Exclusion Criteria
Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT) > 1.5 x Upper Limit of Normal (ULN)
boolean
Bilirubin > 1.5 x ULN
boolean
Relevant airways obstruction (i.e. pre-bronchodilator FEV1/FVC < 0.7)
boolean
Patient likely to have lung transplantation during study (being on transplantation list is acceptable for participation)
boolean
Myocardial infarction within 6 months
boolean
Unstable angina within 1 month
boolean
Bleeding risk (genetic predisposition; fibrinolysis or full-dose therapeutic anticoagulation or high dose antiplatelet therapy; history of hemorrhagic CNS event within 12 months; haemoptysis or haematuria or active gastro-intestinal bleeding or ulcers or major injury or surgery within 3 months);
boolean
Thrombotic risk (inherited predisposition; history of thrombotic event (including stroke and transient ischemic attacks) within 12 months;
boolean
International normalised ratio (INR) > 2, prolongation of prothrombin time (PT) and partial thromboplastin time (PTT) by > 50% of institutional ULN)
boolean
N-ACetyl Cystein, prednisone > 15mg/day or equivalent received within 2 weeks of visit 1
boolean
Pirfenidone, azathioprine, cyclophosphamide, cyclosporine A received within 8 weeks of visit 1
boolean