ID

28648

Beskrivning

Traumatic brain injury (TBI) is a leading cause of death and disability. A reliable prediction of outcome on admission is of great clinical relevance. Using several large patient series for model development as available in the International Mission for Prognosis and Analysis of Clinical Trials in TBI (IMPACT) project, three prognostic models of increasing complexity (Core, Core + CT, Core + CT + Lab) were developed. They provide adequate discrimination between patients with good and poor 6 month outcomes after TBI, especially if CT and laboratory findings are considered in addition to traditional predictors. The model predictions may support clinical practice and research, including the design and analysis of randomized controlled trials. Reference: Steyerberg, E. W., Mushkudiani, N., Perel, P., Butcher, I., Lu, J., McHugh, G. S., ... & Maas, A. I. (2008). Predicting outcome after traumatic brain injury: development and international validation of prognostic scores based on admission characteristics. PLoS medicine, 5(8), e165. http://www.tbi-impact.org/?p=impact/calc

Länk

http://www.tbi-impact.org/?p=impact/calc

Nyckelord

Versioner (2)
  1. 2017-07-28 2017-07-28 -
  2. 2018-01-25 2018-01-25 -
Rättsinnehavare

Ewout Steyerberg

Uppladdad den

25 januari 2018

DOI

För en begäran logga in.

Licens

Creative Commons BY-NC 3.0
Modellkommentarer :

Här kan du kommentera modellen. Med hjälp av pratbubblor i Item-grupperna och Item kan du lägga in specifika kommentarer.

Tillbaka till modellkommentarer
Itemgroup-kommentar för :

Item-kommentar för :

Du måste vara inloggad för att kunna ladda ner formulär. Var vänlig logga in eller registrera dig utan kostnad.

IMPACT model for 6 month outcome after TBI

Engelsk

IMPACT model for 6 month outcome after TBI

1 Formulär  
Core data
Beskrivning

Core data

Age
Beskrivning

Age

Datatyp

integer

Måttenheter
  • years
Alias
UMLS CUI [1]
C0001779
Motor score
Beskrivning

Motor score

Datatyp

integer

Alias
UMLS CUI [1]
C2960436
Pupillary reactivity
Beskrivning

Pupillary reactivity

Datatyp

integer

Alias
UMLS CUI [1]
C0234671
CT data
Beskrivning

CT data

Hypoxia
Beskrivning

Hypoxia

Datatyp

integer

Alias
UMLS CUI [1]
C0242184
Hypotension
Beskrivning

Hypotension

Datatyp

integer

Alias
UMLS CUI [1]
C0020649
CT classification
Beskrivning

CT classification

Datatyp

integer

Alias
UMLS CUI [1]
C0040405
Traumatic subarachnoid hemorrhage (CT)
Beskrivning

Traumatic subarachnoid hemorrhage

Datatyp

integer

Alias
UMLS CUI [1]
C0038525
Epidural hematoma (CT)
Beskrivning

Epidural hematoma

Datatyp

integer

Alias
UMLS CUI [1,1]
C0014537
UMLS CUI [1,2]
C0018944
Sub score CT
Beskrivning

Sub score CT = hypoxia + hypotension + CT characteristics

Datatyp

integer

Alias
UMLS CUI [1,1]
C0449820
UMLS CUI [1,2]
C0040405
Lab data
Beskrivning

Lab data

Glucose
Beskrivning

Glucose

Datatyp

integer

Måttenheter
  • mmol/L
Alias
UMLS CUI [1]
C0202042
Hb
Beskrivning

Hemoglobin

Datatyp

integer

Måttenheter
  • g/dL
Alias
UMLS CUI [1]
C0019046
Sub score lab
Beskrivning

glucose + Hb

Datatyp

integer

Alias
UMLS CUI [1]
C0202113
Sum scores
Beskrivning

Sum scores

Sum score: core model
Beskrivning

Sum score core model = age + motor score + pupillary reactivity. The probability of 6 mo outcome is defined as 1 / (1+e^-LP), where LP refers to the linear predictor in a logistic regression model. LP core, mortality = -2.55 + 0.275 x sum score core. LP core, unfavorable outcome = -1.62 + 0.299 x sum score core.

Datatyp

integer

Alias
UMLS CUI [1]
C2964552
Sum score: extended model
Beskrivning

Sum score extended model = core + hypoxia + hypotension + CT characteristics. The probability of 6 mo outcome is defined as 1 / (1+e^-LP), where LP refers to the linear predictor in a logistic regression model. LP extended, mortality = -2.98 + 0.256 x (sum score core + subscore CT). LP extended, unfavorable outcome = -2.10 + 0.276 x (sum score core + subscore CT).

Datatyp

integer

Alias
UMLS CUI [1]
C2964552
Sum score: lab model
Beskrivning

Sum score lab model = core + hypoxia + hypotension + CT + glucose + Hb. The probability of 6 mo outcome is defined as 1 / (1+e^-LP), where LP refers to the linear predictor in a logistic regression model. LP lab, mortality = -3.42 + 0.216 x (sum score core + subscore CT + subscore lab). LP lab, unfavorable outcome = -2.82 + 0.257 x (sum score core + subscore CT + subscore lab).

Datatyp

integer

Alias
UMLS CUI [1]
C2964552
Tillbaka till toppen

Similar models

IMPACT model for 6 month outcome after TBI

1 Formulär
Name
Typ
Description | Question | Decode (Coded Value)
Datatyp
Alias
Item Group
Core data
Item
Age
integer
C0001779 (UMLS CUI [1])
Age
Code List
Age
CL Item
≤30 (0)
CL Item
30-39 (1)
CL Item
40-49 (2)
CL Item
50-59 (3)
CL Item
60-69 (4)
CL Item
70+ (5)
Item
Motor score
integer
C2960436 (UMLS CUI [1])
Motor score
Code List
Motor score
CL Item
None/extension (6)
C0231448 (UMLS CUI-1)
(Comment:en)
CL Item
Abnormal flexion (4)
C1290991 (UMLS CUI-1)
(Comment:en)
CL Item
Normal flexion (2)
C1290990 (UMLS CUI-1)
(Comment:en)
CL Item
Localizes/obeys (0)
C0517994 (UMLS CUI-1)
(Comment:en)
CL Item
Untestable/missing (3)
(Comment:en)
Item
Pupillary reactivity
integer
C0234671 (UMLS CUI [1])
Pupillary reactivity
Code List
Pupillary reactivity
CL Item
Both pupils reacted (0)
C0437599 (UMLS CUI-1)
(Comment:en)
CL Item
One pupil reacted (2)
C0437599 (UMLS CUI-1)
(Comment:en)
CL Item
No pupil reacted (4)
C0437599 (UMLS CUI-1)
(Comment:en)
Item Group
CT data
Item
Hypoxia
integer
C0242184 (UMLS CUI [1])
Hypoxia
Code List
Hypoxia
CL Item
Yes or suspected (1)
CL Item
No (0)
Item
Hypotension
integer
C0020649 (UMLS CUI [1])
Hypotension
Code List
Hypotension
CL Item
Yes or suspected (2)
CL Item
No (0)
Item
CT classification
integer
C0040405 (UMLS CUI [1])
CT classification
Code List
CT classification
CL Item
I (-2)
CL Item
II (0)
CL Item
III/IV/V/VI (2)
Item
Traumatic subarachnoid hemorrhage (CT)
integer
C0038525 (UMLS CUI [1])
Traumatic subarachnoid hemorrhage
Code List
Traumatic subarachnoid hemorrhage (CT)
CL Item
Yes (2)
CL Item
No (0)
Item
Epidural hematoma (CT)
integer
C0014537 (UMLS CUI [1,1])
C0018944 (UMLS CUI [1,2])
Epidural hematoma
Code List
Epidural hematoma (CT)
CL Item
Yes (-2)
CL Item
No (0)
Sub score CT
Item
Sub score CT
integer
C0449820 (UMLS CUI [1,1])
C0040405 (UMLS CUI [1,2])
Item Group
Lab data
Item
Glucose
integer
C0202042 (UMLS CUI [1])
Glucose
Code List
Glucose
CL Item
<6 (0)
CL Item
6-8.9 (1)
CL Item
9-11.9 (2)
CL Item
12-14.9 (3)
CL Item
15+ (4)
Item
Hb
integer
C0019046 (UMLS CUI [1])
Hemoglobin
Code List
Hb
CL Item
<9 (3)
CL Item
9-11.9 (2)
CL Item
12-14.9 (1)
CL Item
15+ (0)
Sub score lab
Item
Sub score lab
integer
C0202113 (UMLS CUI [1])
Item Group
Sum scores
Sum score core model
Item
Sum score: core model
integer
C2964552 (UMLS CUI [1])
Sum score extended model
Item
Sum score: extended model
integer
C2964552 (UMLS CUI [1])
Sum score lab model
Item
Sum score: lab model
integer
C2964552 (UMLS CUI [1])
Tillbaka till toppen 

Kontakt

Använd detta formulär för feedback, frågor och förslag på förbättringar.

Fält markerade med * är obligatoriska.

Hjälp

Do you need help on how to use the search function? Please watch the corresponding tutorial video for more details and learn how to use the search function most efficiently.

Watch Tutorial