Ausschlusskriterien
prurigo nodularis with massive excoriations and/or local infections
boolean
atopic dermatitis, predisposition for atopic dermatitis
boolean
Itch intensity <VAS 4 (visual analoge scale 0 to 10)
boolean
Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a female after conception and until the termination of gestation, confirmed by a positive hCG test. Pregnancy should be ruled out before stating the study by a b-subunit HCG test.
boolean
Females of childbearing potential and not practicing a medically approved, highly effective (low failure rate) method of contraception during and up to at least 4 weeks after the end of treatment. 'Medically approved' contraception may include implants, injectables, combined oral contraceptives, some IUDs (e.g. intrauterine device), sexual abstinence or if the woman has a vasectomized partner.
boolean
active psychosomatic and psychiatric diseases
boolean
History of active malignancy of any organ system
boolean
actual diseases which need therapy and may induce pruritus (e.g. deficiency of iron, zinc)
boolean
Systemic immunosuppression
boolean
Topical use of tacrolimus, pimecrolimus, steroids or capsaicin within 2 weeks prior to study entry
boolean
current and past (within 2 weeks prior to study entry) systemic use of antihistamines, steroids, cyclosporin A and other immunosuppressants, paroxetin, fluvoxamine (selective serotonin reuptake-inhibitors, study possible in case of medication since 6 months due to depression without having any Antipruritic effect) naltrexone and UV-therapy.
boolean
wound healing disturbances, disposition for keloids, current medication which leads to increased bleeding during procedure e.g. acetylsalicylic acid (ASS), marcumar (no suction blister possible)
boolean
History of hypersensitivity to pimecrolimus 1% cream or hydrocortisone 1% cream
boolean
Participation in other clinical studies within the last 4 weeks
boolean