age up to 364 Days
Item
age up to 364 Days
boolean
C0001779 (UMLS CUI 2011AA)
397669002 (SNOMED CT 2011_0131)
Previously untreated T-lineage or precursor B-lineage ALL or biphenotypic leukaemia according to EGIL criteria.
Item
Previously untreated T-lineage or precursor B-lineage ALL or biphenotypic leukaemia according to EGIL criteria.
boolean
C0205156 (UMLS CUI 2011AA)
9130008 (SNOMED CT 2011_0131)
C1518422 (UMLS CUI 2011AA)
CL415147 (UMLS CUI 2011AA)
Morphological verification of the diagnosis, confirmed with cyto-chemistry and immunophenotyping.
Item
Morphological verification of the diagnosis, confirmed with cyto-chemistry and immunophenotyping.
boolean
C0332437 (UMLS CUI 2011AA)
116676008 (SNOMED CT 2011_0131)
MTHU008051 (LOINC Version 232)
C1711411 (UMLS CUI 2011AA)
C0011900 (UMLS CUI 2011AA)
439401001 (SNOMED CT 2011_0131)
MTHU008876 (LOINC Version 232)
C0750484 (UMLS CUI 2011AA)
C0010741 (UMLS CUI 2011AA)
C0079611 (UMLS CUI 2011AA)
414466002 (SNOMED CT 2011_0131)
10071534 (MedDRA 14.1)
Written informed consent of the parents or other legally authorised guardian of the patient.
Item
Written informed consent of the parents or other legally authorised guardian of the patient.
boolean
C0021430 (UMLS CUI 2011AA)
Treatment according to protocol INTERFANT 06
Item
Treatment according to protocol INTERFANT 06
boolean
C0039798 (UMLS CUI 2011AA)
C0332290 (UMLS CUI 2011AA)
385433004 (SNOMED CT 2011_0131)
C0332152 (UMLS CUI 2011AA)
288556008 (SNOMED CT 2011_0131)
C0442711 (UMLS CUI 2011AA)
258049002 (SNOMED CT 2011_0131)
Mature B-lineage ALL, defined by the immunophenotypical presence of surface immunoglobulins or t(8;14) and breakpoint as in B-ALL.
Item
Mature B-lineage ALL, defined by the immunophenotypical presence of surface immunoglobulins or t(8;14) and breakpoint as in B-ALL.
boolean
C0023435 (UMLS CUI 2011AA)
22197008 (SNOMED CT 2011_0131)
10003917 (MedDRA 14.1)
C1704788 (UMLS CUI 2011AA)
C0456570 (UMLS CUI 2011AA)
277251009 (SNOMED CT 2011_0131)
C0150312 (UMLS CUI 2011AA)
52101004 (SNOMED CT 2011_0131)
C0034789 (UMLS CUI 2011AA)
66875007 (SNOMED CT 2011_0131)
C0040715 (UMLS CUI 2011AA)
15897004 (SNOMED CT 2011_0131)
C2717920 (UMLS CUI 2011AA)
C1883713 (UMLS CUI 2011AA)
C1292769 (UMLS CUI 2011AA)
128823009 (SNOMED CT 2011_0131)
10003890 (MedDRA 14.1)
The presence of the t(9;22)(q34;q11) or bcr-abl fusion in the leukaemic cells.
Item
The presence of the t(9;22)(q34;q11) or bcr-abl fusion in the leukaemic cells.
boolean
C0150312 (UMLS CUI 2011AA)
52101004 (SNOMED CT 2011_0131)
C1515809 (UMLS CUI 2011AA)
C0004891 (UMLS CUI 2011AA)
56564003 (SNOMED CT 2011_0131)
MTHU021298 (LOINC Version 232)
C1517806 (UMLS CUI 2011AA)
Systemic use of corticosteroids < 4 weeks before diagnosis. Patients who received corticosteroids by aerosol are eligible.
Item
Systemic use of corticosteroids < 4 weeks before diagnosis. Patients who received corticosteroids by aerosol are eligible.
boolean
C0205373 (UMLS CUI 2011AA)
31099001 (SNOMED CT 2011_0131)
C1524063 (UMLS CUI 2011AA)
260676000 (SNOMED CT 2011_0131)
C0001617 (UMLS CUI 2011AA)
79440004 (SNOMED CT 2011_0131)
Known allergy to any ASNase preparation.
Item
Known allergy to any ASNase preparation.
boolean
C0020517 (UMLS CUI 2011AA)
257550005 (SNOMED CT 2011_0131)
T78.40 (ICD-10-CM Version 2010)
C0003993 (UMLS CUI 2011AA)
371014004 (SNOMED CT 2011_0131)
C0013227 (UMLS CUI 2011AA)
Pre-existing known coagulopathy (e.g. haemophilia).
Item
Pre-existing known coagulopathy (e.g. haemophilia).
boolean
C2347662 (UMLS CUI 2011AA)
C0005779 (UMLS CUI 2011AA)
64779008 (SNOMED CT 2011_0131)
10009802 (MedDRA 14.1)
D68.9 (ICD-10-CM Version 2010)
C0684275 (UMLS CUI 2011AA)
90935002 (SNOMED CT 2011_0131)
10061992 (MedDRA 14.1)
Pre-existing pancreatitis.
Item
Pre-existing pancreatitis.
boolean
C2347662 (UMLS CUI 2011AA)
C0030305 (UMLS CUI 2011AA)
75694006 (SNOMED CT 2011_0131)
10033645 (MedDRA 14.1)
K85.9 (ICD-10-CM Version 2010)
577.0 (ICD-9-CM Version 2011)
E10930 (CTCAE 1105E)
Liver insufficiency (bilirubin > 50 micromol/L, SGOT/SGPT > 10 x the upper limit of normal).
Item
Liver insufficiency (bilirubin > 50 micromol/L, SGOT/SGPT > 10 x the upper limit of normal).
boolean
C1306571 (UMLS CUI 2011AA)
59927004 (SNOMED CT 2011_0131)
10056542 (MedDRA 14.1)
C0011221 (UMLS CUI 2011AA)
79706000 (SNOMED CT 2011_0131)
1975-2 (LOINC Version 232)
C0004002 (UMLS CUI 2011AA)
26091008 (SNOMED CT 2011_0131)
MTHU004883 (LOINC Version 232)
C0001899 (UMLS CUI 2011AA)
56935002 (SNOMED CT 2011_0131)
MTHU006766 (LOINC Version 232)
C1519815 (UMLS CUI 2011AA)