ID

28648

Beschreibung

Traumatic brain injury (TBI) is a leading cause of death and disability. A reliable prediction of outcome on admission is of great clinical relevance. Using several large patient series for model development as available in the International Mission for Prognosis and Analysis of Clinical Trials in TBI (IMPACT) project, three prognostic models of increasing complexity (Core, Core + CT, Core + CT + Lab) were developed. They provide adequate discrimination between patients with good and poor 6 month outcomes after TBI, especially if CT and laboratory findings are considered in addition to traditional predictors. The model predictions may support clinical practice and research, including the design and analysis of randomized controlled trials. Reference: Steyerberg, E. W., Mushkudiani, N., Perel, P., Butcher, I., Lu, J., McHugh, G. S., ... & Maas, A. I. (2008). Predicting outcome after traumatic brain injury: development and international validation of prognostic scores based on admission characteristics. PLoS medicine, 5(8), e165. http://www.tbi-impact.org/?p=impact/calc

Link

http://www.tbi-impact.org/?p=impact/calc

Stichworte

Versionen (2)
  1. 28.07.17 28.07.17 -
  2. 25.01.18 25.01.18 -
Rechteinhaber

Ewout Steyerberg

Hochgeladen am

25. Januar 2018

DOI

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Lizenz

Creative Commons BY-NC 3.0
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IMPACT model for 6 month outcome after TBI

Englisch

IMPACT model for 6 month outcome after TBI

1 Formulare  
Core data
Beschreibung

Core data

Age
Beschreibung

Age

Datentyp

integer

Maßeinheiten
  • years
Alias
UMLS CUI [1]
C0001779
Motor score
Beschreibung

Motor score

Datentyp

integer

Alias
UMLS CUI [1]
C2960436
Pupillary reactivity
Beschreibung

Pupillary reactivity

Datentyp

integer

Alias
UMLS CUI [1]
C0234671
CT data
Beschreibung

CT data

Hypoxia
Beschreibung

Hypoxia

Datentyp

integer

Alias
UMLS CUI [1]
C0242184
Hypotension
Beschreibung

Hypotension

Datentyp

integer

Alias
UMLS CUI [1]
C0020649
CT classification
Beschreibung

CT classification

Datentyp

integer

Alias
UMLS CUI [1]
C0040405
Traumatic subarachnoid hemorrhage (CT)
Beschreibung

Traumatic subarachnoid hemorrhage

Datentyp

integer

Alias
UMLS CUI [1]
C0038525
Epidural hematoma (CT)
Beschreibung

Epidural hematoma

Datentyp

integer

Alias
UMLS CUI [1,1]
C0014537
UMLS CUI [1,2]
C0018944
Sub score CT
Beschreibung

Sub score CT = hypoxia + hypotension + CT characteristics

Datentyp

integer

Alias
UMLS CUI [1,1]
C0449820
UMLS CUI [1,2]
C0040405
Lab data
Beschreibung

Lab data

Glucose
Beschreibung

Glucose

Datentyp

integer

Maßeinheiten
  • mmol/L
Alias
UMLS CUI [1]
C0202042
Hb
Beschreibung

Hemoglobin

Datentyp

integer

Maßeinheiten
  • g/dL
Alias
UMLS CUI [1]
C0019046
Sub score lab
Beschreibung

glucose + Hb

Datentyp

integer

Alias
UMLS CUI [1]
C0202113
Sum scores
Beschreibung

Sum scores

Sum score: core model
Beschreibung

Sum score core model = age + motor score + pupillary reactivity. The probability of 6 mo outcome is defined as 1 / (1+e^-LP), where LP refers to the linear predictor in a logistic regression model. LP core, mortality = -2.55 + 0.275 x sum score core. LP core, unfavorable outcome = -1.62 + 0.299 x sum score core.

Datentyp

integer

Alias
UMLS CUI [1]
C2964552
Sum score: extended model
Beschreibung

Sum score extended model = core + hypoxia + hypotension + CT characteristics. The probability of 6 mo outcome is defined as 1 / (1+e^-LP), where LP refers to the linear predictor in a logistic regression model. LP extended, mortality = -2.98 + 0.256 x (sum score core + subscore CT). LP extended, unfavorable outcome = -2.10 + 0.276 x (sum score core + subscore CT).

Datentyp

integer

Alias
UMLS CUI [1]
C2964552
Sum score: lab model
Beschreibung

Sum score lab model = core + hypoxia + hypotension + CT + glucose + Hb. The probability of 6 mo outcome is defined as 1 / (1+e^-LP), where LP refers to the linear predictor in a logistic regression model. LP lab, mortality = -3.42 + 0.216 x (sum score core + subscore CT + subscore lab). LP lab, unfavorable outcome = -2.82 + 0.257 x (sum score core + subscore CT + subscore lab).

Datentyp

integer

Alias
UMLS CUI [1]
C2964552
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Ähnliche Modelle

IMPACT model for 6 month outcome after TBI

1 Formulare
Name
Typ
Description | Question | Decode (Coded Value)
Datentyp
Alias
Item Group
Core data
Item
Age
integer
C0001779 (UMLS CUI [1])
Age
Code List
Age
CL Item
≤30 (0)
CL Item
30-39 (1)
CL Item
40-49 (2)
CL Item
50-59 (3)
CL Item
60-69 (4)
CL Item
70+ (5)
Item
Motor score
integer
C2960436 (UMLS CUI [1])
Motor score
Code List
Motor score
CL Item
None/extension (6)
C0231448 (UMLS CUI-1)
(Comment:en)
CL Item
Abnormal flexion (4)
C1290991 (UMLS CUI-1)
(Comment:en)
CL Item
Normal flexion (2)
C1290990 (UMLS CUI-1)
(Comment:en)
CL Item
Localizes/obeys (0)
C0517994 (UMLS CUI-1)
(Comment:en)
CL Item
Untestable/missing (3)
(Comment:en)
Item
Pupillary reactivity
integer
C0234671 (UMLS CUI [1])
Pupillary reactivity
Code List
Pupillary reactivity
CL Item
Both pupils reacted (0)
C0437599 (UMLS CUI-1)
(Comment:en)
CL Item
One pupil reacted (2)
C0437599 (UMLS CUI-1)
(Comment:en)
CL Item
No pupil reacted (4)
C0437599 (UMLS CUI-1)
(Comment:en)
Item Group
CT data
Item
Hypoxia
integer
C0242184 (UMLS CUI [1])
Hypoxia
Code List
Hypoxia
CL Item
Yes or suspected (1)
CL Item
No (0)
Item
Hypotension
integer
C0020649 (UMLS CUI [1])
Hypotension
Code List
Hypotension
CL Item
Yes or suspected (2)
CL Item
No (0)
Item
CT classification
integer
C0040405 (UMLS CUI [1])
CT classification
Code List
CT classification
CL Item
I (-2)
CL Item
II (0)
CL Item
III/IV/V/VI (2)
Item
Traumatic subarachnoid hemorrhage (CT)
integer
C0038525 (UMLS CUI [1])
Traumatic subarachnoid hemorrhage
Code List
Traumatic subarachnoid hemorrhage (CT)
CL Item
Yes (2)
CL Item
No (0)
Item
Epidural hematoma (CT)
integer
C0014537 (UMLS CUI [1,1])
C0018944 (UMLS CUI [1,2])
Epidural hematoma
Code List
Epidural hematoma (CT)
CL Item
Yes (-2)
CL Item
No (0)
Sub score CT
Item
Sub score CT
integer
C0449820 (UMLS CUI [1,1])
C0040405 (UMLS CUI [1,2])
Item Group
Lab data
Item
Glucose
integer
C0202042 (UMLS CUI [1])
Glucose
Code List
Glucose
CL Item
<6 (0)
CL Item
6-8.9 (1)
CL Item
9-11.9 (2)
CL Item
12-14.9 (3)
CL Item
15+ (4)
Item
Hb
integer
C0019046 (UMLS CUI [1])
Hemoglobin
Code List
Hb
CL Item
<9 (3)
CL Item
9-11.9 (2)
CL Item
12-14.9 (1)
CL Item
15+ (0)
Sub score lab
Item
Sub score lab
integer
C0202113 (UMLS CUI [1])
Item Group
Sum scores
Sum score core model
Item
Sum score: core model
integer
C2964552 (UMLS CUI [1])
Sum score extended model
Item
Sum score: extended model
integer
C2964552 (UMLS CUI [1])
Sum score lab model
Item
Sum score: lab model
integer
C2964552 (UMLS CUI [1])
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