type

integer

Measurement units
  • g/dL
Alias
UMLS CUI [1]
C0019046
Sub score lab
Description

glucose + Hb

Data type

integer

Alias
UMLS CUI [1]
C0202113
Sum scores
Description

Sum scores

Sum score: core model
Description

Sum score core model = age + motor score + pupillary reactivity. The probability of 6 mo outcome is defined as 1 / (1+e^-LP), where LP refers to the linear predictor in a logistic regression model. LP core, mortality = -2.55 + 0.275 x sum score core. LP core, unfavorable outcome = -1.62 + 0.299 x sum score core.

Data type

integer

Alias
UMLS CUI [1]
C2964552
Sum score: extended model
Description

Sum score extended model = core + hypoxia + hypotension + CT characteristics. The probability of 6 mo outcome is defined as 1 / (1+e^-LP), where LP refers to the linear predictor in a logistic regression model. LP extended, mortality = -2.98 + 0.256 x (sum score core + subscore CT). LP extended, unfavorable outcome = -2.10 + 0.276 x (sum score core + subscore CT).

Data type

integer

Alias
UMLS CUI [1]
C2964552
Sum score: lab model
Description

Sum score lab model = core + hypoxia + hypotension + CT + glucose + Hb. The probability of 6 mo outcome is defined as 1 / (1+e^-LP), where LP refers to the linear predictor in a logistic regression model. LP lab, mortality = -3.42 + 0.216 x (sum score core + subscore CT + subscore lab). LP lab, unfavorable outcome = -2.82 + 0.257 x (sum score core + subscore CT + subscore lab).

Data type

integer

Alias
UMLS CUI [1]
C2964552
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Similar models

IMPACT model for 6 month outcome after TBI

1 forms
Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
Item Group
Core data
Item
Age
integer
C0001779 (UMLS CUI [1])
Age
Code List
Age
CL Item
≤30 (0)
CL Item
30-39 (1)
CL Item
40-49 (2)
CL Item
50-59 (3)
CL Item
60-69 (4)
CL Item
70+ (5)
Item
Motor score
integer
C2960436 (UMLS CUI [1])
Motor score
Code List
Motor score
CL Item
None/extension (6)
C0231448 (UMLS CUI-1)
(Comment:en)
CL Item
Abnormal flexion (4)
C1290991 (UMLS CUI-1)
(Comment:en)
CL Item
Normal flexion (2)
C1290990 (UMLS CUI-1)
(Comment:en)
CL Item
Localizes/obeys (0)
C0517994 (UMLS CUI-1)
(Comment:en)
CL Item
Untestable/missing (3)
(Comment:en)
Item
Pupillary reactivity
integer
C0234671 (UMLS CUI [1])
Pupillary reactivity
Code List
Pupillary reactivity
CL Item
Both pupils reacted (0)
C0437599 (UMLS CUI-1)
(Comment:en)
CL Item
One pupil reacted (2)
C0437599 (UMLS CUI-1)
(Comment:en)
CL Item
No pupil reacted (4)
C0437599 (UMLS CUI-1)
(Comment:en)
Item Group
CT data
Item
Hypoxia
integer
C0242184 (UMLS CUI [1])
Hypoxia
Code List
Hypoxia
CL Item
Yes or suspected (1)
CL Item
No (0)
Item
Hypotension
integer
C0020649 (UMLS CUI [1])
Hypotension
Code List
Hypotension
CL Item
Yes or suspected (2)
CL Item
No (0)
Item
CT classification
integer
C0040405 (UMLS CUI [1])
CT classification
Code List
CT classification
CL Item
I (-2)
CL Item
II (0)
CL Item
III/IV/V/VI (2)
Item
Traumatic subarachnoid hemorrhage (CT)
integer
C0038525 (UMLS CUI [1])
Traumatic subarachnoid hemorrhage
Code List
Traumatic subarachnoid hemorrhage (CT)
CL Item
Yes (2)
CL Item
No (0)
Item
Epidural hematoma (CT)
integer
C0014537 (UMLS CUI [1,1])
C0018944 (UMLS CUI [1,2])
Epidural hematoma
Code List
Epidural hematoma (CT)
CL Item
Yes (-2)
CL Item
No (0)
Sub score CT
Item
Sub score CT
integer
C0449820 (UMLS CUI [1,1])
C0040405 (UMLS CUI [1,2])
Item Group
Lab data
Item
Glucose
integer
C0202042 (UMLS CUI [1])
Glucose
Code List
Glucose
CL Item
<6 (0)
CL Item
6-8.9 (1)
CL Item
9-11.9 (2)
CL Item
12-14.9 (3)
CL Item
15+ (4)
Item
Hb
integer
C0019046 (UMLS CUI [1])
Hemoglobin
Code List
Hb
CL Item
<9 (3)
CL Item
9-11.9 (2)
CL Item
12-14.9 (1)
CL Item
15+ (0)
Sub score lab
Item
Sub score lab
integer
C0202113 (UMLS CUI [1])
Item Group
Sum scores
Sum score core model
Item
Sum score: core model
integer
C2964552 (UMLS CUI [1])
Sum score extended model
Item
Sum score: extended model
integer
C2964552 (UMLS CUI [1])
Sum score lab model
Item
Sum score: lab model
integer
C2964552 (UMLS CUI [1])
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