Elig.phs001215.v4.p2.1
Item
*SAFHS*
boolean
C2348560 (UMLS CUI [1,1])
Elig.phs001215.v4.p2.2
Item
The SAFHS began in 1991, and included 1,431 individuals in 42 extended families at baseline. Probands were 40 to 60 year old low-income Mexican Americans selected at random without regard to presence or absence of disease, almost exclusively from Mexican American census tracts in San Antonio, Texas. All first, second, and third degree relatives of the proband and of the proband's spouse, aged 16 years or above, were eligible to participate in the study. As part of our ongoing studies, we have recruited new family members from the original families, expanding the cohort to almost 3,000 individuals.
boolean
C1512693 (UMLS CUI [1,1])
C0237401 (UMLS CUI [1,2])
C1292711 (UMLS CUI [1,3])
C0015341 (UMLS CUI [1,4])
C1442488 (UMLS CUI [1,5])
C0681850 (UMLS CUI [2,1])
C0001779 (UMLS CUI [2,2])
C1331016 (UMLS CUI [2,3])
C3829110 (UMLS CUI [2,4])
C0439605 (UMLS CUI [2,5])
C0242802 (UMLS CUI [2,6])
C1298908 (UMLS CUI [2,7])
C0518609 (UMLS CUI [2,8])
C3854307 (UMLS CUI [2,9])
C0332197 (UMLS CUI [2,10])
C0012634 (UMLS CUI [2,11])
C1517194 (UMLS CUI [3,1])
C1519210 (UMLS CUI [3,2])
C3639750 (UMLS CUI [3,3])
C1948021 (UMLS CUI [3,4])
C0162409 (UMLS CUI [3,5])
C0001779 (UMLS CUI [3,6])
C0013893 (UMLS CUI [3,7])
C0242800 (UMLS CUI [4,1])
C0205314 (UMLS CUI [4,2])
C0086282 (UMLS CUI [4,3])
C0205313 (UMLS CUI [4,4])
C0015576 (UMLS CUI [4,5])
Elig.phs001215.v4.p2.3
Item
*WGS efforts*
boolean
C4483680 (UMLS CUI [1,1])
Elig.phs001215.v4.p2.4
Item
The first T2D-GENES sequencing effort chose the twenty largest pedigrees from SAFHS, constituting approximately 600 individuals. Sequencing in the R01HL113322 "Whole Genome Sequencing to Identify Causal Genetic Variants Influencing CVD Risk" project selected the next largest pedigrees and participants most informative for imputation, a total of 931 individuals. Finally, sequencing of the remaining SAFHS participants (1199 individuals) was supported by the TOPMed program.
boolean
C0205435 (UMLS CUI [1,1])
C3640076 (UMLS CUI [1,2])
C3715212 (UMLS CUI [1,3])
C0443228 (UMLS CUI [1,4])
C0030761 (UMLS CUI [1,5])
C0242802 (UMLS CUI [2,1])
C0205117 (UMLS CUI [2,2])
C0443228 (UMLS CUI [2,3])
C0030761 (UMLS CUI [2,4])
C0205393 (UMLS CUI [2,5])
C2986490 (UMLS CUI [2,6])
C2699638 (UMLS CUI [2,7])
C3640076 (UMLS CUI [3,1])
C1527428 (UMLS CUI [3,2])
C0679646 (UMLS CUI [3,3])
C0242356 (UMLS CUI [3,4])
C3484370 (UMLS CUI [3,5])