*Cases:* *Inclusion criteria:*
Item
*Cases:* *Inclusion criteria:*
boolean
C1706256 (UMLS CUI [1,1])
C1512693 (UMLS CUI [1,2])
Children less than 5 years
Item
Children less than 5 years
boolean
C0008059 (UMLS CUI [1,1])
C0001779 (UMLS CUI [1,2])
Child is not currently enrolled as a case (not previously enrolled for diarrhea within the last 60 days)
Item
Child is not currently enrolled as a case (not previously enrolled for diarrhea within the last 60 days)
boolean
C0008059 (UMLS CUI [1,1])
C5239242 (UMLS CUI [1,2])
Presence of acute, moderate-to-severe diarrhea and/or vomiting within the past 10 days. Diarrhea is defined by the WHO as three or more liquid stools in a 24 hour period.
Item
Presence of acute, moderate-to-severe diarrhea and/or vomiting within the past 10 days. Diarrhea is defined by the WHO as three or more liquid stools in a 24 hour period.
boolean
C0546816 (UMLS CUI [1,1])
C1299393 (UMLS CUI [1,2])
C0740441 (UMLS CUI [1,3])
C0332185 (UMLS CUI [1,4])
C0679227 (UMLS CUI [2,1])
C0043237 (UMLS CUI [2,2])
C0011991 (UMLS CUI [2,3])
Diarrhea is moderate to severe, and must meet at least one of the following criteria. <dl><dd>- Sunken eyes, confirmed by parent/caretaker</dd> <dd>- Loss of skin turgor by skin pinch (≤2s slow, or >2 very slow)</dd> <dd>- IV rehydration prescribed or administered</dd> <dd>- Dysentery (1 or more bloody stools)</dd> <dd>- Evaluated in the Emergency Department or admitted to the hospital for diarrhea</dd></dl>
Item
Diarrhea is moderate to severe, and must meet at least one of the following criteria. <dl><dd>- Sunken eyes, confirmed by parent/caretaker</dd> <dd>- Loss of skin turgor by skin pinch (≤2s slow, or >2 very slow)</dd> <dd>- IV rehydration prescribed or administered</dd> <dd>- Dysentery (1 or more bloody stools)</dd> <dd>- Evaluated in the Emergency Department or admitted to the hospital for diarrhea</dd></dl>
boolean
C0011991 (UMLS CUI [1,1])
C1299393 (UMLS CUI [1,2])
C0679228 (UMLS CUI [1,3])
C0423224 (UMLS CUI [2,1])
C0521093 (UMLS CUI [2,2])
C0030551 (UMLS CUI [2,3])
C4554594 (UMLS CUI [2,4])
C4264625 (UMLS CUI [3,1])
C1123023 (UMLS CUI [3,2])
C0427081 (UMLS CUI [3,3])
C0348016 (UMLS CUI [4,1])
C0034997 (UMLS CUI [4,2])
C0278329 (UMLS CUI [4,3])
C0806914 (UMLS CUI [4,4])
C0277526 (UMLS CUI [5,1])
C0220825 (UMLS CUI [6,1])
C0562508 (UMLS CUI [6,2])
C0184666 (UMLS CUI [6,3])
Children will still be eligible for enrollment even if they have received antibiotics within the last 14 days.
Item
Children will still be eligible for enrollment even if they have received antibiotics within the last 14 days.
boolean
C1548635 (UMLS CUI [1,1])
C1516879 (UMLS CUI [1,2])
C0003232 (UMLS CUI [1,3])
C0420210 (UMLS CUI [1,4])
C0332185 (UMLS CUI [1,5])
Children who reside within the catchment area of the city Bucaramanga, Colombia and its surrounding suburbs including the municipalities of: Girón, Floridablanca y Piedecuesta. *Exclusion criteria*
Item
Children who reside within the catchment area of the city Bucaramanga, Colombia and its surrounding suburbs including the municipalities of: Girón, Floridablanca y Piedecuesta. *Exclusion criteria*
boolean
C0008059 (UMLS CUI [1,1])
C0237096 (UMLS CUI [1,2])
C3245499 (UMLS CUI [1,3])
C0557849 (UMLS CUI [1,4])
C055775 (UMLS CUI [1,5])
C0557755 (UMLS CUI [1,6])
C0680251 (UMLS CUI [2,1])
Children older than 60 months of age
Item
Children older than 60 months of age
boolean
C0001779 (UMLS CUI [1,1])
C0008059 (UMLS CUI [1,2])
Presence of chronic diarrhea (>10 days) or other co-morbid conditions such as Crohn's disease or ulcerative colitis.
Item
Presence of chronic diarrhea (>10 days) or other co-morbid conditions such as Crohn's disease or ulcerative colitis.
boolean
C0401151 (UMLS CUI [1,1])
C1275743 (UMLS CUI [1,2])
C0010346 (UMLS CUI [1,3])
C0009324 (UMLS CUI [1,4])
Children with URI symptoms including: runny nose, sneezing, cough, congestion, sore throat, and ear ache.
Item
Children with URI symptoms including: runny nose, sneezing, cough, congestion, sore throat, and ear ache.
boolean
C0008059 (UMLS CUI [1,1])
C0041912 (UMLS CUI [1,2])
C1457887 (UMLS CUI [1,3])
C0242429 (UMLS CUI [1,4])
C0010200 (UMLS CUI [1,5])
C1260880 (UMLS CUI [1,6])
C0497339 (UMLS CUI [1,7])
C0013456 (UMLS CUI [1,8])
Children who live outside of Bucaramanga and its surrounding suburbs.
Item
Children who live outside of Bucaramanga and its surrounding suburbs.
boolean
C0008059 (UMLS CUI [1,1])
C0237096 (UMLS CUI [1,2])
C0557849 (UMLS CUI [1,3])
C0557755 (UMLS CUI [1,4])
*Healthy Controls:* *Inclusion criteria:*
Item
*Healthy Controls:* *Inclusion criteria:*
boolean
C0009932 (UMLS CUI [1,1])
C1512693 (UMLS CUI [1,2])
Children who reside within the catchment area of the city Bucaramanga, Colombia and its surrounding suburbs: Girón, Floridablanca y Piedecuesta.
Item
Children who reside within the catchment area of the city Bucaramanga, Colombia and its surrounding suburbs: Girón, Floridablanca y Piedecuesta.
boolean
C0008059 (UMLS CUI [1,1])
C0237096 (UMLS CUI [1,2])
C3245499 (UMLS CUI [1,3])
C0557849 (UMLS CUI [1,4])
C055775 (UMLS CUI [1,5])
C0557755 (UMLS CUI [1,6])
Matched to cases for age. Age matching is ±2 months for 0-11 months, ±4months for 12-59 months. (Cannot exceed the stratum boundaries of the case). *Exclusion criteria:*
Item
Matched to cases for age. Age matching is ±2 months for 0-11 months, ±4months for 12-59 months. (Cannot exceed the stratum boundaries of the case). *Exclusion criteria:*
boolean
C0150103 (UMLS CUI [1,1])
C0001779 (UMLS CUI [1,2])
C5453780 (UMLS CUI [1,3])
Diarrhea, as defined by the WHO, in the previous 7 days (regardless of whether they develop diarrhea after enrollment).
Item
Diarrhea, as defined by the WHO, in the previous 7 days (regardless of whether they develop diarrhea after enrollment).
boolean
C0011991 (UMLS CUI [1,1])
C0679227 (UMLS CUI [1,2])
C0332185 (UMLS CUI [1,3])
Children older than 60 months of age
Item
Children older than 60 months of age
boolean
C0008059 (UMLS CUI [1,1])
C0001779 (UMLS CUI [1,2])
Presence of chronic diarrhea (>10 days) or other co-morbid conditions such as Crohn's disease or ulcerative colitis.
Item
Presence of chronic diarrhea (>10 days) or other co-morbid conditions such as Crohn's disease or ulcerative colitis.
boolean
C0401151 (UMLS CUI [1,1])
C1275743 (UMLS CUI [1,2])
C0010346 (UMLS CUI [1,3])
C0009324 (UMLS CUI [1,4])
Children who live outside of Bucaramanga and its surrounding suburbs.
Item
Children who live outside of Bucaramanga and its surrounding suburbs.
boolean
C0008059 (UMLS CUI [1,1])
C0557849 (UMLS CUI [1,2])
C0557755 (UMLS CUI [1,3])
C0237096 (UMLS CUI [1,4])
*Rationale for Exclusion/Inclusion Criteria:* Children from outlying municipalities will be included in this study because the volume of children with diarrhea at the central study site, Universidad de Santander, is not sufficient for the purposes of this study to not utilize outlying health care facilities. The population distribution is equitable between these two locations in terms of socioeconomic factors and there is not transportation limitation between the two. The suburbs have access to pediatricians and health clinics, so no sampling bias will be introduced by including this population.
Item
*Rationale for Exclusion/Inclusion Criteria:* Children from outlying municipalities will be included in this study because the volume of children with diarrhea at the central study site, Universidad de Santander, is not sufficient for the purposes of this study to not utilize outlying health care facilities. The population distribution is equitable between these two locations in terms of socioeconomic factors and there is not transportation limitation between the two. The suburbs have access to pediatricians and health clinics, so no sampling bias will be introduced by including this population.
boolean
C2827031 (UMLS CUI [1,1])
C0008059 (UMLS CUI [1,2])
C0600182 (UMLS CUI [1,3])
C1512693 (UMLS CUI [1,4])
C4035618 (UMLS CUI [1,5])
C0018704 (UMLS CUI [1,6])
C0032666 (UMLS CUI [2,1])
C0205163 (UMLS CUI [2,2])
C0037464 (UMLS CUI [2,3])
C1298908 (UMLS CUI [2,4])
C4534518 (UMLS CUI [2,5])
C0557755 (UMLS CUI [3,1])
C0444454 (UMLS CUI [3,2])
C0237433 (UMLS CUI [3,3])
C0035960 (UMLS CUI [3,4])
C1298908 (UMLS CUI [3,5])
C0005349 (UMLS CUI [3,6])
C1512693 (UMLS CUI [3,7])
C1257890 (UMLS CUI [3,8])
In prior studies, antibiotic use has been used as exclusion criteria for cases. The rationale for this has been primarily for the benefit of the research team. That is, in patients with prior antibiotic use bacterial species, such as E. coli, are very difficult to culture (and thus may skew the data). However, the most commonly used antibiotics in Colombia are older and include ampicillin, bactrim, and first generation penicillins. Since there is high resistance among E. coli strains for these antibiotics, we feel that their use will not necessarily prevent use from recovering these bacteria in laboratory culture.
Item
In prior studies, antibiotic use has been used as exclusion criteria for cases. The rationale for this has been primarily for the benefit of the research team. That is, in patients with prior antibiotic use bacterial species, such as E. coli, are very difficult to culture (and thus may skew the data). However, the most commonly used antibiotics in Colombia are older and include ampicillin, bactrim, and first generation penicillins. Since there is high resistance among E. coli strains for these antibiotics, we feel that their use will not necessarily prevent use from recovering these bacteria in laboratory culture.
boolean
C0332152 (UMLS CUI [1,1])
C0240320 (UMLS CUI [1,2])
C0003232 (UMLS CUI [1,3])
C2828389 (UMLS CUI [1,4])
C0814225 (UMLS CUI [2,1])
C0035168 (UMLS CUI [2,2])
C0871489 (UMLS CUI [2,3])
C3695179 (UMLS CUI [2,4])
C0002680 (UMLS CUI [3,1])
C0591139 (UMLS CUI [3,2])
C0030842 (UMLS CUI [3,3])
C0949669 (UMLS CUI [4,1])
C0430402 (UMLS CUI [4,2])