Ausschlusskriterien
primary cancer treatable by operational larynx-conserving procedures
boolean
distant metastases (M1-Status)
boolean
total tumor volume exceeding 80 ml or larynx skeleton punctuated with infiltration of surrounding soft tissues respectively the esophageal aditus (exclusive cartilage infiltration represents no exclusion criteria)
boolean
tumor-specific prior chemo- or radiotherapy
boolean
metachronous or synchronous malignant tumor (exception basalioma) [in case of a controlled tumor of different localization with a non-treated interval over 5 years to the present therapy the patient can be included after consultation with the coordinating investigator]
boolean
life expectancy < 3 month
boolean
Karnofsky performance status < 70%
boolean
serious cardiopulmonary concomitant disease (cardiac insufficiency grade III and IV according NYHA status, myocardial infarction, angina pectoris, respiratory global insufficiency)
boolean
Chronic diseases with permanent-therapy (uncontrolled diabetes, active rheumatoid arthritis)
boolean
recurrent pneumonia, COPD GOLD stage <2, chronic inflammation of intestine or any other concomitant diseases, which disallow study participation in the opinion of the responsible physician
boolean
Other circumstances (contra-indications), which disallow treatment with Docetaxel, Cisplatin, 5-FU, Cetuximab or radiotherapy
boolean
Expected absent patient compliance
boolean
Periodic follow-up not possible (for example address outside germany)
boolean
Pregnant or breast-feeding woman
boolean
Absent or constricted legal capacity
boolean
Participation to another clinical trial with any investigational study within 30 days prior to study screening
boolean